Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…Five cycles of treatment were applied with the following doses per cycle: irradiation 3 Gy, hyperthermia 1 h at 42 °C, cisplatin at 2 mg/kg, and twice PARP1-i at 50 mg/kg.Results: Quadruple treatment, combining radiotherapy, hyperthermia, cisplatin and PARP1-i, was very effective but also lead to severe side effects causing severe weight loss and death. …”
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Variation in Phenolic, Mineral, Dietary Fiber, and Antioxidant Activity across Southern Tunisian Pearl Millet Germplasm by Tebra Triki, Samir Tlahig, Mohamed Ali Benabderrahim, Walid Elfalleh, Mahmoud Mabrouk, Mohamed Bagues, Hédi Yahia, Khaled Belhouchette, Ferdaous Guasmi, Mohamed Loumerem

“…The content of NDF, ADF, and ADL per dry weight varied from 20 to 31%, 1 to 4.2%, and 0.4 to 2.3%, respectively. …”
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A genogeographic study of the Kyrgyz mountain merino via microsatellite markers by A. В. Bekturov, Zh. T. Isakova, V. N. Kipen, T. Dzh. Chortonbaev, S. B. Mukeeva, S. K. Osmonaliev, К. A. Aitbaev

“…There were 6 to 16 alleles in each locus (mean 10.500 ± 0.957 alleles per locus). We identified 67 rare alleles (prevalence less than 5.0 %), which made up 53.2 % of all alleles found. …”
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Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons by Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Yu-Xin Chen, Long-Ji Sun, Shi-Hao Li, Wen-Rui Wang, Fan Yang

“…Thirty pigeons were randomly divided into three groups (IM, IV, and PO; n = 10 per group). Difloxacin was administered at 10 mg/kg body weight (BW) via each route. …”
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Returning to the emergency department: a retrospective analysis of mental health re-presentations among young people in New South Wales, Australia by Rebecca Ivers, Michael Dinh, Patricia Cullen, Bette Liu, Katharine Steinbeck, Natasha Walker, Robert Neil Leong

“…On average, patients re-presented 0.61 times per 365 person-days, with average time until first re-presentation of ~92 days but greatest risk of re-presentation within first 30–60 days. …”
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Activity of sorghum aphid and its natural enemies in the context of agroecological and weather conditions by Tomasz E. Koralewski, Tomasz E. Koralewski, Michael J. Brewer, Leonel L. Deleon, Norman C. Elliott, Kristopher Giles, Adrianna Szczepaniec, Ashleigh M. Faris, Ashleigh M. Faris

“…We built multiple regression models using data from the years 2017–2019 for metrics such as maximum number of insects per leaf, response time of natural enemies to pest presence, and speed of increase in insect abundance. …”
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ĮGALINANČIŲ SOCIALINIŲ PASLAUGŲ VIENIŠOMS MOTINOMS KONSTRAVIMAS: BIOGRAFINIO PASAKOJIMO PERSPEKTYVA by Emilija Papreckytė, Aristida Čepienė

“…Jos teigiamai vertina valstybės piniginę paramą, tačiau teigia, kad ji yra per maža, neatliepianti jų poreikių. Taip pat labai vertinama socialinio darbuotojo, psichologo, vaiko teisių specialisto pagalba. …”
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Nonfimbrial Adhesin Mutants Reveal Divergent Escherichia coli O157:H7 Adherence Mechanisms on Human and Cattle Epithelial Cells by Matthew R. Moreau, Indira T. Kudva, Robab Katani, Rebecca Cote, Lingling Li, Terrance M. Arthur, Vivek Kapur

“…Supershedding (SS) is a phenomenon that has been reported in some cattle that shed more than 104 colony-forming units of O57:H7 per gram of feces, 100–1000 times more or greater than normal shedders. …”
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Genome constitution and differentiation of subgenomes in Siberian and Far Eastern endemic species of the genus Elymus (Poaceae) according to the sequencing of the nuclear gene waxy by A. V. Agafonov, S. V. Asbaganov, E. V. Shabanova (Kobozeva), I. V. Morozov, A. A. Bondar

“…To determine the species’ genomic constitution and to evaluate the level of phylogenetic differentiation, we examined the GBSS1 gene in 18 species of Elymus from Siberia and the Russian Far East, including the fol- lowing 14 endemics: E. charkeviczii, E. jacutensis, E. kamczadalorum, E. komarovii, E. kronokensis, E. lenensis, E. macrourus, E. margaritae, E. subfibrosus, E. sajanensis, E. transbaicalensis, E. peschkovae, E. uralensis, and E. viridiglumis.PCR amplification products of GBSS1 gene fragments (including exons 9–14) were cloned and 6–8 clones per accession were sequenced. It appears that all the species studied have St and H subgenomic gene variations. …”
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Prevalence and predictors of short stature in children aged 3–18 years in Hainan Province, China: a cross-sectional study by Mi Yan, Mi Yan, Yingying Qin, Yingying Qin, Hongai Li, Chuican Huang, Haidan Li, Li Liu, Yuhua Cai, Lichun Fan, Wei Xiang, Xiaoyan Huang, Xiaoyan Huang

“…Children's short stature was significantly related to seven factors: area, birth weight, body mass index z score (BAZ), maternal education, family income (RMB per year), frequency of bean intake and frequency of egg intake. …”
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Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers by Kiki W. K. Kuijpers, Karl Andersson, Karl Andersson, Maria Winkvist, Marieke Niesters, Monique van Velzen, Fred Nyberg, Albert Dahan, Markku D. Hämäläinen

“…Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.MethodsIn this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18–70 years old, all with informed consent, 12 subjects per drug). Videos captured by smartphones at ~50 lux and ~ 500 lux documented the eye’s reaction before and after controlled intake of single doses of oral oxycodone (20 mg), lorazepam (2 mg), lisdexamphetamine (70 mg) and inhaled cannabis flos (65 mg with 22% THC) over a 5-h test period. …”
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Volumetric and End-Tidal Capnography for the Detection of Cardiac Output Changes in Mechanically Ventilated Patients Early after Open Heart Surgery by Ingrid Elise Hoff, Lars Øivind Høiseth, Knut Arvid Kirkebøen, Svein Aslak Landsverk

“…We investigated whether CO2 measured as end-tidal concentration (EtCO2) and eliminated volume per breath (VtCO2) reflect sudden changes in cardiac output (CO). …”
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Assessment of the Heterotrophic Bacterial Contamination in Waterlines of Dental Units as a Potential Health Risk Factor in Occupational and Patient’s Exposures by Ali Shahryari, Amineh Zahed, Abdolhalim Rajabi, Maryam Shafipour, Niloufar Emrani, Hadi Rahimzadeh, Hamidreza Heidari

“…Bacterial contamination in the waterlines, dental handpieces, and other water-related components of dental units was investigated and analyzed in terms of Colony-Forming Units per milliliter (CFU/ml). The data were analyzed using the Kruskal-Wallis and Wilcoxon signedrank tests using SPSS version 23.Results: The mean and standard deviation of bacterial contamination across all studied departments were significantly higher than the recommended limit of 500 CFU/ml (ranging from 10,250.00±8,924.28 CFU/ml for the inlet to the water tank in the pediatric department to 275,625.00±41,520.86 CFU/ml for the air-water syringe before flushing in the surgery department). …”
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Response Time Threshold for Predicting Outcomes of Patients with Out-of-Hospital Cardiac Arrest by Ling Hsuan Huang, Yu-Ni Ho, Ming-Ta Tsai, Wei-Ting Wu, Fu-Jen Cheng

“…The adjusted OR of EMS response time for survival to hospital discharge was 1.217 (per minute shorter, CI: 1.140–1299, p<0.001) and 1.992 (<6.2 min, 95% CI: 1.496–2.653, p<0.001). …”
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Hospital Financial Burden of Surgical Procedures for Periprosthetic Total Hip Arthroplasty Infection by Jesus M. Villa, MD, Tejbir S. Pannu, MD, MS, Robert B. Eysler, BA, Vivek Singh, MD, MPH, Alison K. Klika, MS, Carlos A. Higuera, MD

“…Demographics, professional (ie, physicians), and technical (ie, room, implants) hospital charges per case were compared between 6 different surgery types: (1) aseptic revision (control; n = 364); (2) debridement, antibiotics, and implant retention (n = 11); (3) explantation (n = 145); (4) spacer exchange (n = 7); (5) 2-stage reimplantation (n = 59); and (6) 1-stage reimplantation (n = 10). …”
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Evaluation of topical 1% posaconazole therapy in refractory fungal keratitis by Murugesan Vanathi, Devendra K Yadav, Thirumurthy Velpandian, Nishat Hussain Ahmed, Manu Muraleekrishna, Abhijeet Beniwal, Neiwete Lomi, Noopur Gupta, Radhika Tandon, Maroof A Khan

“…Fusarium isolates showed greater susceptibility to natamycin in our study per MIC50 values, with susceptibility to the common antimycotic agents varying between the Aspergillus spp. in both PCZ treatment and conventional treatment groups. …”
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Goitre Prevalence and Urinary Iodine Concentration in School-Aged Children in the Ashanti Region of Ghana by Daniel Gyamfi, Yaw Amo Wiafe, Enoch Ofori Awuah, Evans Asamoah Adu, Emmanuel Kodie Boadi

“…The criteria of thyroid volume per age yielded a goitre prevalence of 2.2%. In contrast, the criteria of thyroid volume by body surface area yielded a goitre prevalence of 0.9%. …”
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Phenolic Compounds from Water-Ethanol Extracts of Tetrapleura tetraptera Produced in Cameroon, as Potential Protectors against In Vivo CCl4-Induced Liver Injuries by Peter William Kemewele Saague, Bruno Moukette Moukette, Jacques Romain Njimou, Prosper Cabral Nya Biapa, Francine Nzufo Tankeu, Vicky Joseline Ama Moor, Constant Anatole Pieme, Jeanne Yonkeu Ngogang

“…The extract of T. tetraptera was administered at doses of 50 mg/kg and 100 mg/kg for 07 per os to rats before the induction of hepatotoxicity with of 2 ml/kg of 1:1 (v/v) carbon tetrachloride (CCl4) and olive oil through intraperitoneal route. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Subgroup analysis will be stratified by age, sex, sample size, New York Heart Association scale, cardiac Troponin T, N-terminal prohormone of brain natriuretic peptide, C reactive protein, number of lymphocytes per mm2 in the endomyocardial biopsy.Ethics approval and dissemination This study does not require ethics approval. …”
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High-Energy Burst-Mode 3.5 μm MIR KTA-OPO by Haowen Guo, Chunyan Jia, Shuai Ye, Yongping Yao, Tiejun Ma, Jiayu Zhang, Meng Bai, Jinbao Xia, Hongkun Nie, Bo Yao, Jingliang He, Baitao Zhang

“…The KTA-OPO produced a 3.5 μm MIR burst-mode laser output with 4 to 11 sub-pulses per pulse envelope. The output energies were 2.9 mJ, 2.81 mJ, and 2.79 mJ at 100 Hz, as well as 2.8 mJ, 2.75 mJ, and 2.72 mJ at 200 Hz, with corresponding conversion efficiencies of 9.6%, 9.3%, and 9.3% at 100 Hz, as well as 9.3%, 9.2%, and 9.1% at 200 Hz, respectively. …”
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