Cutting-edge: bionanomaterial solutions in the battle against Severe Acute Respiratory Syndrome Coronavirus 2 by U. Saeed, R. Uppal, M. H. Najmi, I. Fazal, A. A. Khan, Z. Z. Piracha, M. R. Uppal, H. N. Ijaz, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…These microscopic champions effectively hinder viral ingress into host cells and orchestrate the controlled release of antiviral agents, casting a profound influence on the course of viral infections. …”
Get full text

Biopolitical Strategies in Media Discourses: Responses to the COVID-19 Pandemic in Russia, Germany, and France by N. K. Radina, Yu. V. Balakina, K. V. Bannikov

“…Additionally, the study found that all examined media outlets participated in promoting vaccination campaigns orchestrated by the governments of Russia, Germany, and France, indicating a widespread alignment with state-led biopolitical strategies.The analysis also shows that the insecuritization of public life during the pandemic affected various sectors including social relations, the economy, healthcare, and education. …”
Get full text

Mexicanidad und Ironie durch die Revolution hindurch. Kompositionsstrategien in und diskursive Konstellationen um Revueltas’ Janitzio by Jonas Reichert

“…This article explores the much-discussed irony in Silvestre Revueltas’ music, taking his orchestral composition Janitzio (1933) as an example. …”
Get full text

Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…Follicular helper CD4+ T (TFH) cells are a specialized subset of effector T cells that play a central role in orchestrating adaptive immunity. TFH cells mainly promote germinal center (GC) formation, provide help to B cells for immunoglobulin affinity maturation and class-switch recombination of B cells, and facilitate production of long-lived plasma cells and memory B cells. …”
Get full text

Les Archives photographiques Notman au Musée McCord by Noëlle Charpentier

“…Triggs et Hélène Samson. Tout deux ont orchestré, au cours de leur mandat, une activité scientifique intégrant un discours spécifique et propre à leur époque. …”
Get full text

Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine by Marina Agueda-Oyarzabal, Marie S. Isidor, Kaja Plucińska, Lars R. Ingerslev, Oksana Dmytriyeva, Patricia S.S. Petersen, Sara Laftih, Axel B. Pontoppidan, Jo B. Henningsen, Kaja Rupar, Erin L. Brown, Thue W. Schwartz, Romain Barrès, Zachary Gerhart-Hines, Camilla C. Schéele, Brice Emanuelli

“…We therefore aimed to study brown adipocyte-derived secreted factors that may be involved in adipocyte function and/or may orchestrate intercellular communications. For this, mRNA levels in mature adipocytes from mouse adipose depots were assessed using RNA sequencing upon chronic cold acclimation, and bioinformatic analysis was used to identify secreted factors. …”
Get full text

High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. …”
Get full text

Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Results Our study identified enhancer-specific activation within epithelial cells orchestrated by the three-dimensional structure of chromatin that regulates SERPINH1 transcription, and promotes the epithelial-mesenchymal transition (EMT) and metastasis of ESCC. …”
Get full text

Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors by Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone

“…The fully automated architecture exemplifies the execution of online sampling, automatic sample preparation, and subsequent online UPLC analysis. This carefully orchestrated PAT framework effectively supports the requirements of QbD‐driven continuous bioprocessing.…”
Get full text

S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

“…Here, we identify sphingosine-1-phosphate receptor 3 (S1PR3) as a critical regulator of STAT3 activation and psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustains keratinocyte hyperproliferation and chronic inflammation. …”
Get full text

D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…We find that D-mannose protects keratinocytes from high glucose stimulation via inhibition of AGEs formation as well as orchestrates inflammatory microenvironment in diabetic wounded skin, suggesting its supplementation as a potential therapy to promote refractory wound healing in diabetic patients.…”
Get full text

IMMUnity Unveiled: A Translational NETwork for tackling PARKinson's Disease – IMMUPARKNET [version 2; peer review: 2 approved] by Tamara Saksida, Alessia di Flora, Marina Romero-Ramos, Vladimirs Pilipenko, Laura Muñoz Delgado, Franca Marino, Yasemin Gursoy Ozdemir, Neda Nikolovski, Cristoforo Comi, Dale Lawson, Inês Figueira, Mitilda Gugu, Simona Poletti, Shubhra Acharya, Dogukan Pira

“…This unmet need sparked the idea of orchestrating a collaborative effort via a common network – IMMUPARKNET (The role of IMMUnity in tackling PARKinson’s disease through a Translational NETwork). …”
Get full text

A 7-Amino Acid Peptide Mimic from Hepatitis C Virus Hypervariable Region 1 Inhibits Mouse Lung Th9 Cell Differentiation by Blocking CD81 Signaling during Allergic Lung Inflammation by Wanzhou Zhao, Conghao Tan, Xi Yu, Ruihe Yu, Qibing Mei, Yun Cheng

“…T helper (Th) cells orchestrate allergic lung inflammation in asthma pathogenesis. …”
Get full text

Transcriptomic reprogramming and epigenetic regulation underlying pollination-dependent and auxin-induced fruit set in tomato by Xiaohan Li, Xiaohan Li, Xiaohan Li, Bing He, Anis Djari, Pierre Frasse, Elie Maza, Farid Regad, Julien Pirrello, Guojian Hu, Guojian Hu, Guojian Hu, Guojian Hu, Mondher Bouzayen

“…Taken together, the data support the idea that auxin serves as the central hormone orchestrating the extensive gene reprogramming associated with fruit initiation in tomato.…”
Get full text

Generation and characterization of chicken monocyte-derived dendritic cells by Elie Ngantcha Tatchou, Elie Ngantcha Tatchou, Romane Milcamps, Romane Milcamps, Guillaume Oldenhove, Bénédicte Lambrecht, Fiona Ingrao

“…IntroductionDendritic cells (DCs) play a crucial role in orchestrating immune responses by bridging innate and adaptive immunity. …”
Get full text

CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway. by Shuaini Yang, Jinxi Yu, Xue Dong, Jiajia Zeng, Lu Tan, Hong Zhang, Ruoyuan Sun, Yuqing Tuo, Jing Yang, Chunxiao Wan, Hong Bai

“…These findings underscore the pivotal role of CCR2, a chemokine receptor, in orchestrating the immune response to Chlamydia infection by facilitating Th1 cells differentiation while restraining Th2-type and Th17-type immune responses, thereby alleviating pulmonary inflammation.…”
Get full text

Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…Fiscal commitments at the county level were imperative for facilitating the mobility of MDTs and orchestrating community outreach initiatives. Reimbursements from the National Hospital Insurance Fund (NHIF) served as a pivotal financial conduit for the sustenance of primary care facilities.ConclusionThe study finds that robust leadership, funding, collaboration, and planning were crucial for the effective operationalization and financial structuring of PCNs. …”
Get full text

Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model by Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi

“…Cytokines play a crucial role in the development of diabetes, orchestrating the recruitment and action of immune cells, to not only destroy insulin-producing cells but also preserve them. …”
Get full text

›Schreiben‹ als Differenz von Stille und Klang. Aspekte der musikalischen Form in Helmut Lachenmanns Schreiben. Musik für Orchester by Cosima Linke

“…The presented analysis of Helmut Lachenmann’s orchestral composition Schreiben. Musik für Orchester (2002–03, revised 2004/05) examines the relationship between sound and form on different micro- and macroformal levels from a reception-oriented perspective. …”
Get full text

Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress by Chao Du, Xinyu Ni, Mengjiao Yan, Qinghan Meng, Junying He

“…In response to drought stress, G. przewalskii orchestrates reactive oxygen species scavenging, proline biosynthesis, and other intricate physiological processes, with substantial contributions from plant hormones and transcription factors. …”
Get full text