Interferons and Interferon Regulatory Factors in Malaria by Sin Yee Gun, Carla Claser, Kevin Shyong Wei Tan, Laurent Rénia

“…Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. …”
Get full text

Focal hand dystonia due to hemorrhage of the cervical spinal mass: a case report by Pelin Analay, Hazal Sevinç, Hilmi Berkan Abacıoğlu, Rahşan Göçmen, Bayram Kaymak, Levent Özçakar

“…Although dystonia is traditionally considered a disorder of the basal ganglia, it has been observed in association with lesions at various sites of the motor and sensory pathways, including spinal cord pathologies such as syringomyelia, tumors, and demyelinating lesions. …”
Get full text

Interdisciplinary Management of Cystic Neoplasms of the Pancreas by Linda S. Lee, Thomas Clancy, Vivek Kadiyala, Shadeah Suleiman, Darwin L. Conwell

“…Though reliable biomarkers are lacking, a wide spectrum of diagnostic modalities are available to evaluate pancreatic cystic neoplasms, including radiologic, endoscopic, laboratory, and pathologic analysis. An interdisciplinary approach to management of these lesions which incorporates recent, specialty-specific advances in the medical literature is herein suggested.…”
Get full text

Protocol for investigating astrocytic mitochondria in neurons of adult mice using two-photon microscopy by Jian Zhou, Fengling Du, Fan Zhang, Xianhui Zhang, Yuanyuan Wu, Lifang Zhang, Ping Liao, Tianqi Tu, Jianhua Peng, Tao Li, Yong Jiang

“…Summary: Under pathological conditions, astrocytes can transfer mitochondria to neurons, where they exert neuroprotective effects. …”
Get full text

Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value by Yuanyuan Shao, Xiaofeng Pan, Rong Fu

“…Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. …”
Get full text

A Rare Case of Functioning Adrenocortical Oncocytoma Presenting as Cushing Syndrome by Nicola Tartaglia, Pasquale Cianci, Amedeo Altamura, Vincenzo Lizzi, Fernanda Vovola, Alberto Fersini, Antonio Ambrosi, Vincenzo Neri

“…Laparoscopic adrenalectomy was performed and the tumor was pathologically confirmed as benign adrenocortical oncocytoma. …”
Get full text

Colo-colic intussusception secondary to a giant lipoma: A case report by Karine Ibrahim, MD, Christele Lahoud, MD, Rachele Lahoud, MD, Kamal Hachem, MD, Chadi Braidy, MD

“…Intussusception in adults is a rare condition often associated with a pathological lead point, which is frequently malignant but can occasionally be benign, such as colonic lipomas. …”
Get full text

Heterotopic Ossification in the Abdomen of an Elderly Patient, as an Incidental Finding During Elective Surgery: A Case Report by Gordana Bozhinovska-Beaka, Biljana Prgova Veljanova, Tatjan Troik, Ivica Stojanovski, Patricija Kalamaras, Nadica Bozhinovska-Dimova

“…Heterotopic ossification (HO) is a rare diverse pathologic process, with broad spectrum. Case report. …”
Get full text

Role of Microglia in CNS Autoimmunity by Tobias Goldmann, Marco Prinz

“…The disease is characterized histologically by the infiltration of encephalitogenic TH1/TH17-polarized CD4+ T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. …”
Get full text

The Rise of CRISPR/Cas for Genome Editing in Stem Cells by Bing Shui, Liz Hernandez Matias, Yi Guo, Ying Peng

“…Genetic manipulation is a powerful tool to establish the causal relationship between a genetic lesion and a particular pathological phenotype. The rise of CRISPR/Cas9 genome-engineering tools overcame the traditional technical bottleneck for routine site-specific genetic manipulation in cells. …”
Get full text

Case report: Complete response of recurrent locally advanced basal cell carcinoma following addition of vismodegib to neoadjuvant cemiplimab therapy by Chalette Lambert-Swainston, Wolfram Samlowski, Wolfram Samlowski, Wolfram Samlowski, Brandon Reynolds, Amin Hedayat, Amin Hedayat

“…A wide excision demonstrated a pathologic complete response. Further evaluation of cemiplimab and hedgehog inhibitor combination therapy in la BCC appears warranted.…”
Get full text

Arthroscopic Treatment of a Case with Concomitant Subacromial and Subdeltoid Synovial Chondromatosis and Labrum Tear by Nevres Hurriyet Aydogan, Onur Kocadal, Ahmet Ozmeric, Cem Nuri Aktekin

“…Advantages of arthroscopic surgery in the presence of intra- and extra-articular combined pathologies are also discussed.…”
Get full text

Xanthogranuloma of the External Auditory Canal Mimicking a Benign Tumor: A Case Report by Keisuke Yoshihama, Yasumasa Kato, Yuh Baba

“…CT revealed the soft tissue mass without bony erosion, and MRI revealed that the mass showed a homogenous, iso signal intensity on a both T1- and T2-weighted image, suggesting that the mass is a benign tumor such as adenoma. Pathological examination showed that the specimen demonstrated xanthogranuloma in the external auditory canal. …”
Get full text

The significance of radiological methods in the diagnostics of Gastroenterological diseases (according to the materials of the 18th Russian Gastroenterology Week) by Z. A. Lemeshko

“…They play the important role in the follow-up of the course of the pathological processes.…”
Get full text

Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation by Shyi-Jou Chen, Yung-Liang Liu, Huey-Kang Sytwu

“…In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.…”
Get full text

Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors by Hajaralsadat Hosseini-Dastgerdi, Fatemeh Kharazmi, Ali-Asghar Pourshanazari, Mehdi Nematbakhsh

“…Therefore, in many pathological conditions associated with an increased renal sympathetic tone, these receptors’ expression changes and renal denervation can normalize these changes and improve the diseases. …”
Get full text

A Rare Form of Chronic Granulomatous Disease (Type Iva) Presenting as Inflammatory Bowel Disease by Francisco A Sylvester

“…Neutrophil dysfunction syndromes can sometimes mimic the clinical and pathological features of inflammatory bowel disease. …”
Get full text

Fever by Tamas Bartfai, Bruno Conti

“…We also show how temperature elevation is common to different pathologies and how the molecular components of the fever-generation pathway represent drug targets for antipyretics, such as acetylsalicylic acid, the first “blockbuster drug”. …”
Get full text

Cecocolic Intussusception in Adult Caused by Acute Appendicitis by Jeonghyun Kang, Kang Young Lee, Seung-Kook Sohn

“…Although this patient underwent laparoscopic right hemicolectomy under suspicion of malignancy at cecum base, final pathologic diagnosis revealed only acute appendicitis. …”
Get full text

Role of microRNAs in Stroke and Poststroke Depression by Han Yan, Min Fang, Xue-Yuan Liu

“…They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. …”
Get full text