NLR, A Convenient Early-Warning Biomarker of Fatal Outcome in Patients With Severe Fever With Thrombocytopenia Syndrome by Yuanyuan Wei, Yuanyuan Wei, Zilong Wang, Luyang Kang, Lingling He, Lingling He, Nan Sheng, Nan Sheng, Jiangfeng Qin, Jiangfeng Qin, Shuangshuang Ma, Honghai Xu, Lifen Hu, Guizhou Zou, Yufeng Gao, Yufeng Gao, Jiabin Li, Jiabin Li

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A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model by Fengyu Chi, Fengyu Chi, Xu Zhang, Xu Zhang, Dong Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li, Yuming Li, Yuming Li

“…Immune sera provided complete protection against lethal EV-A71 challenge, significantly reducing viral load and pathology.DiscussionThis study demonstrates that the mRNA vaccine exhibits significant potential for combating non-enveloped viruses. …”
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Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with <i>M. bovis</i> BCG or Other Therapies by Inmaculada Ruiz-Lorente, Lourdes Gimeno, Alicia López-Abad, Pedro López Cubillana, Tomás Fernández Aparicio, Lucas Jesús Asensio Egea, Juan Moreno Avilés, Gloria Doñate Iñiguez, Pablo Luis Guzmán Martínez-Valls, Gerardo Server, Belén Ferri, José Antonio Campillo, María Victoria Martínez-Sánchez, Alfredo Minguela

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FTO rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control Study by Salum KCR, Assis ISS, Kopke ÚA, Palhinha L, Abreu GM, Gouvêa LW, Teixeira MR, Mattos FCC, Nogueira Neto JF, Felício RFM, Rosado EL, Zembrzuski VM, Campos Junior M, Maya-Monteiro CM, Cabello PH, Carneiro JRI, Bozza PT, Kohlrausch FB, da Fonseca ACP

“…Kaio Cezar Rodrigues Salum,1,2 Izadora Sthephanie da Silva Assis,1,2 Úrsula de Almeida Kopke,3 Lohanna Palhinha,4 Gabriella de Medeiros Abreu,2,5 Laura Wendling Gouvêa,1,2 Myrela Ribeiro Teixeira,2,6,7 Fernanda Cristina C Mattos,5 José Firmino Nogueira Neto,8 Rafaela de Freitas Martins Felício,9,10 Eliane Lopes Rosado,5 Verônica Marques Zembrzuski,2 Mario Campos Junior,2 Clarissa Menezes Maya-Monteiro,4 Pedro Hernán Cabello,2 João Regis Ivar Carneiro,1 Patrícia Torres Bozza,4 Fabiana Barzotto Kohlrausch,6 Ana Carolina Proença da Fonseca2,4,11 1Medical Clinic Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Human Genetics Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil; 3Chester Medical School, University of Chester, Chester, UK; 4Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil; 5Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 6Human Genetics Laboratory, Institute of Biology, Federal Fluminense University Niterói, Rio de Janeiro, Brazil; 7Postgraduate in Sciences and Biotechnology, Fluminense Federal University Niterói, Rio de Janeiro, Brazil; 8Department of Pathology and Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil; 9Birth Defect Epidemiology laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil; 10Health Care Network for Congenital Anomalies of the Central Nervous System, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; 11Genetics Laboratory, Grande Rio University, Rio de Janeiro, BrazilCorrespondence: Ana Carolina Proença da Fonseca, Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), 4365 Brasil Avenue, 108 Building – Office 44, Rio de Janeiro, 21040-360, Brazil, Tel +55(21)38658192, Email ana.proenca@ioc.fiocruz.br Kaio Cezar Rodrigues Salum, Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), 4365 Brasil Avenue, Leônidas Deane Building – Office 611/615, Rio de Janeiro, 21040-360, Brazil, Tel +55 21 38658213, Fax +55 21 38658239, Email kaio.salum@hotmail.comPurpose: Obesity is a complex disease caused by a combination of genetic, environmental, and epigenetic factors, and is associated with an increased risk of chronic diseases. …”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

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Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

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Spondilitis Tuberkulosa Cervical by Roni Eka Saputra, Irsal Munandar

“…At 5.6 C spondylitis vertebre anterior corpectomi following surgery,<br />microsurgery with iliac graft, and insertion one level anterior plate. Anatomical Pathology examination showed<br />caseating tuberculosis spodilitis. …”
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Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 &ndash; 2021) by Le HHL, Thuc LC, Ta TB, Tran TV, Hung DV, Kien HT, Le MN, Luong VH, Nguyen VTH, Pham HQ, Le HV, Viet NH, Hoang LH, Nguyen TT, Latsavong M, Le TD, Trong Tuan D, An NV

“…Hai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,15 Mixay Latsavong,16 Tuan Dinh Le,17 Dao Trong Tuan,18 Nguyen Van An19 1Department of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 3Cardiovascular Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 4Respiratory Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 6Department of Psychiatry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 7Department of Immunology, Vietnam Military Medical University, Hanoi, Vietnam; 8Tay Nguyen Institute of Science Research, Vietnam Academy of Science and Technology, VAST, Hanoi, Vietnam; 9Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Tokyo, Japan; 10Department of Laser and Skincare, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 11Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam; 12Department of General Planning, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 13Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 14Molecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 15Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam; 16Department of Nephrology-Hemodialysis, Military Central Hospital 103, Vientiane, Laos; 17Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 18ENT Department, Central Military Hospital 108, Hanoi, Vietnam; 19Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, VietnamCorrespondence: Nguyen Van An, Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, 100000, Vietnam, Tel + 84 982 860 055, Email ank59hvqy@gmail.comPurpose: In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) of common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 and 2021.Methods: From 4060 urine samples collected, common pathogens were isolated using quantitative culture on brilliance UTI Clarity agar and blood agar. …”
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Investigating the Effect of Chicken Manure and Potassium Sulfate on the Physiological Properties of Fenugreek )Trigonella foenum-graecum L.( Medicinal Plant by Mohammad hossein Aminifard, Sajjad Nadafa, Hassan Hassan, Mehdi Jahani

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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…These findings highlight the complex role of PCSK9 in cardiac pathology and caution against the assumption that PCSK9 inhibitors will necessarily yield cardiovascular benefits similar to genetic PCSK9 deficiency.…”
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Life after prostate cancer diagnosis: protocol for a UK-wide patient-reported outcomes study by David H Brewster, Victoria Cairnduff, Eila Watson, Amy Downing, Adam W Glaser, Penny Wright, William Cross, Conan Donnelly, Anna Gavin, Carol Rivas, Richard Wagland, Peter Selby, Luke Hounsome, Therese Kearney, Rebecca Mottram, Majorie Allen, Oonagh McSorley, Hugh Butcher, Paul Kind, James W H Catto, Dyfed Huws, Emma McNair, Lauren Matheson, Johana Nayoan, Mike Horton, Jessica Corner, Julia Verne

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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

“…These analyses revealed a sustained upregulation of a transcriptional profile of purinergic receptors and ectonucleotidases in cGVHD WT PECs, which displayed a coordinated expression with several type I interferon-stimulated genes (ISGs) and with key molecules involved in the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, two hallmarks in the lupus pathology. A second purinergic receptor transcriptomic profile, which included P2rx7 and P2rx4, showed a coordinated gene expression of the components of the NLRP3 inflammasome with its potential activators. …”
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Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Ob... by Satoru Kagami, Kimihiko Funahashi, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Heita Ozawa, Fumikazu Koyama, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka

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Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…Particularly, hUCMSCs demonstrated potential in mitigating lung pathology in a SARS-CoV-2 infection model, suggesting their promising therapeutic efficacy.…”
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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

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Evaluation of oral health status in patients with type 2 diabetes by Tahmineh Khoshbakhti, Vajehallah Raeesi, Gholamreza Sharifzadeh, Leili Alizadeh

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