Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma by Yuan Tian, Qun Zhao, Yong Li, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Bibo Tan, Dong Wang, Peigang Yang

“…A total of 93, 92, and 95 patients were enrolled in the DOX, XELOX, and surgery groups, respectively. The pathological complete response (pCR) rate was 16.1% in the DOX group and 4.3% in the XELOX group (P=0.008). …”
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Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy by Qiaoyun Gong, Jia’nan Xie, Yang Liu, Ying Li, Guanfang Su

“…The pathological mechanisms of diabetic retinopathy (DR), a leading cause of blindness in adults with diabetes mellitus, remain incompletely understood. …”
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Specific Features of Mental Health of Law Enforcement Officers – Participants of the Anti-Terrorist Operation by O. I. Kudermina

“…Law enforcement officers, who received psychological assistance in connection with clear features of post-traumatic disorder, on the background of significant reduction of psycho-pathological symptoms, there is tendency to socially approved behaviors, while emotional limitation – “insensitivity”, is formed, which is evidenced for the need to conduct psychological rehabilitation with them. …”
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Conjugation of Short-Chain Fatty Acids to Bicyclic-Amines for Analysis by Liquid Chromatography Tandem Mass Spectroscopy by Daniel N. Darlington

“…Because SCFAs are an index of microbiome diversity in the gastrointestinal track, this method will allow us to study changes in SCFAs and the microbiome in pathologic conditions including trauma, hemorrhage, and sepsis.…”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…PPAR-alpha activation by fenofibrate reverts some of the effects caused by these pathologies. Recently, nonclassical RAS components have been implicated in the pathogenesis of hypertension and myocardial dysfunction; however, their cardiac functions are still controversial. …”
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UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation by Li Long, Lei Wang, Yiran Liang, Fangzhou Ye, Yuhan Jin, Dan Luo, Xiaoyan Li, Yajie Wang, Yaming Li, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Qifeng Yang

“…Additionally, findings from our cohorts indicated that higher levels of UGCG expression correlated with a lower rate of pathological complete response (pCR), suggesting it could serve as an independent predictor of chemotherapy effectiveness. …”
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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

“…Abstract Chikungunya virus (CHIKV) is a mosquito‐borne alphavirus that is primarily known for causing severe joint and muscle symptoms, but its pathological effects have extended beyond these tissues. …”
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Hybridization of Aminoadamantanes with Cinnamic Acid Analogues and Elucidation of Their Antioxidant Profile by Maya Chochkova, Almira Georgieva, Tsvetelina Ilieva, Madlena Andreeva, Georgi Pramatarov, Nejc Petek, Petranka Petrova, Martin Štícha, Yavor Mitrev, Jurij Svete

“…Thus, these promising antioxidants could have beneficial effects in various pathological conditions, where oxidative stress is implicated.…”
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Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide by Tiago Venancio da Silva, André Luiz do Nascimento Silva, Karine Nathiele Nogueira Farias, Carla Leticia Gediel Rivero Wendt, Lucas de Oliveira Brasileiro, Edilaine Fogaça, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco-Belussi, Carlos Eurico S. Fernandes

“…We sought to identify pathological changes and compare liver histometric remodeling in fish subjected to acute and chronic toxicity tests. …”
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Pancreatoduodenectomy for Periampullary Tumors Presenting with Acute Pancreatitis by Xuefeng Cao, Xixiu Wang, Xiaoliang Xu, Yanmin Lu, Baolei Zhao, Xingyuan Zhang, Qiangpu Chen

“…A retrospective review of clinical, radiological, surgical, and pathological data was conducted for patients admitted to the Binzhou Medical University Hospital during the period from January 2010 to December 2017, for AP or ARP caused by PT. …”
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Protective effect of exercise on animals with sepsis: a systematic review of the existing literature by Na Yang, Nan Jiang, Chunming Shen, Ming Gao, Qian Tong, Jian Sun

“…And its possible mechanisms were involved improving the general condition of sepsis animals, pathological and cell number of organs, anti-inflammation, anti-oxidative stress, anti-DNA damage, and so on. …”
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Mucosal snare resection-endoscopic submucosal excavation for gastric submucosal tumors: a retrospective study (with video) by Wei Wei, Xiaolong Zheng, Yongli Ye, Hongxia Li, Yiping Hong, Jianting Cai

“…Factors such as operation time, intraoperative perforation, postoperative adverse events, postoperative fasting time, antibiotic use, hospitalization duration, costs, and pathological diagnosis were compared between the two procedures.ResultsA total of 180 patients with submucosal tumors were included in this study. …”
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FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2 by Kongyan Zhang, Fei Zhang, Jiahe Wang

“…Results An upregulation of FTO was observed in colon cancer through data mining and analysis of pathological specimens. Besides, we discovered that the impact of FTO on colon cancer glycolysis has significant implications for colon proliferation, invasion, and metastasis. …”
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ASSOCIATION BETWEEN CHRONIC APICAL PERIODONTITIS AND OXIDATIVE STRESS OR META-INFLAMMATION: A CROSS-SECTIONAL OBSERVATIONAL STUDY by Antonia Boca, Ada Delean, Sanda Ileana Cîmpean, Adina Bianca Boșca, Cosmina Ioana Bondor, Sebastian Candrea, SALIVAGES Project group, Aranka Ilea

“…However, its cumulative effect with other associated pathologies could impact the overall modulation of the inflammatory response and general homeostasis. …”
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Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis by Li Zhang, Runlin Xing, Zhengquan Huang, Nongshan Zhang, Li Zhang, Xiaochen Li, Peimin Wang

“…To conclude, synovial macrophage pyroptosis may occur in the pathological processes of KOA and inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in KOA model rats.…”
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Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera) by Andrea Becchimanzi, Giovanna De Leva, Rosanna Mattossovich, Serena Camerini, Marialuisa Casella, Giovanni Jesu, Ilaria Di Lelio, Sabrina Di Giorgi, Joachim R. de Miranda, Anna Valenti, Silvia Gigliotti, Francesco Pennacchio

“…Among the co-immunoprecipitated proteins, one of the most interesting was arginine kinase (ArgK), a conserved protein playing multiple roles both in physiological and pathological processes and stress response in general. …”
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NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…Taken together, these data indicate that NR2A receptor activation may be important in limiting Tau phosphorylation by a PKC/GSK3β pathway and strengthen the idea that these receptors might act as an important molecular device counteracting neuronal cell death mechanisms in various pathological conditions.…”
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Survival and prognostic factors among different types of liposarcomas based on SEER database by Jiaqi Zhao, WenLi Du, XiaoLiang Tao, AiAi Li, Yi Li, Shuai Zhang

“…Male gender, higher pathological grade, and primary tumor sites outside the extremities were identified as risk factors for the prognosis of subtypes other than pleomorphic liposarcoma. …”
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Molecular Subtypes of Breast Carcinoma and Their Association with Clinicopathological Features by Ambreen Bari, Sumayyah Shawana

“…The study identified pT2 and pT3 as the most frequent pathological stages, with 74 cases (38.1%) and 71 cases (34.4%), respectively. …”
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms by Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu

“…Comprehensive understanding on changes of gut microbiota during aging, in particular gut microbiota characteristics of centenarians, can provide us possibility to achieving healthy aging or intervene pathological aging through gut microbiota-directed strategies. …”
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