The unexpected role of the STING protein in lipid metabolism by Vila, Isabelle K., Laguette, Nadine

“…Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. …”
Get full text

Biomaterial-based regenerative therapeutic strategies for spinal cord injury by Keyi Chen, Wei Yu, Genjiang Zheng, Zeng Xu, Chen Yang, Yunhao Wang, Zhihao Yue, Weien Yuan, Bo Hu, Huajiang Chen

“…Unfortunately, due to the complex pathological mechanisms and unique postinjury microenvironment, there is currently no way to completely repair the injured spinal cord. …”
Get full text

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors by Vladimir S. Naumenko, Evgeni Ponimaskin

“…This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.…”
Get full text

Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic functions in various physiological and pathological processes, such as inflammation-associated signal transduction. …”
Get full text

A Technical Nuance to Avoid Lumbar Five Radiculopathy with Anterior Lumbar Fusion and Posterior Instrumentation by Matthew T. Neal, Maziyar A. Kalani, Mark K. Lyons

“…The anterior lumbar interbody fusion (ALIF) is a well-established procedure used to treat a multitude of spinal pathologies. When performed at the L5-S1 level, the ALIF is often supplemented with posterior pedicle screw and rod fixation. …”
Get full text

Therapeutic Application of rTMS in Atypical Parkinsonian Disorders by Chrysi Petsani, Athina-Maria Aloizou, Vasileios Siokas, Lambros Messinis, Eleni Peristeri, Christos Bakirtzis, Grigorios Nasios, Efthimios Dardiotis

“…Brain stimulation via repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive intervention using a magnetic coil, and it is considered an alternative therapy in various neuropsychiatric pathologies. In this paper, we review the available studies that investigate the efficacy of rTMS in the treatment of these APDs and Parkinson plus syndromes. …”
Get full text

Restenosis and Therapy by Laszlo Denes, Laszlo Entz, Veronika Jancsik

“…Various insults are shown to initiate the phenotype switch of VSMCs. The pathological process, leading to activated inflammatory process, complement activation, and release of growth factors, initiate the proliferation of VSMCs in the media and cause luminal narrowing and impaired vascular function. …”
Get full text

The Importance of Lung Innate Immunity During Health and Disease by Gusty Rizky Teguh Ryanto, Ratoe Suraya, Tatsuya Nagano

“…Disturbances in lung innate immunity properties and processes, whether over-responsiveness of the process triggered by innate immunity or lack of responses due to dysfunctions in the immune cells that make up the innate immunity system of the lung, could be correlated to various pathological conditions. In this review, we discuss globally how the components of lung innate immunity are important not only for maintaining lung homeostasis but also during the pathophysiology of notable lung diseases beyond acute pulmonary infections, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.…”
Get full text

Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

“…In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities.…”
Get full text

A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma by J. K. Ma, J. Barr, S. Vijayakumar

“…The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bone and acetabulum, who experienced pathological fracture at presentation. This report describes a multidisciplinary approach to the management that includes initial incisional biopsy, curettage, and bone grafting, followed by Intensity Modulated Radiation Therapy. …”
Get full text

Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
Get full text

Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice by Qianqian Zhang, Xiaofeng Yu, Linghan Tian, Yanjun Cong, Linfeng Li

“…The main evaluation indexes used were levels of mast cell proteases, histamine, and specific antibody immunoglobulin E (IgE), as well as cytokine secretion and pathological observation. The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice. …”
Get full text

Advanced Role of Neutrophils in Common Respiratory Diseases by Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang

“…They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. …”
Get full text

THE ROLE OF ERYTHROPOIETIN IN TREATMENT OF ANEMIA IN CANCER PATIENTS by P. G. Berezin, V. V. Milovanov, A. A. Ivannikov

“…Malignant neoplasms are a serious pathological condition, both in terms of the course of the disease and the need for treatment, and a prognosis for the life of patients. …”
Get full text

A Case of Primary Signet-Ring Cell Cervical Carcinoma Treated with Chemoradiation, Brachytherapy, and Adjuvant Hysterectomy by Nicole Salmen, Dominic LaBella, Kenneth Strumpf, Wiley Douglas Bunn, Paul Aridgides

“…Approximately 20 cases of primary signet-ring cell carcinoma of the cervix have been reported. Pathologic examination shows that adenocarcinomas with mucin accumulation in intracytoplasmic vacuoles displacing the nucleus indicate signet-ring cell carcinoma. …”
Get full text

Postoperative Acute Exacerbation of IPF after Lung Resection for Primary Lung Cancer by Atsushi Watanabe, Nobuyoshi Kawaharada, Tetsuya Higami

“…Nevertheless, some IPF patients experience acute exacerbations generally characterized by suddenly worsening and fatal respiratory failure with new lung opacities and pathological lesions of diffuse alveolar damage. Acute exacerbation of idiopathic pulmonary fibrosis (AEIPF) is a fatal disorder defined by rapid deterioration of IPF. …”
Get full text

Gait and Function in Class III Obesity by Catherine Ling, Teresa Kelechi, Martina Mueller, Sandra Brotherton, Sheila Smith

“…The findings indicate that Class III-related gait is pathologic and not a normal adaptation.…”
Get full text

Less Is More: Evaluating the Benefits of Minimally Invasive Spinal Surgery by Ali A. Mohamed, Rakan Alshaibi, Steven Faragalla, Garrett Flynn, Asad Khan, Emma Sargent, Youssef Mohamed, Camberly Moriconi, Cooper Williams, Zev Karve, Daniel Colome, Phillip Mitchell Johansen, Brandon Lucke-Wold

“…Various approaches, including endonasal cervical, transoral cervical, transcervical, mini-open/percutaneous, tubular, and endoscopic techniques, provide alternatives for current approaches to a range of spinal pathologies. The main findings of this review highlight potential advantages of MISS over traditional open surgery, including reduced complications, shorter hospital stays, and improved patient outcomes. …”
Get full text

Speech and the Right Hemisphere by E. M. R. Critchley

“…The importance of the right hemisphere in speech is suggested by pathological studies, blood flow parameters and analysis of learning strategies. …”
Get full text

Role of macrophage in intervertebral disc degeneration by Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang

“…To gain a deeper understanding of the inflammatory microenvironment of intervertebral disc degeneration, this review will summarize the role of macrophages in the pathological process of intervertebral disc degeneration, analyze the regulatory mechanisms involving macrophages, and review therapeutic strategies targeting macrophage modulation for the treatment of intervertebral disc degeneration. …”
Get full text