Barriers and facilitators to implementation of non-medical independent prescribing in primary care in the UK: a qualitative systematic review by Nicola Carey, Judith Edwards, Melaine Coward

“…Enhancement, substitution and role-specific implementation models reflected three main ways that the IP role was used in primary care.Conclusions In order to address global deficits, there is increasing need to optimise use of IP capability. Although the number of independent prescribers continues to grow, numerous barriers to implementation persist. …”
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‘I can’t understand why others don’t screen more’: a qualitative study exploring why Australian general practitioners screen for primary aldosteronism by Sanne Peters, Jun Yang, Grant Russell, Abhir Krishan Nainani

“…Most of these practical barriers could be addressed by relatively simple educational and practice modifications to increase PA screening rates and optimise detection for the most common cause of secondary hypertension in primary care.…”
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Codesign approaches involving older adults in the development of electronic healthcare tools: a systematic review by Karthik Adapa, Lukasz Mazur, Amy C Cole, Amro Khasawneh, Daniel R Richardson

“…This is important because higher levels of participation may increase the user’s knowledge of technology, enhance learning and empower participants. To ensure studies optimise participation and learning of older adults when developing EHTs, there is a need to place more emphasis on the approaches promoting mutual learning.PROSPERO registration number CRD42021240013.…”
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Prevalence Of Rifampicin Resistance in New Cases Of Pulmonary Tuberculosis In Children by Sonia Saleem, Aneela Shaheen, Muhammad Naeem, Shahid Mehmood Sahi, Sara Rubab, Bint-Ul- Huda

“…The higher resistance rate suggests exploring alternative treatment options, optimising drug regimens, and developing interventions to prevent and manage drug-resistant tuberculosis effectively in children. …”
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Methods for identifying adverse drug reactions in primary care: A systematic review. by Vera Logan, David Hughes, Adam Turner, Neil Carter, Sue Jordan

“…When considered as a whole, findings are equivocal and the data are too heterogenous to warrant any firm conclusions, beyond the need for more research to optimise strategies to safeguard patient wellbeing.…”
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Assessing the impact of antimicrobial resistance policies on antibiotic use and antimicrobial resistance-associated mortality in children and adults in low and middle-income countr... by Günther Fink, Jay Patel, Kyaw Zay Ya

“…In recent years, many low and middle-income countries (LMICs) have implemented policies to optimise antibiotic use in both formal and informal healthcare settings. …”
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The profile of long-stay patients in a psychiatric hospital in KwaZulu-Natal, South Africa by Siziphiwe Y. Myeni, Vuyokazi Ntlantsana, Andrew Tomita, Ugochukwu S. Aguwa, Reyanta Bridgmohun, Sinethemba Shabalala

“…Contribution: This study highlights the burden of inpatient care for psychotic disorders and the need for interventions that optimise care and promote remission. To reduce the economic impact of prolonged hospitalisations, early intervention and enhanced community-based mental healthcare services focused on psychotic disorders are recommended.…”
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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. by Elizabeth A Cromwell, Joshua C P Osborne, Thomas R Unnasch, Maria-Gloria Basáñez, Katherine M Gass, Kira A Barbre, Elex Hill, Kimberly B Johnson, Katie M Donkers, Shreya Shirude, Chris A Schmidt, Victor Adekanmbi, Olatunji O Adetokunboh, Mohsen Afarideh, Ehsan Ahmadpour, Muktar Beshir Ahmed, Temesgen Yihunie Akalu, Ziyad Al-Aly, Fahad Mashhour Alanezi, Turki M Alanzi, Vahid Alipour, Catalina Liliana Andrei, Fereshteh Ansari, Mustafa Geleto Ansha, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Benjamin F Arnold, Marcel Ausloos, Martin Amogre Ayanore, Atif Amin Baig, Maciej Banach, Aleksandra Barac, Till Winfried Bärnighausen, Mohsen Bayati, Krittika Bhattacharyya, Zulfiqar A Bhutta, Sadia Bibi, Ali Bijani, Somayeh Bohlouli, Mahdi Bohluli, Oliver J Brady, Nicola Luigi Bragazzi, Zahid A Butt, Felix Carvalho, Souranshu Chatterjee, Vijay Kumar Chattu, Soosanna Kumary Chattu, Natalie Maria Cormier, Saad M A Dahlawi, Giovanni Damiani, Farah Daoud, Aso Mohammad Darwesh, Ahmad Daryani, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Hoa Thi Do, Maysaa El Sayed Zaki, Maha El Tantawi, Demelash Abewa Elemineh, Anwar Faraj, Majid Fasihi Harandi, Yousef Fatahi, Valery L Feigin, Eduarda Fernandes, Nataliya A Foigt, Masoud Foroutan, Richard Charles Franklin, Mohammed Ibrahim Mohialdeen Gubari, Davide Guido, Yuming Guo, Arvin Haj-Mirzaian, Kanaan Hamagharib Abdullah, Samer Hamidi, Claudiu Herteliu, Hagos Degefa de Hidru, Tarig B Higazi, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D Ilic, Irena M Ilic, Usman Iqbal, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Farahnaz Joukar, Jacek Jerzy Jozwiak, Zubair Kabir, Leila R Kalankesh, Rohollah Kalhor, Behzad Karami Matin, Salah Eddin Karimi, Amir Kasaeian, Taras Kavetskyy, Gbenga A Kayode, Ali Kazemi Karyani, Abraham Getachew Kelbore, Maryam Keramati, Rovshan Khalilov, Ejaz Ahmad Khan, Md Nuruzzaman Nuruzzaman Khan, Khaled Khatab, Mona M Khater, Neda Kianipour, Kelemu Tilahun Kibret, Yun Jin Kim, Soewarta Kosen, Kris J Krohn, Dian Kusuma, Carlo La Vecchia, Van Charles Lansingh, Paul H Lee, Kate E LeGrand, Shanshan Li, Joshua Longbottom, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Afshin Maleki, Abdullah A Mamun, Ali Manafi, Navid Manafi, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Walter Mendoza, Endalkachew Worku Mengesha, Desalegn Tadese Mengistu, Seid Tiku Mereta, Tomislav Mestrovic, Ted R Miller, Mohammad Miri, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Shafiu Mohammed, Salahuddin Mohammed, Masoud Moradi, Rahmatollah Moradzadeh, Paula Moraga, Jonathan F Mosser, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gurudatta Naik, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Rajan Nikbakhsh, Bogdan Oancea, Tinuke O Olagunju, Andrew T Olagunju, Ahmed Omar Bali, Obinna E Onwujekwe, Adrian Pana, Hadi Pourjafar, Fakher Rahim, Mohammad Hifz Ur Rahman, Priya Rathi, Salman Rawaf, David Laith Rawaf, Reza Rawassizadeh, Serge Resnikoff, Melese Abate Reta, Aziz Rezapour, Enrico Rubagotti, Salvatore Rubino, Ehsan Sadeghi, Abedin Saghafipour, S Mohammad Sajadi, Abdallah M Samy, Rodrigo Sarmiento-Suárez, Monika Sawhney, Megan F Schipp, Amira A Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Kiomars Sharafi, Aziz Sheikh, B Suresh Kumar Shetty, B Suresh Kumar Shetty, Jae Il Shin, K M Shivakumar, Biagio Simonetti, Jasvinder A Singh, Eirini Skiadaresi, Amin Soheili, Shahin Soltani, Emma Elizabeth Spurlock, Mu'awiyyah Babale Sufiyan, Takahiro Tabuchi, Leili Tapak, Robert L Thompson, Alan J Thomson, Eugenio Traini, Bach Xuan Tran, Irfan Ullah, Saif Ullah, Chigozie Jesse Uneke, Bhaskaran Unnikrishnan, Olalekan A Uthman, Natalie V S Vinkeles Melchers, Francesco S Violante, Haileab Fekadu Wolde, Tewodros Eshete Wonde, Tomohide Yamada, Sanni Yaya, Vahid Yazdi-Feyzabadi, Paul Yip, Naohiro Yonemoto, Hebat-Allah Salah A Yousof, Chuanhua Yu, Yong Yu, Hasan Yusefzadeh, Leila Zaki, Sojib Bin Zaman, Maryam Zamanian, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Simon I Hay, David M Pigott

“…Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. …”
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Production-living-ecological functions measurement and spatio-temporal evolution of the coastal zone under the perspective of land-sea coordination: a case study of Liaoning Coasta... by Lina Ke, Lei Wang, Quanming Wang, Zhiyu Ren, Yao Lu, Shusheng Yin, Yu Zhao, Qin Tan, Yibo Li

“…Exploring the spatial distribution patterns of land-sea and its spatio-temporal evolution characteristics is an important initiative to resolve conflicts and optimise the spatial structure of land-sea use. Taking the Liaoning Coastal Economic Belt as an example, this paper constructs a system to measure the value of Production-Living-Ecological Functions (PLEF) of the coastal zone and realizes the identification of Production-Living-Ecological Spaces (PLES) and the division of their combination patterns. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

“…The 10% longest waits ranged between 101 and 209 days (Sweden and Ontario).Conclusions Large international differences in breast cancer diagnostic pathways exist, suggesting some jurisdictions develop more effective strategies to optimise pathways and reduce time intervals. Targeted awareness interventions could also facilitate more timely diagnosis of breast cancer.…”
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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…This platform is characterised by utilising an optimised solution of cellular machinery to facilitate protein synthesis in vitro. …”
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Automatic three-dimensional reconstruction of the oesophagus in achalasia patients undergoing POEM: an innovative approach for evaluating treatment outcomes by Alanna Ebigbo, Helmut Messmann, Vivian Grünherz, Miriam Elia, Alessandra Brunner, Tamara Krafft, Leo Pöller, Pia Schneider, Fabian Stieler, Bernhard Bauer, Anna Muzalyova, Sandra Nagl

“…It may contribute to refining our approach to achalasia treatment and optimising treatment outcomes.Trial registration number 22-0149.…”
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The Role of Motivation to Promote Personal and Social Responsibility Through PE and Sport: A Comparative Exploratory Investigation of Prospective PE Teachers and Sports Leaders in... by Istvan Soos, Ian Whyte, Diana Szekeres, Karoly Ozsvath, Attila Szabo, Jonathan Ling, Jose Francisco Jiménez-Parra, Alfonso Valero-Valenzuela

“…Discussion: We suggest that a hybridised model incorporating Teaching Personal and Social Responsibility and the Sports Education Model is employed with sport and physical education students to optimise potential for transfer of values and behaviours.…”
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Integration of wireless power transfer and low power wide area networks in IoT applications—A review by Molefi J. Makhetha, Elisha D. Markus, Adnan M. Abu-Mahfouz

“…Furthermore, for LPWAN end-devices, energy profiling of such devices is discussed through recent work aiming to optimise their power consumption. Specifically, we discuss factors affecting LPWAN end-devices’ power consumption which comprises the spreading factor, communication range and bit-rate. …”
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Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches by Xuehua Jin, Ching Tat Lai, Sharon L. Perrella, Xiaojie Zhou, Ghulam Mubashar Hassan, Jacki L. McEachran, Zoya Gridneva, Nicolas L. Taylor, Mary E. Wlodek, Donna T. Geddes

“…Additionally, a simplified model, optimised for clinical applicability, maintained a reasonable accuracy of 78.8%, an AUPRC of 0.776, and an AUC of 0.794. …”
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Factors associated with prolonged length of stay following cardiac surgery in a major referral hospital in Oman: a retrospective observational study by Paul Aylin, Ahmed Almashrafi, Hilal Alsabti, Mirdavron Mukaddirov, Baskaran Balan

“…The latter was the most important determinant of postoperative LOS.Conclusions Patient management can be tailored for individual patient based on their treatments and personal attributes to optimise resource allocation. Moreover, a simple predictive score system to enable identification of patients at risk of prolonged CICU stay can be developed using data that are routinely collected by most hospitals.…”
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An exergy-based analysis for the synthesis of aromatics from biomass by Mohammed Usman, Joseph Akintola, Gabriel Umoh, Joseph Akpan, Ekpotu Wilson, Queen Moses, Philemon Udom, Edose Osagie

“…This study demonstrates the two process routes’ long-term economic viability and efficiency, which can be further optimised in future studies to achieve sustainable process implementation.…”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Chronotherapy and chronopharmacotherapy are promising approaches to resynchronise circadian rhythms or leverage circadian rhythms to optimise medication efficacy, respectively, and hold much potential in the treatment of sepsis and septic shock. …”
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Does knowledge of sleep hygiene recommendations match behaviour in Australian shift workers? A cross-sectional study by Grace E Vincent, Sally A Ferguson, Caroline M Rampling, Charlotte Cecelia Gupta, Alexandra E Shriane, Gabrielle Rigney

“…Future research should focus on the development of sleep hygiene interventions that accommodate the unique challenges of shift work to optimise sleep.…”
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Tailoring lipid management interventions to reduce inequalities in cardiovascular disease risk management in primary care for deprived communities in Northern England: a mixed-meth... by Julia L Newton, Yu Fu, Sarah Sowden, Paula Whitty, Eugene YH Tang

“…This study describes the protocol for the development of a tailored intervention aiming to optimise lipid management in primary care settings to help reduce inequalities in CVD risks and improve outcomes in deprived communities.Methods and analysis A mixed-methods approach will be employed consisting of four work packages: (1) rapid review and logic model; (2) assessment and comparison of CVD risk management for deprived with non-deprived populations in Northern England to England overall; (3) interviews with health professionals; and (4) intervention development. …”
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