Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients with chronic coronary artery disease (CAD) - current state of knowledge and perspective... by Hubert Bochenek, Anna Bielicka, Michał Bzoma, Julia Gugulska, Irmina Czerepak, Marcin Kapij, Karolina Niewczas, Adrianna Brzozowska

“…Current strategies emphasize balancing ischemic and bleeding risks in optimising treatment. Although significant progress has been made, optimal DAPT regimens for specific patient groups remain uncertain, particularly in cases of shortened or intensified therapy. …”
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Involvement of HLADQA1*05 in Patients with Inflammatory Bowel Disease Treated with Anti-TNF Drugs by Anna Pau, Ilaria Galliano, Elisa Barnini, Maddalena Dini, Antonio Pizzol, Alice Ponte, Stefano Gambarino, Pier Luigi Calvo, Massimiliano Bergallo

“…Testing for HLA-DQA105 can aid in personalising treatment and optimising therapy to minimise immunogenicity risks.…”
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Cataract surgery has minimal effect on corneal shape by Vito Romano, Stephen B Kaye, Keri McLean, Luca Pagano, Esmaeil M Arbabi, Fadi Alfaqawi, Ahmed Al-Maskari, Gabriella Czanner

“…Greater emphasis, however, should be placed on eye-specific factors, such as biometry, or patient-related factors to optimise refractive outcomes.…”
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Delirium and Cognitive Screening in National Hip Fracture Registries: Scoping Review Protocol [version 2; peer review: 2 approved] by Pamela Hickey, Rose S. Penfold, Louise Brent, Niamh A. Merriman, Eithne Sexton, Tara Coughlan, Mary E. Walsh, Antony Johansen, Catherine Blake, Alasdair M. J. MacLullich, Andrew J. Hall, Cristina Ojeda-Thies

“…Conclusion By identifying existing heterogeneity in delirium and cognitive screening tool use and administration, it is hoped that administration and specific screening tool use will become standardised to optimise comparability across countries and ensure that high quality and reliable data are included across international registry reports.…”
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Application of photogrammetry and laser scanner on the Bronze Age structures of the Castillejos de Luna cist tomb necropolis (Pizarra, Spain) by Alejandro Muñoz-Muñoz, Diego Fernández-Sánchez, Eduardo Vijande-Vila, Serafín Becerra-Martín, Juan Jesús Cantillo-Duarte, Salvador Domínguez-Bella, Virgilio Martínez Enamorado, Francisca Rengel Castro, Pedro Cantalejo Duarte, María del Mar Espejo-Herrerías, José Suárez-Padilla, Juan Antonio Martín-Ruiz, José Ramos-Muñoz

“…The preliminary results are published in the web repository of 3D models Sketchfab, where the users can see a preview of one of the tombs before and after being optimised with retopology through Blender. The authors provide a socio-historical analysis of Bronze Age necropolises in central Andalusia, within the framework of a debate on the western expansion of the El Argar Culture.…”
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Interpretation services used for non-English language speaking patients with head and neck cancer: Findings from a tertiary London cancer centre by Maesaya Chartkul, Florence Cook, Roganie Govender

“…Future research should investigate how this can be optimised to ensure necessary language support is provided consistent with guidelines that promote equality, diversity, and inclusion.…”
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Teamwork between registered nurses and unlicensed assistive personnel in acute care settings: A scoping review by Kang Lynn Wong, Wei Ling Chua, Peter Griffiths, Qin Ling Pearlyn Goh, Kye Wern Chelsea Low, Jia Qi Apphia Tan, Sok Ying Liaw

“…Future research should focus on optimising communication processes and enhancing registered nurses’ delegation skills through education.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…Future studies will focus on optimising these candidates and assessing their efficacy in vivo glioblastoma models, reassuring the thoroughness of our research and the potential for further advancements.…”
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Epidemiology, microbiology and clinical impacts of non-tuberculous mycobacteria in adult patients with cystic fibrosis by Zoltán Örlős, Lilla Katalin Lőrinczi, Balázs Antus, Imre Barta, Zsuzsanna Miklós, Ildikó Horváth

“…Detailed description of regional NTM prevalence and distribution, and identification of predictors of NTM acquisition in CF are essential to optimise treatment and surveillance guidelines. Methods: A retrospective, multi-center analysis was conducted between the years 2020 and 2022 on data from 232 adult patients registered in the Hungarian CF Registry in 2022. …”
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Comparative evaluation of funduscopy, PCR and serology in the diagnosis of ocular toxoplasmosis at ECWA Eye Hospital, Kano by Biodun Bintu Adebakin, Mayor Orezime Atima, Ugbede Idakwo, Jamilu Abubakar Bala, Alhasan Sharif Abdullahi, Auwal Bello Muhammad, Jah Douglas Pam, Emeka John Dingwoke, Florence Olufunke Darda

“…Accurate diagnosis is essential to prevent retinal damage and optimise treatment. This study aimed to compare three diagnostic methods funduscopy, serology (ELISA), and PCR in detecting ocular toxoplasmosis in patients at ECWA Eye Hospital, Kano, Nigeria.Methods and analysis A total of 264 patients suspected of having ocular toxoplasmosis were enrolled. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The findings arising from the Delphi process provide valuable insights into the unmet needs in the management of moderate-to-severe ulcerative colitis from the clinician’s perspective, while emphasising the benefits of therapeutic individualization and suggesting areas that need additional study with the aim of optimising the treatment of patients with ulcerative colitis.…”
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Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom by Sanjib Kumar Sharma, Emilie Alirol, Anup Ghimire, Suman Shrestha, Rupesh Jha, Surya B. Parajuli, Deekshya Shrestha, Surya Jyoti Shrestha, Amir Bista, David Warrell, Ulrich Kuch, Francois Chappuis, Walter Robert John Taylor

“…Severe ARA was common and recurrent and had overlapping signs with severe neurotoxic envenoming. Optimising the management of ARA at different healthy system levels needs more research. …”
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Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

“…Findings from this study will be shared with the academic and medical community and the patient organisations to optimise and individualise medical care of patients with implantation failure and miscarriages.Trial registration number NTR7571, registered 28 February 2019.…”
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Lysine requirement of weaned piglets by S. Goethals, P. Bikker, J.H.M. Rijpert, B. Ampe, J.W. Spek, S. Millet

“…Variability in lysine requirements arises due to factors such as age, sex and environmental conditions. Optimising pig health and production efficiency and minimising nitrogen excretion require accurate knowledge of estimated lysine requirements accounting for factors such as genetics, feeding practices, scientific advancements, and environmental considerations. …”
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Heart rate cost as a tool for monitoring recovery between acute training sessions by José Morais Souto Filho, Milton Rocha de Moraes, Patrício Lopes de Araújo Leite, Larissa Alves Maciel, Andréa Cândida Arruda Andrade Rezende, Thiago dos Santos Rosa, Fabiana Andrade Machado, Sergio Rodrigues Moreira, Ricardo Yukio Assano, Marcelo Magalhães Sales, Herbert Gustavo Simões

“…Purpose Effective recovery monitoring is crucial to optimise performance and prevent overreaching, injuries, and overtraining. …”
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Adaptations to the welsh national exercise referral scheme during the COVID-19 pandemic: a qualitative study exploring the experiences of service users and providers and supplement... by Katie Newby, Neil Howlett, Adam P. Wagner, Nigel Lloyd, Imogen Freethy, Charis Bontoft, Olujoke Fakoya, Shelley Jackson, Carla Jackson, Wendy Wills, Mary-Ann McKibben, Annie Petherick, Katherine E. Brown

“…Findings provide wider evidence to inform adaptations that could be made to ensure that other exercise referral schemes can optimise virtual delivery.…”
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Solid-State Modification Strategies for Alpha-Mangostin Solubility Enhancement: A Review on Recent Progress by Nurin Syamimi Ahmad Izuren Shah, Muhammad Taher Bakhtiar, Syarifah Abd Rahim, Fatmawati Adam, Wan Hazman Danial, Mohd Rushdi Abu Bakar

“…These findings highlight the potential of solubility enhancement strategies to optimise AM’s pharmaceutical applications and provide a framework for improving the bioavailability of other poorly water-soluble compounds. …”
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Experience of being a frequent user of primary care and emergency department services: a qualitative systematic review and thematic synthesis by Catherine Hudon, Maud-Christine Chouinard, Magaly Brodeur, Eva Margo-Dermer

“…In the recent years, many jurisdictions have attempted to implement different public policies to optimise the use of health services by frequent users. …”
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Exploring nursing students’ learning experiences within tripartite meetings in nursing home clinical placements: a qualitative study using video-stimulated recall interviews by Ingrid Espegren Dalsmo, Kristin Alstveit Laugaland, Stephen Billett, Else Mari Ruberg Ekra

“…Therefore, the study’s findings suggest that targeted efforts are warranted to optimise and enhance the learning potential offered in tripartite meetings in clinical education, such as paying a greater attention to the start-up conversation and facilitating comprehensive supervisory and assessment content in the meetings.…”
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What can qualitative research do for randomised controlled trials? A systematic mapping review by J Hewison, A O'Cathain, A Rudolph, K J THOMAS, S J Drabble

“…The potential value included optimising the intervention and trial conduct, facilitating interpretation of the trial findings, helping trialists to be sensitive to the human beings involved in trials, and saving money by steering researchers towards interventions more likely to be effective in future trials.Conclusions A large amount of qualitative research undertaken with specific trials has been published, addressing a wide range of aspects of trials, with the potential to improve the endeavour of generating evidence of effectiveness of health interventions. …”
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