The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration by Lisa Schwarz, Grit Vollmer, Christiane Richter-Landsberg

“…The upregulation of HSP27 in tauopathies with gial pathology implies distinct mechanisms for glial and neuronal cells. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…However, it is not known whether Sig-1R can ameliorate pathological neuroinflammation in DNP. The present study used a rat model of DNP and a highly selective agonist of Sig-1R to assess the effects of the protein on neuropathic pain in rats with type 2 diabetes mellitus. …”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Daily treatment with OB-002 altered immune gene transcription in the lungs, and reduced pathology following infection, but did not prevent weight loss or viral replication in the lungs of infected animals, even in combination with the antiviral drug remdesivir. …”
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Assessing the Clinical and Functional Status of COPD Patients Using Speech Analysis During and After Exacerbation by Mayr W, Triantafyllopoulos A, Batliner A, Schuller BW, Berghaus TM

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Editorial: Artificial intelligence and imaging for oncology by Yuxiang Zhou, Zhimin Li, Poonam Yadav

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Reproductive problems in water buffalo cows associated with non-diagnosed genital lepto- spirosis. Preliminary results by Rosaura Pérez-Gil

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The diagnosis and treatment of 56 cases of breast hamartoma: a single-center analysis and a review of the literature by Hao Su, Caiyun Bai, Zhimin Fan, Di Wu, Fengjiang Qu

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Changes in the histological structure of tissues and organs of pikeperch (Sander lucioperca Linnaeus, 1758) and perch (Perca fluviatilis Linnaeus, 1758) from the Zaporizhzhia Reser... by P. Korzhenevska, T. Sharamok, A. Doroshenko

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Comparison of molecular analysis results determined by next-generation sequencing to immunohistochemical indicators and clinicopathological parameters in prostate adenocarcinomas by Merve Çırak Balta, İbrahim Halil Erdoğdu, Esin Oktay, Nil Çulhac

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Diagnostic value of dual-layer spectral detector CT parameters for differentiating high- from low-grade bladder cancer by Li Chen, Lili Xu, Xiaoxiao Zhang, Jiahui Zhang, Xin Bai, Qianyu Peng, Erjia Guo, Xiaomei Lu, Shenghui Yu, Zhengyu Jin, Gumuyang Zhang, Yi Xie, Huadan Xue, Hao Sun

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Assessment of ante mortem welfare indicators and the pathophysiology of captive-bolt trauma in equids at slaughter by Katharine A Fletcher, Barbara Padalino, Martina Felici, Daniele Bigi, Georgina Limon-Vega, Andrew Grist, Troy J Gibson

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« Petits meurtres entre amis ». Approche psychosomatique et psychodynamique du harcèlement moral au travail by Marie Grenier-Pezé

Subjects: “…pathology of loneliness…”
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Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer by Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao, Zaiyi Liu

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Free radical processes in rat liver in experimental diabetes, malignant growth and their combination by I. A. Goroshinskaya, E. M. Frantsiyants, I. V. Kaplieva, L. A. Nemashkalova, L. K. Trepitaki, P. S. Kachesova, E. I. Surikova, V. A. Bandovkina, M. I. Morozova, I. M. Kotieva

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Imagery Rescripting (ImRs) and Eye Movement Desensitization and Reprocessing (EMDR) as treatment of childhood-trauma related post-traumatic stress disorder (Ch-PTSD) in adults: eff... by Martine Daniëls, Marie-Louise Meewisse, Annet Nugter, Sophie A. Rameckers, Eva Fassbinder, Arnoud Arntz

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Routine Histopathological Evaluation of Benign Anorectal Interventions: Essentiality or Excess? by Ramazan Kozan, Enes Aksu, Kürşat Dikmen

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Comparison of Asymptomatic Brain Lesions Between Thalassemia Major and Sickle Cell Anemia Patients by Derya Yavuz Demiray, Özge Eriş Davut, Gönül Oktay

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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR41 and GPR43 by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…Conclusions Taken together, our results demonstrate that A. muciniphila and its metabolite propionate protect against AD-like pathological events in AD mouse models by targeting mitochondrial homeostasis, making them promising therapeutic candidates for the prevention and treatment of AD. …”
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Raman Microspectral Study and Classification of the Pathological Evolution of Breast Cancer Using Both Principal Component Analysis-Linear Discriminant Analysis and Principal Component Analysis-Support Vector Machine by Heping Li, Yu Ren, Fan Yu, Dongliang Song, Lizhe Zhu, Shibo Yu, Siyuan Jiang, Shuang Wang

“…Both classification models were principal component analysis-linear discriminant analysis to be extremely efficient on discriminating tissue pathological types with 99% accuracy for PCA-LDA and 100%, 100%, and 96.7% for PCA-SVM analysis based on linear kernel, polynomial kernel, and radial basis function (RBF), respectively, while PCA-SVM algorithm greatly simplified the complexity of calculation without sacrificing performance. …”
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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection by Alexsia Richards, Andrew S. Khalil, Max Friesen, Troy W. Whitfield, Xinlei Gao, Tenzin Lungjangwa, Roger D. Kamm, Zhengpeng Wan, Lee Gehrke, David Mooney, Rudolf Jaenisch

“…Here, we develop a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells (ECs), pericytes (PCs), and smooth muscle cells (SMCs) to recapitulate the vascular pathology associated with SARS-CoV-2 exposure. Our results demonstrate that perivascular cells, particularly SMCs, are a susceptible vascular target for SARS-CoV-2 infection. …”
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