Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways by Hong Duan, Wei Wang, Shu Li, Han Li, Ghulam Jilany Khan, Yong Ma, Fawang Liu, Kefeng Zhai, Henggui Hu, Zhaojun Wei

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uPAR在类风湿关节炎成纤维样滑膜细胞中的功能及机制

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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

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RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 by Duanfeng Jiang, Xin Wu, Xiaoying Sun, Wei Tan, Xin Dai, Youbang Xie, Ashuai Du, Qiangqiang Zhao

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Exploring the inhibitory effect and mechanism of isorhamnetin therapy on oral squamous cell carcinoma based on network pharmacology and molecular docking by YU Fangfang, ZHOU Jingjing, YANG Jie, QU Huijuan, HUI Guangyan

Subjects: “…isorhamnetin|oral squamous cell carcinoma|pi3k/akt signaling pathway|src tyrosine kinase|estrogen receptor-1|network pharmacology|molecular docking|experimental verification <i>in vitro</i>…”
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Expanding the therapeutic horizon in acute myeloid leukemia: The role of phosphoinositide-3-kinase-γ inhibition by Soumyajit Das, Mahendra Pratap Singh, Nishant Rai, Sanjit Sah

“…This study investigates the role of phosphoinositide-3-kinase-γ (PI3Kγ) in AML and explores the therapeutic potential of the PI3Kγ inhibitor, eganelisib, in preclinical models. …”
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Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase by Julie Simard, Matthieu Boucher, Rachel Massé, Terence E. Hébert, Guy Rousseau

“…Thus, the physical proximity of activated β2-AR and PI-3K allows the activation of the latter. In contrast, it has been observed that the β1-AR is unable to activate the PI-3K/Akt pathway. …”
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FAK抑制剂对肝癌HCC-LM3细胞骨架重排和侵袭的作用机制 by 姚红兵, 肖芳, 郭威, 吴嘉兴, 文雪霖, 蒋建晖, 华赟鹏

“…目的基于FAK/PI3K/Akt通路，探讨FAK抑制剂CT-707对人肝癌HCC-LM3细胞骨架重排、侵袭、迁移及裸鼠皮下移植瘤生长的影响和机制。…”
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Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition by Linli Yao, GuangHui Zi, Miao He, Yuhong Xu, Lulu Wang, Baowei Peng

“…Mechanically, by co-immunoprecipitation and in vitro enzymatic cleavage assays, we identified the regulatory subunit p85 of class IA PI3K phosphatidylinositol 3-kinase (PI3K), as a substrate of AEP. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…Western blots confirmed that the expression of PI3K/Akt/mTOR pathway-related proteins (p-PI3K, p-AKT, and mTOR) in BC cells was decreased after knocking down SAE1. …”
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ET-1通过上调CXCR4表达促进鼻咽癌低转移 细胞株6-10B的迁徙

“…【目的】 探讨内皮素-1(ET-1)上调CXCR4表达促进鼻咽癌低转移细胞株6-10B迁徙的机制【方法】 加入不同浓度的ET-1以及同时加入SDF-1α处理6-10B细胞,趋化实验检测ET-1对6-10B细胞迁徙能力的影响分别采用Real-time PCR以及Western Blot方法检测ET-1上调后CXCR4在基因以及蛋白水平的变化Western Blot方法检测用特异性的ETAR抑制剂或者PI3K/AKT/mTOR或MARK1/ERK1/2抑制剂预处理6-10细胞后,ET-1对CXCR4表达水平的变化;并探讨ET-1处理后,PI3K/AKT/mTOR以及MARK1/ERK1/2信号通路中蛋白磷酸化水平的改变【结果】 趋化实验显示6-10B细胞丧失对SDF-1α的趋化能力,但不同浓度的ET-1刺激后6-10B细胞对SDF-1α的迁徙能力明显增强(P < 0.05),10 nmol/L ET-1的作用最明显Real-time PCR以及Western Blot结果显示,不同浓度的ET-1处理6-10B细胞后,ET-1在基因以及蛋白的水平可以呈剂量依赖性及时间依赖性地上调CXCR4的表达用特异性的内皮素受体A(ETAR)抑制剂或者PI3K/AKT/mTOR或MARK1/ERK1/2通路的抑制剂,能够明显抑制ET-1对CXCR4表达的上调Western blot检测显示ET-1能激活PI3K/AKT/mTOR及MAPK1/ERK1/2信号通路【结论】 ET-1能上调6-10B细胞功能性CXCR4的mRNA和蛋白表达,并能明显增强6-10B细胞对SDF-1α的迁徙能力CXCR4的上调主要是通过ETAR介导,激活PI3K/AKT/mTOR和MAPK1/ERK1/2信号通路…”
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Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…We test the apoptosis and proliferation and the level of PI3K and RAS in osteoblasts after 5 d intervention. …”
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Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia by Wanyi Zhang, Rina Su, Hui Feng, Li Lin, Chen Wang, Huixia Yang

“…The expression of ARHGEF11, ROCK1, PI3K, and AKT was tested in the liver and muscle tissue of F2 offspring. …”
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Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2 by Bin Ke, Ting Wei, Yuanyuan Huang, Yuxin Gong, Gang Wu, Junfang Liu, Xiaoting Chen, Lin Shi

“…By inhibiting IL-7 signaling via IL-7R knockdown or activating PI3K/AKT signaling via PI3K activation, the resensitization to DDP by IL-7 was abrogated, and the expression levels of ABCG2, p-PI3K, and p-AKT were found to be significantly higher. …”
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…Mechanistically, we revealed that the lncRNA UCA1, by binding to miR-134, modulated the PI3K/AKT pathway in macrophages via targeting LAMC2. …”
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PLIN1 suppresses glioma progression through regulating lipid metabolism by Kui Luo, Kai Zhuang, Hao Wu, Yuanbing Chen, Yi Liu, Fan Yang, Zhifei Wang

“…Mechanically, we revealed that the PI3K/AKT axis could regulate PLIN1 levels in glioma, that inhibition of the activity of PI3K/AKT axis could increase PLIN1 levels in glioma. …”
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Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…It focuses on evaluating the role of exosomal MALAT1 in the progression of dysplasia to OSCC by influencing the PI3K/AKT pathway. Method: This cross-sectional study evaluated MALAT1 expression and PI3K/AKT pathway components in exosomes derived from plasma samples of patients with various stages of oral dysplasia, OSCC and compared with normal. …”
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The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells by Sabine M. Ivison, Mohammed A. S. Khan, Nicholas R. Graham, Leila A. Shobab, Yu Yao, Arnawaz Kifayet, Laura M. Sly, Theodore S. Steiner

“…Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). However, PI3K has been reported to be either pro- or anti-inflammatory in different model systems. …”
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MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension by Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian

“…HE4 promoted myocardial fibroblast fibrosis and activated the PI3K/AKT pathway. In addition, HE4 affected myocardial fibroblast fibrosis through the PI3K/AKT pathway. …”
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