Designing a Multimodal and Culturally Relevant Alzheimer Disease and Related Dementia Generative Artificial Intelligence Tool for Black American Informal Caregivers: Cognitive Walk... by Cristina Bosco, Ege Otenen, John Osorio Torres, Vivian Nguyen, Darshil Chheda, Xinran Peng, Nenette M Jessup, Anna K Himes, Bianca Cureton, Yvonne Lu, Carl V Hill, Hugh C Hendrie, Priscilla A Barnes, Patrick C Shih

“…Despite being the primary individuals responsible for the care of individuals with ADRD, these caregivers often lack sufficient knowledge about ADRD-related health literacy and feel ill-prepared for their caregiving responsibilities. Generative AI has become a new promising technological innovation in the health care domain, particularly for improving health literacy; however, some generative AI developments might lead to increased bias and potential harm toward Black American communities. …”
Get full text

One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS by Shouhong Gao, Zhengbo Tao, Jingya Zhou, Zhipeng Wang, Yunlei Yun, Mingming Li, Feng Zhang, Wansheng Chen, Yejun Miao

“…One-step solid-phase extraction was successfully applied using an Ostro sample preparation 96-well plate for plasma samples pretreated with acetonitrile containing 0.1% formic acid. …”
Get full text

A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…Study staff and participants were blinded to treatment assignment, except for pharmacy staff preparing the study drug. The ratio of active:placebo randomization to each cohort was set at 3:1. …”
Get full text

Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis by Quan Nha Hong, Esther McSween-Cadieux, Maxime Guillette, Luiza Maria Manceau, Jingjing Li, Vera Granikov, Marie-Pascale Pomey, Marie-Pierre Gagnon, Saliha Ziam, Christian Dagenais, Pierre Dagenais, Alain Lesage, Thomas G. Poder, Martin Drapeau, Valéry Ridde, Julie Lane

“…Conclusions This project led to the development of a collective action plan aimed at preparing the Quebec ecosystem and other similar jurisdictions to meet knowledge needs more effectively in times of health emergency. …”
Get full text

Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…Furthermore, we found that highly-purified phage preparations did not activate mouse or human derived toll like receptor (TLR) 4 or TLR9 in HEKblue reporter assays. …”
Get full text

Transauricular vagus nerve stimulation in preventing post-traumatic stress disorder in emergency trauma surgery patients in China: a study protocol for a multicenter, double-blind,... by Jun Zhang, Xin Yu, Gang Chen, Yu Li, Qi-Hong Shen, Xinru Lin, Tieshuai Liu, Yunyun Yu, Jingwen Liang

“…The initial intervention will begin once informed consent is obtained and randomisation is completed in the preoperative preparation room, continuing until the surgery is finished. …”
Get full text

Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2 by Lukas Kröger, Sebastian Borgert, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch

“…Starting with the lead furocarbazole W16 (<b>4</b>) inhibiting the CK2α/CK2β interaction, analogous pyrrolocarbazoles were prepared and tested for their protein–protein interaction inhibition (PPII). …”
Get full text

Double degree programs and education for sustainable development implementation: Experience of Ukrainian and UK universities cooperation in wartime by Iryna Skliar, Mykola Kostel’, Olena Melnyk, Kseniia Bliumska-Danko

“…Acknowledgment This contribution is prepared with the support and funding under Researchers at Risk Fellowships Programme led by the British Academy in partnership with the Academy of Medical Sciences, the Royal Academy of Engineering, the Royal Society and Council for At-Risks Academics (CARA), and in the framework of the realization the Erasmus+ KA 2 CBHE project “Universities-Communities: Strengthening Cooperation” (Grant Agreement 101083077), and Jean Monnet Centre of Excellence “EU Studies of Social Innovations in Education” (ESSIE) – 101085552 – ERASMUS-JMO-2022-COE.The European Commission’s support for the production of this publication does not constitute an endorsement of the contents that reflect the views only of the authors, and the Commission cannot be held responsible for any use that may be made of the information contained therein.…”
Get full text

Transition to home after very preterm birth: improving outcomes of children and their families—a systematic review protocol by Beatrice Latal, Ulrike Held, Ursula Kiechl-Kohlendorfer, Sandra Siegfried, Vivienne Engel, Valentina Mauron-Papadimitriou, Lea Bührer, Laura Ebner, Lena Keller, Martina Gosteli

“…According to the WHO, preparation for this transition yields positive effects on crucial aspects such as nutrition, parent–child interaction and parental well-being. …”
Get full text

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…We hypothesized that: (1) applying melanoma-derived peptides topically, in proximity to LC, could be immunogenic and safe, with low vaccine-site toxicity and (2) topical toll-like receptor 7 (TLR7) agonist would increase immunogenicity of the peptide vaccine.Methods Twelve melanoma peptides plus a tetanus helper peptide were combined with granulocyte macrophage colony stimulating factor (GM-CSF) and were administered topically on days 1, 8, and 15, to 28 patients randomized to one of four adjuvant preparations: (1) incomplete Freund’s adjuvant (IFA); (2) IFA plus a TLR7 agonist (imiquimod) administered on days 0, 7, 14; (3) dimethyl sulfoxide (DMSO) or (4) DMSO+ imiquimod administered on day 0, 7, 14. …”
Get full text

CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation by Hussain Z, Abdulrahim Abdul Moti L, Jagal J, Thu HE, Khan S, Kazi M

“…In this research, we aimed to design a multiprong targeting strategy for concurrent action against different phenotypes of BC (MCF-7 and SK-BR-3) and tumor-associated macrophages (TAMs) for relapse-free treatment of BC.Methods: Paclitaxel (PTX) and tamoxifen (TMX) co-loaded chitosan (CS) nanoparticles (NPs) were prepared using the ionic-gelation method and optimized using the Design Expert® software by controlling different material attributes. …”
Get full text

Socio-demographic portrait of the applicant and the main motives for choosing the "Therapy and rehabilitation" speciality by S.V. Zakharov, O.B. Nekhanevych, O.O. Rusakova, O.V. Smolianova

“…Most applicants entering the speciality 227 "Therapy and rehabilitation" are goal-oriented, highly motivated, and prepared for rigorous study, which is the key to developing into competent and competitive specialists.…”
Get full text

Biodesulfurization of high-sulfur oil from the Karazhanbas field of Kazakhstan with deep eutectic solvents by A.O. Akimbek, G.A. Jamalova, A.K. Yernazarova, G.K. Kaiyrmanova, B.K. Yelikbayev, M.C. Pagano, A.G. Zazybin, Kh. S. Rafikova

“…The research methodology was based on the application of the Koch methods to determine the total number of microorganisms; light microscopy – for the study of microbiological preparations; genetic identification of bacteria based on the analysis of the nucleotide sequence of a fragment of the 16S rRNA gene; synthesis of deep eutectic solvents; testing of isolated bacteria – for sensitivity to Cr (VI), for the ability of microorganisms to use hydrocarbons of high-sulfur oil, for activity in sulfur-containing crude oil, for determination of the mass fraction of sulfur. …”
Get full text

Evaluasi Kinerja pelaksanaan Anggaran Berbasis Fuzzy Inference System by Sukarna Sukarna, Irman Hermadi, Yani Nurhadryani

“…The results of this studied are monitoring and evaluation of the web-based work unit in the form of real performance status as a basis for preparing recommendations in  order to improve budget performance.  …”
Get full text

Construction and performance of oxidized coal powders based hydrovoltaic devices by Jianhang ZHAO, Zhichao ZUO, Wenwen YU, Yanan YE, Fengbo ZHU, Qiang ZHENG

“…Combining with a filtration method, modified coal powder/filter paper composite was prepared to assemble a steam-based hydrovoltaic power generator. …”
Get full text

Perinatal outcomes and predictors of placental abruption: a retrospective study in an Ethiopian tertiary care center by Mesfin Tadese, Gebresenbet Getachew, Tirusew Nigussie Kebede, Toyba Ebrahim Yesuf, Saba Desta Tessema, Wogene Asefa Damesa, Gebeyehu Shumet Solomon

“…Data was collected using a checklist prepared with the KOBO collect tool and then exported to SPSS version 25.0. …”
Get full text

Experiences of midwifery students and graduates in Somalia: evidence from qualitative data by Hawa Abdullahi, Asia Mohamed Mohamud, Maryan Abdulkadir Ahmed, Mohamed Ahmed Omar, Abdirisak A. Dalmar, Hannah Tappis, Shatha Elnakib

“…In terms of perceived preparedness, graduates felt well prepared for their role but identified gaps in abortion care, neonatal resuscitation, and usage of basic ultrasound.ConclusionThe challenges faced by midwifery students and newly graduated midwives have direct implications for the health outcomes of mothers and infants in conflict-affected settings. …”
Get full text

The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception by Blair R. McCallie, Mary E. Haywood, Lauren N. Henry, Rachel M. Lee, William B. Schoolcraft, Mandy G. Katz-Jaffe

“…Biopsied trophectoderm cells were then lysed, and the isolated DNA was whole-genome amplified followed by library preparation. Next-generation sequencing was performed for PGT-A, and excess whole-genome amplified DNA was utilized for single nucleotide polymorphism beadchip array analysis. …”
Get full text

Value Propositions for Digital Shared Medication Plans to Boost Patient–Health Care Professional Partnerships: Co-Design Study by Benjamin Bugnon, Francesca Bosisio, Alain Kaufmann, Pascal Bonnabry, Antoine Geissbuhler, Christian von Plessen

“…The experience-based co-design had 4 phases: capturing, understanding, and improving experiences, followed by preparing recommendations and next steps. A qualitative, participatory methodology was used to iteratively explore collaborative medication management experiences and identify barriers and enabling mechanisms, including technology. …”
Get full text

Buffalo whey proteins as innovative raw material for nanoparticles building by Pablo A. Solis Cizek, Gustavo A. Crudeli, Darío Spelzini, Franco E. Vasile

“…An aqueous suspension containing BWPC (0.1% w/v) and GA (0.05% w/v) was prepared for this purpose. For comparative purposes, the behavior of mixtures containing cow whey (WPC) and GA, and the single components were also studied. …”
Get full text