Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…These effects were associated with decreased GPX4 expression and suppression of EGFR, phosphorylated PI3K, and phosphorylated AKT. ORes inhibited tumour growth, enhanced iron deposition, and reduced GPX4 expression in tumour tissues in vivo. …”
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RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells by Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M

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NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats by Yonglian Liu, Wenjuan Wang, Bing Liang, Zhonglan Zou, Aihua Zhang

“…Notably, these arsenic-induced effects were reversed by MCC950, an NLRP3 inflammasome inhibitor, and Extendin-4, an agonist of the IRS-1/PI3K/AKT signaling pathway. Collectively, these findings demonstrate that NLRP3 inflammasome activation disrupts the IRS-1/PI3K/AKT signaling pathway, contributing to arsenic-induced pancreatic beta cells dysfunction in rats.…”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…These therapeutic effects are mediated through the activation of the PI3K/Akt/mTOR signaling pathway and regulation of apoptosis-related proteins. …”
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Effects of Exercise Preconditioning Mediating Oxidative Stress to Regulate PI3K/Akt and Nrf2/HO-1 Pathways to Alleviate Cognitive and Learning Disorders in Rats by KONG Haijun, LI Xinlong, WANG Fenghua, CHEN Xiaoan

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PI3K/Akt通路介导Apelin后处理减轻离体大鼠心脏缺血再灌注损伤 by 彭龙云, 王业松, 刘丽娟, 何旭瑜, 郭晓刚, 劳妙嫦, 高修仁

“…【结论】 Apelin后处理能够减轻离体大鼠心脏缺血再灌注损伤,PI3K/Akt信号通路参与介导Apelin后处理的心脏保护作用.…”
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BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation by Jialu Xu, Chunyu Li, Rongping Fan, Jiaxin Yin, Lei Xie, Xuemin Peng, Jing Tao, Weijie Xu, Shujun Zhang, Xiaoli Shi, Kun Dong, Xuefeng Yu, Xi Chen, Yan Yang

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Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity by Boyuan Peng, Ziwei Li, Yong Cheng, Henghua Jiang, Qingsong Ye, Guangli Han

“…This effect was mediated by the PI3K/Akt/NF-κB signaling pathway and could be reversed by the PI3K activator insulin-like growth factor-1 (IGF-1). …”
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Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation. by Vishal Jain, Iswar Baitharu, Dipti Prasad, Govindasamy Ilavazhagan

“…Also brain-derived neurotrophic factor (BDNF) plays a major role in EE mediated neuroprotection and it effectively prevented neurodegeneration by activating PI3K/AKT pathway resulting in GSK3β inactivation which further inhibits apoptosis. …”
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脂肪组织中IRS-1相关的PI3K活性在多囊巢综合征 胰岛素抵抗中的作用

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Metformin Facilitates Osteoblastic Differentiation and M2 Macrophage Polarization by PI3K/AKT/mTOR Pathway in Human Umbilical Cord Mesenchymal Stem Cells by Min Shen, Huihui Yu, Yunfeng Jin, Jiahang Mo, Jingni Sui, Xiaohan Qian, Tong Chen

“…Molecularly, these metformin-stimulated M2 macrophages facilitated osteogenesis via activating the PI3K/AKT/mTOR pathway. As demonstrated by using PI3K-specific inhibitor LY294002, we found that the pathway inhibitor partly reversed osteoinductive activity which was activated by coculture of metformin-treated M2 macrophages. …”
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Early Changes in [18F]FDG Uptake as a Readout for PI3K/Akt/mTOR Targeted Drugs in HER-2-Positive Cancer Xenografts by Yanina Dockx, Christel Vangestel, Tim Van den Wyngaert, Manon Huizing, Sven De Bruycker, Patrick Pauwels, Steven Staelens, Sigrid Stroobants

“…We investigated the potential use of [18F]FDG PET as a response biomarker for PI3K pathway targeting therapies in two HER-2-overexpressing cancer models. …”
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Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia by Michael Loke, DO, Vishal Sehgal, MD, Niraj Gupta, MD

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APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K/AKT/mTOR pathway by Jing Gao, Xiaojuan Lu, Guanglei Wang, Tanling Huang, Zhongyu Tuo, Weiwei Meng

“…Similarly, in vivo studies demonstrated that APOC1 knockdown significantly reduced tumor growth, angiogenesis-related proteins, and phosphorylated PI3K/AKT/mTOR pathway proteins in nude mice. APOC1 knockdown promotes apoptosis and suppresses angiogenesis in DLBCL cells by inhibiting the PI3K/AKT/mTOR pathway. …”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbiome by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

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Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis by Manting Liu, Jiexiang Ye, Runtian Wu, Dongqiang Luo, Tao Huang, Dandan Dai, Kexin Wang, Yanping Du, Junwen Ou

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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

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Retraction: Enriched Environment Prevents Hypobaric Hypoxia Induced Memory Impairment and Neurodegeneration: Role of BDNF/PI3K/GSK3β Pathway Coupled with CREB Activation. by PLOS ONE Editors

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Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration by Qian Du, Jiaojiao Xu, Miao Zhang, Jianhong Yang

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PI3K抑制剂XC302连续给药治疗晚期实体肿瘤的I期临床耐受性试验

Subjects: “…PI3K抑制剂…”
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