Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro by E. G. Zakirova, Y. V. Vyatkin, N. A. Verechshagina, V. V. Muzyka, I. O. Mazunin, K. E. Orishchenko

“…It means that due to a high copy number of the mitochondrial genome, mutant copies of mtDNA coexist with wild-type molecules in the same organelle. The clinical symptoms of mitochondrial diseases and the degree of their manifestation directly depend on the number of mutant mtDNA molecules in the cell. …”
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Deletion of a Putative GPI-Anchored Protein-Encoding Gene Aog185 Impedes the Growth and Nematode-Trapping Efficiency of Arthrobotrys oligospora by Disrupting Transmembrane Transpor... by Hui Peng, Hengqian Lu, Xinyuan Dong, Xiao Liang, Kangliang Sheng, Jingmin Wang, Xiaowei Kong, Xiangdong Zha, Yongzhong Wang

“…Specifically, knockout of Aog185 disrupted transmembrane transport homeostasis during the phagocytosis, cell autophagy, and oxidative phosphorylation processes, which were associated with the fusion of cells and organelle membranes, transport of ions and substrates, and energy metabolism. …”
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A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer by Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu

“…Golgi apparatus, a crucial cellular organelle involved in tumorigenesis, remains underexplored in GC research. …”
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…GO enrichment analysis showed that these DEGs were mainly enriched in mitotic nuclear division, organelle fission, chromosome segregation, nuclear division, and sister chromatid segregation. …”
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Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy by Jie Ma, Hongtao Wang, Zhengwei Gui, Yuanrong Yang

“…This may be a volatile effect through Organelle fission, chromosome segregation, nuclear division, etc. …”
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Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy by Shan Wang, Qiang Wang, Yang Lv, Zhe Liu, Kippeum Lee, Dongeun Kim, Miae Won, Jianliang Shen, Jong Seung Kim

“…In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle‐targeted PDT strategy is supposed to be quite promising. …”
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Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases by Jiao Lv, Honghai Yu, Sasa Du, Pengyu Xu, Yunyun Zhao, Wenxiu Qi, Xiuge Wang

“…Abstract The endoplasmic reticulum (ER) is a vital organelle responsible for protein quality control, including the folding, modification, and transport of proteins. …”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. …”
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A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…GO enrichment and KEGG pathway analyses suggested that RNF187 may play a role in the pathogenesis of cancer through processes such as "bounding membrane of organelle," "macroautophagy," "proton-transporting V-type ATPase complex," "autophagy," "Ubiquitin mediated proteolysis," "Ferroptosis," "Phagosome," and etc. …”
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Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication by Jessica K. Heatlie, Joanna Lazniewska, Courtney R. Moore, Ian R. D. Johnson, Bukuru D. Nturubika, Ruth Williams, Mark P. Ward, John J. O’Leary, Lisa M. Butler, Doug A. Brooks

“…PCa TNTs and EVs transported proteins and organelles, which may contain specialist signalling, programming, and energy requirements that support cancer growth and progression. …”
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Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice by Xiaolong Fu, Linqing Zhang, Yecheng Jin, Xiaoyang Sun, Aizhen Zhang, Zongzhuang Wen, Yichen Zhou, Ming Xia, Jiangang Gao

“…MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement. …”
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Molecular Mechanism During Mycelium Subculture Degeneration of <i>Volvariella volvacea</i> by Lidan Feng, Lujuan Wang, Yuanxi Lei, Jie Li, Fengyun Zhao

“…GO enrichment analysis showed that the differentially expressed genes were mainly enriched in metabolic processes, organelle components, and catalytic activities. KEGG enrichment analysis showed that the differentially expressed genes were mainly enriched in metabolic pathways. …”
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Aggregation‐based dual‐target probe for dual‐colour super‐resolution monitoring mitophagy and evaluating drugs regulating mitochondria by Xiu‐Zhi Yang, Hongbao Fang, Shumeng Li, Chengyan Chu, Yunhua Zhang, Ying Yang, Weijiang He, Yuncong Chen, Zijian Guo

“…This work provides a powerful dual‐colour super‐resolution imaging agent for real‐time monitoring the dynamics of organelle interactions and oxidative stress.…”
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Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage by Na Yeon Park, Doo Sin Jo, Jae-Yoon Yang, Ji-Eun Bae, Joon Bum Kim, Yong Hwan Kim, Seong Hyun Kim, Pansoo Kim, Dong-Seok Lee, Tamotsu Yoshimori, Eun-Kyeong Jo, Eunbyul Yeom, Dong-Hyung Cho

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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…The nucleolus is a dynamic non-membrane-bound nuclear organelle, which plays key roles not only in ribosome biogenesis but also in many other cellular processes. …”
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Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells by Jeong Eon Lee, Bong Jong Seo, Min Ji Han, Yean Ju Hong, Kwonho Hong, Hyuk Song, Jeong Woong Lee, Jeong Tae Do

“…During embryonic development, cells undergo changes in gene expression, signaling pathway activation/inactivation, metabolism, and intracellular organelle structures, which are mediated by mitochondria. …”
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USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

“…Abstract Background Intracellular membraneless organelles formed by liquid-liquid phase separation (LLPS) function in diverse physiological processes and have been linked to tumor-promoting properties. …”
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Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary col... by Policar, Clotilde, Delsuc, Nicolas, Bertrand, Hélène Charlotte

“…Strategies to develop peptide-based metal complexes through conjugation of a LMW complex with peptides aimed at targeting specific organelle will be presented. Peptides can also be used to coordinate the metal ion: a combinatorial approach, with an activity-based screening, or and a rationale design using three-stranded coil-coiled, will also be presented.The cellular activity of a molecule is strongly dependent on its sub-cellular location. …”
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Inventarisation of Parasite in ”Dumbo” Catfish Clarias sp. from Bogor Region by Y. Hadiroseyani, P. Hariyadi, Sri Nuryati

“…Few quantities of parasite infection may still be tolerated by the host, however high intensity of infection can impair to fish metabolism or even damage of organelle.  Proper treatment can be done when parasite infecting fish is known.  …”
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Genome-Wide Identification and Expression Analysis of bHLH-MYC Family Genes from Mustard That May Be Important in Trichome Formation by Jianzhong Li, Guoliang Li, Caishuo Zhu, Shaoxing Wang, Shifan Zhang, Fei Li, Hui Zhang, Rifei Sun, Lingyun Yuan, Guohu Chen, Xiaoyan Tang, Chenggang Wang, Shujiang Zhang

“…The subcellular localization results indicated that the transcription and translation products of these five genes were expressed in the same organelle: the nucleus. This finding provides a basis for elucidating the roles of bHLH-MYC family members in plant growth and development, and the molecular mechanisms underlying trichome development in mustard leaves.…”
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