Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma by Angela J. Yoon, Richard D. Carvajal, Evan M. Graboyes, John M. Kaczmar, William G. Albergotti, Alexandra E. Kejner, Scott H. Troob, Elizabeth Philipone, Jean-Sebastien Anoma, Kent E. Armeson, Elizabeth G. Hill, Mary S. Richardson, Tina R. Woods, Bhishamjit S. Chera, Farzad Nourollah-Zadeh, Byung J. Lee, Subramanya Pandruvada, Antonis Kourtidis, Christina Kingsley, Elizabeth C. O’Quinn, Stephanie Mills, Victoria C. Jordan, Mike Spencer, Danielle Fails, Trevor D. McKee, Mark Zaidi, Alan Brisendine, Shane Horn, Shikhar Mehrotra, Besim Ogretmen, Jason G. Newman

“…Similarly, 60% of patients had immune-related major pathologic response (irMPR) with two complete pathologic responses, and 40% had partial response (PR) with the percent residual viable tumor ranging from 25% to 65%. …”
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Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient by Tiphaine Goletto, Flora Crockett, Selim Aractingi, Cecile Toper, Patricia Senet, Jacques Cadranel, Jean-Marc Naccache

“…Werner syndrome (WS) is a progeroid or premature aging syndrome characterized by early onset of age-related pathologies and cancer. The average life expectancy of affected people is 52.8 years and tends to increase. …”
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Intelligent Medical Auxiliary Diagnosis Algorithm Based on Improved Decision Tree by Yuntao Wei, Xiaojuan Wang, Meishan Li

“…Finally, the attribute feature quantity of IMAD with pathological characteristics is extracted, and the improved decision tree model is used to realize intelligent medical auxiliary, assist in the optimal decision of diagnosis, and realize the effective classification and recognition of pathological characteristics. …”
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Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review by Yiting Ze, Yongyao Wu, Zhen Tan, Rui Li, Rong Li, Wenzhen Gao, Qing Zhao

“…Deletion of the core clock gene Bmal1 leads to pathological bone alterations, while the phenotypes are not consistent. …”
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Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization by Hidehiko Okamoto

“…Recent studies attempted to noninvasively visualize pathological neural activity in the living human brain and reverse maladaptive cortical reorganization by the suitable manipulation of auditory inputs in order to alleviate detrimental auditory symptoms. …”
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Mapping Pituitary Neuroendocrine Tumors: An Annotated MRI Dataset Profiling Tumor and Carotid Characteristics by A. S. Pandit, A. Keenlyside, D. Z. Khan, G. Reischer, M. A. Kamal, N. Yoh, Z. Jaunmuktane, A. Borg, N. L. Dorward, S. E. Baldeweg, I. Davagnanam, H. Hyare, P. Nachev, H. J. Marcus

“…We introduce an open dataset comprising high-resolution T1 contrast-enhanced MR scans of 136 patients with pituitary tumors, annotated for tumor segmentation and accompanied by clinical, radiological and pathological metadata. This diverse dataset captures variations in tumor size, location, and pathological activity, essential for understanding this complex condition. …”
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Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis by Hugh James Freeman

“…Almost half were Indo-Canadians, and atypical perinuclear-staining antineutrophil cytoplasmic antibody was also detected in five (28%), similar to the detection rate for Crohn's disease and other less commonly detected forms of colitis, such as lymphocytic or collagenous colitis. Careful pathological review of all endoscopic biopsies and surgically resected colonic tissues did not reveal evidence of vasculitis or so-called 'palisading' granulomas, which is a typical pathological change of Wegener's granulomatosis, an entity that has been traditionally characterized by the detection of cANCA. …”
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Signal integrator function of CXXC5 in Cancer by Zihao An, Jiepu Wang, Chengzuo Li, Chao Tang

“…CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers. …”
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Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation by Audrey Ortega-Ramírez, Rosario Vega, Enrique Soto

“…This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.…”
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Epidemiological Research Advances in Vascular Calcification in Diabetes by Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao, Zhongqun Wang

“…Various pathological types have been described, such as calcification and valve calcification. …”
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Hemorrhagic Transformation in Stroke by Dianarelys Villafuerte Delgado, Odalys Yanes Isray, Félix González Pérez

“…It is presented a case of a patient with pathological antecedents of hypertension and ischemic heart disease who was admitted after having had a brain tomography without contrast which showed mild signs of diffuse cortical atrophy. …”
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Brooke–Spiegler Syndrome: Familial Cylindromatosis, a Rare Variant of a Rare Familial Syndrome by Harsh Patel, William Naber, Austin Cusick, Craig Oser

“…The patient had undiagnosed cylindromas growing for 36 years at presentation; however, he did not seek out healthcare evaluation. Excision and pathologic investigation of three large masses from different body sites determined a shared phenotype of cylindromas. …”
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Mature Cystic Teratoma Hiding in the Retroperitoneum of an Adult by Yardesh Singh, Shamir O. Cawich, Thivy Kuruvilla, Sidiyq Mohammed, Ammiel Arra

“…We review the radiologic and pathologic features of this rare lesion.…”
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Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases by Magdalena Klink, Henryk Tchorzewski, Zofia Sulowska

“…Since the neutrophils play a pathological role in ischaemic heart disease, it is important to understand the direct action of nitrovasodilators on their function.…”
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Neoadjuvant chemotherapy combined with antiangiogenic therapy and immune checkpoint inhibitors for the treatment of locally advanced gastric cancer: a real - world retrospective co... by Zhouwei Zhan, Bijuan Chen, Shaohua Xu, Ruyu Lin, Haiting Chen, Xiaohuan Ma, Xuanping Lin, Wanting Huang, Changhua Zhuo, Yu Chen, Zengqing Guo

“…The rates of major pathological response (MPR) and pathological complete response (pCR) were 47.4% and 23.7%, respectively. …”
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Sebaceous Carcinoma of the Penis: A Rare, Dangerous Clinical Entity and the Importance of Immunohistochemistry in Diagnosis by Vikram Sahni, David S. Cassarino

“…We report a very rare case of pathologically confirmed sebaceous carcinoma of the glans penis with multiple areas of lymphovascular and perineural invasion and multiple lymph node metastases. …”
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Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases by Fabio Morandi, Roberta Rizzo, Enrico Fainardi, Nathalie Rouas-Freiss, Vito Pistoia

“…Here, we have reviewed novel findings on HLA-G functions in different physiological and pathological settings, which have been published in the last two years. …”
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Evaluation of renoprotective effect of Chinese chive extracts on adenine-induced chronic renal failure by Qiang-Ming Li, Jian-Ping Luo, Li-Hua Pan, Xue-Qiang Zha

“…Results showed that the renal pathological damages and the enhancement of serum creatinine and blood urea nitrogen of CRF mice could be significantly alleviated by the treatment of CCWE, but not CCEE. …”
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Antifibrotic Activity of Acylated and Unacylated Ghrelin by Elia Angelino, Simone Reano, Michele Ferrara, Emanuela Agosti, Andrea Graziani, Nicoletta Filigheddu

“…Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. …”
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Steroids and/or Cytotoxic Agents Should Be Used Early in the Management of Patients with IPF -- The Pro Argument by Sat Sharma

“…Katzenstein and Myers (1) classified these disorders according to several pathologically distinct categories: usual interstitial pneumonitis (UIP), desquamative interstitial pneumonitis ? …”
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