Regulatory Effect of Pyroptosis Related Genes Expression in Adipose Tissue of Aging Rats by Long-Time Weight-Bearing Running by GONG Lijing, TANG Shuning, YANG Luyao, SU Hao, NI Zhen, FU Pengyu

“…ObjectiveTo explore the effect of long-time weight-bearing running on the expression of NLRP3-mediated pyroptosis-related genes and proteins in adipose tissue of aging rats.MethodsA total of thirty-five 8-month-old SD rats were randomly divided into three groups: the baseline group (the samples were taken after 3 days of adaptive feeding); the control group (fed for 32 weeks, without exercise); and the resistance training group (fed for 32 weeks, with 3 times/week of weight-bearing running training), with 10 mice per group (5 mice died). After the intervention, the body weight, body composition, perirenal and subcutaneous adipose tissue (p/sWAT) wet weight and blood lipids were measured; the morphology of adipocytes were observed by HE staining, and the cross-sectional area (CSA) of adipocyte was calculated; the relative expression level of ASC, NF-κB, IL-1β, GSDMD, NLRP3 and Caspase1 mRNA were tested by RT-PCR; the immunopositive expression of ASC, IL-1β, GSDMD, NLRP3 and Caspase1 were observed by Immunofluorescence, and the integral optical density (IOD) value was calculated.Results(1) After the intervention, the body weight of rats in the control group was higher than that in the baseline group, and the body weight of rats in the resistance training group was lower than that in the control group (<italic>P</italic>&lt;0.05); the body fat percentage of the resistance training group was lower than those in the control and baseline groups (<italic>P</italic>&lt;0.05), respectively; the muscle content percentage of rats in the control group was lower than that in the baseline group, and the muscle content percentage of rats in the resistance training group was higher than that in the control group (<italic>P</italic>&lt;0.05). (2) After 32 weeks of intervention, the plasma levels of TG, TC, HDL-C, LDL-C and FFA of rats in the control group were higher than those in the baseline group, and the levels of TG and FFA of rats in the resistance training group were lower than those in the control group (<italic>P</italic>&lt;0.05). (3) After 32 weeks of intervention, the wet weight percentages of pWAT and sWAT of rats in the control group were higher than those in the baseline group; the wet weight percentage of pWAT of rats in the resistance training group was lower than those in both the control and baseline groups, and the wet weight percentage of sWAT of rats was lower than that in the control group (<italic>P</italic>&lt;0.05); the CSA of adipocyte of sWAT and pWAT of rats in the resistance training group was smaller than those in the control and baseline groups (<italic>P</italic>&lt;0.05), respectively. (4) After 32 weeks of intervention, the relative expression levels of ASC, NF-κB, IL-1β, NLRP3 and Caspase1 mRNA in pWAT of rats in the control group were higher than those in the baseline group, and the relative expression levels of NF-κB and IL-1β mRNA in sWAT were higher than those in the baseline group (<italic>P</italic>&lt;0.05). …”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…Our patient consumed at least 24 oral nicotine pouches (containing 11 mg nicotine each) per day. We consider the patient's COL4A2 mutation in combination with his substantial nicotine consumption as likely predisposition to multiple ICHs precipitated by stereo‐EEG. …”
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AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology by Yingnan Zhao, Huifen Ye, Jing Yang, Su Yao, Maohua Lv, Zhihong Chen, Yunrui Ye, Qingru Hu, Cheng Lu, Zaiyi Liu, Ke Zhao, Zhihua Chen

“…Results: The AutoLDP system was 20 times faster than manual labeling. The files per minute in the solid-state drives of CRAFT ​+ ​ParSeq were the highest among all methods at 136.95 in validation set 1 and 170.95 in validation set 2. …”
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Evaluation of the adherence of municipalities and states to the Ministry of Health’s microplanning for high-quality vaccination activities and the increase in vaccination coverage... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Gustavo Velasquez-Melendez, Luciana Maiara Diogo Nascimento, Carla Conceição Ferraz, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Methods Adopting an epidemiological approach with an ecological design, this study analyzed data on the adherence of the 27 Brazilian federative units to HQVA, as reported through the REDCap electronic form in 2023, as per an agreement with the Ministry of Health. The criteria for assessing the states’ adherence to the OM included: (1) Formation of a coordination committee for the OM for HQVA; (2) Inclusion of representatives from Primary Care in the committee; (3) Inclusion of representatives from COSEMS in the committee; (4) Regular coordination meetings between health surveillance and primary care for vaccination actions; and (5) Utilization of a management tool for decision-making and strategic planning (e.g., SWOT). …”
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ACUTE LEUKEMIA AND LATENT TUBERCULOSIS INFECTION IN ITALY: QUANTIFERON-TB TEST SCREENING IN A LOW TUBERCULOSIS INCIDENCE COUNTRY by Andrea Nunzi, Luigi Della Valle, Elisa Linnea Lindfors Rossi, Giorgia Ranucci, Flavia Mallegni, Federico Moretti, Elisa Meddi, Luca Guarnera, Ilaria Tiravanti, Kristian Taka, Elisa Buzzatti, Fabiana Esposito, Roberto Secchi, Francesca Di Giuliano, Flavia Chirico, Raffaele Palmieri, Luca Maurillo, Francesco Buccisano, Carmelo Gurnari, Giovangiacinto Paterno, Adriano Venditti, Maria Ilaria Del Principe

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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…Methods This protocol describes a cluster randomized controlled trial (RCT) conducted among ESICM-affiliated ICUs, consisting of at least 73 clusters with in average of 50 respondents per cluster, totaling approximately 7300 participants. …”
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A survey of knowledge about health education and self-management behavior in 118 patients with early diabetic nephropathy (118例早期糖尿病肾病患者健康教育知识水平及自我管理行为现状调查)... by CHEN Furong (陈芙蓉), ZHOU Jianping (周建平), MAO Dandan (毛丹旦), BO Jing (薄静), ZHUANG Ji (庄姬)

“…There were 39(33. 05%)smokers who consumed averaged 19. 01 cigarettes per day. Conclusion Patients with early diabetic nephropathy had poor knowledge about health education, practically in knowledge about diet and exercise. …”
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Evaluation of the Chemical Properties and Absorption Capacity of Different Manganese Sources using Everted Gut Sacs Technique and Their Effects on the Performance and Immune Respon... by Farogh Kargar, Hasan Kermanshahi, Ali Javadmanesh, Reza Majidzadeh Heravi

“…Chickens were grouped into three treatments with Hydroxychloride, organic and manganese sulfate sources with 6 replications and 10 pieces per replication. Three parts were selected from each replication for the test steps (Feng et al., 2006). …”
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Long-term exposure to fine particulate matter components with obesity in children and adolescents in China: The age-sex disparities and key effect modifiers by Jinling Wang, Xinyi Li, Guannan Bai, Rachel Huxley, Kejia Hu, Jinna Yuan, Xuelian Zhou, Xiaochi Zhang, Ke Huang, Guanping Dong, Wei Wu, Bingyan Cao, Rongxiu Zheng, Chunlin Wang, Haiyan Wei, Yan Liang, Hui Yao, Feihong Luo, Pin Li, Zhe Su, Ruimin Chen, Shaoke Chen, Jingsi Luo, Hongwei Du, Mireguli. Maimaiti, Jianwei Zhang, Yu Yang, Min Zhu, Qi Zhao, Junfen Fu

“…The odds ratio of childhood obesity was 1.28 (95 %CI: 1.15–1.43) for per interquartile range increase in PM2.5, with organic matter identified as the key contributor. …”
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CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian ham... by Jyotsna Dandotiya, Neeta Adhikari, Manas Ranjan Tripathy, Manas Ranjan Tripathy, Kamini Jakhar, Sudipta Sonar, Dibya Ranjan Pati, Vibhu Kanchan, Varsha S. Prasad, Jitendra Kumar, Nitesh K. Senapati, Arti Bharmoria, Neeraj Rani, Monika Lakhanpal, CS. Patil, Nishan Singh, Lovely Khan, Lavit Jambu, Naveen K. Jain, Syed Khalid Ali, Priyanka Priyadarsiny, Amulya K. Panda, Rajesh Jain, Shailendra Mani, Sweety Samal, Amit Awasthi, Amit Awasthi, Zaigham Abbas Rizvi, Zaigham Abbas Rizvi

“…In the current study, we demonstrate a consistent manufacturing process under Good Manufacturing Practice for the development of CoviWall and its characterization using various analytical methods as per regulatory compliance. In addition, we provide pre-clinical immunogenicity and protective efficacy data of the CoviWall vaccine. …”
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Spatiotemporal optimization of irrigation practices for winter wheat in China: Rationale, implications, and solutions by Luchen Zhang, Yuan Cao, Weihao Qian, Junning Tian, Shengshi Huang, Xiaolei Qiu, Bing Liu, Liang Tang, Liujun Xiao, Weixing Cao, Yan Zhu, Leilei Liu

“…Over the past four decades, due to the intensification of drought stress, winter wheat yield in China has been declining at a rate of 0.36 % per year. Compared to the irrigation practices of farmers, the optimal irrigation practices not only increased the wheat yield, water use efficiency (WUE), and irrigation water use efficiency (IWUE) by 468–5034 kg·ha−1, 1–13 kg·ha−1·mm−1, and 1–30 kg·ha−1·mm−1, respectively, but also reduced the irrigation amount and frequency by 4–118 mm and 0–2 times, respectively. …”
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Effects of Density Stress on Growth and Physiology of Epinephelus fuscoguttatus ♀×Epinephelus lanceolatus ♂ by Xianhong ZHANG, Wenyang LI, Baoliang LIU, Fan FEI, Xiaoqiang GAO, Ran GUO, Shuquan CAO, Zhiwen ZHU

“…In the LD, MD, and HD groups, 100, 200, and 300 pearl gentian groupers were added per barrel with a density of (3.14±0.13), (6.31±0.13), and (9.56±0.24) kg/m3, respectively. …”
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The establishment of blue-sky index: how to quantify the aerosol optical impacts on sky color by Sunan Shen, Jiandong Wang, Chao Liu, Jia Xing, Jiaping Wang, Jing Cai, Zeyuan Tian, Peng Wang, Guangjie Zheng, Yuzhi Jin, Chenggang Wang, Le Cao, Zhouyang Zhang, Bin Wang, Aijun Ding, Shuxiao Wang

“…The results reveal that the relationship between aerosol concentration and sky color change follows a logarithmic-like distribution: the higher the concentration, the weaker the change in sky color per unit increase in aerosol concentration. Consequently, during the early phases of air pollution control implementation, there may be minimal observable changes in the color of the sky. …”
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Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular ta... by Jingyang Xie, Alicia S. Bicu, Melanie Grehn, Mustafa Kuru, Adrian Zaman, Xinyu Lu, Christian Janorschke, Luuk H.G. van der Pol, Martin F. Fast, Jens Fleckenstein, Marcus Both, Stephan Hohmann, Egor Borzov, Peter Winkler, Roland R. Tilz, Dirk Rades, Frank A. Giordano, Daniel Buergy, Boris Rudic, David Duncker, Roland Merten, Tomer Charas, Mahmoud Suleiman, Thomas Brunner, Daniel Scherr, Evgeny Lian, Achim Schweikard, Oliver Blanck, Judit Boda-Heggemann, Lena Kaestner

“…Results: The CTVs (center of mass) moved 3.4 ± 1.4 mm and the ICD lead tips moved 4.9 ± 2.2 mm. The maximum motion per patient was observed in basal and mid-cavity LV segments in 3D. …”
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Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases by Yanjuan Wu, Yuting Zhang, Jingcun Wang, Qiming Gan, Xiaofen Su, Sun Zhang, Yutong Ding, Xinyan Yang, Nuofu Zhang, Kang Wu

“…Multivariate MR (MVMR) was performed to adjust for potential smoking-related confounders, such as cigarettes per day, household smoking, exposure to tobacco smoke at home, ever smoked, second-hand smoke, smoking initiation, and age at smoking initiation, as well as the independent effects of each air pollutant. …”
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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

“…., exposure-proximal hazard ratio per 10-fold increase in BA.1 titer 0.74 (95% CI 0.59, 0.94) for naïve vs. 0.41 (95% CI 0.23, 0.64) for non-naïve; interaction p = 0.013]. …”
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Spatial and temporal changes of breast-conserving surgery rates and its influential factors among Chinese patients with breast cancer from 2013 to 2019: a registry-based study by Pengpeng Ye, Yuan Yang, Wei Hu, Lingyan Dai, Erwei Song, Shunrong Li, Liling Zhu, Kai Chen, Yanjie Xu, Xiaoyu Wang, Jianli Zhao, Jianrong He, Queran Lin, Tongrui Shang, Xiujuan Gui, Ziliang Zhong, Qianru Chen, Qing Yan, Xiaoliang Huang, Zijian Liang

“…Patients who were employed (vs unemployed, 1.58, 95% CI 1.49 to 1.68), received cross-city surgery (vs local surgery, 1.37, 95% CI 1.31 to 1.44), lived in a high-income city (vs low-income city, β=4.40, 95% CI 1.55 to 7.24) or in a city with a higher number of physicians per 100 000 residents (0.57, 95% CI 0.31 to 0.82) were more likely to receive BCS.Conclusions and relevance This study suggests a significant increase in BCS rates from 2013 to 2019 in Guangdong, China. …”
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Development of a Transcultural Social Ethical and Integrated Care Model, for Dependent and Older People Populations at Risk of Exclusion in the Mediterranean Sea Basin (TEC-MED): A... by Ana María Porcel-Gálvez, Elena Fernández-García, Soledad Vázquez-Santiago, Sergio Barrientos-Trigo, María Dolores Mateos-Garcia, Mercedes Bueno-Ferrán, Jalila El Ati, Hajer Aounallah-Skhiri, Marta Lima-Serrano

“…The pilot phase uses qualitative-quantitative method to assess the impact of the TEC-MED project, it is expected to train 36 Training Agents, six per country, who apply to a total of 28,200 people (mainly elders and their caregivers). …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…There were significantly fewer average post-treatment radiation oncology appointments per patient in the intervention group compared to the control group (0.69 versus 1.27, P = 0.013) at 24-months. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…In patients with HCC undergoing resection, higher CD8+ TIL density correlates with better OS, as per ATLS-8 assessment. This system is a promising tool for advancing clinical immune microenvironment assessment and outcome prediction. …”
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