Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection by Marcos Daniel Mendes Padilha, Francisco Tiago de Vasconcelos Melo, Rogério Valois Laurentino, Andrea Nazaré Monteiro Rangel da Silva, Rosimar Neris Martins Feitosa

“…If the microbiota is unbalanced, both exogenous and symbiotic microorganisms can affect a pathological process. It is well understood that the microbiota plays a role in viral diseases and infections, specifically the hepatic portal pathway has been linked to the gut-liver axis. …”
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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Correlation and Cox regression analyses have revealed that TNM staging, pathological staging, age, outcome assessment, postoperative tumor residue, and PAPPA expression are prognostic determinants in GC. …”
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Exosomes in neuron-glia communication: A review on neurodegeneration by Naeimeh Akbari-Gharalari, Sina Khodakarimi, Farshad Nezhadshahmohammad, Mohammad Karimipour, Abbas Ebrahimi-Kalan, Jiagian Wu

“…Conclusion: By delving into the intricate dynamics of exosomal communication in the CNS, this review contributes to a deeper understanding of the roles of exosomes in both physiological and pathological processes, thereby paving the way for potential therapeutic advancements in the field of neurological disorders.…”
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Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study by V. N. Afonyushkin, O. E. Sysoeva, O. S. Kozlova, D. V. Shamovskaya

“…To date, the reisreason to believe that, unlike classical a cuterespiratory virusinfections caused by adenoviruses, rhinoviruses, orthomyxoviruses, COVID-19 behaves completely differently. Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensurest heelimination of the virus from the organism. …”
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The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement by Xuedi Chen, Cuixia Gao, Ningning Gong, Yu Wang, Limin Tian

“…Histopathological examination revealed the pathological changes in the sHT rats’ heart. L-T4 administration reduced TSH level and improved left ventricular function. …”
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Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease by Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou

“…The oligomeric form of A<i>β</i> is acknowledged as the most neurotoxic, propelling the pathological progression of AD. Interestingly, besides A<i>β</i>, other proteins are co-localized within amyloid plaques. …”
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Development of a cross-cultural scale on attitudes toward gender and sexual diversity (AGSD) by Daniel Oleas, Xochitl Garza-Olivares, Fernando Silva Teixeira-Filho, Guido Mascialino, Jose A. Rodas, Jose A. Rodas

“…The final scale comprised 18 items across three factors: social coexistence, moral and pathological views, and stereotypes.ResultsThe scale demonstrated sound psychometric properties, with acceptable internal consistency (Cronbach's α = 0.74–0.77). …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…Similarly, the VEGF/VEGFR axis demonstrates a complex contribution to DKD, where VEGF-A promotes pathological angiogenesis and glomerular damage, but its inhibition requires careful modulation to prevent adverse effects. …”
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Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia by Anastasia A. Zabolotneva, Katerina E. Popruga, Valentin V. Makarov, Sergei M. Yudin, Andrei M. Gaponov, Sergei A. Roumiantsev, Aleksandr V. Shestopalov

“…Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions. Methods: In this study, the researchers conducted a broad parallel investigation of olivetol’s effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia. …”
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Colesterolemia de riesgo by Carlos Gaimetea Castillo, Marcos D. Iraola Ferrer

“…</p>This article presents the optimal lipids level along with their risk and pathologic ranges. The clinical approach that should be followed to define the type of dyslipidemia in the patients and its association to other risk markers is indicated. …”
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Minimally Invasive Bilateral Lung Resections and CABG through 5 Ports by N. Asemota, M. J. Rouhani, L. Harling, H. Raubenheimer, A. C. De Souza, E. Lim

“…Multiple sequential minimally invasive procedures are now routine and can be performed safely in patients with a complex combination of pathologies. In this case, bilateral single-port (anatomic and nonanatomic) lung resections were undertaken followed by coronary revascularisation with a total of 5 minimal access ports.…”
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Association of Serum CXCL13 with Intrarenal Ectopic Lymphoid Tissue Formation in Lupus Nephritis by De Ning He, Wen Li Chen, Kang Xia Long, Xiao Zhang, Guang Fu Dong

“…The coexpression patterns of CD3, CD20, and CD21 in the renal tissue of LN patients with different WHO pathological types were significantly different. Serum CXCL13 levels were significantly higher in ELT-2 type LN patients than in 0 or 1 type LN patients. …”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The vedolizumab is anti-α4β7-integrin humanized class IgG1 antibodies which suppresses migration of leukocytes in intestinal tissue, interfering thereby with development of pathologic inflammation. GEMINI-1 study of ulcerative colitis has demonstrated efficacy of the drug in remission induction (clinical response rate of 47,1% of patients, clinical remission of 16,9% and endoscopic remission of 40,9% at the 6th week) and in remission maintenance (percent of patients in clinical remission at 52nd week at drug injection every 4 weeks - 44,8%). …”
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Diagnosis and Treatment of Peptic Ulcer in Adults (Clinical Guidelines of the Russian Gastroenterological Association, Russian Society of Colorectal Surgeons and the Russian Endosc... by V. T. Ivashkin, I. V. Maev, P. V. Tsar’kov, M. P. Korolev, D. N. Andreev, E. K. Baranskaya, S. G. Burkov, A. A. Derinov, S. K. Efetov, T. L. Lapina, P. V. Pavlov, S. S. Pirogov, A. V. Tkachev, A. S. Trukhmanov, E. D. Fedorov, A. A. Sheptulin

“…PU can be an independent disease or represent symptomatic ulcers of the stomach and duodenum (medicinal, as a result of stress or endocrine pathologies, associated with chronic diseases of internal organs). …”
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Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone? by Lara Russo, Serena Babboni, Maria Grazia Andreassi, Jalil Daher, Paola Canale, Serena Del Turco, Giuseppina Basta

“…Numerous factors, including extracellular vesicles, mediate pathological communication between the vascular system and adipose tissue, amplifying metabolic imbalances. …”
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VCAM-1 Promotes Angiogenesis of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Trauma-Induced Osteonecrosis of the Femoral Head by Regulating the Apelin/CCN2 Pathway by Yiming Shao, Lei Sun, Baodong Ma, Ranran Jin, Yueyao Ban, Ruibo Li, Jianfa Wang, Hongkai Lian, Han Yue

“…Trauma-induced osteonecrosis of the femoral head (TI-ONFH) is a pathological process in which the destruction of blood vessels supplying blood to the femoral head causes the death of bone tissue cells. …”
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2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv... by Wei Dong, Yujia Peng, Guijie Chen, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan

“…Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer’s disease, have been closely associated with microbial alteration via the gut-brain axis. …”
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Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness by Sandip Ghosh, Yun‐Han Su, Chia‐Jung Yang, Jui‐Yang Lai

“…In a rabbit model of corneal dryness, topical single‐dose nanoformulation (high quercetin‐functionalized gold nano‐urchins (NU‐Q(H))) demonstrated remarkable efficacy in stimulating tear production (30‐fold improvement), inhibiting inflammatory IL‐6 expression (49‐fold improvement), attenuating pathological angiogenesis (32‐fold improvement), and promoting nerve regeneration (18‐fold improvement) compared to high quercetin‐functionalized gold nanoparticles (NP‐Q(H)). …”
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Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation by Roberta Ramonda, Leonardo Punzi, Anna Scanu, Francesca Oliviero, Roberto Luisetto, Paola Galozzi, Marta Favero

“…Usually, PTA recoveries spontaneously, but the persistence of symptoms after 6 months may be considered pathological and so-called chronic PTA. A variety of molecular, mechanobiological and cellular events involved in the pathogenesis and the progression of PTA have been identified. …”
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Molecular Identification, Histopathology and Antibiotic Susceptibility Profiling of Aeromonas veronii Isolated from Oreochromis niloticus in Bangladesh by Sayed Mashequl Bari, Mohammad Muttakinul Islam, Aktia Amina, Marufa Khatun, A. M. Shahabuddin

“…Histopathological analysis revealed gross pathological changes like necrosis, hypertrophy and inflammation in muscle tissues. …”
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