Exploring medicine classification and accessibility: a qualitative study by Awangku Khairi Wazien Pengiran Umar, Hui Poh Goh, Zaidah Rizidah Murang, Andi Hermansyah, Inayat Ur Rehman, Khang Wen Goh, Kwan Foong Chee, Long Chiau Ming

“…By drawing from the first-hand experiences of practicing pharmacists, it offers actionable insights that could guide future policy developments, optimise medicine dispensation and regulation, and shape the evolving role of pharmacists in Brunei Darussalam.…”
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First validation of the novel Freiburg Neurointerventional Score purposely designed for use by emergency medical dispatchers for detecting anterior circulation large-vessel occlusi... by Erik Farin-Glattacker, Christian A Taschner, Hans-Jörg Busch, Wolf-Dirk Niesen, Matthias L Herrmann, Florian F Schuchardt, Clara Franck, Simone Meier, Max Henningsen, Friederike S Brohl, Christoph Sonntag, Nicole Wimmesberger, Jochen Brich

“…Background Detecting an anterior circulation large-vessel occlusion (aLVO) as a cause of stroke during emergency calls could optimise dispatch, particularly in rural areas. Numerous stroke severity scales assessing motor and cortical signs have been designed for direct patient contact; however, none have been purposely designed for emergency calls. …”
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Artificial intelligence as an asset for the improvement of decision-making cycle in military operations by Pavić Aleksandar M., Jelić Dragan R., Đokić Miodrag S.

“…The use of artificial intelligence can be one of the potential solutions to the said challenge, because it can significantly optimise and speed up the decision-making process in modern military operations. …”
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From Integer Programming to Machine Learning: A Technical Review on Solving University Timetabling Problems by Xin Gu, Muralee Krish, Shaleeza Sohail, Sweta Thakur, Fariza Sabrina, Zongwen Fan

“…This study explores various integer programming techniques and their effectiveness in optimising complex scheduling requirements in higher education institutions. …”
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The noninvasive ventilation outcomes score in patients requiring NIV for COPD exacerbation without prior evidence of airflow obstruction by Nicholas D. Lane, Tom M. Hartley, John Steer, Stephen C. Bourke

“…Accurate diagnosis is critical to ensure that acute and long-term treatment is optimised; this study highlights failings in the follow-up of such patients.…”
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The leading “blended” civil medical evacuation operation (MEDEVAC) in unforeseen health emergency. From military use to civil development by Nazzareno Fagoni, Giuseppe Stirparo, Giuseppe Maria Sechi, Andrea Comelli, Gabriele Perotti, Guido Francesco Villa, Alberto Zoli, Marco Botteri

“…This study proposes the development of a shared protocol for air transport of patients and a model for international cooperation among emergency response agencies to optimise future medical evacuation activities in civil context.…”
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COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study by Jackie A Cassell, Laura J Hughes, Elizabeth Ford, Priyamvada Paudyal, Kavian Kulasabanathan, Jo Armes, Rebecca Sharp, Saliha Majeed-Hajaj, Emily Skinner, Naresh Khapangi Magar, Debbie Isobel Keeling

“…Participants highlighted the need for information in multiple formats and languages, and discussed the importance of culturally appropriate avenues, such as community centres and religious sites, for information dissemination.Conclusion This study, undertaken during the COVID-19 pandemic, provides insight into how health information can be optimised for ethnic minority older adults in terms of content, format and cultural relevance. …”
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Effect of ultrasonic amplitude on microstructure and properties of wire arc additive manufactured ultra-high strength steel deposited metal by Tianli Zhang, Weifeng Li, Wen Wu, Lianyong Xu, Donghai Hu, Geng Chen, Wei Li, Erika Hodúlová

“…Therefore, the applied ultrasonic amplitude has a positive effect on optimising the microstructure and inclusion size of the deposited metal in wire arc additive manufacturing of ultra-high strength steel, as well as improving the mechanical properties.…”
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Prevalence and predictors of NTM in presumed/confirmed drug-resistant TB by E.T. Abbew, R. Laryea, F. Sorvor, Y.A. Poku, N. Lorent, D. Obiri-Yeboah, L. Lynen, L. Rigouts

“…NTM species were isolated from 46 patients, with four classified as NTM pulmonary disease CONCLUSION: Enhancing our understanding of local NTM epidemiology and improving local diagnostic capabilities can optimise patient management strategies and outcomes.…”
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Andrographolide-encapsulated nanoliposomes with gum Arabic surface modification inhibits cervical cancer growth: In vitro and in silico approaches by Rahmalillah Khairiah, Dwi Hudiyanti, Parsaoran Siahaan, Fadzilah Adibah Abdul Majid, Enny Fachriyah, Nor Hafizah Zakaria

“…High EE (87.7 % for CLAND and 92.9 % for CLANDGA) and suitable PS (66.2 nm for CLAND and 92.6 nm for CLANDGA) were shown by the optimised formulations, AND-loaded nanoliposomes (CLAND) and AND-loaded nanoliposomes modified with GA (CLANDGA). …”
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Impact of physician’s sex/gender on processes of care, and clinical outcomes in cardiac operative care: a systematic review by Louise Y Sun, Sylvain Boet, Amy Johnston, Katina Zheng, Mimi Deng, Fadi Mansour, Hussein Said, Cole Etherington

“…Results highlight the need for primary research to determine how these factors may influence cardiac operative practice, in order to optimise provider’s performance and improve outcomes in this high-risk patient group.…”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Despite advancements in anticancer drugs and optimised chemotherapy regimens that have improved cure rates for malignant tumours, the presence of tumour heterogeneity has resulted in substantial variations among patients in terms of disease progression, clinical response, sensitivity to therapy, and prognosis, posing significant challenges in attaining optimal therapeutic outcomes for each patient. …”
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Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial by Alberto Esteban-Fernández, Alberto Esteban-Fernández, Alejandro Recio-Mayoral, Raquel López-Vilella, Raquel López-Vilella, Gregorio de Lara, Moisés Barrantes-Castillo, Inés Gómez-Otero, Inés Gómez-Otero, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Carolina Robles-Gamboa, José López-Aguilera, Ángel Iniesta-Manjavacas, Paula Fluviá, Francisco Pastor-Pérez, Laia Belarte-Tornero, Gonzalo Alonso-Salinas, Pablo Díez-Villanueva

“…Despite the more severe disease in the VERISEC cohort, the implementation of guideline-directed medical therapy was greater than in VICTORIA, although vericiguat was initiated at lower blood pressure levels.ConclusionsPatients in the VERISEC registry had more severe illness and higher comorbidities compared to those in the VICTORIA, despite receiving optimised treatments. Further research is needed to identify which patients may benefit the most from vericiguat treatment.…”
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Multiangle Correlation Feature Extraction and Disease Prediction Model Construction for Patients With Post-Stroke Dysarthria by Ting Zhu, Shufei Duan, Huizhi Liang, Fujiang Li, Wei Zhang

“…Both proposed models achieved a high prediction accuracy, with an adjusted R2 value of 0.85 for GRA-DBN and 0.92 for optimised model. This study fills the gap in the international multimodal emotional pathological expression dataset and provides a comprehensive framework for analyzing the association between mental state, emotional expression, and the degree of dysarthria. …”
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What’s in it for citizen scientists? An Analysis of Participant Inclusivity in Citizen Science Projects in Advanced Physics Research [version 3; peer review: 1 approved, 2 approved... by Claudia Magdalena Fabian, Elisabeth Unterfrauner, Beatriz Garcia, Gary Hemming

“…Citizen science projects optimise the democratisation of the production of scientific knowledge. …”
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A patient-led survey on information and communication needs of patients with metastatic breast cancer in Ireland and Northern Ireland (CTRIAL-IE 23–05) by Siobhan Gaynor, Yvonne O'Meara, Emer Mulvaney, Rachel J. Keogh, Catherine S. Weadick, Fran J. Duane, Ann Mc Brien, Helen Greally, Mary Jane O'Leary, Ieva Teiserskyte, Isabel Beristain, Jacinta Marron, Eibhlin Mulroe, Vicky Donachie, Sarah Mc Loughlin, Seamus O'Reilly

“…The routine early provision of palliative care, psycho-oncology, medical social worker and dedicated liaison nurse supports guided by national guidelines and education for healthcare professionals, integrated with living well with cancer clinics and a dedicated medically verified website would provide an ecosystem where MBC care could be optimised for patients and their families.…”
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Experience of induction of labour: a cross-sectional postnatal survey of women at UK maternity units by Helen Cheyne, Christine McCourt, Dharmintra Pasupathy, Julia Sanders, Sarah Jane Stock, Mairead Black, Cassandra Yuill, Mairi Harkness, Neelam Heera, Chlorice Wallace

“…There is urgent need for research to better target IOL and optimise safety and experience for women and their babies. …”
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Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

“…Therefore, resources should be focused on optimising reception testing rather than undertaking repeated HITTs.…”
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Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study by Lehana Thabane, Lawrence Mbuagbaw, Michael Paterson, Laura Targownik, Mei Wang, Anne Holbrook, Deborah Siegal

“…The study will provide useful evidence to optimise the coprescription of DOACs and PPIs in practice.…”
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Digital technologies for water use and management in agriculture: Recent applications and future outlook by Carlos Parra-López, Saker Ben Abdallah, Guillermo Garcia-Garcia, Abdo Hassoun, Hana Trollman, Sandeep Jagtap, Sumit Gupta, Abderrahmane Aït-Kaddour, Sureerat Makmuang, Carmen Carmona-Torres

“…UAV-mounted multispectral cameras) can accurately monitor soil moisture to optimise irrigation scheduling, while AI-driven models (e.g. random forest or neural networks) can predict groundwater recharge or forecast rainfall events. …”
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