Is It the pH That Matters? Challenging the Pathophysiology of Acidemia in a Case of Severe Hypercapnia Secondary to Intraoperative CO2 Insufflation by Evan Merle, Saad Zaatari, Rory Spiegel

“…In this case, the patient experienced no respiratory insult leading to an increase in blood CO2 but rather had CO2 iatrogenically introduced into the circulatory system, effectively detaching the deleterious effects of CO2 from the respiratory pathologies that so often cause its accumulation. Conclusion. …”
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Oxidative Stress and Heme Oxygenase-1 Regulated Human Mesenchymal Stem Cells Differentiation by Luca Vanella, Christopher Sanford, Dong Hyun Kim, Nader G. Abraham, Nabil Ebraheim

“…In this paper, we define HO-1 as a target molecule in the modulation of adipogenesis and osteogenesis from MSCs and examine the role of the HO system in diabetes, inflammation, osteoporosis, hypertension, and other pathologies, a burgeoning area of research.…”
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Clinical and Imaging Prognosis in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning by Jinzhi Liu, Zhihua Si, Jie Liu, Yan Lin, Jing Yuan, Shan Xu, Yan He, Tao Zhang, Aihua Wang

“…MRI revealed lesions in the bilateral cerebral white matter and/or basal ganglia. Except for the pathologically confirmed DEACMP, epileptic seizure, hemiplegia, and vegetative state, the remaining symptoms had been improved, especially the cognitive impairment, which had been decreased from 95% to 25% and psychiatric symptoms also decreased from 95% to 55% at the 6-month follow-up. …”
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SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature by Prajwal Boddu, Abdul S. Mohammed, Chandrahasa Annem, Winston Sequeira

“…The cause and effect relationships of lymphoma in SLE have been subject to extensive scrutiny with several studies reporting on clinic-pathologic characteristics and risk factors predicting lymphoma development in SLE. …”
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Skeletal Muscle Haemangioma: A Cause for Chronic Pain about the Knee: A Case Report by Kopuri Ravi Kiran, T. V. Suresh Babu, S. Suresh Babu, K. Deepti

“…The clinical features, radiological picture, pathological histology, diagnostic tools, and treatment options have been discussed.…”
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Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning by Jianfeng Chen, Fuwei Qi, Guanshen Li, Qiaosong Deng, Chenlin Zhang, Xiaojun Li, Yafeng Zhang

“…Intervertebral disc degeneration (IDD), which is distinguished by a variety of pathologic alterations, is the major cause of low back pain (LBP). …”
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Leukocytoclastic Vasculitis in a Patient with Ankylosing Spondylitis by Senol Kobak, Hatice Yilmaz, Ahmet Karaarslan, Murat Yalcin

“…Based on clinical, laboratory, radiological, and pathological examinations, the patient was diagnosed with ankylosing spondylitis and leukocytoclastic vasculitis. …”
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Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines by Gabriela Loredana Popa, Mircea Ioan Popa

“…On the one hand, they contribute to parasitic clearance, and on the other, they are responsible for pathological changes encountered in malaria. Cytokine-modulating strategies may represent a promising modern approach in disease management. …”
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Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy by Lin Mu, Dahu Wang, Zhiguo Dong, Jiajun Wu, Xiaoyu Wu, Jing Su, Yinjian Zhang

“…This study shows that ferroptosis-related biomarkers may be involved in the pathological process of DR and can be used as one of the biomarkers of DR.…”
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Mathematical modelling of cardiac pulse wave reflections due to arterial irregularities by Alexandre Cornet

“…An iterative algorithm is developed and applied to pathological scenarios to predict the pressure waveform of the reflected wave due to the presence of successive arterial irregularities. …”
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Biofabrication of brain-like living tissue: structure to intelligence by Ling Wang, Sen Wang, Yingjie Liu, Bowen Zhang, Zhaoyu Pan, Luge Bai, Siqi Yao, Chenrui Zhang, Huangfan Xie, Jiankang He, Dichen Li

“…Therefore, constructing brain-like models—both in morphology and function—possesses significant scientific value for advancing brain science and pathological pharmacology research, representing the frontiers in the biomanufacturing field. …”
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Positive Findings of Blood Cultures in Febrile Children Presenting with Thalassemia Major in a Tertiary Care Hospital by Itrat Fatima, Wafia Affan, Hira Hameed, Wajeeha Amber, Sumbal Saeed, Imran Mahmood Khan

“…Their demographic characteristics and pathological findings were noted in this study. Standardized approach was followed for blood withdrawal and sample collection required for performing blood cultures. …”
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Role of Apolipoprotein E in Anxiety by Jacob Raber

“…Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. …”
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Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification by Jantana Keereetaweep, Kent D. Chapman

“…Further, the altered levels of these molecules often reflect pathological conditions associated with tissue damage. …”
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Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model by Jenny Castro, Guillermo Lopez-Lluch, Juan Carlos Rodríguez, Rocío de la Puerta, Lía Barrios, Rubén Salas, Luis Franco

“…Dietary supplementation with golden berry attenuates the pathological symptoms of colitis. This effect may be associated with the inhibition of neutrophil infiltration and impacts on the production of IL-6, IL-1β, IL-10, TNF-α, and ROS. …”
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DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer by Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Abdelaali Balahbib, Abdelhakim Bouyahya, Chrismawan Ardianto, Long Chiau Ming, Hooi Leng Ser

“…DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. Recent discoveries on the differentiated roles of DNMTs in DNA methylation, and their implication in various cancers, open the way to new therapeutic approaches targeting these enzymes to treat epigenetic diseases. …”
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Down-Turner Syndrome: A Case with Double Monoclonal Chromosomal Abnormality by Gioconda Manassero-Morales, Denisse Alvarez-Manassero, Alfredo Merino-Luna

“…Female, 28 months old, with pathological short stature from birth, with the following dysmorphic features: tilted upward palpebral fissures, short neck, brachycephaly, and low-set ears. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA2s are classified into calcium dependent and independent. …”
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Complex Brain Network Analysis and Its Applications to Brain Disorders: A Survey by Jin Liu, Min Li, Yi Pan, Wei Lan, Ruiqing Zheng, Fang-Xiang Wu, Jianxin Wang

“…These findings provide not only a new perspective to explore the pathological mechanisms of brain disorders, but also guidance for early diagnosis and treatment of brain disorders. …”
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The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…In this review, we elaborate on the key pathological mechanisms that unfold following ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, and present evidence demonstrating that 12/15-LOX inhibition could be used to treat ischemic stroke through various avenues. …”
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