Infected burn wound healing using Hydroxy-propyl-methyl cellulose gel containing bacteriophages against Pseudomonas aeruginosa and Klebsiella pneumoniae by Meysam Adibi, Kazem Javanmardi, Noor Al-Huda Ali A.H. Saeed, Mohammad Ali Mobasher, Javad Jokar, Abdolmajid Ghasemian, Niloofar Rahimian, Ava Soltani Hekmat

“…Results: Phages appear to be effective in gel forms. Pathologic samples of different groups confirmed therapeutic results of phages. …”
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Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis by Jiasheng Xu, Kaili Liao, Weimin Zhou

“…Exosomes, as extracellular vesicles, participate in physiological and pathological processes by transmitting signaling molecules such as proteins, nucleic acids, and lipids. …”
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PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib by Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu

“…Abstract As a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage‐based chemotherapy remains largely unexplored. …”
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Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency by Ziying Xu, Yagang Gao, Zihui Yu, Rui Zhang, Ruikun Wang, Shang Li, Shuowen Wang, Bing Du, Ziyan Tian, Lijuan Huang, Zanbo Ding, Jing Yuan

“…Abstract Aldehyde dehydrogenase 2 (Aldh2) Glu504Lys mutation, common in East Asians, is linked to various alcohol-related pathologies, notably fatty liver disease. Recent findings suggest that high ethanol-producing Klebsiella pneumoniae(HiAlc Kpn) exacerbates liver injury in non-alcoholic fatty liver disease (NAFLD). …”
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RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research by I. V. Chadaeva, S. V. Filonov, K. A. Zolotareva, B. M. Khandaev, N. I. Ershov, N. L. Podkolodnyy, R. V. Kozhemyakina, D. A. Rasskazov, A. G. Bogomolov, E. Yu. Kondratyuk, N. V. Klimova, S. G. Shikhevich, M. A.  Ryazanova, L. A. Fedoseeva, О. Е. Redina, О. S. Kozhevnikova, N. A. Stefanova, N. G. Kolosova, A. L. Markel, M. P. Ponomarenko, Yu. D. Oshchepkov

“…RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. The rat DEGs put in RatDEGdb were annotated with equal changes in the expression of their human homologs in affected people. …”
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Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study by Hidayet Sal, Erhan Huseyin Comert, Yasin Semih Ekici, Turhan Aran

“…Demographic questionnaire and face to face interview were used to obtain data including immune system diseases and respiratory system pathologies in infants. Results: A total of 100 fetuses with echogenic bowel were included in the study. …”
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Numerical characterization of hemodynamics conditions near aortic valve after implantation of left ventricular assist device by Annalisa Quaini, Sunčica Čanić, David Paniagua

“…The use of LVADs has been associated with thrombus formation next to the aortic valve and close to the anastomosis region,especially in patients in which the native cardiac function isnegligible and the aortic valve remains closed.Stagnation points and recirculation zones have been implicated as the main fluid dynamics factors contributing to thrombus formation.The purpose of the present study was to develop and use computer simulations based on afluid-structure interaction (FSI) solver to study flow conditions corresponding to different strategies inLVAD ascending aortic anastomosis providing a scenario with the lowest likelihood of thrombus formation.A novel FSI algorithm was developed to dealwith the presence of multiple structures corresponding to different elastic properties ofthe native aorta and of the LVAD cannula.A sensitivity analysis of different variables was performed to assess their impact of flow conditionspotentially leading to thrombus formation.It was found that the location of the anastomosis closest to the aortic valve(within 4 cm away from the valve)and at the angle of 30$^\circ$ minimizes the likelihood of thrombus formation.Furthermore, it was shownthat the rigidity of the dacron anastomosis cannula plays almost no role in generating pathologicalconditions downstream from the anastomosis.Additionally, the flow analysis presented in this manuscriptindicates that compliance of the cardiovascular tissue acts as a natural inhibitor of pathological flow conditions conducive to thrombus formationand should not be neglected in computer simulations.…”
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Clinical characteristics of pediatric patients with SARS-CoV-2 infection. Cienfuegos, 2020-2021 by Mercedes Fonseca Hernández, Dunia María Chávez Amaro, Vivian Isabel Chávez Pérez, Julio Héctor Jova Dueñas, Tamara L. Jiménez Sáez, Ifrain Machín Caride

“…The analyzed variables were: age, sex, origin, personal pathological history, initial symptoms, nutritional status, source of infection, laboratory results, persistence of positive RT-PCR, associated clinical manifestations to treatment and evolution. …”
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Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota by Bowen Li, Mingming Liu, Wenjing Du, Shuaidong Wang, Zekang Xu, Xiaoqian Zhang, Yang Zhang, Song Hua

“…The findings showed that mice receiving twice injections of 2.08 × 108 copies of Mccp suffered significant pathological damage to their lungs and colons. Additionally, there was a notable upsurge in inflammatory factors within the affected tissues. 16 S rDNA sequencing revealed alterations in the colonic microbiota, including a decrease in the abundance of beneficial bacteria such as Corynebacterium_glutamicum and Candidatus_Saccharimonas, and an increase in the abundance of potential pathogens like Lachnospiraceae_NK4A136_group and Escherichia-Shigella. …”
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Clinical-histopathological concordance in head and neck lesions. by Sahily Espino Otero, Julio Romero Rodrígez, Yordany Boza Mejías, Odalys Acevedo Sierra, Iván Quintana Hijano, Phede Selme

“…Required data was taken from clinical histories and records from Pathological Anatomy, which were transferred to a form design for that purpose. …”
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Development and Validation of an Immunotherapy-Related Prognostic Signature Based on Lymph Node Ratio for Gastric Cancer by Jianxin Li, Ting Han, Xin Wang, Yinchun Wang, Xuan Chen, Wangsheng Chen, Qingqiang Yang

“…We then evaluated the risk score signature from the viewpoints of survival, clinic-pathological characteristics, tumor microenvironment (TME), tumor mutation burden (TMB), and immunotherapeutic and chemotherapeutic efficacy. …”
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Chemo-proteomics reveals dihydrocaffeic acid exhibits anti-inflammation effects via Transaldolase 1 mediated PERK-NF-κB pathway by Guanjun Li, Huiying Li, Peili Wang, Xinzhou Zhang, Wenhua Kuang, Ling Huang, Ying Zhang, Wei Xiao, Qingfeng Du, Huan Tang, Jigang Wang

“…Abstract Background Acute pneumonia is a kind of widespread inflammatory pathological process. Dihydrocaffeic acid (DA), metabolite of chlorogenic acid, possesses potent pharmacologic activity for the therapy of a wide range of disorders and various biological properties, such as anti-inflammation. …”
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Risk and protective factors associated with adolescent depression in Singapore: a systematic review by Wei Sheng Goh, Jun Hao Norman Tan, Yang Luo, Sok Hui Ng, Mohamed Sufyan Bin Mohamed Sulaiman, John Chee Meng Wong, Victor Weng Keong Loh

“…The four factors associated with adolescent depression identified were: (1) sociodemographic factors (gender, ethnicity); (2) psychological factors, including childhood maltreatment exposure and psychological constructs (hope, optimism); (3) coexisting chronic medical conditions (asthma); and (4) lifestyle factors (sleep inadequacy, excessive internet use and pathological gaming). Conclusion: The identified factors were largely similar to those reported in the global literature, except for sleep inadequacy along with conspicuously absent factors such as academic stress and strict parenting, which should prompt further research in these areas. …”
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Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases by O. V. Khlynova, E. A. Stepina

“…A statistically significant relationship has been established between ED indicators and the severity and localisation of the pathological process, the extra-intestinal manifestations and complications of the disease. …”
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Early Cessation of Breastfeeding and Determinants: Time to Event Analysis by Ebrahim Babaee, Babak Eshrati, Mehran Asadi-Aliabadi, Majid Purabdollah, Marzieh Nojomi

“…An infant’s birth weight (2500–4000 gr) (hazard ratio: 0.54), neonatal birth order (hazard ratio: 0.69), neonatal pathologic jaundice (hazard ratio: 1.52), starting time of using complementary food (hazard ratio: 2.45), using pacifier (hazard ratio: 2.82), and the status of using artificial milk (hazard ratio: 3.29) were significantly associated with cessation of breastfeeding before 24 months of age. …”
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Relevance of histamine and tryptase concentrations in nasal secretions after nasal challenges with phosphate buffered saline and allergen by D. Wang, P. Clement, J. Smitz, M.-P. Derde

“…The aim of the study was to determine the normal and pathological concentrations of these important mediators in nasal secretions. …”
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Morphometric Changes in Patients with Chronic Kidney Disease who Died Related to Diabetes Mellitus, Arterial Hypertension and Obesity by Ivette Gómez Fernández, Adys Castro Barberena, Greta Margarita Arrechea García, Georgina Jiménez Estrada, Javier Martínez Navarro, Domingo Fuentes Febles

“…The variables studied were: age, sex, weight and height for the calculation of the body mass index, personal pathological history, the clinical stage of chronic kidney disease and renal morphometry to each organ separately, the measurements made were: weight, longitudinal diameter, transverse diameter, thickness or thickness of the renal cortex. …”
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Application of large language models in disease diagnosis and treatment by Xintian Yang, Tongxin Li, Qin Su, Yaling Liu, Chenxi Kang, Yong Lyu, Lina Zhao, Yongzhan Nie, Yanglin Pan, Yuanyuan Ji

“…Building on their image-recognition abilities, multimodal LLMs (MLLMs) show promising potential for diagnosis based on radiography, chest computed tomography (CT), electrocardiography (ECG), and common pathological images. These models can also assist in treatment planning by suggesting evidence-based interventions and improving clinical decision support systems through integrated analysis of patient records. …”
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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Putative tumor-reactive cells (pTRC) identified via MANAscore in anti-PD-1-treated lung tumors had higher expression of checkpoint and cytotoxicity-related genes relative to putative non-tumor-reactive cells. pTRC in pathologically responding tumors showed distinguished gene expression patterns and trajectories. …”
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Evaluation of cervical cytological abnormalities in correlation with clinical findings in Iraqi patients by Zainab Abbas Hassooni, Wafaa Redha Mohammed Al-Sabbagh, Taqi Mohammed Jwad Taher

“…Abstract Objective: Many articles study the efficiency of pap smears in detecting cervical disease and precancerous lesions; however, in Iraq, only few researches study the clinic-pathological correlation in pap smear results. In this study, we will highlight the correlation of pap smears with the most important and frequent clinical data and findings on cervical examination. …”
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