Pretreatment of Small-for-Size Grafts In Vivo by γ-Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation by Tomohide Hori, Shinji Uemoto, Lindsay B. Walden, Feng Chen, Ann-Marie T. Baine, Toshiyuki Hata, Justin H. Nguyen

“…GABAR regulation appeared to reduce DNA damage via the ATM/H2AX pathway and to promote cell survival via the PI3K/Akt pathway. Conclusions. Pretreatment in vivo by GABAR regulation improves graft damage after SOLT with an SFSG. …”
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H-89和wortmannin对霍乱毒素促进受损视网膜节细胞再生作用的影响

“…【目的】研究蛋白激酶A(PKA)抑制剂H-89和磷酸肌醇3-激酶(PI3-K)特异抑制剂wortmannin对霍乱毒素(CTx)促进受损视网膜节细胞(RGCs)再生的影响,探讨CTx促进受损视网膜节细胞(RGCs)再生的作用机制。…”
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Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model by Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu

“…These results showed that RIC protected the myocardium from I/R injury by suppressing Rho-kinase and the underlying mechanism may be related to enhancing autophagy via the PI3K/AKT pathway.…”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…LF-Exos may inhibit the activity of the NLRP3 inflammasome and activate the PI3K-AKT signaling pathway to exert protective effects on acutely injured hepatocytes and a mouse model of ALF.…”
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Bioinformatics Analysis for Identifying Differentially Expressed MicroRNAs Derived from Plasma Exosomes Associated with Radiotherapy Resistance in Non-Small-Cell Lung Cancer by Lirong Zeng, Guilin Zeng, Zhong Ye

“…Among the 135 identified target genes of miR-92a-3p, 4 were involved in the PI3K-Akt signaling pathway (the downstream pathway of the Ras gene) and 3 in the cAMP signaling pathway (the upstream pathway of the Ras gene). …”
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Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition by Jiayu Zhang, Jianmin Peng, Siyu Wang, Li Wang, Yutong Sun, Juan Xia, Bin Cheng, Qinchao Hu

“…Besides, PLIN2 up-regulation activated the PI3K pathway and subsequently enhanced EMT in OSCC cells in vitro. …”
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Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis by Zhengyu Jiang, Yan Meng, Lulong Bo, Changli Wang, Jinjun Bian, Xiaoming Deng

“…Mechanistic evidence was also investigated in the present study as sophocarpine inhibited hepatic expression of the CYP2E/Nrf2 pathway during oxidative stress, inactivated p38/JNK cascade and NF-κB pathway, and, meanwhile, suppressed PI3K/AKT signaling that reduced apoptosis. Conclusively, the present study unveiled the protective role of sophocarpine in LPS-stimulated oxidative reaction, inflammation, and apoptosis by suppressing the CYP2E/Nrf2/ROS as well as PI3K/AKT pathways, suggesting its promising role in attenuating inflammation and liver injury of septic endotoxemia.…”
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Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells by Liping Mai, Guodong He, Jing Chen, Jiening Zhu, Shaoxian Chen, Xinghua Hou, Hui Yang, Mengzhen Zhang, Yueheng Wu, Qiuxiong Lin, Min Yang, Xiaohong Li

“…Such effects were markedly reduced by the PI3K agonist, 740 Y-P, and attenuated by LY294002. …”
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Comprehensive Analysis of PDLIM3 Expression Profile, Prognostic Value, and Correlations with Immune Infiltrates in Gastric Cancer by Xinpeng Hu, Minfeng Chen, Qiang Ruan, Changzheng Shi, Jinghua Pan, Liangping Luo

“…Finally, correlations were found between PDLIM3 and crucial markers of signaling pathways involving PI3K/Akt and p38 MAPK. Thus, upregulation of PDLIM3 was significantly associated with poor prognosis, immune cell infiltration, and activation of two key signal pathways in gastric cancer. …”
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Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Lei Li, Wuping Yang, Yawei Xu, Jingcheng Zhou, Kaifang Ma, Kenan Zhang, Hongkai Zhuang, Yanqing Gong, Kan Gong

“…Functional enrichment analysis illustrated that TGF-β-SMAD2/3, Notch, and PI3K-Akt-mTOR signaling pathways may be potential signaling pathways of FXYD2 in ccRCC. …”
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Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue by Shun Shi, Xiaohui Sun, Chunnuan Zhang, Chenran Lv, Yajuan Liu, Juan Du, Qian Qi

“…Especially, the phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt) signaling pathway had the maximum quantity of DEGs in all the three groups. …”
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Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells by Qiao Jiang, Li Wang, Xu Si, Yuanyuan Bian, Weijia Zhang, Huijun Cui, Hailong Gui, Ye Zhang, Bin Li, Dehong Tan

“…This study proposes that Pte can inhibit Hcy-induced oxidative stress and apoptosis of HUVECs, and the PI3K/Akt/p53 signaling pathway of apoptosis was revealed. …”
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TREM-1在细菌性化脓性角膜炎中的作用及其分子机制

“…【结果】 PA感染的C57BL/6小鼠角膜中TREM-1表达高于BALB/c小鼠;体外研究显示PA感染和LPS刺激均诱导TREM-1高表达;TREM-1通过MAPK和PI3K-Akt通路调节促炎因子生成;Th1细胞因子促进TREM-1表达,而Th2细胞因子不影响TREM-1的表达。…”
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Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response by Jing Wu, Qi Lu, Jing Hou, Yueqin Qiu, Min Tian, Li Wang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…Baicalein inhibited the entry of PRRSV by blocking EGFR phosphorylation and the downstream PI3K-AKT signaling pathway. This was confirmed by a decrease in the expression of p-EGFR/EGFR, p-AKT/AKT, PI3K, and SRC following treatment with baicalein. …”
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3D printed magnesium silicate/β-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis by Lulu Wang, Mingkui Shen, Zhongxin Tang, Jun Tan, Kuankuan Li, Haijun Ma

“…In addition, RNA sequencing (RNA-seq) revealed MS/β-TCP scaffold plays a dual role in osteogenesis and angiogenesis by activating PI3K/Akt signal pathway, whereas the expression of genes and proteins associated with osteogenesis and angiogenesis was significantly downregulated the PI3K/Akt signaling pathway was inhibited. …”
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Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats by Xiaohong Wang, Guoxiong Zhou, Chun Liu, Ronglong Wei, Shunxing Zhu, Yuefen Xu, Mengjie Wu, Qing Miao

“…Serum amylase levels, protein, and mRNA expression levels of nucleus NF-κB p65, LC3-II, and Beclin-1 protein, mRNA expression levels of PI3K-III, and pathological score of the pancreas in both treatment groups were significantly lower than those in SAP group at 12 and 24 h after operation (P<0.05 or 0.01). …”
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Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats by Yuka Toyoshima, Katsuyuki Nakamura, Yusuke Taguchi, Reiko Tokita, Shiho Takeuchi, Hayato Osawa, Naomi Teramoto, Hidetoshi Sugihara, Fumiaki Yoshizawa, Keitaro Yamanouchi, Shiro Minami

“…In addition, despite the increased activity of insulin-stimulated IRS-2-associated phosphatidylinositol-3 kinase (PI3K), insulin-induced phosphorylation of the kinases downstream of PI3K was suppressed in the liver and skeletal muscle of IRS-1 KO rats. …”
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G蛋白 βγ亚基介导的信号转导途径与心肌细胞肥大 by 郑　猛综述, 余细勇审校

“…异三聚体G 蛋白由 α、β 和γ亚基所组成,最近发现 Gβγ可以激活 PI3Kγ、Ras、MAPKs 等,参与引起心肌细胞肥大反应的细胞内信号转导通路,可作为防治心肌肥厚的新靶点。…”
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fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils by María A. Hidalgo, María D. Carretta, Stefanie E. Teuber, Cristian Zárate, Leonardo Cárcamo, Ilona I. Concha, Rafael A. Burgos

“…Because the role of ROS on IL-8 release in neutrophils is until now controversial, we assessed if NADPH oxidase is involved in the IL-8 secretions and PI3K/Akt, MAPK, and NF-κB pathways activity induced by fMLP. …”
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Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells by Yueguo Wang, Zhenxing Ding, Youhui Tu, Xu Wu, Wenying Zhang, Shuang Ji, Jilong Shen, Li Zhang, Huimei Wu, Guanghe Fei

“…Furthermore, inhibiting of PI3K-AKT signaling notably attenuated LPS-induced Poldip2/Nox4 activation. …”
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