D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier by Xuejiao Zhang, Ang Li, Yuanyifei Wang, Jin Wang, Bowei Zhang, Yan Zhang, Jingmin Liu, Shuo Wang

“…Here, we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 mice. The pathological symptoms, inflammatory cytokines levels, gut microbiota composition, short chain fatty acids (SCFAs) production and colonic barrier integrity were comprehensively evaluated. …”
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Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro by Lina Zhao, Xianyu Zhang, Chunhai Zhang

“…Here, we found that methimazole could effectively inhibit the GFAP expression in physiological and pathological conditions. Moreover, we scratched primary cultures of cerebral cortical astrocytes with and without methimazole pretreatment and investigated whether methimazole could slow the healing process in these cultures. …”
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Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control by T. I. Eliseeva, S. V. Krasilnikova, N. A. Geppe, S. Yu. Babaev, E. V. Tush, O. V. Khaletskaya, D. Yu. Ovsyannikov, I. I. Balabolkin, S. K. Ignatov, N. I. Kubysheva

“…Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). …”
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Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan by Ippei Tanaka, Shuhei Unno, Kazuki Yamamoto, Yoshitaka Nawata, Kimihiro Igarashi, Tomoki Matsuda, Dai Hirasawa

“…Multivariate analysis revealed long-segment Barrett’s esophagus (LSBE) as the sole significant risk factor for BEA (odds ratio, 12.17; 95% confidence interval, 2.84–47.6; p=0.001). Regarding pathological analysis, significant differences were observed in the length and width of the foveolar structure between cancerous and surrounding mucosa in the CD group (p=0.03 and p=0.00, respectively); however, no significant difference was observed in the UD group (p=0.53 and p=0.72, respectively). …”
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Influence of cataract surgery in biopsychosocial adaptation in the elderly by Leonor Rosario Diaz Alfonso, Elvira Machado Héctor, Bárbara Suárez Rodríguez, Mariela Julia Curbelo Gómez

“…Most frequent personal pathological records were arthropathies, diabetes mellitus and hypertension. …”
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Role of bovine respiratory syncytial virus in etiology of respiratory diseases on milk farms by S. V. Koteneva, A. V. Nefedchenko, T. I. Glotova, A. G. Glotov

“…The agent spreads widely in all the countries with intensive livestock farming and can cause pathologic changes in respiratory system either alone or in combination with other viruses and bacteria. …”
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Introduction : « La Duchesse d’Amalfi, des humeurs baroques à une passion moderne ? » by Gisèle Venet

“…Webster uses his stage to dissect the pathologically perverse and dominating brothers as in a « Barber-Chirurgeon's-hall », with Bosola as the actor and stage-manager of their passions. …”
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Therapeutic Potential of Stem Cells in Follicle Regeneration by Agnieszka Owczarczyk-Saczonek, Magdalena Krajewska-Włodarczyk, Anna Kruszewska, Łukasz Banasiak, Waldemar Placek, Wojciech Maksymowicz, Joanna Wojtkiewicz

“…We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. …”
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Clinical case of combined correction of children's psychotraumatic experience and distress in the development of cancer by K. A. Blinova, E. V. Pchelintseva, N. P. Lapochkina

“…The clinical example described in the article illustrates the close pathological relationship of childhood traumatic experience and the occurrence of the disease, and also confirms the presence of a nonspecific psychosomatic disease in the framework of the diathesis-stress model. …”
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Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer by Michelle Wilson, Naveen S Vasudev, Grant D Stewart, Adebanji Adeyoju, Jon Cartledge, Michael Kimuli, Shibendra Datta, Damian Hanbury, David Hrouda, Grenville Oades, Poulam Patel, Naeem Soomro, Mark Sullivan, Jeff Webster, Peter J Selby, Rosamonde E Banks

“…Comprehensive clinico-pathological and outcome data were also collected.Outcomes Type and frequency of reported symptoms, incidental diagnosis rate, metastasis-free survival and cancer-specific survival.Results Of 706 patients recruited between 2011 and 2014, 608 patients with a confirmed RCC formed the primary study population. …”
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Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review by Haijuan Shi, Yan Yin, Shoujun Liang, Chuanzhong Liu, Yibao Huang, Bingfeng Lu, Liying Zhang

“…This study aims to provide clinical guidance on the clinicopathological features and appropriate treatment options for patients with uterine PEComas of uncertain malignant potential.CasesThis case series summarises the clinical courses of 13 patients diagnosed with uterine PEComas of uncertain malignant potential, including clinical and pathological data as well as their outcomes. We identified one case at our hospital, and data for the other 12 cases were extracted from the PubMed database. …”
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Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

“…Gaining traction in this field is the use of disease data linking genes with pathological phenotypes and combining this with drugtarget interaction data.MethodsWe introduce methodology to associate drugs with effects, both intended and adverse, using a tripartite network approach that combines drug-target and target-phenotype data, in which targets can be represented as proteins and protein domains.ResultsWe were able to detect associations for over 140,000 ChEMBL drugs and 3,800 phenotypes, represented as Human Phenotype Ontology (HPO) terms. …”
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Interaction of Cu(II) and Ni(II) with Ypk9 Protein Fragment via NMR Studies by Massimiliano Francesco Peana, Serenella Medici, Alessia Ledda, Valeria Marina Nurchi, Maria Antonietta Zoroddu

“…Here, we tested PK9-H with Cu(II) and Ni(II) ions, the former because it is an essential element ubiquitous in the human body, so its trafficking should be strictly regulated and one cannot exclude that Ypk9 may play a role in it, and the latter because, besides being a toxic element for many organisms and involved in different pathologies and inflammation states, it seems that the protein confers protection against it. …”
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Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression by Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

“…We also examine the interplay between altered gut-related factors and the accumulation of pathological α-synuclein in the gut of Parkinson’s disease patients. …”
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Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia by Vilen Molotov-Luchanskiy, Altynbek Nukhuly, Larissa Muravlyova, Ryszhan Bakirova, Aruna Kossybayeva, Dmitry Klyuyev, Ludmila Demidchik, Irina Beinikova

“…Materials and Methods. 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. …”
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Comparative analysis of allele frequencies for DNA polymorphisms associated with disease and economically important traits in the genomes of Russian and foreign cattle breeds by A. V. Igoshin, G. A. Romashov, E. N. Chernyaeva, N. P. Elatkin, N. S. Yudin, D. M. Larkin

“…The genetic makeup of a breed including its genetic differences from other breeds determines its appearance and characteristics, including economically important traits and resistance to pathologies. To date, many loci controlling significant phenotypes have been identified, which is successfully used in the world practice of marker-assisted selection to improve breed properties. …”
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Individualized autoregulation-guided arterial blood pressure management in neurocritical care by Jonathan R. Gomez, Bhagyashri U. Bhende, Rohan Mathur, L. Fernando Gonzalez, Vishank A. Shah

“…Utilizing these monitors, researchers have been able to discern CA patterns in several pathological states, such as but not limited to acute ischemic stroke, spontaneous intracranial hemorrhage, aneurysmal subarachnoid hemorrhage, sepsis, and post-cardiac arrest, and they have found CA to be altered in these patients. …”
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Assessment and follow-up of interstitial lung disease by Devarasetti Phani Kumar

“…A multidisciplinary approach involving the pathologist, rheumatologist, pulmonologist, and radiologist allows the correlation of the clinical, radiologic, and pathologic findings to arrive at the right diagnosis. …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Oxidative stress has been associated with a variety of pathologic conditions, including diabetes mellitus (DM), cancer, atherosclerosis, neurodegenerative diseases, rheumatoid arthritis, ischemia/reperfusion injury, obstructive sleep apnea, and accelerated aging. …”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

“…At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, 𝑃=.0021). …”
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