Evolution of the umbilical cord blood proteome across gestational development by Leena B. Mithal, Nicola Lancki, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Nathaniel J. Rhodes, Byoung-Kyu Cho, William A. Grobman, Judd F. Hultquist, Denise Scholtens, Karen K. Mestan, Patrick C. Seed

“…These data contribute to the knowledge of the physiologic state of neonates across gestational age, which is crucial to understand as we strive to best support postnatal development in preterm infants, determine mechanisms of pathology causing adverse health outcomes, and develop cord blood biomarkers to help tailor our diagnosis and therapeutics for critical neonatal conditions.…”
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Angiomatous Meningioma in the Craniocervical Junction by Shunsuke Ito, Yoichi Iizuka, Masanori Aihara, Hiromi Koshi, Tokue Mieda, Eiji Takasawa, Sho Ishiwata, Yusuke Tomomatsu, Akira Honda, Kazuhiro Inomata, Hirotaka Chikuda

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Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment by Christof Meigen, Adrienne Csutak, Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy

“…Objective To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters on treatment outcomes.Methods and analysis This retrospective observational study included 62 individuals aged 4–17 years (mean±SD: 10.21±2.70) with progressing myopia but without ocular pathology with a range of −0.88 to −8.25 D spherical equivalent refraction (SER) (−3.73±1.56), coupled with astigmatism up to −3.25 D cylindrical. …”
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Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome by Arturs Zemitis, Arturs Zemitis, Juris Vanags, Juris Vanags, Theresa Schiemer, Theresa Schiemer, Kristaps Klavins, Kristaps Klavins, Guna Laganovska, Guna Laganovska

“…Our study investigates whether metabolomics can provide insights into this ocular pathology.MethodsThe study included 183 patients undergoing cataract surgery at Pauls Stradins Clinical University Hospital. 104 patients did not have PEXS, while 79 were diagnosed with the condition. …”
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Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? by Karaninder S. Mehta, Vikram K. Mahajan, Pushpinder S. Chauhan, Anju Lath Sharma, Vikas Sharma, C. Abhinav, Gayatri Khatri, Neel Prabha, Saurabh Sharma, Muninder Negi

“…A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma. The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

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Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation by Qian-Lu Wang, Lei Yang, Yue Peng, Min Gao, Ming-Shi Yang, Wei Xing, Xian-Zhong Xiao

“…For septic mice, lung tissue pathology was examined, plus ELISA assay for serum cytokines. …”
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Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis by Zenghui Li, Xinghui Li, Hui Jiang, Jingdong Li, Bin Xiao, Yong Chen, Shunhai Jian, Mei Zeng, Xiaoming Zhang

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Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017) by Gábor Tóth, Nóra Szentmáry, Gábor László Sándor, Béla Csákány, Erika Maka, Jeannette Tóth, Zsuzsanna Antus, Milán Tamás Pluzsik, Achim Langenbucher, Zoltán Zsolt Nagy, Olga Lukáts

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Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Ca... by Tsutomu Takenami, Shingo Tsujinaka, Jun Takahashi, Sawako Tamaki, Ryo Maemoto, Rintaro Fukuda, Hideki Ishikawa, Nao Kakizawa, Fumi Hasegawa, Rina Kikugawa, Yasuyuki Miyakura, Koichi Suzuki, Akira Tanaka, Toshiki Rikiyama

“…The histological examination revealed pathological complete response (pCR). The final diagnosis was ypStage 0 (ypT0ypN0M0). …”
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HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS by Tânia Gisela Biberg-Salum, Maria de Lourdes Veronese Rodrigues, Ana Paula Morais Fernandes, Neifi Hassan Salum Deghaide, Jayter Silva de Paula, Erick C. Castelli, Celso Teixeira Mendes-Junior, Eduardo Antonio Donadi

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Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…Results NR2 ameliorated albuminuria, renal function and renal pathology in db/db mice. The activation of c-Src was suppressed in db/db mice and in HK-2 cells exposed to HGPA. …”
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Association of vaginal oestradiol and the rate of breast cancer in Denmark: registry based, case-control study, nested in a nationwide cohort by Christian Torp-Pedersen, Lina Steinrud Mørch, Nelsan Pourhadi, Amani Meaidi, Ellen Christine Løkkegaard

“…To each woman who developed breast cancer during follow-up (18 997), five women in the control group (94 985) were incidence density matched by birth year.Main outcome measure The main outcome was pathology confirmed breast cancer diagnosis.Results 2782 (14.6%) women with breast cancer (cases) and 14 999 (15.8%) women with no breast cancer diagnosis (controls) had been exposed to vaginal oestradiol tablets with 234 cases and 1232 controls having been in treatment for at least four years at a high intensity (>50 micrograms per week). …”
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Rice genotypes (Oryza sativa) respond to varying planting dates and environmental conditions by 1Asif Ali Kaleri, 1Danish Manzoor,1Rabia Laghari,2Muzamil Awan, 3Bina Khanzada, 4Hafsa Munir, 2Saba Solangi, 2Tameer Hyder Shah.5Ameer Jan, 6Laiba Ashfaq, 2Ghulam Sajjad Kaleri Kaleri

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The evaluation of safe zones for the corona mortis using a cadaver simulation of the Modified Stoppa approach by Jade Naicker, Zithulele Nkosinathi Tshabalala, Andries Masenge, Obakeng Modisane, Steven Matshidza, Nkhensani Mogale

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A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome by Kentaro Tojo, Takuya Yazawa

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Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study by Tsutomu Takeda, Kenshi Matsumoto, Akihito Nagahara, Hiroyuki Komori, Yoichi Akazawa, Yuta Nakagawa, Kentaro Izumi, Kohei Matsumoto, Hiroya Ueyama, Yuji Shimada, Daisuke Asaoka, Mariko Hojo, Takashi Yao, Sumio Watanabe

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Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence by Ina Bähr, Vincent Goritz, Henriette Doberstein, Grit Gesine Ruth Hiller, Philip Rosenstock, Janine Jahn, Ole Pörtner, Tobias Berreis, Thomas Mueller, Julia Spielmann, Heike Kielstein

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Rare coinheritance of hemoglobin vancleave with severe beta-thalassemia mutation in a patient with secondary erythrocytosis by Nur Aisyah Aziz, Nurul Hidayah Musa, Melina Mathews, Komalah Thevii Rajenderan, Faidatul Syazlin Abdul Hamid, Syahzuwan Hassan, Syahira Lazira Omar, Wan Nurul Afiqha Binti Wan Yusoff, Melanie Ling Binti Mohd Din, Nurul Amira Binti Jamaludin, Wan Rohani Wan Taib, Ezalia Esa, Norafiza Mohd Yasin

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A human oral commensal-mediated protection against Sjögren’s syndrome with maintenance of T cell immune homeostasis and improved oral microbiota by Yu-Chao Tseng, Kai-Sheng Liao, Wei-ting Lin, Chin Li, Chia-Bin Chang, Jie-Wei Hsu, Chin-Pui Chan, Chun-Ming Chen, Hon-Pin Wang, Hsiu-Chuan Chien, Jann-Tay Wang, Song-Chou Hsieh, Shu-Fen Wu

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