PTEN Gene: A Model for Genetic Diseases in Dermatology by Corrado Romano, Carmelo Schepis

“…PTEN gene is considered one of the most mutated tumor suppressor genes in human cancer, and it’s likely to become the first one in the near future. …”
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Cowden syndrome: Familial presentation and genetic insights by K. C. Shashidhara, Keerthi Yenamala, Prajval Reddy Nachu, L. K. Prajwal, Sai Surya Chukkapalli

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PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis by Naoko Okumura, Hitomi Yoshida, Yasuko Kitagishi, Mutsumi Murakami, Yuri Nishimura, Satoru Matsuda

“…The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. …”
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lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia by Jing Liu, Lin Yang, Xiaojun Liu, Lu Liu, Menghan Liu, Xuefeng Feng, Jianmin Luo

“…To investigate that HOTTIP suppressed PTEN gene expression and was involved in IM resistance in chronic myeloid leukemia through recruitment of EZH2 protein. …”
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<i>CCND1</i> and <i>PTEN</i> genes as markers of progression in vulvar cancer by A. V. Busarova, N. A. Petrusenko, P. A. Kruze, N. V. Porhanova

“…In the 2nd group of patients, a statistically significant 1.7-fold increase in RCQ of the CCND1 gene (p &lt; 0.05) and a 1.9-fold decrease in RCQ of the PTEN gene (p &lt; 0.05) were found.Conclusion. In the study, CCND1 amplification events and/or PTEN loss were associated with lymph node metastasis in RV patients. …”
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Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway by Adam Šafanda, Nikola Hájková, Michaela Kendall Bártů, Marián Švajdler, Radoslav Matěj, Jitka Hausnerová, Tomáš Zima, Pavel Dundr, Kristýna Němejcová

“…However, no mutations, deletions (as assessed by CNV analysis), or promoter hypermethylation in the PTEN gene were detected. Conclusion The results of our study further support the hypothesis that the pathogenesis of JGCT may be driven by activation of the PIK3/AKT/mTOR pathway. …”
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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Formalin-fixed and paraffin-embedded tissue samples with simple hyperplasia (3), complex hyperplasia (5), atypical complex hyperplasia (7), endometrioid carcinomas G1 (20) and G3 (5), and serous carcinoma (5) were evaluated for the presence of mutations in coding regions of PTEN gene, the most frequently mutated tumor suppressor gene in endometrial carcinoma. 75% of the detected mutations were clustered in exons 5 and 8. …”
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Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch by Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Sun

“…To investigate the effects of miR-144-3p-targeted regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene on proliferation, apoptosis, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) under retraction force. …”
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Efficacy of Next-Generation Sequencing in Identifying Genetic Markers for Prostate Cancer Risk by Fahad H. Alaithan, Raghad H. Alaithan, Tauheed Ahmed

“…Furthermore, CNVs in the MYC and PTEN genes were observed in 15% and 10% of the patients, respectively. …”
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