Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction by Jingyi Tan, Anna Dai, Lai Pan, Lan Zhang, Zhongxiu Wang, Ting Ke, Weilian Sun, Yanmin Wu, Pei-Hui Ding, Lili Chen

“…However, the definite mechanism of aging-related inflammation in PD pathology needs further investigation. Our study is aimed at exploring the effect of inflamm-aging-related cytokines of interleukin-17 (IL-17) and interferon-γ (IFN-γ) on osteoclastogenesis in vitro and periodontal destruction in vivo. …”
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Effects of Binahong (Anredera cordifolia (Tenore) Steenis) Extracts on the Levels of Malondialdehyde (MDA) in Cataract Goat Lenses by Feriyani Feriyani, Hady Maulanza, Rodiah Rahmawaty Lubis, Ummu Balqis, Darmawi Darmawi

“…Oxidative stress can form pathological conditions such as cataracts. This oxidative stress ability can be measured by the malondialdehyde (MDA) biomarker. …”
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Adenosine A2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia by Felicita Pedata, Anna Maria Pugliese, Elisabetta Coppi, Ilaria Dettori, Giovanna Maraula, Lucrezia Cellai, Alessia Melani

“…Ischemia is a multifactorial pathology characterized by different events evolving in the time. …”
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Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats by Afrina Mustari, Mahabub Alam, Samia Rashid, A.G.M.Sofi Uddin Mahamud, Mohammad Alam Miah, Emdadul Hauqe Chowdhury

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Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody by Takako Miyamae, Takuma Hara, Aki Hanaya, Yumi Tani, Takayuki Kishi, Hisashi Yamanaka

“…Further experience is needed to determine the pathology, severity, and prognosis of this type of arthritis.…”
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Does bladder outflow obstruction obfuscate the traditional clinical factors that are used to assess the risk of prostate cancer at rapid‐access diagnostic clinics? by Thomas Philip Cahill, Samuel Joseph Withey, Steve Hazell, Declan Cahill, Netty Kinsella

“…The cohort characteristics between the groups were compared and logistic regression analyses were performed to assess associations between clinical predictive factors (age, PSA density, ethnicity, family history, digital rectal examination, urinary symptom severity and magnetic resonance imaging using the PI‐RADS scoring system) and clinically significant prostate cancer (csPCa) on biopsy (defined as International Society of Urological Pathology grade of greater than or equal to two). Results The obstructed group (n = 80) had significantly larger prostates and worse symptom severity (p < 0.05). …”
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Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients by Loren Masterson, Bryan J. Thibodeau, Laura E. Fortier, Timothy J. Geddes, Barbara L. Pruetz, Rajwant Malhotra, Richard Keidan, George D. Wilson

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Usefulness of Double-Balloon Endoscopy in the Postoperative Gastrointestinal Tract by Masaki Endo, Yukito Abiko, Syuhei Oana, Norihiko Kudara, Takashi Kosaka, Toshimi Chiba, Yasuhiro Takikawa, Kazuyuki Suzuki, Tamotsu Sugai

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Association of high organochlorine pesticide serum levels with oxidative stress in intestinal metaplasia and gastric cancer by Gholamreza Asadikaram, Mohammad Reza Ashrafi, Sodaif Darvish Moghaddam, Moslem Abolhassani, Fatemeh Bagheri

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Age and diet affect self-resilience of intestinal microbiome in mice by Chenyi Shao, Shenmin Chen, Huan Yang, Mufan Li, Yinhui Liu, Shu Wen, Jing Xiao, Li Tang

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Catastrophic Brain Aspergillosis after Liver Transplantation by Mohammadmahdi Abbasi, Shirin Shams Ardakani, Nasir Fakhar, Hamid Eshaghi, Hosein Alimadadi, Toktam Faghihi, Behdad Gharib, Meisam Sharifzadeh, Masoomeh Safaei

“…Intravenous antibiotics were initiated but the patient’s condition was not improving; therefore, surgical drainage of the abscess was performed. The pathological investigation was compatible with aspergillosis. …”
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FLIGHT HOURS AND BMI AGAINST TUC IN HYPOBARIC CHAMBER ALTITUDE 25.000 FEET by Zakiah Nada Nuralfilail, Pritha Maya Savitri, Niniek Hardini, Aulia Chairani, Andriyanto, Agus Budi Maryoto, Samsul A., Yaya Kardiana, Agus Cakrahaya

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Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture by Katharina Ritter, Kirsten Jung, Christopher Dolderer, Dominik Appel, Christine C. Oswald, Ulrike Ritz, Michael K. E. Schäfer

“…Concomitant extracranial injury such as long bone fracture was reported to exacerbate TBI pathology. However, early reciprocal effects and mechanisms have been barely investigated. …”
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Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or witho... by Andrew E. Potter, Christopher Baker, Stephen Shumack, Robert Sinclair, Walter J. Curran, David Christie, Bradley Wong, Peter Foley, Peter O’Brien, Lynda Spelman

“…The frequency of Grade 3 acute skin toxicities was low.Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. …”
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Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies by Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode

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Hereditary transthyretin amyloidosis incidentally diagnosed by video-associated lung surgery for lung cancer: A case report by Katsuhiro Itogawa, Shintaro Sato, Hideaki Yamakawa, Keiichi Akasaka, Masako Amano, Akiko Adachi, Hidekazu Matsushima

“…A genetic mutation screening test revealed pathological TTR gene mutation of heterozygous Tyr114His (p.Tyr134His). …”
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A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

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Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis by Wenrong An, Kegong Tang, Juan Liu, Wenfei Zheng, Guoxia Li, Yunsheng Xu

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Pembrolizumab in a Patient with Treatment-Naïve Unresectable BRAF-Mutation Negative Anaplastic Thyroid Cancer by Fadi Nabhan, Elizabeth Kander, Rulong Shen, Amit Agrawal, Vineeth Sukrithan, Ye Zhou, Ashima Goyal, Katie Roll, Manisha Shah, Bhavana Konda

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Biomonitoring PhIP, a Potential Prostatic Carcinogen, in the Hair of Healthy Men of African and European Ancestry by Robert J. Turesky, Clarence Jones, Jingshu Guo, Kari Cammerrer, Laura A. Maertens, Emmanuel S. Antonarakis, Zhanni Lu, Logan G. Spector

“…Frequent consumption of well-done meats containing 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP), a prevalent HAA that is a prostatic carcinogen in rodents and DNA-damaging agent in human prostate cells, has been linked to aggressive prostate cancer (PC) pathology. African American (AA) men face nearly twice the risk for developing and dying from PC compared to White men. …”
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