The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives by Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang

“…This review explores the multifaceted roles of TRIM proteins in IVDD, highlighting their contributions to pathological pathways and their potential as therapeutic targets. …”
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THE USE OF ANTIBIOTICS IN THE DENTAL FIELD – THE PHENOMENON OF ANTIBIOTIC RESISTANCE by Alina Anton, Iasmina Alexandra Predescu, Nuca Cristina, Mariana Păcurar, Ștefania Dinu

“…Phytotherapy represents an undeniable source of therapeutic solutions for various pathologies, including bacterial contamination. Thus, the effect of antimicrobial resistance can be reduced by replacing common antibiotics with phytocompounds, if this switch is admissible.…”
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Unilateral reexpansion pulmonary edema (clinical observations) by Oleg I. Nikitin, Aracbathinia O. Khalimalova, Andrey L. Yudin, Elena A. Yumatova

“…These complications have developed as a consequence of rapid evacuation of the pathological content from the pleural cavity. CONCLUSION: Reexpansion pulmonary edema is a rare, though potentially life-threatening condition, which usually occurs as a result of rapid expansion of long-term collapsed lung, for example, in cases of pneumothorax and pleural effusion. …”
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A Curious Case Report of “Nosey” Calcification by S Padmavathi, G Anuradha, A Kannan, C L Krithika

“…Ectopic mineralization, or pathologic calcifications, occur outside the skeletal system. …”
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Role of serotonin in physiology and diseases of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…To analyze the information published in scientific literature on a role of serotonin in regulation of structural homeostasis of gastro-intestinal tract (GIT) organs, realizations of compensatory-adaptive and pathological processes at ulcerogenesis in gastroduodenal zone.Original positions. …”
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Positive Psychotherapy in action: the “DYNAMICS” method for formulating basic conflicts by Ali Eryilmaz

“…With this method, clients realize their unmet needs and how they create pathological and healthy patterns to meet these needs. …”
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Study on the Dynamics of Cortisol Secretions in Hypertensive Elderly Patients by Doina Carstea, Diana-Maria Trasca, A. P. Carstea, E. T. Trasca

“…Ageing is defined as a slow, irreversible process of cellular changes, that are due to a lack of balance between degradation and repair, a continuous interaction between physiological and pathological processes. Physiological aspects in elderly people are often confused with disease. …”
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Biomarkers for Hepatocellular Carcinoma by Tara Behne, M. Sitki Copur

“…Increased understanding of cancer biology and technological advances have enabled identification of a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis leading to discovery of numerous potential biomarkers in this disease. …”
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Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease by Yu-Hong Fan, Siyao Zhang, Ye Wang, Hongni Wang, Hongliang Li, Hongliang Li, Hongliang Li, Lan Bai

“…This disease is closely associated with metabolic disorders driven by overnutrition, with key pathological processes including lipid dysregulation, impaired lipid autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and local inflammation. …”
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Diagnostic challenges in differentiating mediastinal tuberculosis from mediastinal tumors: A case report by Aida, Noni Novisari Soeroso, Herani Mutia Riandini

“…This case underscores the importance of comprehensive diagnostic evaluation, including histopathological and microbiological tests, to distinguish TB from other mediastinal pathologies and ensure appropriate treatment.…”
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Research on full-field optical coherence tomography by Ning MU, Wan-rong GAO, Zhe-qiang WEI

“…Full-field optical coherence tomography(FFOCT)was used for imaging the interior part of an object.Firstly，the mathematical modeling and performance analysis of the FFOCT system mounted was provided.Secondly，images of several different human tissues were obtained by FFOCT system，including esophagus，uterus，etc.The images of different depths of the same tissue were shown and compared.It was the first time in China that FFOCT was used for generating depth images on human esophagus and uterus;high-resolution images had been obtained for different depths without cutting the tissue sample，in which intercellular substance and myofibril structure could be clearly identified.As the in-depth structure could be imaged without the process needed for frozen and paraffin sectioning methods，the technology could been highly valuable for early cancer diagnosis and pathological analysis in tumor research.…”
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Hyperresponsiveness in the Human Nasal Airway: New Targets for the Treatment of Allergic Airway Disease by P. J. Turner, J. C. Foreman

“…Allergic rhinitis is a condition which affects over 15% of the population in the United Kingdom. The pathological process involves two stages: nasal inflammation, and the development of nasal airway hyperresponsiveness (AHR) to allergen and a number of other stimuli. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS. The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.…”
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Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, although studies that utilize both methods often result in equivocal findings, possibly due to variability in cognitive test performance that may be capturing distinct phenotypes. …”
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Physiopathology of Bone Modifications in β-Thalassemia by Carlo Perisano, Emanuele Marzetti, Maria Silvia Spinelli, Cinzia Anna Maria Callà, Calogero Graci, Giulio Maccauro

“…β-thalassemia major (βTM) or Cooley anemia is characterized by significantly reduced or absent synthesis of β-globin chains, which induces important pathologic consequences including hemolytic anemia, altered erythropoiesis, and bone marrow overstimulation. …”
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ArterioVenous Malformation within Jejunal Diverticulum: An Unusual Cause of Massive Gastrointestinal Bleeding by Jeffrey K. Lee, John M. Carethers, Pradipta Ghosh

“…We report a case of massive gastrointestinal bleeding from an arteriovenous malformation (AVM) within a jejunal diverticulum to underscore the significance of such coexisting pathologies. Mesenteric angiogram was chosen to help identify the source of bleeding and to offer an intervention. …”
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The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer by Xiaosi Gu, Xin Hu, Sijia Zhang, Xiaoyu Zhang, Yong Wang, Lianlian Li, Lianlian Li

“…HOXC13 antisense RNA (HOXC13-AS, also known as HOXC-AS5) is a long non-coding RNA that is expressed abnormally in various types of tumors and is closely related to clinical staging, clinical pathological features, and patient survival. HOXC13-AS is involved in the occurrence and development of tumors, affecting cell proliferation, migration, invasion, epithelial–mesenchymal transition, and tumor growth. …”
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Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? by Eduardo Mansilla, Vanina Díaz Aquino, Daniel Zambón, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H. Riordan, Amit Patel, Flavio Sturla, Gustavo Larsen, Rubén Spretz, Luis Núñez, Carlos Soratti, Ricardo Ibar, Michiel van Leeuwen, José María Tau, Hugo Drago, Alberto Maceira

“…This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. …”
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Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. by Shi-Hsia Hwa, Yock Ann Lee, Joseph N Brewoo, Charalambos D Partidos, Jorge E Osorio, Joseph D Santangelo

“…A toxicology study of the vaccine formulations planned for human use performed in rabbits showed no vaccine-related pathological changes and all animals remained healthy. …”
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Diagnosis and Management of Pulmonary Arterial Hypertension by Jeanne Houtchens, Douglas Martin, James R. Klinger

“…Right heart catheterization with vasodilator challenge is critical to the proper assessment of pulmonary hemodynamics and to determine whether patients are likely to benefit from vasodilator therapy. Pathologically, the disease is characterized by deleterious remodeling of the distal pulmonary arterial and arteriolar circulation, which results in increased pulmonary vascular resistance. …”
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