Nonspecific response of Lake Baikal phytoplankton to anthropogenic impact by A. A. Nikonova, S. S. Vorobyeva

“…The presence of these substances in a water ecosystem can result in exhausting of phytoplankton cell resources, homeostasis imbalance, stress, pathological changes, and rearrangements in phytoplankton assemblage.…”
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Breeding results for Echinacea purpurea (L.) Moench in Moscow Province by I. N. Korotkikh, E. Yu. Babaeva, A. E. Burova

“…Preparations from crude herbal materials of E. purpurea have a widerange effect against pathologies of the immune system, infectious and inflammatory diseases of the respiratory tract, genitourinary system and musculoskeletal system. …”
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Transplantation of mitochondria from human malignant tumor cells as a method of tumor growth formation in the lungs of laboratory animals by O. I. Kit, E. M. Frantsiyants, A. I. Shikhlyarova, I. V. Neskubina

“…Multinucleated cells, as well as pathological mitoses with clearly marked division figures, which testified to their proliferative activity, were encountered with a rather high frequency.Conclusions. …”
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Antimicrobial Resistance Genes in Clinical <i>Escherichia coli</i> Strains from Livestock and Poultry in Shandong Province, China During 2015–2020 by Miaoli Wang, Shaopeng Wu, Yao Wang, Feng Chen, Zhangqi Shen, Zouran Lan

“…<b>Objective:</b> The aim of this study was to explore the genetic characteristics, co-occurrence, and correlations between ARGs of <i>E. coli</i> isolated from the pathological tissues of livestock and poultry in Shandong Province, East China during 2015–2020. …”
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Machine learning for predicting neoadjuvant chemotherapy effectiveness using ultrasound radiomics features and routine clinical data of patients with breast cancer by Pu Zhou, Pu Zhou, Hongyan Qian, Pengfei Zhu, Jiangyuan Ben, Jiangyuan Ben, Guifang Chen, Qiuyi Chen, Lingli Chen, Jia Chen, Ying He, Ying He

“…BackgroundThis study explores the clinical value of a machine learning (ML) model based on ultrasound radiomics features of primary foci, combined with clinicopathologic factors to predict the pathological complete response (pCR) of neoadjuvant chemotherapy (NAC) for patients with breast cancer (BC).MethodWe retrospectively analyzed ultrasound images and clinical information from 231 participants with BC who received NAC. …”
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Estudio genético en adultos con glomeruloesclerosis focal y segmentaria by Melissa Pilco-Terán, Amir Shabaka, Mónica Furlano, Ana Tato Ribera, Isabel Galán Carrillo, Eduardo Gutiérrez, Roser Torra, Gema Fernández-Juárez

“…Abstract: Focal segmental glomerulosclerosis (FSGS) is a histological pattern of injury that derives from various pathological processes that affect podocytes, resulting in loss of selectivity of the glomerular filtration membrane, proteinuria and the development of renal failure that progresses to end-stage kidney disease in a significant number of patients. …”
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Healthcare practitioners as accomplices: a qualitative study of gender affirmation in a context of ambiguous regulation in Indonesia by Benjamin Hegarty, Alegra Wolter, Amalia Puri Handayani, Kevin Marian, Jamee Newland, Dede Oetomo, Ignatius Praptoraharjo, Angela Kelly-Hanku

“…Conclusions An empirical study based on an “ethics from below” helps to show that arguments grounded in autonomy, or based on biomedical evidence, are unlikely to alter unjust laws or facilitate a change to pathologizing guidelines governing understanding of trans people’s healthcare and legal needs in Indonesia. …”
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Clinicopathological characteristics and survival outcomes of women aged ≤45 and >45 years with endometrial adenocarcinoma in tertiary referral hospital: a 21-year cohort study by Tarinee Manchana, Pinyada Panyavaranant, Juthamas Rattanachaipipat

“…Among the population, 188 patients (16.9%) were ≤45 years old and 926 patients (83.1%) were &gt;45 years old.Outcome measures The primary outcome measures were disease-free survival (DFS) and overall survival (OS) at 5, 10 and 15 years, with an analysis of survival rates based on patient age groups and prognostic factors.Results Younger patients (≤45 years) displayed significantly higher rates of obesity, nulliparity and polycystic ovary syndrome (PCOS), as well as favourable pathological characteristics such as well-differentiated tumours and lower rates of myometrial invasion. …”
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Correction of Dysbiosis in Diversion Proctitis: Possibilities of Intraluminal Sanitation and the Prevention of Complications after Reconstructive Surgery by V. S. Groshilin, D. V. Martynov, Yu. L. Naboka, M. Yu. Bakulyarov, G. A. Mrykhin

“…Rifaximin-α (Alpha Normix®) intolerance and pathological reactions associated with its use were not observed. …”
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Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…On the 18th day animals in groups M and H were induced by LPS (10 mg/kg).ResultsThe results showed the weight of mice in group MH significantly dropped (P &lt; 0.0001), while mice in the PK group had a higher weight (P &lt; 0.01). Pathological analysis found that the majority of the villi in mice induced by LPS were broken and short, while PK-treated animals had longer and considerably integrated villi. …”
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Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes by LIN Qin, ZHU Yingkai, LIN Yanming, LAN Shujie, CHEN Changxing, FU Changlong

“…In vitro experiments, Lenti-lncRNA GAS5 was used to infect sodium nitroprusside (SNP)-induced chondrocytes, and the expression of lncRNA GAS5 was detected by fluorescence in situ hybridization in rat chondrocytes; after silencing of lncRNA GAS5, the expression level of lncRNA GAS5 in rat chondrocytes was detected by Real-time PCR; Western blot detected the protein levels of Caspase-3, Bax, MMP-13 and Cyt-C.Results① Pathological changes of cartilage tissue: The articular cartilage matrix in naringenin group was relatively complete, the surface was relatively smooth, the structure was clear, the tide line was more complete, the number of chondrocytes was more full, the arrangement was more orderly, the cartilage staining was more uniform, and the structure was significantly restored than that in the model group. ② lncRNA GAS5 expression in cartilage tissue: Compared with model group, lncRNA GAS5 expression in naringin group was decreased (<italic>P</italic>&lt;0.01). ③ Expression of proteins related to mitochondrial apoptosis in cartilage tissues: Compared with model group, the expressions of Caspase-3, Bax, MMP-13 and Cyt-C in cartilage tissues of naringin group were decreased (<italic>P</italic>&lt;0.01). ④ Fluorescence expression of lncRNA GAS5 in chondrocytes: FISH results showed that the fluorescence expression of lncRNA GAS5 was decreased after naringin treatment of SNP-induced chondrocytes (<italic>P</italic>&lt;0.01). ⑤ The protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in chondrocytes: Compared with the model group, the protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in naringin group were significantly decreased (<italic>P</italic>&lt; 0.01). …”
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Analyzing Serum Level Changes in Dehydroepiandrosterone Sulfate, Dihydrotestosterone, Progesterone, and Prolactin after Radioactive Iodine Treatment for Papillary Thyroid Carcinoma by Mehrosadat Alavi, Mohammad Atefi, Farzaneh Raeisi

“…Introduction: Effective treatment of papillary thyroid carcinoma (PTC) is total thyroidectomy which is followed by radioactive iodine therapy (RIT) to ablate pathologic thyroid remnants and treat metastatic tumors. …”
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Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro by Yuanyuan Sun, Dadong Guo, Bin Liu, Xuewei Yin, Huixia Wei, Kai Tang, Hongsheng Bi

“…Further, the inflammatory manifestation of the anterior segment and pathological examination of the eye were explored in experimental autoimmune uveitis (EAU) rats. …”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…Tau protein aggregation, a key pathological feature of AD, is closely associated with neurodegeneration and cognitive decline. …”
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Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…Conversely, the administration of colchicine negatively correlated to the development of pathologic proteinuria (p<0.05). Both NSAIDs and colchicine were used as monotherapy more frequently in the LP group compared to the HP group (p<0.01). …”
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Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analys... by Catey Bunce, Gwyn Samuel Williams, David Owens, Wen Xing, Rhianon Reynolds, Antra Zekite, Declan Flanagan, RL Thomas, Rebecca John

“…This analysis included all causes, and where both the main cause was diabetic eye disease or where diabetic eye disease was a contributory cause among multiple pathologies. Poisson regression was employed to analyse changes in trends over time for certifications of vision impairment.Results In England, from 2010 to 2020, there was a small but significant reduction (p&lt;0.001) in the overall rate of certifications for SI and SSI due to any cause, from 43.4 certifications per 100 000 people to 41.7 per 100 000 people. …”
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

“…Puerarin also ameliorated hepatic pathological changes and inflammatory responses, and attenuated oxidative stress and iron overload in KKAy mice. …”
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Fabry cardiomyopathy: Gb3‐induced auto‐reactive panmyocarditis requiring heart transplantation by Andrea Frustaci, Maurizio Scarpa, Rosalia Maria da Riol, Chiara Agrati, Nicoletta Finato, Romina Verardo, Claudia Grande, Cristina Chimenti, Concetta Di Nora, Matteo Antonio Russo, Ugolini Livi

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Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

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Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, follo... by G. Menardi, A. Castellino, C. Castellino, M. E. Bersia, E. Grande, G. Fraternali, M. Massaia, C. Fruttero

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