Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

“…Our results suggest that compounds 14 and 22 can be served as lead compounds of PD-L1/class I HDACs dual inhibitors for further optimisation.…”
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Production of ferric ammonium sulfate (FAS) dodecahydrate from pyrite (FeS2) by Wilson Kobal, Rachel A. Pepper, Jose A. Alarco, Wayde Martens, Sara J. Couperthwaite

“…As pyrite samples contain various minerals, the acid leachates contained impurities, such as Al, Ca, Mn, and therefore optimisation studies to produce FAS from pyrite leachates was undertaken based on type of acid, concentration and residence time for leach and crystallisation stages. …”
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Implications for cost and access of site-of-service referrals for ancillary medical services in a US Medicaid population: analysis of claims data from Maryland, USA by Maqbool Dada, Simrita Singh, Kelsey J Rydland, Chester Chambers, Vishal Mundlye, Edward Kumian, Kayode Ayodele Williams

“…We used location-allocation optimisation models to find the optimal sites to minimise net costs.Setting Coverage area included Medicaid patients throughout the state of Maryland.Participants All rural and urban members of this Medicaid cohort.Primary and secondary outcome measures Change in payer costs and member travel times on shifting ancillary bundles from regulated to unregulated sites.Results Procedure cost and travel time differentials between regulated and unregulated sites strongly correlated with the percentage of procedures referred to regulated sites. …”
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PathoGD: an integrative genomics approach to primer and guide RNA design for CRISPR-based diagnostics by Soo Jen Low, Matthew O’Neill, William J. Kerry, Natasha Wild, Marcelina Krysiak, Yi Nong, Francesca Azzato, Eileen Hor, Lewis Williams, George Taiaroa, Eike Steinig, Shivani Pasricha, Deborah A. Williamson

“…Abstract Critical to the success of CRISPR-based diagnostic assays is the selection of a diagnostic target highly specific to the organism of interest, a process often requiring iterative cycles of manual selection, optimisation, and redesign. Here we present PathoGD, a bioinformatic pipeline for rapid and high-throughput design of RPA primers and gRNAs for CRISPR-Cas12a-based pathogen detection. …”
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Teachers’ autonomous motivation and work engagement: The role of the principal’s democratic leadership style and psychological climate by L. A. Mokretsova, O. A. Sychev, A. M. Bespalov, M. S. Vlasov, M. M. Prudnikova

“…The revealed effect of partial mediation of relations between democratic leadership style and autonomous motivation of teachers through psychological climate clarifies the ideas about the system of socio-psychological factors of professional motivation.Practical significance consists in usage of the results for improvement of psychological training of principals, optimisation of their leadership style for creating better psychological atmosphere and support for teachers’ productive motivation.…”
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Effects of falls prevention interventions on falls outcomes for hospitalised adults: protocol for a systematic review with meta-analysis by Anne-Marie Hill, Meg E Morris, David L Carey, Susan C Slade

“…The extent to which hospital falls are prevented by evidence-based practice, patient self-management initiatives, environmental modifications and optimisation of falls prevention systems awaits confirmation. …”
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A CRITIC-BPNN APPROACH TO FRICTION STIR WELDING PARAMETRIC SELECTION AND PREDICTION USING AA6082-T6 MATERIAL by Mufutau Adeniyi Abolarin, Adeyinka Oluwo, John Rajan, Swaminathan Jose, Sunday Ayoola Oke |, Alexander Iwodi Agada, Ayomide Sunday Ibitoye

“…This paper fills the gap by introducing an integrated CRITIC-BPNN (CRiteria Importance Through Intercriteria Correlation-Back Propagation Neural Network) method to investigate the selection and optimisation characteristics of the friction stir welding process for AA6082-T6 material. …”
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A Descriptive Analysis of the Fastest Race Courses for Triathletes by Mabliny Thuany, David Valero, Elias Villiger, Marilia Andrade, Katja Weiss, Pantelis T. Nikolaidis, Rodrigo Luiz Vancini, Thomas Roseman, Beat Knechtle

“…Conclusion: These results are useful for athletes’ strategic planning and inform event organisers about the strengths of different courses, aiding in the optimisation and promotion of future Ironman® 70.3 races worldwide. …”
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MLHI-Net: multi-level hybrid lightweight water body segmentation network for urban shoreline detection by Jianhua Ye, Pan Li, Yunda Zhang, Ze Guo, Shoujin Zeng, Youji Zhan

“…Then, we design a multi-branch two-layer attention fusion module (MDA), which achieves diverse attention and global optimisation of edge details by connecting spatial attention, channel attention and pixel attention in parallel. thereby guiding feature fusion and solving the problem of receptive field mismatch. …”
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Macronutrient-Based Predictive Modelling of Bioconversion Efficiency in Black Soldier Fly Larvae (<i>Hermetia illucens</i>) Through Artificial Substrates by Laurens Broeckx, Lotte Frooninckx, Siebe Berrens, Sarah Goossens, Carmen ter Heide, Ann Wuyts, Mariève Dallaire-Lamontagne, Sabine Van Miert

“…This study explores the optimisation of rearing substrates for black soldier fly larvae (BSFL). …”
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Detection of Aflatoxin and Ochratoxin A in Spices by High-Performance Liquid Chromatography by Zahra Zareshahrabadi, Robab Bahmyari, Hasti Nouraei, Hossein Khodadadi, Pouyan Mehryar, Fatemeh Asadian, Kamiar Zomorodian

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Conductive polymers and derivatives as recognition element for electrochemical sensing of food and drug additives: A brief perspective by Hassan O. Shoyiga, Omolola E. Fayemi

“…Nevertheless, additional systematic research is required to enhance the comprehension of the design and optimisation of nanocomposite-based electrodes for more effective sensing performance.…”
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Open-source implementation of polarisation-resolved single-shot differential phase contrast microscopy (pDPC) on a modular openFrame-based microscope by Huihui Liu, Sunil Kumar, Edwin Garcia, William Flanagan, Jonathan Lightley, Christopher Dunsby, Paul M.W. French

“…With improved hardware and software, this new pDPC implementation provides a real-time readout of phase across a field of view that facilitates optimisation of system alignment. We also provide protocols for background subtraction and correction of crosstalk.…”
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Performance Understanding and Learning System (PULSE-KEY): development of a framework for implementation and performance evaluation of healthcare delivery models of care by Katrina L Campbell, Rumbidzai N Mutsekwa, Russell Canavan, Rebecca L Angus, Joshua Byrnes, Liza-Jane McBride

“…Objectives Efficient performance evaluation is essential for driving improvement, ensuring accountability and optimisation of outcomes in healthcare delivery. However, its complexity often leads to ineffective implementation. …”
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Using machine learning models to plan HIV services: Emerging opportunities in design, implementation and evaluation by T Dzinamarira, E Mbunge, I Chingombe, D F Cuadros, E Moyo, I Chitungo, G Murewanhema, B Muchemwa, G Rwibasira, O Mugurungi, G Musuka, H Herrera

“…However, barriers such as lack of engagement, limited availability of early HIV-infection detection tools, high rates of HIV/sexually transmitted infections (STIs), barriers to access antiretroviral therapy, lack of innovative resource optimisation and distribution strategies, and poor prevention services for vulnerable populations still exist and substantially affect the attainment of the UNAIDS 95-95-95 targets. …”
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Mechanical property strengthening by post-heat treatments in NiTiCu shape memory alloys fabricated by twin-wire arc additive manufacturing by Long Chen, Miao Zhao, Jiehao Wu, J. P. Oliveira, Fissha Biruke Teshome, Bowen Pang, Jiajia Shen, Yiming Wu, Naixun Zhou, Norbert Schell, Zhi Zeng

“…This work provides practical significance for the twin-wire arc additive manufacturing and performance optimisation of NiTi-based ternary alloys.…”
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ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Following iterative optimisation and pharmacological validation, ZSH‐2208 was identified as the most promising candidate for effectively targeting ESCC tumour‐repopulating cells (TRCs). …”
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Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches by Alessia Caputo, Gian Marco Elisi, Elisabetta Levati, Giulia Barotti, Sara Sartini, Jerome Wagner, Dominique Y. Burnouf, Simone Ottonello, Silvia Rivara, Barbara Montanini

“…This screening campaign unveiled new chemical classes of α/β-clamp PPI disruptors capable of inhibiting DNA polymerase III activity, which lend themselves for further optimisation to improve their antibacterial efficacy.…”
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Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking by Marie Dorn, Christine Ferng, Kerensa Klottrup-Rees, Kenneth Lee, Martina Micheletti

“…Perfusion mode is typically applied at bench-scale for optimisation purposes, while process development and cell clone screening studies at mL-scale still commonly use fed-batch methods. …”
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Greener and rapid magnetic solid phase microextraction method using Fe3O4@Al2O3/AC for chromatographic determination of neonicotinoid pesticides in vegetable oils by Musiiwa V. Sengane, Masixole Sihlahla, Philiswa N. Nomngongo, Nomvano Mketo

“…The most influential parameters affecting MSPμE of NEOs by Fe3O4@Al2O3/AC were examined using a multivariate optimisation approach and 8 min extraction time, 13 pH, 9 mg adsorbent mass, and 0.5 mL eluent volume were optimal parameters. …”
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