Jejunal Intussusception: A Rare Presentation of Carcinoid Tumor by Umashankkar Kannan, Amir A. Rahnemai-Azar, Ashish N. Patel, Vinaya Gaduputi, Ajay K. Shah

“…The involved small bowel segment was resected with primary anastomosis and liver was biopsied. Pathological examination showed multifocal deposits of well-differentiated carcinoids in the jejunum. …”
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Electrolyte disorders in athletes by Michał Rogulski, Yauheniya Patarocha, Aleksandra Ślusarska, Jolanta Mędyk, Paulina Błasiak, Małgorzata Wirkijowska, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski

“…Moreover, it was scientifically proven that one of the reasons for the development of muscle cramps (EAMC) and hyponatremia (EAH) is electrolyte imbalance.That is why, we create this systematic review in order to report extensively on the role of electrolyte consumption in endurance and ultra-endurance athletes, the connection between the quantity consumed and the development of pathological disorders, the effectiveness of concurrent hydration, and whether an imbalance of this substance contributes to EAH and EAMC. …”
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HUBUNGAN EKSPRESI NEGATIF MLH-1 DENGAN GAMBARAN KLINIKOPATOLOGIK KARSINOMA KOLOREKTAL by Selly Alinta Syukri, Tofrizal Tofrizal, Aswiyanti Asri, Salmiah Agus

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Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders by Emanuela Castiglioni, Dario Finazzi, Stefano Goldwurm, Gianni Pezzoli, Gianluca Forni, Domenico Girelli, Federica Maccarinelli, Maura Poli, Maurizio Ferrari, Laura Cremonesi, Paolo Arosio

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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…Diabetic plasma sEV significantly activated cardiac caspase 9 but not caspase 8, suggesting that diabetic sEV induces cardiac apoptosis via the mitochondrial pathway. These pathologic alterations were phenotyped by intramyocardial injection of sEV isolated from diabetic adipocytes or HGHL-challenged 3T3L1 adipocytes. …”
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Retrospective analysis of amantadine response and predictive factors in intensive care unit patients with non-traumatic disorders of consciousness by Corinna Blum, Constanze Single, Kornelia Laichinger, Anna Hofmann, Tim W. Rattay, Tim W. Rattay, Kamaldeen Adeyemi, Reimer Riessen, Michael Haap, Helene Häberle, Ulf Ziemann, Annerose Mengel, Katharina Feil

“…Higher premorbid mRS, and pathological cerebral imaging were key predictors of non-response, offering potential avenues for patient selection and treatment customization. …”
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Thyroid cancer survival and prognostic factors in Yantai, China (2012–2022): a population-based study by Haiyun Liu, Shuxia Zhang, Xiaohui Liu, Qianqian Wang, Hongjie Zhang, Weihong Cui

“…Disparities in the OS of thyroid cancer patients were found across different diagnosis periods, genders, age groups, places of residence, occupational classes, tumor sites and sizes, cervical lymph node metastasis statuses, TgAb levels, pathological types, clinical stages and treatment timings (all p < 0.05). …”
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Crocin Alleviates Hippocampal Neuron Injury in Rats with Cerebral Ischemia-Reperfusion by Inhibiting JAK2/STAT3 Signaling Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, YAO Li, HU Ke, FENG Lina, WANG Xudong

“…The cerebral infarction rate was detected using TTC staining. The neuron pathological changes of hippocampal CA1 and CA3 were observed using HE staining, and the neuronal apoptosis of hippocampal CA1 and CA3 was examined by TUNEL staining. …”
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Effects of Electroacupuncture Preconditioning at Baihui and Zusanli Acupoints on the Expression of Inflammatory Factors in Brain and Intestines of Rats with Cerebral Ischemia/Reper... by ZHANG Jiyao, TANG Qiang, ZHU Luwen

“…Before surgery for one day, after reperfusion for 12 h and after reperfusion for 1,3,7 days, the grip tester was used to measure the forelimb grasping strength; after reperfusion for 7 days, ELISA methods was used to determine the content of IL-17A and IL-10 in serum, Western blot method was used to detect the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue, immunohistochemistry method was used to calculate the average optical density (AOD) value of IL-17A and IL-10 in ischemic cortex and colon tissue, and HE staining method was used to observe the pathological change of ischemic cortex.Results① Forelimb grasping strength: compared with the S-con group, the forelimb grasping strength of rats in the M-con group after reperfusion for 12 h, 1 d, 3 d, 7 d was decreased significantly (<italic>P</italic>&lt;0.05); compared with the M-con group, the forelimb grasping strength of rats in the EP group was increased significantly (<italic>P</italic>&lt;0.05). ② Content of IL-17A and IL-10 in serum: after reperfusion for 7 days , compared with the S-con group, the content of serum IL-17A and IL-10 of rats in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the content of serum IL-17A in the EP group were significantly decreased (<italic>P</italic>&lt;0.05), and IL-10 in the EP group were significantly increased (<italic>P</italic>&lt;0.05). ③ Expression of IL-17A and IL-10 protein: after reperfusion for 7 days, compared with the S-con group, the expression of IL-17A and IL-10 protein in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the expression of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), and the expression of IL-10 protein in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ④ AOD value of IL-17A and IL-10: after reperfusion for 7 days, compared with the S-con group, the AOD value of IL-17A and IL-10 in ischemic cortex and colon tissue in the M-con group were significantly increased (<italic>P</italic>&lt;0.05); compared with the M-con group, the AOD value of IL-17A in the EP group was significantly decreased (<italic>P</italic>&lt;0.05), the AOD value of IL-10 in the EP group was significantly increased (<italic>P</italic>&lt;0.05). ⑤ Pathological change of ischemic cortex: after reperfusion for 7 days, compared with the M-con group, the pathological change of ischemic cortex in EP group was significantly decreased (<italic>P</italic>&lt;0.05).ConclusionElectroacupuncture preconditioning at Baihui and Zusanli acupoints can reduce the pathological damage degree of the ischemic cortex and intestinal-central inflammation, improve neurobehavioral function, which may be related to brain-gut protection.…”
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Interferon‐β–Induced Injury During Pediatric Muscle Differentiation: Insight Into Juvenile Dermatomyositis Pathogenesis by Lauren T. Covert, Alaa Osman, George A. Truskey

“…These findings implicate a pathologic role for IFNβ in JDM by impairing myoblast differentiation, leading to subsequent loss of function and ongoing need for muscle regeneration and repair.…”
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Surgery versus concurrent chemoradiotherapy for stage III non-small cell lung cancer: a retrospective study with propensity score matching by Takao Shigenobu, Yuri Taniguchi, Takahiro Suzuki, Yuya Tabuchi, Mizuki Sato, Kazumasa Odagiri, Yukiko Nakamura, Tsuneo Shimokawa, Hiroaki Okamoto, Akira Yoshizu

“…We analyzed patients with pathological stage III NSCLC who underwent complete surgical resection and those with clinical stage III NSCLC who underwent definitive cCRT. …”
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Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors by Estela Regina Ramos Figueira, Julia Fray Ribeiro, Thiago Costa Ribeiro, Ricardo Jureidini, Guilherme Naccache Namur, Thiago Nogueira Costa, Telesforo Bacchella, Ivan Cecconello

“…The incidence of postoperative complications was 42.86%, the 30-day mortality was zero, and the length of follow-up was 3.31±3.0 years. The results of pathological evaluations revealed WHO grade I in 42.86% of cases, II in 21.43%, and neuroendocrine carcinoma in 35.71%. …”
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The impact of Sudafed on spleen of albino mice by L. Alsaadi Yasmin, K. Abdul Ameer Bassam, Jasim Mohamad Ban, Kathum Omra Faiza

“…While less powerful effects or no detectable pathological alterations were seen at lower doses (125, 62.52, and 31.24 mg/Kg). …”
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Treatment with Herbal Formula Extract in the hSOD1G93A Mouse Model Attenuates Muscle and Spinal Cord Dysfunction via Anti-Inflammation by Eun Jin Yang, Sun Hwa Lee, Mudan Cai

“…Amyotrophic lateral sclerosis (ALS), a multicomplex neurodegenerative disease, has multiple underlying pathological factors and can induce other neuromuscular diseases, leading to muscle atrophy and respiratory failure. …”
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Association between adiponectin single nucleotide polymorphisms and the risk of diabetic polyneuropathy by Noha M. Bakr, Noha A. Hashim, Nevin F. Ibrahim, Sara F. Saadawy

“…Contrariwise, the + 276 TT genotype carriers had lower mean values for the same clinic-pathological features. For the T allele carriers, the same results were observed in case of duration of the disease and TCSS value. …”
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Adjuvant chemotherapy followed by concurrent chemoradiation is associated with improved survival for resected stage I‐II pancreatic cancer by Sung Jun Ma, Gregory M. Hermann, Kavitha M. Prezzano, Lucas M. Serra, Austin J. Iovoli, Anurag K. Singh

“…Conclusion This NCDB study using propensity score matched analysis suggests an OS benefit for C + CRT compared to C or CRT alone following surgical resection of pancreatic cancer, particularly for patients with pathologically positive lymph nodes.…”
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Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…Tumor height from the anal verge, pathological T4 disease, pathological stage III/IV, positive perineural invasion, and R1 resection were significant risk factors for LR in multivariable analysis. …”
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Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets by Lianying Cheng, Xiaofeng Rong

“…Methods RA clinical samples from patients with different pathological processes were collected, and the correlations between the subsets of FLSs and STMs and pathological processes were analyzed via flow cytometry. …”
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Automatic assessment of nailfold capillaroscopy software: a pilot study by Olga Elżbieta Brzezińska, Krzysztof Andrzej Rychlicki-Kicior, Joanna Samanta Makowska

“…The sensitivity of the automatic tool relative to manual assessment in classification of correct vs. pathological images was 89.0%, specificity 89.4% for the training group, in validation 89.0% and 86.9% respectively. …”
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Risk Factors Associated with Breast Cancer in Women in a Health Area by Naifi Hierrezuelo Rojas, Mileidy Cordoví Hierrezuelo, Naiovis Neira Hierrezuelo

“…<br /><strong>Results:</strong> age over 60 years (OR=3.47), personal pathological history (OR=3.83), early menarche (OR=5.65), late menopause (OR=5.16), abandonment of breastfeeding (OR=6.59), smoking (OR=8.28) and obesity (OR=7.21) were associated with the appearance of breast cancer. …”
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