Ameliorative Effects of Polygonatum kingianum Polysaccharides on Lipid Metabolism Disorders and Brain Function Impairments in Obese Mice by XU Yuncong, YAN Qiaojuan, ZHU Chunhua, YANG Shaoqing, LI Houjiang, JIANG Zhengqiang

“…Changes in body mass and blood lipids, as well as pathological changes in liver and adipose tissue were observed. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Our work addresses the critical question of how these skeletal pathologies emerge. Here, we show the abundant expression of LRP1 in skeletal progenitor cells at mouse embryonic stage E10.5 and onwards, especially in the perichondrium, the stem cell layer surrounding developing limbs essential for bone formation. …”
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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…This review examines the regulatory mechanisms and pathological implications of pseudouridylation in human diseases, with a focus on its involvement in tumourigenesis. …”
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Magnetic resonance imaging-based deep learning for predicting subtypes of glioma by Zhen Yang, Zhen Yang, Peng Zhang, Yi Ding, Liyi Deng, Tong Zhang, Yong Liu

“…PurposeTo explore the value of deep learning based on magnetic resonance imaging (MRI) in the classification of glioma subtypes.MethodsThis study retrospectively included 747 adult patients with surgically pathologically confirmed gliomas from a public database and 64 patients from our hospital. …”
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Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision by Chenglong Fan, Guanglin Yang, Cheng Li, Jiwen Cheng, Shaohua Chen, Hua Mi

“…Abstract Introduction Diabetic nephropathy (DN) is a common diabetes-related complication with unclear underlying pathological mechanisms. Although recent studies have linked glycolysis to various pathological states, its role in DN remains largely underexplored. …”
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Nephroprotective effects of Foeniculum vulgare mill (Apiaceae Family) hydromethanol leaf extract against cisplatin-induced nephrotoxicity on Swiss albino mice by Kibur Hunie Tesfa, Chernet Desalegn Gebeyehu, Tiget Ayelgn Mengstie, Hiwot Tezera Endale

“…The group of mice treated with 200 mg/kg, 400mg/kg of extract, and silymarin control significantly reduced the serum kidney markers and prevented pathological damage to the kidney compared to the negative control group. …”
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Effect of Bacillus subtilis JZXJ-7, a Strain Isolated from Shrimp Paste, on Colonic Function and Microbial Community in Mice Infected with Vibrio parahaemolyticus by ZHOU Kui, WANG Rundong, GONG Mengxue, MOU Jingyuan, DENG Yijia, LI Xuepeng, ZHANG Yuhao, LI Jianrong

“…In summary, JZXJ-7 can effectively alleviate colonic pathological damage in Vp infected mice and maintain intestinal functions, and the underlying mechanism may be related to its regulatory effect on the intestinal microbiota.…”
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Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): safety, efficacy, and exploratory biomarker analysis by Jeff Clarke, Xiaofei Wang, Thomas Stinchcombe, Scott J Antonia, Jeffrey Crawford, Neal Ready, Konstantin H Dragnev, Lin Gu, Cameron Wood, James M Isaacs, Liliana Lyniv, Kent Weinhold, Jacob M Kaufman, Eziafa I Oduah, Betty C Tong, Dennis Wigle

“…A 5-year progression-free survival (PFS) from time of surgery was 72.0% (56.4%–91.9%) and overall survival (OS) from time of surgery was 75.8% (60.7%–94.7%). Major pathological response (MPR) was found in seven tumors (28%) including two complete responses (4%). …”
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Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization by Feng Zhao, Wenlei Fei, Zhouyue Li, Hanyang Yu, Lei Xi

“…Background. Pathological neovascularization, which involves a disruption in the balance between angiogenic and antiangiogenic factors under pathological conditions, is the basis of many intraocular diseases. …”
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Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma by Lorenza Bridi Todeschini, Rita de Cássia Sant’Anna Alves, Adriana Vial Roehe

“…The data were correlated with clinical and pathological characteristics of the patients. Results: The mean age of the patients was 72.1 years. …”
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High Lyso-Gb3 Plasma Levels Associated with Decreased miR-29 and miR-200 Urinary Excretion in Young Non-Albuminuric Male Patient with Classic Fabry Disease by Sebastián Jaurretche, Germán R. Perez, Graciela Venera

“…Renal involvement is associated with a greater morbidity and mortality in Fabry disease. Pathological albuminuria, the first Fabry nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo-interstitial fibrosis and glomerulosclerosis are present or may precede the onset of pathological albuminuria. …”
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MM-HiFuse: multi-modal multi-task hierarchical feature fusion for esophagus cancer staging and differentiation classification by Xiangzuo Huo, Shengwei Tian, Long Yu, Wendong Zhang, Aolun Li, Qimeng Yang, Jinmiao Song

“…The proposed architecture combines low-level to deep-level features of both pathological and endoscopic images to achieve accurate classification results. …”
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Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice by Rosangela Alquieri Fedato, Júlio César Francisco, Gabriel Sliva, Lúcia de Noronha, Márcia Olandoski, Jose Rocha Faria Neto, Priscila Elias Ferreira, Rossana Baggio Simeoni, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho, Luiz César Guarita-Souza

“…Objective. Achilles tendon pathologies occur frequently and have a significant socioeconomic impact. …”
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Clinical characteristics of and growth hormone treatment effects on short stature with type 1 insulin-like growth factor receptor (IGF1R) gene alteration by Yuki Kawashima-Sonoyama, Keisuke Wada, Kei Yamamoto, Masanobu Fujimoto, Noriyuki Namba, Takeshi Taketani

“…Cases with deletions showed a more severe degree of growth impairment (–4.5 ± 0.43 SD) than those caused by pathological variants (–2.71 ± 0.15 SD) and were accompanied by neurodevelopmental delay. …”
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Leptospirosis Prevalence in Patients with Initial Diagnosis of Dengue by A. Dircio Montes Sergio, E. González Figueroa, Verdalet Guzmán María Saadia, Soler Huerta Elizabeth, Rivas Sánchez Beatriz, M. Altuzar Aguilar Víctor, J. Navarrete Espinosa

“…It is necessary the intentional search of other pathologies, such as influenza, rickettsiosis, and brucella, among others.…”
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Deep learning based tractography with TractSeg in patients with hemispherotomy: Evaluation and refinement by Johannes Gruen, Tobias Bauer, Theodor Rüber, Thomas Schultz

“…Even though it has exclusively been trained on healthy subjects, a certain level of generalization to different pathologies has been demonstrated, and TractSeg is now increasingly used for clinical cases. …”
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Obesity and Cardiometabolic Risk Stratification in Schoolchildren from Santa Clara by Elizabeth Fernández Martínez, Clara Luz Rodríguez Cervera, Emilio González Rodríguez, Yosvani García Nóbrega, Alianny Rodríguez Urrutia, Merlin Gari Llanes

“…These include: obesity, high blood pressure and diabetes mellitus. These pathologies appear from childhood and their prevention must begin from an early age. …”
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Atherogenic Risk Factors in Medical Students by Airam Navarro Palacios, Miguel Ángel Serra Valdés, Rafael Comas Valdespino, Girelda Cordero López, Alain Landrian Davis, Adrian Landrian Davis

“…The variables considered were: sex, body mass index (BMI), smoking habit, arterial hypertension, hypercholesterolemia, hypertriglyceridemia, nutritional habits, alcohol consumption and family pathological history.<br /> <strong>Results:</strong> the most frequent atherogenic risk factors detected were: obesity (17.65 %), dyslipidemia (16.7 %), smoking (33.5 %), arterial hypertension (9.4 %), frequent consumption of alcoholic beverages (28.2 %), related family pathological history (22.9 %) and inadequate diets (62.2 %), whose values in the statistical analysis were significant. …”
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Driving brain state transitions via Adaptive Local Energy Control Model by Rong Yao, Langhua Shi, Yan Niu, HaiFang Li, Xing Fan, Bin Wang

“…An in-depth exploration of brain state transitions is crucial for revealing functional changes in both health and pathological states and realizing precise brain function intervention. …”
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Airway approach in a pediatric patient with Noonan syndrome. Presentation of a case by Dayane García Jiménez, Rolando Javier Álvarez Pérez, Robin Fajardo Alcalá, Ivanis Idael Corría Milán

“…A 13-year-old male patient was presented with a personal pathological history of Noonan syndrome genotype PTPN11, hypothyroidism, mild intellectual disability who attended the Surgical Guard Corps due to abdominal pain of 16 hours duration. …”
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