Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran by Leila Mobasheri, Tayyebeh Chahkandi, Amir Talebpour, Gholamreza Anani Sarab

“…Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. …”
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Crack growth based life prediction approach under LCF-HCF interaction by Aritra Sarkar, M. Okazaki, A. Nagesha, R. Sandhya

“…Prediction of cyclic life under low cycle fatigue - high cycle fatigue (LCF-HCF) interaction is of paramount importance in the context of structural integrity of components in the primary side of fast reactors where such damage under LCF-HCF interaction occurs. …”
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On Risk Assessment for Out-of-Distribution Detection by Anton Vasiliuk

“…Our framework offers both theoretical insights and practical guidelines for deploying ML models in high-stakes applications, where trust and reliability are paramount.…”
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Biological therapy for inflammatory bowel disease: cyclical rather than lifelong treatment? by Christian Philipp Selinger, Konstantina Rosiou, Marco V Lenti

“…Despite their beneficial risk–benefit profile, these treatments are not without risk of side effects, are costly to healthcare providers and pose a burden to the patient. It is, therefore, paramount to examine in which circumstances a temporary cessation of therapy can be attempted without undue clinical risk. …”
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Aviation Fueling: A Cleaner, Greener Approach by Robert C. Hendricks, Dennis M. Bushnell, Dale T. Shouse

“…Projected growth of aviation depends on fueling where specific needs must be met. Safety is paramount, and along with political, social, environmental, and legacy transport systems requirements, alternate aviation fueling becomes an opportunity of enormous proportions. …”
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Congenital Ventricular Diverticulum or Aneurysm: A Difficult Diagnosis to Make by Lloyd Halpern, Carl Garabedian, Neil K. Worrall

“…Echocardiography is paramount in the diagnosis and characterization of these lesions. …”
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Computational Reconstruction of the Volatility Term Structure in the General Hull–White Model by Slavi G. Georgiev, Lubin G. Vulkov

“…Volatility recovery is of paramount importance in contemporary finance. Volatility levels are heavily used in risk and portfolio management. …”
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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts by Zhongsong Zhang, Long Chen

“…Abstract Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within the tumor microenvironment (TME), this review illuminates the role of inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges as a robust strategy in the evolving landscape of cancer immunotherapy. …”
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Coordinate Descent-Based Sparse Nonnegative Matrix Factorization for Robust Cancer-Class Discovery and Microarray Data Analysis by Melisew Tefera Belachew

“…Nonnegative matrix factorization (NMF) plays a paramount role as an efficient data exploratory tool for extracting basis features inherent in massive data. …”
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Disease Specific to Chronic Lymphedema and Class III Obesity by Karen G. Figenshau, Matthew B. Lindquist

“…First, clinicians should explore the etiology of patients’ secondary lymphedema, as this is paramount in determining treatment for ENV. The fundamental goal is alleviating lymphatic obstruction. …”
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Exploiting the similarity of dissimilarities for biomedical applications and enhanced machine learning. by Mohammad Neamul Kabir, Li Rong Wang, Wilson Wen Bin Goh

“…In the realm of personalized AI and precision medicine, the importance of dissimilarities is paramount. Personalized AI builds local models for each sample by identifying a network of neighboring samples. …”
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Interpreting Myocardial Enzymatic Biomarkers in the Setting of Acute Myocardial Infraction AMI by Khawla A. Kasar, Maha H. Al-Bahrani, Ahmed A. Mohsin

“…Over the past decade, biochemical marker testing are an important step in the diagnosis, and management of heart failure and in lowering one's risk of developing cardiovascular disease. Early diagnosis is paramount to choosing a clear and effective treatment strategy. …”
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Investigating the Quality of DermaMNIST and Fitzpatrick17k Dermatological Image Datasets by Kumar Abhishek, Aditi Jain, Ghassan Hamarneh

“…However, while large datasets play a crucial role in the development of reliable deep neural network models, the quality of data therein and their correct usage are of paramount importance. Several factors can impact data quality, such as the presence of duplicates, data leakage across train-test partitions, mislabeled images, and the absence of a well-defined test partition. …”
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National interests in Russia’s foreign policy by V. P. Nazarov

“…Through analysis of strategic policy documents, the author discerns instances where policy objectives are conflated with the national interests, diverging from their realization.Given Russia's distinctive geopolitical position and security challenges, the author defines the paramount Russia's national interest – establishing a secure periphery characterized by cooperative relationships with neighboring states and ensuring unimpeded access to global maritime routes.…”
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Midventricular Obstructive Hypertrophic Cardiomyopathy during Pregnancy Complicated by Pulmonary Embolism: A Case Report by Leila Abid, Ahmed Tounsi, Dorra Abid, Mourad Hentati, Samir Kammoun

“…We concluded that simple measures such as communication between the cardiology and obstetric teams, understanding of the hemodynamic changes, anesthetic planning, and monitoring were paramount for the success in our patient.…”
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Deep Learning Approaches for the Prediction of Protein Functional Sites by Borja Pitarch, Florencio Pazos

“…Knowing which residues of a protein are important for its function is of paramount importance for understanding the molecular basis of this function and devising ways of modifying it for medical or biotechnological applications. …”
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The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder by Claudia Camerino

“…Multisensory processing is of paramount importance in building a perceptual and cognitive representation of reality. …”
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Environment, Leptin Sensitivity, and Hypothalamic Plasticity by Marco Mainardi, Tommaso Pizzorusso, Margherita Maffei

“…On the other hand, knowledge on how brain sensitivity to leptin can be modulated is only beginning to accumulate. This point is of paramount importance if one considers that pathologically obese subjects have high levels of plasmatic leptin. …”
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Nutrient Status of Vermicompost of Urban Green Waste Processed by Three Earthworm Species—Eisenia fetida, Eudrilus eugeniae, and Perionyx excavatus by Swati Pattnaik, M. Vikram Reddy

“…Thus, vermicomposting is the paramount approach of nutrient recovery of urban green waste.…”
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Immune Tolerance Regulation Is Critical to Immune Homeostasis by Lei Han, Tianxiang Wu, Qin Zhang, Anning Qi, Xiaohui Zhou

“…This equilibrium, referred to as immune homeostasis, is paramount for overall health. The regulatory mechanisms governing the maintenance of this delicate immune balance are notably complex. …”
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