Understanding good communication in ambulance pre-alerts to the emergency department: findings from a qualitative study of UK emergency services by Rachel O’Hara, Joanne Coster, Fiona C Sampson, Jaqui Long

“…We undertook qualitative research to understand how pre-alert communication may be improved to optimise the ED response for pre-alerted patients.Design, setting and participants Data collection took place within three UK Ambulance Services and six EDs between August 2022 and April 2023. …”
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TcPO2 as a Predictor of Limb Salvage or Amputation in Patients of Critical Limb Ischemia by Rahul Merkhed, Vikram Patra, Rishi Dhillon, Rohit Mehra, CVNM Dattatreya, Ramandeep Kaur, Gagandeep Singh Vohra, Surjeet Dwivedi

“…By applying a cutoff of 40 mmHg, informed by previous retrospective studies suggesting its predictive efficacy, our approach seeks to standardise decision-making and optimise tissue oxygenation to improve clinical outcomes. …”
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Environmental impacts of crop production systems in subtropical plateau regions: case study of Yunnan, China by Yousheng He, Minghao Li, Wei Zhang, Xinping Chen, Zhengxiong Zhao, Zhi Yao

“…Scenario testing showed that optimised nutrient management practices could increase crop yield and reduce environmental costs. …”
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The impact of trade policy on the export of agricultural products of Azerbaijan by Nazakat Musayeva, Nigar Atakishiyeva, Ulkar Mammadova, Gulnara Tanriverdiyeva, Оlena Lemishko

“…Measures were proposed to optimise subsidy programmes and improve efficiency. …”
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Gestion durable de la biodiversité et promotion des agricultures de type écologique en milieu paysan en Martinique by Jean Miatekela

“…Il s’agit en fait d’optimiser l’accompagnement des paysans afin de mettre en adéquation la gestion durable de la biodiversité et la promotion des agricultures de type écologique. …”
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Evaluating the impact of COVID-19 protection measures and staff absence on radiotherapy practice: A simulation study. by Elisabeth Jambor, Joe Viana, Melanie Reuter-Oppermann, Ralf Müller-Polyzou

“…<h4>Background</h4>Radiotherapy practice for cancer treatment is resource-intensive and demands optimised processes for patient throughput while guaranteeing the quality and safety of the therapy. …”
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The efficiency of short-term crop rotations with different sunflower saturation by Zinaida Dehtiarova, Mykola Shevchenko, Yurii Dehtiarov, Victor Budyonny

“…As a result of implementing the optimised crop rotation system across 78.9 hectares, sunflower seed yields increased by 0.16 t/ha compared to traditional practices. …”
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AI predicting recurrence in non-muscle-invasive bladder cancer: systematic review with study strengths and weaknesses by Saram Abbas, Rishad Shafik, Naeem Soomro, Rakesh Heer, Rakesh Heer, Kabita Adhikari

“…Actionable insights are provided for refining algorithms, optimising multimodal data utilisation, and bridging the gap between predictive accuracy and clinical utility. …”
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A novel machine learning methodology for the systematic extraction of chronic kidney disease comorbidities from abstracts by Eszter Sághy, Mostafa Elsharkawy, Frank Moriarty, Sándor Kovács, István Wittmann, Antal Zemplényi, Antal Zemplényi

“…The resulting disease list and their corresponding abstracts were manually checked and a final disease list was created.FindingsThe SVM model gave the best results and was chosen for further training with active learning. This optimised ML workflow enabled us to discern 68 comorbidities across 15 ICD-10 disease groups contributing to CKD progression or development. …”
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Purification of mesenchymal stromal cell‐derived small extracellular vesicles using ultrafiltration by Rui Lei, Shuai Ren, Hua Ye, Zhanfeng Cui

“…Subsequently, a fed‐batch ultra‐diafiltration (UF/DF) process with optimised filtration parameters was developed and compared with the currently most used ultracentrifugation (UC) method, showing exceptional effectiveness and performance in the isolation of MSC‐sEVs: it increased the recovery of MSC‐sEV from 20.59% to 60.88% (about three folds increase) and nearly doubled the purity, while also reducing processing time from over 4 h to 3.5 h, with a potential further reduction to less than 2.5 h through automation. …”
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Sistem Pengontrol Temperatur dan Kelembaban Otomatis untuk Ruang Penyimpanan Buah by Zulkifli Amin, Muhamad Adha

“…However, in order to optimise the results in fruit preservation, the temperature and humidity are also needed to be varied during priod of storage. …”
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Exploring the experiences of children's palliative care for forced migrant families in the United Kingdom: an interpretative phenomenological study by Marie Clancy, Caroline Bradbury-Jones, Jenny Phillimore, Julie Taylor

“…Compassionate, empathetic, family-centred care which valued family belief systems and coping strategies, optimised care. Learning with and from families was described by all participants, which enhanced understanding and fostered mutual respect. …”
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DIGITAL ECONOMY AND RECRUITMENT POTENTIAL: STRATEGICAL INTERCONNECTION AND PROSPECTS by G. Yu. Peshkova, А. Yu. Samarina

“…The originality of digital economy is in its optimising effect on production and consumption possible because of operativeness and consolidation of information and computing systems. …”
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High-quality DNA extraction for Desmodium gangeticum: A medicinal shrub of Shivalik Himalayas by Shiwani Singh, Maneesh S. Bhandari, Neeraj Dwivedi

“…Methods: Advanced techniques, commercial kits and rigorous modifications in existing DNA extraction buffer conditions and extraction protocols from both fresh and dried leaves are considered to optimise high-quality DNA isolation. Results: With the standardised buffer conditions and protocol, high-quality DNA with purity indicated by a 260/280 nm absorbance ratio in a range of 1.8 to 2.0 with 250 ng/µL – 950 ng/µL concentration from 0.5 g of leaf sample and also validated by agarose gel electrophoresis showing reduced contaminations and intact DNA was isolated. …”
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Integrated Serosurveillance of Infectious Diseases Using Multiplex Bead Assays: A Systematic Review by Selina Ward, Harriet L. S. Lawford, Benn Sartorius, Colleen L. Lau

“…This review demonstrated that the use of MBAs for integrated surveillance of multiple pathogens is gaining traction; however, more research and capabilities in lower- and middle-income countries are needed to optimise and standardise sample collection, survey implementation, and the analysis and interpretation of results. …”
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Grouting Design of Rich Water Tunnels and the Calculation of Distance between Annular Blind Pipes by Helin Fu, Pengtao An, Kai Li, Guowen Cheng, Jie Li, Xiaohui Yu

“…At the same time, the design parameters of the grouting circle are optimised, and then the formula of annular blind pipe spacing is derived according to the design value of the antiwater pressure of the secondary lining structure and the allowable seepage discharge of the tunnel. …”
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Public Sector Contracting Model for Management of Construction Tender Price Volatility by moffat tembo, Charles Kahanji, Erastus Misheng’u Mwanaumo

“…The findings show that governments can maximise social gains from an infrastructure project by deriving accurate technical parameters and optimising procurement. The study identifies four pricing behaviours demonstrated by contractors during tendering: resistance, reactive, anticipatory, and Consultant-based. …”
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Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR by Pui Yeng Lam, Natacha Omer, Josh K. M. Wong, Cui Tu, Louisa Alim, Gustavo R. Rossi, Maria Victorova, Hannah Tompkins, Cheng‐Yu Lin, Ahmed M. Mehdi, Amos Choo, Melissa R. Elliott, Elaina Coleborn, Jane Sun, Timothy Mercer, Orazio Vittorio, Lachlan J. Dobson, Alexander D. McLellan, Andrew Brooks, Zewen Kelvin Tuong, Seth W. Cheetham, Wayne Nicholls, Fernando Souza‐Fonseca‐Guimaraes

“…Advanced preclinical models mimicking human tumour microenvironments are needed to refine and optimise this therapeutic approach.…”
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Creating pathways for collaboration between Argentina and the UK to utilise microbial biofilms in sustainable agriculture by Patricia L. Abdian, Miguel Cámara, Fabricio D. Cassan, Gabriel Castrillo, Marisa Díaz, Gustavo Gonzalez Anta, Claire Hodge, Jo Slater-Jefferies, Cait E. MacPhee, Enzo Moriconi, Paulina D. Rakowska, Rasmita Raval, Duncan Ross, Juan F. Sandoval, Diego O. Serra, Claudio Valverde, Jeremy Webb, Ana Winters

“…It offers a comprehensive summary encompassing the insights, perspectives, and outcomes generated during the discussions among the participants, pinpointing three key priority areas for collaborative activities that were identified: (1) Using plant root biofilm composition as a sensor for soil health and to optimise interventions, (2) Biofilms and soil health resilience in a changing environment, (3) Intelligent seeds and innovative / automated large-scale monitoring systems. …”
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Multicentre study conducted across centres in the USA, Europe and Australia to assess the safety and effectiveness of a bilateral hypoglossal nerve stimulation system for the treat... by B Tucker Woodson, Maria V Suurna, M Boyd Gillespie, Tod C Huntley, Melyssa Hancock, Angela Santos, Jeyakumar Subbaroyan, Fatima Makori, Grégoire Fesneau, Clemens Heiser, David T Kent

“…The device is activated 2 months after implantation with stimulation settings optimised before the final 12-month sleep study. At 12 months, the two coprimary effectiveness endpoints are the percentage of responders based on reduction in the Apnoea-Hypoponea Index, with hypopnoeas associated with 4% oxyhaemoglobin desaturation, and the Oxygen Desaturation Index, using drops in oxygen concentration &gt;4% from baseline (ODI4). …”
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