Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…Introduction Idiopathic nephrotic syndrome is the most common glomerular disease in childhood with an incidence of 1.8 cases per 100 000 children in Germany. The treatment of the first episode implies two aspects: induction of remission and sustainment of remission. …”
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A comprehensive environmental index for monitoring ecological quality of typical alpine wetlands in Central Asia by Jiudan Zhang, Junli Li, Changming Zhu, Anming Bao, Amaury Frankl, Philippe De Maeyer, Tim Van de Voorde

“…The wetland area expanded from 969.11 km2 to 1,108.75 km2 at an average of 1.83 km2 per year. Meanwhile, improvements were also observed in hydrological conditions, vegetation vitality, and aboveground biomass, coupled with a reduction in wetland landscape fragmentation, improving ecological stability. …”
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Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-Helicobacter pylori Eradication in Taiwan by Wei-Chen Tai, Chien-Hua Chiu, Chih-Ming Liang, Kuo-Chin Chang, Chung-Mou Kuo, Yi-Chun Chiu, Keng-Liang Wu, Ming-Luen Hu, Yeh-Pin Chou, Shue-Shian Chiou, King-Wah Chiu, Chung-Huang Kuo, Tsung-Hui Hu, Ming-Tsung Lin, Seng-Kee Chuah

“…Eradication rates attained by EAL-10 and EAL-14 were 75.6%; 95% –85.3% and 92.5%; 95% –98.1%, in the per protocol analysis and 68%; 95% –78.5% and 86%; 95% –93.4%, in the intention-to-treat analysis. …”
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Impact of surgical site infection (SSI) following gynaecological cancer surgery in the UK: a trainee-led multicentre audit and service evaluation by Rachel L O’Donnell, Georgios Angelopoulos, James P Beirne, Ioannis Biliatis, Helen Bolton, Melissa Bradbury, Elaine Craig, Ketan Gajjar, Michelle L Mackintosh, Wendy MacNab, Thumuluru Kavitha Madhuri, Mark McComiskey, Eva Myriokefalitaki, Claire L Newton, Nithya Ratnavelu, Sian E Taylor, Amudha Thangavelu, Sarah A Rhodes, Emma J Crosbie, Richard J Edmondson, Yee-Loi Louise Wan

“…Multivariate analysis found body mass index (BMI) was the strongest risk factor for SSI (OR 1.08[95% CI 1.03 to 1.14] per 1 kg/m2 increase in BMI [p=0.001]). Wound drains (OR 2.92[95% CI 1.41 to 6.04], p=0.004) and staple closure (OR 3.13[95% CI 1.50 to 6.56], p=0.002) were also associated with increased risk of SSI.Conclusions SSI is common in women undergoing surgery for gynaecological cancer leading to delays in discharge and adjuvant treatment. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The rats were divided into Control, Model, Sig-1R agonist PRE-084 (0.3, 0.6, 1 mg/kg), and metformin (Met, 20 mg/kg) groups, with seven rats per group, and their body weight, fasting blood glucose, mechanical withdrawal threshold and thermal withdrawal latency were tested weekly for two weeks. …”
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Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

“…The primary endpoint was the objective response rate per immune-related response criteria (irORR) at week 26 (a lower bound of the 90% confidence interval [CI] of > 10% was considered efficacious). …”
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Analysis and comparison of the trends in burden of spinal cord injury in China and worldwide from 1990 to 2021: an analysis of the global burden of disease study 2021 by Hao Qin, Yuhang Diao, Mingyu Hao, Zhitan Wang, Minghao Xie, Xiaojun Hu, Tao Zhu

“…Projections indicate that by 2036, the ASIR and ASPR for SCI in China will reach 6 and 146 cases per 100,000 people, respectively.ConclusionThe number and burden of SCI in China and globally have increased in the past. …”
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Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period by Mengmeng Xu, Le Liu, Zongze Fan, Lizhu Niu, Wenxi Ning, He Cheng, Mengyun Li, Wenying Huo, Pan Zhou, Hongyu Deng, Wen Chen, Long Che

“…A total of 360 70-week-old Jinghong laying hens were randomly assigned to four groups of six replicates each, with 15 chickens per replicate. Diets with linseed oil to soybean oil ratios of 3:0 (T1), 2:1 (T2), 1:2 (T3), and 0:3 (T4) were fed for 4 weeks. …”
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Performance Evaluation of Dual-Drive Mach-Zehnder Modulator and Optomechanical Crystal Cavity Comb Generation for All-Optical Band Conversion in 5G-Advanced Cellular Systems by Vicente Fito, Raul Ortiz, Maria Morant, Laura Mercade, Alejandro Martinez, Roberto Llorente

“…Multiband operation is a key aspect of emerging 5G-Advanced cellular systems, also named 5.5G, which target seamless provision of multi-gigabit per second connectivity employing sub-6 GHz and mm-wave overlapping coverage. …”
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Temporal and Spatial Patterns of Wind Erosion Climate Indices and Their Responses to Atmospheric and Oceanic Circulation Patterns in the Chinese Mollisol Region over the Past 61 Ye... by HU Wentao, ZHENG Fenli, GAO Xiaoyu, ZHENG Runhe, FU Jinxia, LI Zhi, ZHANG Jiaqiong

“…[Results] The occurrence frequency of ≥ 5 m/s threshold wind speed of transporting sand varied from 5 to 30 times per season, daily maximum wind velocity varied from 6.1 to 8.7 m/s, daily extreme wind velocity varied from 9.8 to 12.2 m/s, and wind erosion climatic erosivity varied from 19.5 to 101.1 in the Chinese Mollisol region form 1960 to 2020. …”
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Magnetocaloric Effect for a <i>Q</i>-Clock-Type System by Michel Aguilera, Sergio Pino-Alarcón, Francisco J. Peña, Eugenio E. Vogel, Natalia Cortés, Patricio Vargas

“…We calculate the thermodynamic quantities using Monte Carlo simulations for even <i>Q</i> numbers, ranging from <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>2</mn></mrow></semantics></math></inline-formula> to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>8</mn></mrow></semantics></math></inline-formula> spin orientations per site in a lattice. We use lattices of different sizes with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>N</mi><mo>=</mo><mi>L</mi><mo>×</mo><mi>L</mi><mo>=</mo><msup><mn>8</mn><mn>2</mn></msup><mo>,</mo><msup><mn>16</mn><mn>2</mn></msup><mo>,</mo><msup><mn>32</mn><mn>2</mn></msup><mo>,</mo><msup><mn>64</mn><mn>2</mn></msup><mo>,</mo><mi>and</mi><mspace width="4pt"></mspace><msup><mn>128</mn><mn>2</mn></msup></mrow></semantics></math></inline-formula> sites, considering free boundary conditions and an external magnetic field varying between <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>B</mi><mo>=</mo><mn>0</mn></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>B</mi><mo>=</mo><mn>1.0</mn></mrow></semantics></math></inline-formula> in natural units of the system. …”
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Production of Arthrospira platensis algae to increase production efficiency and enhance immune system of grass carp, Ctenopharyngodon idella against Aeromonas hydrophila by Hossein Adineh

“…Two hundred and forty fish (7.86 ± 0.47 g) were randomly distributed in 12 tanks (20 fish per 50 L). Also, together with the consumption of basic food (protein 32.29% and energy 3984.80 kcal/kg), different levels of spirulina algae were added with a concentration of 4 × 104, 5 × 104 and 6 × 104 cells/mL (S1, S2 and S3, respectively) and basic food without algae (C), daily to rearing tanks for 60 days. …”
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Cochlear Implant Programming: A Global Survey on the State of the Art by Bart Vaerenberg, Cas Smits, Geert De Ceulaer, Elie Zir, Sally Harman, N. Jaspers, Y. Tam, Margaret Dillon, Thomas Wesarg, D. Martin-Bonniot, L. Gärtner, Sebastian Cozma, Julie Kosaner, Sandra Prentiss, P. Sasidharan, Jeroen J. Briaire, Jane Bradley, J. Debruyne, R. Hollow, Rajesh Patadia, Lucas Mens, K. Veekmans, R. Greisiger, E. Harboun-Cohen, Stéphanie Borel, Dayse Tavora-Vieira, Patrizia Mancini, Helen Cullington, Amy Han-Chi Ng, Adam Walkowiak, William H. Shapiro, Paul J. Govaerts

“…The main focus lies on setting maximum and, to a lesser extent, minimum current levels per electrode. These levels are often determined on a few electrodes and then extrapolated. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Throughout this study time period, methadone dosages will be adjusted by an addiction clinician blind to patient assignment, per standard clinical methods. The primary outcome is methadone dose at 3 months. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…The crude 15-year prevalence of dementia was 2.1%, and the age–sex standardised incidence rate of dementia was 4.3 (95% CI: 4.2 to 4.4) per 1000 person-years. Among the adjusted covariates, CD4 cell count&lt;50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

“…The ICER was US$22 707 (SE: 430) per quality-adjusted life year gained, indicating long-term cost-effectiveness. …”
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Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China by Haoling Tang, Zhiwei Chen, Tianquan Huang, Pingping Yu, Qiao Tang, Yue Qiu, Yunling Xue, Jing Tang, Nan Cai, Hong Ren, Mingli Peng, Peng Hu

“…Forty‐three symptoms were identified during SARS‐CoV‐2 infection (11 symptoms per individual). The common symptoms were fever, cough, headache, phlegm production, and fatigue (60.67%–83.29%). …”
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The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults by Hehua Zhang, Yong Feng, Honghao Yang, Yuqian Li, Zheng Ma, Liuxin Li, Liangkai Chen, Yuhong Zhao, Lishen Shan, Yang Xia

“…During an average follow-up of 11.4 years within 390,054 participants, a total of 11,312 asthma cases occurred with an incidence density of 2.54 per 1000 person years. Participants with the highest PM2.5 and GMA exposure were associated with a 13 % (HR = 1.13, 95 % CI: 1.05, 1.22; P for trend < 0.001) higher and 16 % (HR = 0.84, 95 %CI: 0.74, 0.94; P for trend < 0.01) lower risk of incident asthma, respectively. …”
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Alimentation d’une population historique by Estelle Herrscher

“…Three kinds of tissues per individual were sampled: a growing tooth root, corresponding to a diet signal at the time of death, and two pieces of mandibular bone—one close to a tooth bud and the second close to an erupted tooth - both corresponding to different diet signals prior to the time of death. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…The difference in VAS improvement at 6 months with NB2C adhesive was not inferior to absorbable tacks in intention-to-treat and per-protocol analyses, respectively (0.25 [95% CI, −0.33 to 0.82]; P = 0.013; 0.22 [95% CI, −0.36 to 0.80], noninferiority P = 0.011). …”
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