A look at the global educational crisis through the lens of experience of the history of science. Part II. The structure of general education content by V. L. Gapontsev, V. A. Fedorov, Ye. M. Dorozhkin

“…On this basis, it is possible to optimise the content of education that balances the process of differentiation within scientific knowledge. …”
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Creating accountable hospital service areas in China: a case analysis of health expenditure in the metropolis of Chengdu by Jay Pan, Peiya Cao, Xiaoshuang Zhao, Yili Yang

“…Findings from the HSA-based analysis could inform the formulation of relevant health policies and the optimisation of healthcare resource allocations.…”
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Association between diabetes mellitus and total hip arthroplasty outcomes: an observational study using the US National Inpatient Sample by Jasvinder A Singh, Sumanth Chandrupatla, Kranti Rumalla

“…We noted a lack of some associations in the avascular necrosis and inflammatory arthritis cohorts (p>0.05).Conclusion Diabetes was associated with increased healthcare utilisation, blood transfusion and postprocedural infection risk following primary THA. Optimisation of diabetes with preoperative medical management and/or institution of specific postoperative pathways may improve these outcomes. …”
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Distributed representations enable robust multi-timescale symbolic computation in neuromorphic hardware by Madison Cotteret, Hugh Greatorex, Alpha Renner, Junren Chen, Emre Neftci, Huaqiang Wu, Giacomo Indiveri, Martin Ziegler, Elisabetta Chicca

“…This work introduces a scalable approach to embed robust symbolic computation through recurrent dynamics into neuromorphic hardware, without requiring parameter fine-tuning or significant platform-specific optimisation. Moreover, it demonstrates that distributed symbolic representations serve as a highly capable representation-invariant language for cognitive algorithms in neuromorphic hardware.…”
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Understanding the implementation strategy of a secondary care tobacco addiction treatment pathway (the CURE project) in England: a strategic behavioural analysis by Matthew Evison, Anna Haste, Catherine Haighton, Freya Howle, Angela M Rodrigues, Angela Wearn, Verity Mallion

“…The recommendations provide routes to optimisation that are both theoretically grounded and stakeholder informed. …”
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Geomatics and metaverse for lost heritage sites documentation and dissemination: the case study of Palmyra Roman Theatre (Syria) by Anna Forte, Yara Jamil Alkhatib, Gabriele Bitelli, Eva Savina Malinverni, Roberto Pierdicca

“… • Operationsof polygon decimationto optimise the geometry of the 3D model for virtual reality (VR) and metaverse applications, including texturing operations to enhance realism…”
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Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity by Els F. Halff, Sridhar Natesan, David R. Bonsall, Mattia Veronese, Anna Garcia-Hidalgo, Michelle Kokkinou, Sac-Pham Tang, Laura J. Riggall, Roger N. Gunn, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Oliver D. Howes

“…Our experiments comprised the following assessments: (i) comparison of [18F]-FDOPA uptake between intravenous and intraperitoneal radiotracer administration and optimisation of the time window used for extended Patlak analysis, (ii) comparison of KiMod in a within-subject design of both administration routes, (iii) test-retest evaluation of KiMod in a within-subject design of intraperitoneal radiotracer administration, and (iv) validation of KiMod estimates by comparing the two administration routes in a mouse model of hyperdopaminergia induced by subchronic ketamine. …”
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Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial by Geneviève Héry-Arnaud, Christophe Burucoa, Marie Kempf, David Boutoille, Yohann Foucher, Philippe Lanotte, Maxime Pichon, Stéphane Corvec, Cécile Le Brun, Helene Pailhories

“…Considering that without an identified pathogen, a 10% mortality rate can ensue, documentation is essential to the optimisation of antibiotic therapy. However, blood culture (the reference test) is limited for several reasons: such as fastidious culture, antibiotic treatment prior to sampling or insufficient sample volume. …”
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Ocular biometric parameters in Chinese preschool children and physiological axial length growth prediction using machine learning algorithms: a retrospective cross-sectional study by Yan Li, Kai Wang, Tao Tang, Heng Zhao, Jingwei Zhou, Mingwei Zhao, Duanke Liu, Xuewei Li, Xiaoqing Shi, Jiahui Ma, Chenxu Zhao

“…Predicted AL was obtained through the application of the Gaussian process regression model as an optimisation technique. Subsequently, the annual growth rate of physiological AL for non-myopic preschool children (n=1061) was computed via the backward difference method.Results In total, 85.4% of preschool children (931 individuals) had hyperopic refractive status in the 4–6 years age group, while only 2.7% (29 individuals) showed myopia. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…The developed tool, DigiLoCs, focuses explicitly on accurately describing complex biological processes within liver-chip systems. ODE-constrained optimisation is applied to estimate the clearance of compounds. …”
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Optimization of surgical methods for the treatment of gynecomastia by A.G. Ihnatieva, S.M. Yurchyshyn

“…Gynecomastia has a negative impact on the psychological state of men. Optimisation of surgical treatment for gynecomastia, aimed at minimising unsatisfactory cosmetic consequences of operation, should significantly improve the quality of life of patients. …”
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Unveiling the UNESCO Biosphere Reserve of the Berlengas Archipelago in Portugal as a Hotspot of Fish Species Using eDNA Metabarcoding and the Collaboration of Fishing Crews by Marco Simões, Cátia Costa, Maria da Luz Calado, Nuno Vasco-Rodrigues, Maria Jorge Campos, Sérgio Miguel Leandro, Agostinho Antunes

“…Our study also highlighted eDNA’s role in monitoring fish species by detecting unexpected species for the region, such as Atlantic salmon (<i>Salmo salar</i>) and Atlantic cod (<i>Gadus morhua</i>), while cautioning against false positives like orange clownfish (<i>Amphiprion percula</i>) and blue tilapia (<i>Oreochromis aureus</i>). Future optimisation of our eDNA sampling methodology could better refine marine ecosystem dynamics around the UNESCO Biosphere Reserve of the Berlengas Archipelago, Portugal.…”
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2022 TB programme review in Pakistan: strengthening governance, with better patient diagnosis and treatment by M. van den Boom, K. Bennani, C. Sismanidis, C. Gunneberg, L. Khawaja, M.A. Safdar, C. Muhwa, E. Heldal, D.M. Cirillo, A.W. Khan, R. Fatima, B.J. Khan, S. Tahseen, M.G. ElMedrek, Y. Hutin, Pakistan Joint TB Program Review Mission

“…Bacteriological confirmation using recommended diagnostics also requires further optimisation.…”
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Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research by Foteini Stefania Koumpa, Diamantis Xylas, Maciej Konopka, Dieter Galea, Kirill Veselkov, Anthony Antoniou, Akash Mehta, Reza Mirnezami

“…In vitro and animal model studies were deemed eligible for inclusion in the sections pertaining to biomarkers and therapeutic optimisation, as these areas of research currently remain in the early stages of development. …”
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Microstructure of the human metastatic vertebral body by Giulia Cavazzoni, Giulia Cavazzoni, Giulia Cavazzoni, Enrico Dall’Ara, Enrico Dall’Ara, Marco Palanca, Marco Palanca, Marco Palanca

“…IntroductionBone spinal metastases disrupt the bone homeostasis, inducing a local imbalance in the bone formation and/or resorption, with consequent loss of the structural optimisation of the vertebrae and increase of the risk of fracture. …”
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Effect of Drying and Microwave-Assisted Extraction Parameters on Lippia adoensis Variety Koseret Essential Oil Yield by Bethlehem Worku, Nurelegne Shibeshi, Jong-Bang Eun, Youngmo Yoon

“…Several essential oils were then extracted from the oven-dried samples for a preliminary study, followed by optimisation of the essential oil yield. The Box-Behnken design with response surface methodology was used to optimise the process and effectively analyse the influence and interaction of the factors on the essential oil yield. …”
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Differentiation Potential of Early- and Late-Passage Adipose-Derived Mesenchymal Stem Cells Cultured under Hypoxia and Normoxia by Ashley G. Zhao, Kiran Shah, Julien Freitag, Brett Cromer, Huseyin Sumer

“…With an increasing focus on the large-scale expansion of mesenchymal stem cells (MSCs) required for clinical applications for the treatment of joint and bone diseases such as osteoarthritis, the optimisation of conditions for in vitro MSC expansion requires careful consideration to maintain native MSC characteristics. …”
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Numerical study on the prediction of oil recovery rates in unconventional reservoirs at high temperatures using ecologically friendly hybrid nanofluids by Mudasar Zafar, Hamzah Sakidin, Abida Hussain, Farman Ullah, Mikhail Sheremet, Iskandar Dzulkarnain, Roslinda Nazar, Abdullah Al-Yaari, Liaqat Ali

“…This study also explored the optimisation of recovery rates by analysing several variables using ANSYS Fluent software, such as flow rate, porosity, and volume fraction. …”
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Using Sequence Mining to Predict Complex Systems: A Case Study in Influenza Epidemics by Theyazn H. H. Aldhyani, Manish R. Joshi, Shahab A. AlMaaytah, Ahmed Abdullah Alqarni, Nizar Alsharif

“…This paper presents three adapting intelligence models: support vector machine regression (SVMR), artificial neural network using particle swarm optimisation (ANNPSO), and our intelligent time series (INTS) to predict influenza epidemics. …”
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Evolutionary determinants of reproductive seasonality: A theoretical approach by Burtschell, Lugdiwine, Dezeure, Jules, Huchard, Elise, Godelle, Bernard

“…The goal of this study was to investigate the drivers of evolutionary transitions towards reproductive seasonality using a realistic agent-based optimisation model simulating the life cycle of a female yellow baboon, who typically breeds year-round. …”
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