Transcriptomic Approaches to Investigate the Anti-Aging Effects of Blueberry Anthocyanins in a Caenorhabditis Elegans Aging Model by Jie Ding, Jiahui Liu, Qingqi Guo, Na Zhang

“…Transcriptomic analysis revealed that BA activated anti-aging pathways such as FOXO, IIS, and PI3K/Akt, upregulating critical genes like <i>daf-16</i>. …”
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The effect of caloric restriction on genetical pathways by Mustafa Fevzi Karagöz, A. Gülçin Sağdıçoğlu Celep

“…The suppression of phosphoinositide 3-kinase (PI3K)-/-Akt, and therefore mTOR signal stimulates autophagy and mitophagia, and cleanses damaged cells and organelles. …”
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Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lance... by Xiaobo Yan, Simiao Pan, Xiangxiang Suo, Weibin Huang, Tao Li, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong

“…Above results demonstrated that squalene enhanced immunity and disease resistance in grouper may be related to the activation of PI3K-Akt/ Wnt/β-Catenin signaling pathway, while the activation of β-Catenin could reduce the inflammatory response by inhibiting NF-κB-mediated inflammatory factors. …”
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Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines by Jiandong Li, Yanxin Hu, Jiayao Zhang, Weiguang Zhang, Jianhua Yu, Baochun Lu

“…We then explored potential resistance mechanisms and found that pathways and targets such as epithelial-mesenchymal transition, PI3K/Akt, p53R2, and IGF-1R did not show a significant correlation with ICC resistance. …”
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Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity by Yuanquan Dai, Zheng Yuan, Weisen Fan, Zhiheng Lin

“…These flaws may be linked to aberrant pathways in endometrial stromal cells, such as PI3K/Akt, JAK2/STAT3, and hedgehog. Correcting the abnormal expression of molecules in endometrial stromal cells in the endometrium of patients with adenomyosis may become the focus of research to improve endometrial receptivity and increase the pregnancy rate.…”
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P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…Evidence that P2X7 triggers NFATc1, PI3K/Akt, ROCK, and VEGF pathways in osteoblasts promoting either primary tumor development or osteoblastic lesions is also reported. …”
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Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1 by Shengkai Jin, Yuhua Zhou, Jing Lv, Yichen Lu, Yuwei Zhang, Menglu Li, Ninghan Feng

“…Mechanistic studies indicate that IMP exerts its effects by upregulating PDZK1 expression, which subsequently inhibits the phosphorylation of the PI3K-AKT pathway. Conclusions In conclusion, IMP significantly inhibits the progression of PCa, offering new insights into potential treatments for CRPC.…”
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Multivariate Cox regression analysis of prognostic genes and therapeutic mechanisms of gastric cancer by Yangyang Xiao, Zhiru Zhong, Chunli Yang, Zhiying Lin

“…Functional enrichment analysis showed that KG was mainly involved in cell adhesion molecules, adhesion spots and PI3K/AKT signaling pathway. KG may be a potential therapeutic target for gastric cancer.…”
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Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties by Varun Jaiswal, Hae-Jeung Lee

“…Mechanistic studies of trifolirhizin showed that it could act on important target genes and pathways such as the NF-κB-MAPK, EGFR-MAPK, AMPK/mTOR, and PI3K/Akt signaling pathways. These pathways are also implicated in various other diseases, suggesting the potential of trifolirhizin in therapeutic applications. …”
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Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype by Elena I. Dyachenko, Lyudmila V. Bel’skaya

“…In addition to the main signaling pathway PI3K/Akt/mTOR, the activity of the oncogene c-Myc, HIF, p53, GATA2, NF-kB and MAT2A have a direct effect on the amino acid metabolism of cancer cells, their growth and proliferation, as well as the maintenance of homeostatic equilibrium. …”
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Discovery of potent allosteric antibodies inhibiting EGFR by Léxane Fournier, Lukas Pekar, Birgitta Leuthner, Harald Kolmar, Lars Toleikis, Stefan Becker

“…In particular, we identified one clone that is more potent than the approved blocking antibody cetuximab in inhibiting both PI3K/AKT and MAPK/ERK pathways. Our results suggest that allosteric antibodies may be potential new modalities for therapeutics.…”
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Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer by Gizem Teoman, Zeynep Turkmen Usta, Zeynep Sagnak Yilmaz, Sevdegul Aydin Mungan, Ismail Saygin

“…The enzyme phosphatidylinositide-3-kinase (PI3K) regulates cellular proliferation and apoptosis. …”
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Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15 by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Viviani

“…GS in combination with HG reduced the expression of GIPR and PI3K and abrogated GIP-induced AKT phosphorylation and GIP-stimulated insulin secretion. …”
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Unmasking The Hidden Clues: Shedding Light On The Potential Of Novel Biomarkers In Endometrial Cancer, Comparing RT-Qpcr And Immunohistochemical Analysis In Clinical Specimens by Sampana Fatima, Ayman Sabora, Iqra Anwar, Seher Naeem, Muhammad Abrar

“…Conclusions: RT-qPCR promises a highly sensitive and specific method for screening patients with endometrial carcinoma with expression of HE4, L1CAM, miR-200c, ARID1A, and PI3K. Keywords: Endometrial cancer, Immunohistochemical, biomarkers, radiotherapy. …”
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Characterization of a pleomorphic rhabdomyosarcoma cell line by Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

“…Results of the novel functional BH1522 tests corroborate published tumor sequencing data that demonstrated alterations in receptor tyrosine kinase/MAPK, PI3K/AKT and mutated p53 as suspected drivers of malignant growth.…”
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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…Blockade of Src triggered LC3 and LAMP-1 recruitment around the parasitophorous vacuole (PV) and parasite killing dependent on the autophagy protein, ULK1, and lysosomal enzymes. Src promoted PI3K activation and recruitment of activated Akt to the PV membrane. …”
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Whole exome sequencing identifies genomic alterations in proximal and distal colorectal cancer by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Sheau Sean Khor, Sazuita Saidin, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Zuraini Abd. Razak, Isa Mohamed Rose, Ismail Sagap, Luqman Mazlan, Nadiah Abu, Rahman Jamal

“…Wnt signalling pathway was the most frequently altered pathway in both proximal and distal CRCs whereas TGF-β and PI3K signalling pathways were predominantly altered in the proximal CRCs. …”
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A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges by Erica di Martino, Darren C. Tomlinson, Margaret A. Knowles

“…Fibroblast growth factors (FGFs) orchestrate a variety of cellular functions by binding to their transmembrane tyrosine-kinase receptors (FGFRs) and activating downstream signalling pathways, including RAS/MAPK, PLCγ1, PI3K, and STATs. In the last ten years, it has become clear that FGF signalling is altered in a high proportion of bladder tumours. …”
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Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease by Christopher O'Mahony, Oscar Hidalgo-Lanussa, George E. Barreto

“…We propose that FOXO3 plays a key role in the intersection of menopause and AD, given its dysregulation in both AD patients and postmenopausal women, modulating cellular metabolism through interactions with the AMPK/AKT/PI3K pathways. This relationship highlights the intersection between hormonal changes and increased AD susceptibility. …”
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Inflammatory Signalings Involved in Airway and Pulmonary Diseases by I-Ta Lee, Chuen-Mao Yang

“…The time course and intensity of responses by resident and circulating cells may be regulated by various inflammatory signalings, including Src family kinases (SFKs), protein kinase C (PKC), growth factor tyrosine kinase receptors, nicotinamide adenine dinucleotide phosphate (NADPH)/reactive oxygen species (ROS), PI3K/Akt, MAPKs, nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1), and other signaling molecules. …”
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