Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…To induce ascites, water containing 7 g per liter of salt was provided to the chickens from day 15 of age. …”
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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…Patients with AF aged ≥18 years with moderate or severe MS not planned for valvular intervention in the coming 12 months will be randomised in a 1:1 ratio to receive dabigatran 110 mg or 150 mg two times per day or warfarin with international normalised ratio 2–3 in an open-label design. …”
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Selection of Superior Sugar Beet Genotypes using the Analysis of Quantitative and Qualitative Traits by Mahdi Hassani, Ali Saremirad, Hamed Mansouri

“…Among the experimental hybrids and controls, two controls, 8K801 and BTS 1885, along with genotypes 33, 12, and 24, demonstrated commendable average white sugar yields ranging from 9.15 to 10.52 tons per hectare. These hybrids notably outperformed domestic controls, e.g. …”
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Excess costs of post-traumatic stress disorder related to child maltreatment in Germany by Thomas Grochtdreis, Hans-Helmut König, Falk Leichsenring, Manfred E. Beutel, Lila Feix, Harald Gündel, Andrea Hermann, Melissa Hitzler, Christine Knaevelsrud, Iris-Tatjana Kolassa, Johannes Kruse, Helen Niemeyer, Fatima Nöske, Simone Salzer, Karoline Sophie Sauer, Patrick Schuster, Christiane Steinert, Kerstin Weidner, Jörn von Wietersheim, Jürgen Hoyer, Judith Dams

“…Results The total six-month excess costs associated with PTSD-CM were €8864 (95% CI: €6855 to €10,873) per person. Of this, the excess health care costs accounted for €4647 (95% CI €3296 to €5997) and the excess costs of absenteeism for €4217 (95% CI: €3121 to €5314). …”
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An observational study evaluating the epidemiological and entomological impacts of piperonyl butoxide insecticide-treated nets (ITNs) compared to a combination of indoor residual s... by Banchamlak Tegegne, Delenasaw Yewhalaw, Emily R Hilton, Sarah Zohdy, Cecilia Flatley, Kelly M Davis, Amha Worku, Meshesha Balkew, Peter Mumba, Sheleme Chibsa, Jon Eric Tongren, Gudissa Assefa, Achamyelesh Sisay, Dawit Teshome, Mastewal Worku, Mulat Yimer, Melissa Yoshimizu, Isabel Swamidoss, Carla Mapp, Jimee Hwang, Wendy Inouye, Aklilu Seyoum, Dereje Dengela, Sarah M Burnett

“…The difference in An. gambiae s.l. vector density per trap and indoor resting density (IRD) was assessed between the two arms during the high transmission seasons 2 years after the 2021 campaigns.Results Estimated malaria cases decreased significantly by 53.6% in the postintervention period compared with preintervention in the IRS+Standard Pyrethroid ITN arm (95% CI −72.9%, −29.8%) and by 55.9% in the PBO ITN arm (95% CI −73.0%, −32.5%), with no significant difference between these two arms (95% CI −30.9%, 24.0%). …”
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Evaluating Digital Rehabilitation Outcomes in Chronic Musculoskeletal Conditions Across Non-Obesity, Obesity, and Severe Obesity by Pereira AP, Janela D, Areias AC, Molinos M, Tong X, Bento V, Yanamadala V, Cohen SP, Correia FD, Costa F

“…Fairly similar engagement was observed with both exercise sessions and the educational content (1.9– 2.2 exercise sessions per week; 8.10– 9.31 educational content videos watched). …”
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Addressing the overuse of hospital emergency departments in the Portuguese NHS: a new paradigm by Francisco Goiana-da-Silva, Francisco Goiana-da-Silva, Francisco Goiana-da-Silva, Francisco Goiana-da-Silva, Soraia Costa, Filipa Malcata, Juliana Sá, Juliana Sá, Rafael Vasconcelos, Miguel Cabral, Raisa Guedes, Inês Morais-Vilaça, Lara Pinheiro-Guedes, João Ferreira, Nélson Pereira, José Gaspar-Pais, Judite Neves, Joaquim Monteiro, Vera Pires, Miguel Paiva, Rui Guimarães, Hutan Ashrafian, Hutan Ashrafian, Rita Moreira, Fátima Fonseca, Filomena Cardoso, Filomena Cardoso, Jaime Alves, Ara Darzi, Ara Darzi, Fernando Araújo, Fernando Araújo

“…Portugal faces a notable challenge, reporting one of the highest per capita ED visit rates, with an annual average of approximately 6 million ED visits from 2013 to 2023. …”
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Call for Papers: Demography Prize for Young Researches 2016/2017 by IF and FRFG

“…In a 2013 study published by the Bertelsmann Foundation, and led by Pieter Vanhuysse of the UN’s European Centre for Social Welfare Policy and Research, a total of 29 OECD states were compared on the basis of four indicators: public debt per child; the ecological footprint created by all generations currently alive; the ratio of child- to elderly-poverty; and the distribution of social spending among generations (“elderly-bias indicator of social spending”, EBiSS). …”
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Image Segmentation Method of Chinese Yam Leaves in Complex Background Based on Improved ENet by LU Bibo, LIANG Di, YANG Jie, SONG Aiqing, HUANGFU Shangwei

“…PConv was used to reduce the amount of model computation while increase the number of floating-point operations per second on the hardware device, resulting in lower latency. …”
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Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women by Stephen J Sharp, Kay-Tee Khaw, Robert Luben, Nita G Forouhi, Leila Finikarides, Islam Afzal, Marleen Lentjes

“…Of these, 91 men and women attended a follow-up assessment 4 weeks later.Intervention Participants were randomised to extra virgin coconut oil, extra virgin olive oil or unsalted butter and asked to consume 50 g daily of one of these fats for 4 weeks, which they could incorporate into their usual diet or consume as a supplement.Main outcomes and measures The primary outcome was change in serum LDL-C; secondary outcomes were change in total and high-density lipoprotein cholesterol (TC and HDL-C), TC/HDL-C ratio and non-HDL-C; change in weight, body mass index (BMI), waist circumference, per cent body fat, systolic and diastolic blood pressure, fasting plasma glucose and C reactive protein.Results LDL-C concentrations were significantly increased on butter compared with coconut oil (+0.42, 95% CI 0.19 to 0.65 mmol/L, P<0.0001) and with olive oil (+0.38, 95% CI 0.16 to 0.60 mmol/L, P<0.0001), with no differences in change of LDL-C in coconut oil compared with olive oil (−0.04, 95% CI −0.27 to 0.19 mmol/L, P=0.74). …”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…T-cell receptor (TCR) sequencing was also conducted both in immune competent MM mice and in patients enrolled in a phase 1b trial per a standard 3 + 3 dose escalation schedule. Results Here we show ex vivo and in vivo that proteasome inhibitors (PIs) potentiate reovirus replication in circulating classical monocytes, increasing viral delivery to myeloma cells. …”
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Determinants of tobacco use transitions in smoker nursing students in Catalonia: A prospective longitudinal study by Kenza Laroussy, Esteve Fernández, Yolanda Castellano, Marcela Fu, Antoni Baena, Ariadna Feliu, Armando Peruga, Mercè Margalef, Olena Tigova, Jordi Galimany, Montserrat Puig, Carmen Moreno, Albert Bueno, Antonio López, Judith Roca, Judith Saura, Cristina Martínez

“…We examined transitions in tobacco use patterns between baseline and follow-up among smokers from: 1) daily to nondaily smoking, 2) non-daily to daily smoking, 3) cigarette-only use to polytobacco use, 4) poly-tobacco use to cigarette-only use, 5) between products, 6) reducing consumption by ≥5 cigarettes per day (CPD); and 7) quitting smoking. We applied a Generalized Linear Model with a log link (Poisson regression) and robust variance to identify predictors of reducing cigarette consumption by ≥5 CPD and quitting smoking, obtaining both crude and adjusted (APR) prevalence ratios and their 95% confidence intervals (CIs). …”
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Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) by Rosario Menéndez, Raúl Méndez, Ana Latorre, Paula González-Jiménez, Germán Peces-Barba, María Molina-Molina, Pedro Pablo España, Estela García, Angélica Consuegra-Vanegas, Marta María García-Clemente, Carolina Panadero, Juan Marco Figueira-Gonçalves, David De la Rosa-Carrillo, Oriol Sibila, María Dolores Martínez-Pitarch, Nuria Toledo-Pons, Cecilia López-Ramírez, Wanda Almonte-Batista, Abigail Macías-Paredes, Mercedes Villamon, Marisol Domínguez-Álvarez, Eli Nancy Pérez-Rodas, Javier Lázaro, Sarai Quirós, Rosa Cordovilla, Irene Cano-Pumarega, Antoni Torres

“…In-hospital mortality and subsequent 1-year mortality were greater for C2 (28.6% and 7.1%) and C1 (11.1%, 8.3%) than for C4 (3.3%, 1.8%) and C3 (0%, 0%).Conclusions The cluster analysis identified four clinical phenotypes requiring distinct types of respiratory support, with great differences present per characteristics and outcomes.…”
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Impact of primary care benefits on healthcare utilisation and estimated out-of-pocket expenses in urban, rural and remote settings in the Philippines by Antonio L Dans, Arianna Maever L Amit, Leonila F Dans, Gillian Sandigan, Regine Ynez H De Mesa, Mia P Rey, Josephine T Sanchez, Cara Lois T Galingana, Nannette Bernal-Sundiang, Maria Rhodora N Aquino, Johanna Faye E Lopez, Janelle Micaela S Panganiban, Romelei Camiling-Alfonso, Jose Rafael A Marfori, Ramon Pedro Paterno, Carol Stephanie Chua Tan-Lim, Noleen Marie Fabian, Chad Lester Lastrilla, Miguel Callo

“…In this study, two key outcomes were monitored: (1) monthly healthcare utilisation measured by the total number of outpatient consultations per site and (2) change in OOP expenses from baseline to endline within a 1 year study period.Results All sites had a positive trend in monthly outpatient consultations in healthcare utilisation over 1 year. …”
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Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells by Zhiwei Yuan, Taiyan Yu, Xu Wang, Kelin Meng, Tianlai Wang, Boyu Wang, Yu Xi, Congjian Wang, Chenxi Zeng, Shaojie Hu, Yitao Tian, Hui Xiong, Qi Wang, Wenbin Zou, Xue Wang, Yi Gao, Xiangning Fu, Lequn Li

“…The administration of CQ increased the sensitivity of ASCT2-deficient tumors to anti-PD-L1 therapy. Glutamine deprivation per se leads to resistance to immunotherapy, whereas V9302 treatment results in increased immunotherapy efficacy through impaired lysosomal activity, which is independent of glutamine deprivation.…”
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Effect of the Iridoid-rich Fraction from <italic>Valeriana jatamansi</italic> Jones on Oxidative Stress in Rats with Spinal Cord Injury by Jiaojuan HUANG, Wenchun WANG, Deqi XIONG, Hao LU, Wu XIANG, Xiaohua ZHAO, Ruihan ZHOU, Anren ZHANG

“…Objective:To investigate the effects of iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones on oxidative stress in rats with spinal cord injury(SCI)from the histological and molecular biological levels.Methods:A total of sixty male Sprague-Dawley rats weighing(250±30)g were randomly divided into three groups(20 rats per group):the sham-operated group, the model group, and the treatment group with 10 mg/kg iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones. …”
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Efficacy of Streptococcus agalactiae vaccine strains N3M and N4M in fry tilapia infected by different strains of S. agalactiae by Sukenda, Sukenda, Arif Lukman Firmansyah, Rahman, Rahman, Sri Nuryati, Dendi Hidayatullah

“…Fry tilapia was vaccinated through intraperitoneal injection method with 0.1 mL per fish of N3M and N4M vaccines. Fish reared in aquarium sizing of 60×30×50 cm3 with a density of 10 fishes aquarium-1. …”
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Utilization of fermented sago pulp as a source of carbohydrate in feed for Nile tilapia Oreochromis niloticus by I Kadek Sumiana, Julie Ekasari, Dedi Jusadi, Mia Setiawati

“…Pada uji kecernaan digunakan ikan nila (25 g) yang dipelihara dengan kepadatan tujuh ekor per akuarium. Pada uji ini dilakukan tiga perlakuan pakan dengan empat ulangan, yaitu pakan acuan, ampas sagu tanpa fermentasi (AS), dan ampas sagu fermentasi (ASF). …”
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Interaction of human gut microbiota and local immune system in progression of colorectal adenoma (MIMICA-1): a protocol for a prospective, observational cohort study by Jurate Valciukiene, Egle Lastauskiene, Aida Laurinaviciene, Aida Laurinaviciene, Matas Jakubauskas, Marius Kryzauskas, Ruta Barbora Valkiuniene, Ruta Barbora Valkiuniene, Renaldas Augulis, Renaldas Augulis, Ausra Garnelyte, Justinas Kavoliunas, Ugne Silinskaite, Tomas Poskus

“…Therefore, the purpose of this prospective cohort study (MIMICA-1) is, firstly, to identify the intestinal microbiota and immune infiltration patterns around the normal bowel tissue, early and advanced adenoma, carcinoma in situ, and adenocarcinoma, and secondly, to analyze the immune – microbiome interplay along the steps of conventional colorectal tumorigenesis.Methods and analysesThis study aims to prospectively recruit 40 patients (10 per group) with confirmed colorectal dysplasia undergoing endoscopic polypectomy, endoscopic mucosal resection for colorectal small (≤1cm), and large (&gt;1cm) adenoma or carcinoma in situ, or biopsy and subsequent colon resection for invasive colorectal cancer, and 10 healthy patients undergoing screening colonoscopy. …”
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Study protocol of a population-based cohort investigating Physical Activity, Sedentarism, lifestyles and Obesity in Spanish youth: the PASOS study by Susana Aznar, Camille Lassale, Santiago Felipe Gómez, Clara Homs, Julia Wärnberg, Maria Medrano, Marcela Gonzalez-Gross, Narcis Gusi, Elena Marín Cascales, Miguel González-Valeiro, Lluis Serra-Majem, Nicolás Terrados, Josep A Tur, Marta Segú, Juan Carlos Benavente-Marín, Idoia Labayen, Augusto García Zapico, Jesús Sánchez-Gómez, Fabio Jiménez-Zazo, Pedro Emilio Alcaraz, Marta Sevilla-Sanchez, Estefania Herrera-Ramos, Susana Pulgar, Maria del Mar Bibiloni, Olga Sancho, Helmut Schröder

“…This observational, nationally representative, multicentre study aims to determine the PA levels, sedentary behaviours and prevalence of physical inactivity (defined as &lt;60 min of moderate to vigorous PA per day) in a representative sample of Spanish children and adolescents. …”
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