Roles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage by Jinyao Shi, Zhouqiao Wu, Ziyu Li, Jiafu Ji

“…This review summarizes the currently available evidence regarding the different roles of polarized macrophages in the physiological course of anastomotic healing and their pathological roles in anastomotic leakage, the most dangerous complication after gastrointestinal surgery.…”
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Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation by Eric Moughames, Ana P. Kiess, Lee M. Akst, Antoine Azar

“…After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. …”
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Resolving a Multi-Generational Neuromuscular Mystery in a Family Presenting with a Variable Scapuloperoneal Syndrome in a c.464G>A, p.Arg155His VCP Mutation by Nivedita U. Jerath

“…A 55-year-old woman was labeled as “normal” and “pain medication seeking” after an unrevealing work up of clinical, laboratory, electrodiagnostic, radiographic, pathologic, and genetic testing. She continued to present with chronic neck pain, and had variable features of scapuloperoneal atrophy, which was also seen in her family. …”
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Sjögren Syndrome Complicated with Cystic Lung Disease and Pulmonary Amyloidosis by Koichiro Takahashi, Hironori Sadamatsu, Shinsuke Ogusu, Kazutoshi Komiya, Tomomi Nakamura, Shinya Kimura, Naoko Sueoka-Aragane

“…Surgical lung biopsy was performed and demonstrated pathologic findings of amyloid light-chain deposition and bronchiolitis with lymphocytic infiltration. …”
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Utilizing MSK Ultrasound for Comprehensive Assessment of the Femoral Trochlea: A Game Changer in Sports Medicine by Robert C Manske, Mike Voight, Phil Page, Chris Wolfe

“…Musculoskeletal (MSK) ultrasound has emerged as a valuable tool for sports physical therapists in the assessment and treatment of various knee pathologies. Its ability to provide high-resolution images of soft tissue and superficial bone surfaces makes it especially useful for sports physical therapists and orthopedic clinicians. …”
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Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage by Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, Federico Carrión, Brenda Iglesias, Kevin Madauss, Lucía Canclini

“…The role of amyloids in cancer remains unclear despite their identification in several other pathologies. In this study, we present evidence of amyloids in bladder cancer, both in vitro and in vivo. …”
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COMMUNITY-ACQUIRED PNEUMONIA COMPLICATED BY SEPSIS CAUSED BY KLEBSIELLA PNEUMONIAE: A CASE REPORT by A.V. Lavrenko

“…The clinical picture is systematized and outlined, questions of laboratory diagnostics, the principles of treatment are defined. Analyzed pathological changes that occur in sepsis on the part of various organs and systems . …”
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Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord–Derived Mesenchymal Stem Cell–Mediated Rheumatoid Arthritis Therapy by Guangyang Liu, Herui Wang, Chenliang Zhang, Xin Li, Yi Mi, Yaoyao Chen, Liqiang Xu, Li Miao, Haomiao Long, Yongjun Liu

“…Given the dramatic pathologic differences between hUC-MSCs and siTNFR1-MSCs treatments, we questioned whether production of growth factors and chemokines was significantly influenced by TNFR1. …”
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Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients by Yuqing Qu, Haoming Li, Xianling Wang, Yulong Chen, Qinghua Guo, Yu Pei, Jin Du, Jingtao Dou, Jianming Ba, Zhaohui Lv, Yiming Mu

“…The clinical characteristics, surgical information, and pathological findings were extracted from their medical records and were analyzed. …”
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Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation by Chao Wang, Xiao-xia Hou, Hong-liang Rui, Li-jing Li, Jing Zhao, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng, Yi-Pu Chen

“…The biological parameters of serum and urine and the pathological manifestations of kidney tissue were examined. …”
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A nomogram for predicting prognosis for young cervical neuroendocrine carcinoma: A SEER-based study and external validation by Ning Xie, Haijuan Yu, Jie Lin, Sufang Deng, Linying Liu, Yang Sun

“…Finally, a simplified scoring system for clinical use was constructed by dividing patients into high-risk and low-risk groups.ResultsPathological type, FIGO stage, and surgery were independent risk factors by univariate and multivariate analysis (P < 0.05). …”
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Three-dimensional structure of entire hydrated murine hearts at histological resolution by Jasper Frohn, Frederik Böddeker, Marius Reichardt, Hendrik Bruns, Titus Czajka, Amara Khan, Ludovic Broche, Michael Krisch, Alberto Bravin, Frauke Alves, Jana Zschüntzsch, Tim Salditt

“…Our goal is to provide 3d reconstructions of the cardiomyocyte network in entire hydrated murine hearts, and to develop a methodology for quantitative analysis of heart pathologies based on X-ray phase contrast computed tomography (XPCT). …”
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Using the Oxford Foot Model to determine the association between objective measures of foot function and results of the AOFAS Ankle-Hindfoot Scale and the Foot Function Index: a pr... by Frank Krummenauer, Tanja Kostuj, Felix Stief, Kirsten Anna Hartmann, Katharina Schaper, Mohammad Arabmotlagh, Mike H Baums, Andrea Meurer, Sebastian Lieske

“…Furthermore, factor analysis did not support stratification of the FFI-D into two subscales.Conclusions The AOFAS-AHS showed a good agreement with objective gait parameters and is therefore better suited to evaluate disability and functional limitations of patients suffering from foot and ankle pathologies compared with the FFI-D.…”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Rapamycin alleviated the pathological damage of myocardial tissue, attenuated cardiac dysfunction (left ventricular ejection fraction (LVEF), p<0.05; fractional shortening (FS), p<0.05), and reduced HIF-1a expression (p<0.05). …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…As more patients are reported to have clinical features of autoinflammation and autoimmunity, the boundary between these two pathologic ends is becoming blurred. An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Behçet’s disease, gout, Sjögren’s syndrome, interstitial lung diseases, and Still’s disease is presented to highlight the fundamental points that interleukin-1 displays in the cryptic interplay between innate and adaptive immune systems.…”
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Human Diseases and Microbes

“…Much before the man became conscious of their existence or they became visible with the help of microscopes, they were active in their pathological action against all other living beings, including man. …”
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Menopause mysteries: the exosome-inflammation connection by Aarushi Sultania, Subhashini Brahadeeswaran, Aparna Eledath Kolasseri, Sivaraman Jayanthi, Ramasamy Tamizhselvi

“…It also explores the complex functions of FF exosomal proteins in the pathologies associated with menopause. Graphical Abstract…”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Primary brain injury is an immediate and, therefore, rather irreversible effect of trauma, while secondary brain injury results from a complex cascade of pathological processes, among which oxidative stress and neuroinflammation are the most prominent. …”
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The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…Aberrant PPARγ function seems to be implicated in pathological fibrosis in the skin and lungs. This antifibrotic effect is mainly related to the inhibition of TGF-β/Smad signal transduction but other pathways can be involved. …”
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Risk Factors Predicting Recurrent Small Intestinal Resection for Crohn’s Disease of the Terminal Ileum by Hanna Binder, Hugh J Freeman

“…Univariate and multivariate analyses of multiple demographic, clinical, laboratory and pathological variables revealed two apparent statistically significant independent risk factors for a second intestinal resection: steroid treatment, likely an indirect indication of more severe disease activity; and the presence of an internal fistula, consistent with the emerging concept of a relatively more aggressive clinical form of Crohn’s disease.…”
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