Incidence and Risk Factors of Lumbosacral Complications Following Long‐Segment Spinal Fusion in Adult Degenerative Scoliosis by Tinghua Jiang, Xinuo Zhang, Qingjun Su, Xianglong Meng, Aixing Pan, Hanwen Zhang, Yong Hai

“…These results will improve our ability to predict personal risk conditions and provide better medical optimisation for surgery.…”
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Kinetics, modelling and optimization of Shea butter transesterification via clay doped ionic liquid catalyst by Nwosu-Obieogu Kenechi, Ude Callistus Nonso, Onukwuli Dominic Okechukwu, Ezeugo Joseph

“…Increase in the process parameters significantly affected the yield, with the highest yield of 89.45 % obtained at an agitation of 300rpm while other parameters were kept constant. After optimisation using response surface methodology (RSM), the second-order polynomial model was shown in the ANOVA with R2 values of 0.9952, Adj R2 (0.9862), and Pred R2 (0.8719), demonstrating model acceptability. …”
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Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the insightFall study by Ben Glampson, Clare Leon-Villapalos, Erik Mayer, Rachael Lear, Phoebe Averill, Catalina Carenzo, Rachel Tao, Robert Latchford

“…Prototype testing will be underpinned by the Technology Acceptance Model, comprising a validated survey and think-aloud interviews to inform platform optimisation.Ethics and dissemination This study protocol was approved by the National Institute for Health Research Imperial Biomedical Research Centre Data Access and Prioritisation Committee (Database: iCARE—Research Data Environment; REC reference: 21/SW/0120). …”
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Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…At present, the technology and tools of OBE, despite the criticism, remain relevant for the development and optimisation of the humanities education system.The aim of the present research is to study and analyse the theory of OBE and the practice on the application of pedagogical principles for modernisation of the humanities education in China.Results and scientific novelty. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Effective and scalable interventions are urgently needed to address these challenges.Methods and analysis This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs ‘I Support My Friends’ intervention and engagement booster designed to enhance attendance and programme completion through incentives. …”
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Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions by Yang Liu, Chengquan Zhao, Tiannan Wang, Yuhong Ye, Terrel Jones, Xianxu Zeng

“…Extensive HPV genotyping aids in risk assessment and optimising clinical approaches for women with mild abnormalities in Pap cytology. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…However, in a technologically developed society, there is a contradiction between the increased requirements to young officers’ competencies and the impossibility to achieve a proper complex of graduates’ characteristics by providing education through only standard traditional techniques, which continue to be prevalent in higher education and ensure optimisation of professional activity in general.The aim of the present publication was to present the developed methodology of game-based learning for training of cadets of educational organisations of higher education of the EMERCOM of Russia. …”
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Assainissement des eaux usées et risques socio – sanitaires et environnementaux en zones d’habitat planifié de Yaoundé (Cameroun) by Joseph Wethé, Michel Radoux, Emile Tanawa

“…La mise en œuvre de tels systèmes nécessite de maîtriser les paramètres socio-économiques, urbanistiques, sanitaires et environnement du contexte considéré. L'optimisation de l'efficacité épuratoire des stations extensives nécessite d'organiser et de structurer artificiellement les espèces aquatiques utilisées afin de maximiser la rétention des polluants présents dans les eaux usées. …”
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Protocol for an intervention development and pilot implementation evaluation study of an e-health solution to improve newborn care quality and survival in two low-resource settings... by Hassan Haghparast-Bidgoli, Michelle Heys, Caroline Crehan, Erin Kesler, Monica Lakhanpaul, Emma Wilson, Fabiana Lorencatto, Felicity Fitzgerald, Mario Cortina Borja, Msandeni Chiume, Hannah Gannon, Simbarashe Chimhuya, Gwendoline Chimhini, Tim Hull-Bailey, Tarisai Chiyaka, Yali Sassoon, Deliwe Nkhoma, Nushrat Khan, Alexander G. Stevenson, Kristina Curtis

“…Neotree clinical decision support algorithms will be optimised according to best available evidence and clinical validation studies.Ethics and dissemination This is a Wellcome Trust funded project (215742_Z_19_Z). …”
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Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionResearch in context by Yanan Li, Ru Xu, Fenglei Quan, Yonghua Wu, Yige Wu, Yongyuan Zhang, Yan Liang, Zhenzhong Zhang, Hua Gao, Ruijie Deng, Kaixiang Zhang, Jinghong Li

“…The capacity of CRISPR/Cas13a for discriminating single nucleotide variant (SNV) in viral genome is leveraged by designing synthetic mismatches and hairpin structure in CRISPR RNA (crRNA), enabling robust discrimination of different SARS-CoV-2 variants. Via optimisation of CasTDR3pot to be one-pot assay, CasTDR1pot can detect Omicron and its subvariants, with only a few copies in clinical samples in less than 30 min without pre-amplification. …”
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Stratégies de manipulation d'outil chez les humains et les bonobos by Ameline Bardo, Anthony Borel, Helene Meunier, Mathilde Lemaire, Emeline Lempereur, Jean Pascal Guery, Emmanuelle Pouydebat

“…L'utilisation des deux mains chez les humains pourrait s'expliquer par une saisie plus stable et puissante de l'outil pendant que l'utilisation de deux outils chez les adultes, plus complexe sur le plan de la coordination, pourrait apporter à certains individus une optimisation du trajet de la noix par dissociation des actions de la main droite versus de la main gauche (pousser vs contrôler). …”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…These predictions must be consolidated with experimental screening to enhance further optimisation of the compounds. AICpred is the first of its kind targeting the inhibition of TLR4-MyD88 binding and is freely available at http://197.255.126.13:8080.…”
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Examining the effect of direct-from-blood bacterial testing on antibiotic administration and clinical outcomes: a protocol and statistical analysis plan for a pragmatic randomised... by Li Wang, Wesley H Self, Todd W Rice, Matthew W Semler, Karen F Miller, Cheryl L Gatto, Andrea Fletcher, Romney M Humphries, Joanna L Stollings, Adrienne Baughman, Jakea Johnson, Edward T Qian, Mary Lynn Dear, David C Gaston, Ariel A Lewis, George E Nelson, Benjamin J Ereshefsky, Matthew A Christensen, Ritu Banerjee, Dan Albert, Alison Benton, Laura Bobbitt, Carleigh Burns, Timothy Duff, David C. Gaston, MLS Sharon Glover, Allyson Hobbie, Austin Ing, Gabriel Kemp, Sheryl Mangrum, Geoff Mavrak, Kelly Moser, David Mulherin, Shannon Pugh, Matthew Rodgers, Chrissie Schaeffer, Adam Turner, Sabrina Shipman, Halden Z VanCleave, Hamilton Wen Li Wang, LaKeysha Wiggins

“…Direct-from-blood diagnostics identifying the presence or absence of bacteria and/or resistance genes from whole blood samples within hours of collection could enable earlier antibiotic optimisation for patients suspected to have bacterial infections. …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…Extensive and repeated use of the mined subsurface as a thermal source/store and the optimisation of operational infrastructure encompasses a range of scientific and technical challenges that require broad partnerships to address. …”
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The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

“…This would ensure adequate time for optimisation of high-risk patients preoperatively and limit avoidable day-of-surgery cancellations. …”
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Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups. by Viren Swami, Stefan Stieger, Martin Voracek, Toivo Aavik, Hamed Abdollahpour Ranjbar, Sulaiman Olanrewaju Adebayo, Reza Afhami, Oli Ahmed, Annie Aimé, Marwan Akel, Hussam Al Halbusi, George Alexias, Khawla F Ali, Nursel Alp-Dal, Anas B Alsalhani, Sara Álvarez-Solas, Ana Carolina Soares Amaral, Sonny Andrianto, Trefor Aspden, Marios Argyrides, John Jamir Benzon R Aruta, Stephen Atkin, Olusola Ayandele, Migle Baceviciene, Radvan Bahbouh, Andrea Ballesio, David Barron, Ashleigh Bellard, Sóley Sesselja Bender, Kerime Derya Beydaǧ, Gorana Birovljević, Marie-Ève Blackburn, Teresita Borja-Alvarez, Joanna Borowiec, Miroslava Bozogáňová, Solfrid Bratland-Sanda, Matthew H E M Browning, Anna Brytek-Matera, Marina Burakova, Yeliz Çakır-Koçak, Pablo Camacho, Vittorio Emanuele Camilleri, Valentina Cazzato, Silvia Cerea, Apitchaya Chaiwutikornwanich, Trawin Chaleeraktrakoon, Tim Chambers, Qing-Wei Chen, Xin Chen, Chin-Lung Chien, Phatthanakit Chobthamkit, Bovornpot Choompunuch, Emilio J Compte, Jennifer Corrigan, Getrude Cosmas, Richard G Cowden, Kamila Czepczor-Bernat, Marcin Czub, Wanderson Roberto da Silva, Mahboubeh Dadfar, Simon E Dalley, Lionel Dany, Jesus Alfonso D Datu, Pedro Henrique Berbert de Carvalho, Gabriel Lins de Holanda Coelho, Avila Odia S De Jesus, Sonia Harzallah Debbabi, Sandesh Dhakal, Francesca Di Bernardo, Donka D Dimitrova, Jacinthe Dion, Barnaby Dixson, Stacey M Donofrio, Marius Drysch, Hongfei Du, Angel M Dzhambov, Claire El-Jor, Violeta Enea, Mehmet Eskin, Farinaz Farbod, Lorleen Farrugia, Leonie Fian, Maryanne L Fisher, Michał Folwarczny, David A Frederick, Matthew Fuller-Tyszkiewicz, Adrian Furnham, Antonio Alías García, Shulamit Geller, Marta Ghisi, Alireza Ghorbani, Maria Angeles Gomez Martinez, Sarah Gradidge, Sylvie Graf, Caterina Grano, Gyöngyvér Gyene, Souheil Hallit, Motasem Hamdan, Jonathan E Handelzalts, Paul H P Hanel, Steven R Hawks, Issa Hekmati, Mai Helmy, Tetiana Hill, Farah Hina, Geraldine Holenweger, Martina Hřebíčková, Olasupo Augustine Ijabadeniyi, Asma Imam, Başak İnce, Natalia Irrazabal, Rasa Jankauskiene, Ding-Yu Jiang, Micaela Jiménez-Borja, Verónica Jiménez-Borja, Evan M Johnson, Veljko Jovanović, Marija Jović, Marko Jović, Alessandra Costa Pereira Junqueira, Lisa-Marie Kahle, Adam Kantanista, Ahmet Karakiraz, Ayşe Nur Karkin, Erich Kasten, Salam Khatib, Nuannut Khieowan, Patricia Joseph Kimong, Litza Kiropoulos, Joshua Knittel, Neena Kohli, Mirjam Koprivnik, Aituar Kospakov, Magdalena Król-Zielińska, Isabel Krug, Garry Kuan, Yee Cheng Kueh, Omar Kujan, Miljana Kukić, Sanjay Kumar, Vipul Kumar, Nishtha Lamba, Mary Anne Lauri, Maria Fernanda Laus, Liza April LeBlanc, Hyejoo J Lee, Małgorzata Lipowska, Mariusz Lipowski, Caterina Lombardo, Andrea Lukács, Christophe Maïano, Sadia Malik, Mandar Manjary, Lidia Márquez Baldó, Martha Martinez-Banfi, Karlijn Massar, Camilla Matera, Olivia McAnirlin, Moisés Roberto Mebarak, Anwar Mechri, Juliana Fernandes Filgueiras Meireles, Norbert Mesko, Jacqueline Mills, Maya Miyairi, Ritu Modi, Adriana Modrzejewska, Justyna Modrzejewska, Kate E Mulgrew, Taryn A Myers, Hikari Namatame, Mohammad Zakaria Nassani, Amanda Nerini, Félix Neto, Joana Neto, Angela Nogueira Neves, Siu-Kuen Ng, Devi Nithiya, Jiaqing O, Sahar Obeid, Camila Oda-Montecinos, Peter Olamakinde Olapegba, Tosin Tunrayo Olonisakin, Salma Samir Omar, Brynja Örlygsdóttir, Emrah Özsoy, Tobias Otterbring, Sabine Pahl, Maria Serena Panasiti, Yonguk Park, Muhammad Mainuddin Patwary, Tatiana Pethö, Nadezhda Petrova, Jakob Pietschnig, Sadaf Pourmahmoud, Vishnunarayan Girishan Prabhu, Vita Poštuvan, Pavol Prokop, Virginia L Ramseyer Winter, Magdalena Razmus, Taotao Ru, Mirjana Rupar, Reza N Sahlan, Mohammad Salah Hassan, Anđela Šalov, Saphal Sapkota, Jacob Owusu Sarfo, Yoko Sawamiya, Katrin Schaefer, Michael Schulte-Mecklenbeck, Veya Seekis, Kerim Selvi, Mehdi Sharifi, Anita Shrivastava, Rumana Ferdousi Siddique, Valdimar Sigurdsson, Vineta Silkane, Ana Šimunić, Govind Singh, Alena Slezáčková, Christine Sundgot-Borgen, Gill Ten Hoor, Passagorn Tevichapong, Arun Tipandjan, Jennifer Todd, Constantinos Togas, Fernando Tonini, Juan Camilo Tovar-Castro, Lise Katrine Jepsen Trangsrud, Pankaj Tripathi, Otilia Tudorel, Tracy L Tylka, Anar Uyzbayeva, Zahir Vally, Edmunds Vanags, Luis Diego Vega, Aitor Vicente-Arruebarrena, Jose Vidal-Mollón, Roosevelt Vilar, Hyxia Villegas, Mona Vintilă, Christoph Wallner, Mathew P White, Simon Whitebridge, Sonja Windhager, Kah Yan Wong, Eric Kenson Yau, Yuko Yamamiya, Victoria Wai Lan Yeung, Marcelo Callegari Zanetti, Magdalena Zawisza, Nadine Zeeni, Martina Zvaríková, Ulrich S Tran

“…Based on alignment optimisation methods, partial scalar invariance was achieved across all but three national groups and across all languages represented in the BINS. …”
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Evaluación del rol del equipo de coordinación de nefrología en la consulta externa específica de acceso vascular. ¿Qué podemos aportar de nuevo? by Néstor Fontseré, Gaspar Mestres, Xavi Yugueros, Daniel Gil, Carla Blanco, Valentín Lozano, Lidia María Rodas, Arantxa Gelabert, Paula Escarcena, Rosa Ramos, Francisco Maduell

“…After specific training, the nephrology coordination team can make a proper optimisation of social and health resources by reserving referrals to vascular surgery for those cases of greater complexity.…”
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Artificial intelligence in rheumatology research: what is it good for? by Diego Benavent, José Miguel Sequí-Sabater

“…Artificial intelligence (AI) is transforming rheumatology research, with a myriad of studies aiming to improve diagnosis, prognosis and treatment prediction, while also showing potential capability to optimise the research workflow, improve drug discovery and clinical trials. …”
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Subspace Compressive GLRT Detector for MIMO Radar in the Presence of Clutter by Siva Karteek Bolisetti, Mohammad Patwary, Khawza Ahmed, Abdel-Hamid Soliman, Mohamed Abdel-Maguid

“…The problem of optimising the target detection performance of MIMO radar in the presence of clutter is considered. …”
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