Nomogram models for predicting outcomes in thyroid cancer patients with distant metastasis receiving 131iodine therapy by Shui Jin, Xuemei Ye, Ting Ye, Xinyu Chen, Jianfeng Ji, Jinyu Wang, Xin Zhu, Xiaochun Mao, Takahiro Higuchi, Heqing Yi

“…The training and validation sets included 288 and 124 patients, respectively. Pathological type, first 131I administrated activity, and lesion 131I uptake in lesions were independent predictors for PFS. …”
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Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of <i>Dendrobium officinale</i> Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immuno... by Shengchang Tao, Huan Wang, Qiufeng Ji, Yushan Yang, Gang Wei, Ruiming Li, Benjie Zhou

“…The results of the pathological histology assay and qRT-PCR analysis verified the findings of the integrated metabolomics and transcriptomics analysis. …”
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Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections by Yuehan Ni, Jiamiao Wu, Fengqi Liu, Yating Yi, Xiangjiao Meng, Xiang Gao, Luyi Xiao, Weiwei Zhou, Zexi Chen, Peng Chu, Dan Xing, Ye Yuan, Donghui Ding, Ge Shen, Min Yang, Ronjie Wu, Ling Wang, Luiza Martins Nascentes Melo, Sien Lin, Xiaoguang Cheng, Gang Li, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Hu Zhao, Shentong Fang, Bo Shen

“…Abstract Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular spatial interactions under physiological and pathological conditions. Deciphering the spatial interaction of leptin receptor-expressing (LepR+) stromal cells with other compartments in the bone marrow is crucial for a deeper understanding of the stem cell niche and the skeletal tissue. …”
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The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid Cancer in a Chinese Population by Ziheng Ye, Xiaotian Xia, Peipei Xu, Wenfei Liu, Shoufei Wang, Youben Fan, Minggao Guo

“…The BRAF V600E mutation remains an independent risk factor for PTC recurrence and may be useful for clinical decisions when it combines with some pathological factors.…”
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Application of three-dimensional printing in the planning and execution of aortic aneurysm repair by Harshank Patel, Paul Choi, Jennifer C. Ku, Rosemary Vergara, Rafael Malgor, Dhiren Patel, Yong Li

“…This review examines the application of 3D printing and AI in complex aortic aneurysm repair, highlighting current clinical trends.MethodsAn exhaustive literature review was performed using keywords such as “3D printing,” “Artificial intelligence,” “Thoracoabdominal aneurysm,” “Abdominal aortic aneurysm,” “Aortic arch aneurysm,” “Endovascular repair,” and “Open repair” in PubMed and Google Scholar indexes up to June 2022.ResultsThis analysis included seven studies: four focused on 3D-printed phantoms for endovascular repair of various aortic pathologies (aortic arch, thoracoabdominal aorta, juxtarenal and pararenal aorta), one on open thoracoabdominal aneurysm repair using 3D-printed models for graft construction, and two on the use of convolutional neural networks, an AI-based technology, for the pre-processing of aortic computed tomography angiography images.ConclusionThe application of 3D printing and AI-based image pre-processing in the planning of complex aortic aneurysms offers several benefits, including enhanced patient and trainee education, more accurate fenestration placement, reduced surgical time and complications, and decreased surgeon stress.…”
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Effect of Uncaria rhynchophylla against Thioacetamide-Induced Acute Liver Injury in Rat by Mi-Rae Shin, Min Ju Kim, Jin A Lee, Seong-Soo Roh

“…Both oxidative stress (OS) and inflammation are two fundamental pathological processes of acute liver injury (ALI). The current work is to investigate the effect and possible mechanism of Uncaria rhynchophylla (UR) on thioacetamide- (TAA-) induced ALI in rats. …”
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Research Status and Trends in Periodontal Ligament Stem Cells: A Bibliometric Analysis over the Past Two Decades by Zhengyang Li, Jinyi Li, Shanshan Dai, Ruirui Liu, Qingyu Guo, Fei Liu

“…Infectious inflammation and mechanical stimulation were important pathological conditions and research topics. Conclusion. …”
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Multi-session tDCS over the posterior parietal cortex and associative memory. by Luka Juras, Marina Martinčević, Uroš Konstantinović, Saša R Filipović, Andrea Vranić, Jovana Bjekić

“…Associative memory (AM) plays a crucial role in our ability to link disparate elements of our experiences, yet it is especially vulnerable to age-related decline and pathological conditions. Non-invasive brain stimulation (NIBS), particularly transcranial direct current stimulation (tDCS), has been investigated as a potential intervention to enhance cognitive functions, including AM. …”
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A Case Report of High-Grade Endometrial Stromal Sarcoma: A Rare Cause of Abnormal Uterine Bleeding in a Young Woman by Nuntasiri Eamudomkarn, Yuwadee Itarat, Pilaiwan Kleebkaow, Chumnan Kietpeerakool

“…Immunohistochemical studies showed positive diffuse staining for vimentin, CD 10, and cyclin D1. The pathological diagnosis was HG-ESS stage IIIC. The patient experienced rapid progression of the disease while receiving adjuvant treatment and succumbed eight months after the operation. …”
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Gut microbiota in patients with sarcopenia: a systematic review and meta-analysis by Guangning Wang, Yujie Li, Huisong Liu, Xinjuan Yu

“…BackgroundIntestinal dysbiosis was considered a pivotal pathological mechanism underlying sarcopenia. Despite the fervor surrounding research in this domain, substantial controversy persists regarding the obtained outcomes.ObjectiveTo systematically summarized the disparities in gut microbiota composition between the group afflicted by sarcopenia and non-sarcopenia controls.MethodsPubMed, Medline, CINAHL, EMBASE, Scopus, Web of Science and Google Scholer, Cochrane Library and gray literature sources were systematically searched for in randomized controlled trials. …”
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miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction by Aiming Wu, Lixia Lou, Jianying Zhai, Dongmei Zhang, Limin Chai, Bo Nie, Haiyan Zhu, Yonghong Gao, Hongcai Shang, Mingjing Zhao

“…However, the genomic pathological mechanisms of MI and mechanisms of WXKL are largely unknown. …”
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Identifying unstable CNG repeat loci in the human genome: a heuristic approach and implications for neurological disorders by Varun Suroliya, Bharathram Uppili, Manish Kumar, Vineet Jha, Achal K. Srivastava, Mohammed Faruq

“…This finding validates the approach of evaluating repeat loci in different populations and their possible implications for human pathologies.…”
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Diffuse panbronchiolitis as a rare complication of thymectomy and radiation therapy in a patient with thymoma: a case report by Ye Lu, Qi Qi, Dan Qu, Yu Chen

“…A 47-year-old Chinese man underwent thymectomy due to the presence of a mediastinal mass, and pathological examination confirmed a type B2 thymoma. …”
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Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…Both types of HCM-CMs displayed pathological phenotype of HCM but, more importantly, we found differences between CMs carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn gene mutation in their cellular size, Ca2+ handling, and electrophysiological properties, as well as their gene expression profiles. …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy. …”
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Lysosphingolipids in ceramide-deficient skin lipid models by Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová

“…In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine-phosphorylcholine (SPC), and free fatty acids (FFAs) has been proposed to contribute to impaired skin barrier function. …”
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Mechanism of Action of Lacticaseibacillus paracasei HNU502 and Fecal Microbiota Transplantation in Alleviating Antibiotic Side Effects by CHEN Lin, LI Ao, LI Jiahe, ZHANG Zeng, ZHANG Jiachao

“…In this study, the mechanism of action of FMT and the probiotic Lacticaseibacillus paracasei HNU502 in alleviating the side effects of cefotaxime, a common antibiotic, using combination of metagenomics, pathological analysis and gas chromatography. The findings suggested that FMT alleviated antibiotic side effects by restoring the disturbed gut microbiota, while HNU502 worked by reestablishing the balance of the gut microbiota. …”
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Gastric MALT Lymphoma with Giant Ulcer from Untreated H. pylori: Role of Endoscopic Biopsy – A Case Report. by Hysni Dede, Rovena Roshi, Gentiana Cekodhima, Manjola Tahiraj, Augusto Orlandi

“…It often presents with nonspecific symptoms like dyspepsia, nausea, and epigastric pain and can mimic other gastric pathologies, such as peptic ulcers or gastric cancer. …”
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Gastroesophageal Reflux Disease and Coronary Heart Disease: Is There a “Mutual Burden” Syndrome? by O. P. Alekseeva, D. V. Pikulev

“…A correlation between pathological reflux and ST segment depression has been found. …”
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Cultural foundations of global health: a critical examination of universal child feeding recommendations by Gabriel Scheidecker, Leberecht Funk, Nandita Chaudhary, Bambi L. Chapin, Wiebke J. Schmidt, Christine El Ouardani

“…These recommendations denounce feeding practices that diverge from this style as Non-Responsive Feeding, thereby pathologizing the many valued ways of feeding children in communities all over the world without sound scientific evidence. …”
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