USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

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Polygenic height prediction for the Han Chinese in Taiwan by Chih-Hao Chang, Che-Yu Chou, Timothy G. Raben, Shih-Ann Chen, Yuh-Jyh Jong, Jeng-Yih Wu, Shun-Fa Yang, Hsiang-Cheng Chen, Yen-Lin Chen, Ming Chen, Gwo-Chin Ma, Chih-Yang Huang, Tso-Fu Wang, Sing-Lian Lee, Chen-Fang Hung, See-Tong Pang, Erik Widen, Yao-Ming Chang, Erh-Chan Yeh, Chun-Yu Wei, Chien-Hsiun Chen, Stephen D. H. Hsu, Pui-Yan Kwok

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Global, regional and national burdens of cardiovascular disease attributable to secondhand smoke from 1990–2019: an age-period-cohort analysis by Hong Jiang, Xiang-Bin Pan, Xiaofei Li, Shouzheng Wang, Zeye Liu, Peijian Wei, Fengwen Zhang, Wen-Bin Ou-yang

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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

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The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis by Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C

“…Chenyue Guo,1,* Peiyao Xu,1,* Wenchen Luo,1,* Jinlin Zhang,1,* Xingfeng Sun,2 Harry Hoang,3 Duan Ma,4 Dehua Wu,5 Jing Zhong,1 Changhong Miao1 1Department of Anesthesiology, Zhongshan Hospital Fudan University, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, People’s Republic of China; 2Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People’s Republic of China; 3Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 4Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Collaborative Innovation Center of Genetics and Development, Institute of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 5Department of Anesthesiology, Shanghai Songjiang District Central Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Changhong Miao; Jing Zhong, Email ziteng1934@aliyun.com; jzhong12@fudan.edu.cnBackground: Sepsis is regarded as a dysregulated immune response to infections. …”
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Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients by Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel

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Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages by Jiayi Mao, Wenzheng Xia, Yanglin Wu, Minxiong Li, Yun Zhao, Peisong Zhai, Yuguang Zhang, Tao Zan, Wenguo Cui, Xiaoming Sun

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Network Meta-Analysis and Trial Sequential Analysis of Randomised Controlled Trials Comparing Robotic, Laparoscopic, and Open Pancreatoduodenectomy by Nejo Joseph, MBChB, Chris Varghese, MBChB, James Lucocq, MBChB, Matthew J. McGuinness, MBChB, Samuel Tingle, MBChB, Giovanni Marchegiani, PhD, Kjetil Soreide, PhD, Mohammed Abu-Hilal, Jas Samra, Marc Besselink, PhD, Steve White, Sanjay Pandanaboyana, FRCS

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PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

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Current applications and challenges in large language models for patient care: a systematic review by Felix Busch, Lena Hoffmann, Christopher Rueger, Elon HC van Dijk, Rawen Kader, Esteban Ortiz-Prado, Marcus R. Makowski, Luca Saba, Martin Hadamitzky, Jakob Nikolas Kather, Daniel Truhn, Renato Cuocolo, Lisa C. Adams, Keno K. Bressem

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Long-Term Follow-Up of Patients with Advanced Colorectal Liver Metastasis: A Survival Analysis from the Randomized Controlled Multicenter Trial LIGRO by Dennis Björk, MD, Kristina Hasselgren, MD, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Anna Lindhoff Larsson, RN, Magnus Rizell, MD, PhD, Bergthor Björnsson, MD, PhD, Per Sandström, MD, PhD

“…The objective of this study was to evaluate the long-term oncological outcomes of patients with colorectal liver metastasis (CRLM) randomized for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) or 2-stage hepatectomy (TSH). …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Patients receiving nivolumab plus ipilimumab, compared with patients receiving anti-PD-1 monotherapy or BRAF/MEK inhibitors, had favourable baseline prognostic factors, such as younger age, fewer or smaller brain metastases, better Eastern Cooperative Oncology Group performance status and less frequently elevated lactate dehydrogenase. …”
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The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore by Hui Lionel Raphael Chen, Piea Peng Lee, Yun Zhao, Wei Hao Caleb Ng, Jiashen Zhao, Yu En Christopher Tan, Bo Jie Sean Loh, Kah-Hoe Pierce Chow, Hiang Khoon Tan, Kwong-Wei Emile Tan

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Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma ≤3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Shuanggang Chen,1,2,* Han Qi,1,2,* Hongtong Tan,1,2,* Fei Cao,1,2 Lin Xie,1,2 Tao Huang,1,2 Ying Wu,3 Chunyong Wen,1,2 Yujia Wang,1,2 Lujun Shen,1,2 Weijun Fan1,2 1Department of Minimally Invasive Interventional Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Interventional Therapy, Shenzhen second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weijun Fan, Email fanwj@sysucc.org.cn; Lujun Shen, Email shenlj@sysucc.org.cnBackground: Salvage liver transplantation is promising for hepatocellular carcinoma(HCC) recurrence post-ablation but is significantly affected by recurrence beyond Milan Criteria (RBM).Materials and Methods: A retrospective cohort study of potentially transplantable HCC patients undergoing ablation between 2007 and 2017 assessed median time to recurrence beyond Milan Criteria(TRBM) via Kaplan-Meier curves and predictive capacity of recurrence and RBM for overall survival(OS) via Receiver Operating Characteristic Curves, and identified independent risk factors for TRBM and RBM via Cox and binary logistic regression models.Results: We enrolled 191 potentially transplantable patients with early-stage HBV-related HCC ≤ 3 cm who underwent ablation. …”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

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Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

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Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics by Mikhail T. Silk, Nina Mikkilineni, Tarik C. Silk, Emily C. Zabor, Irina Ostrovnaya, Ari A. Hakimi, James J. Hsieh, Etay Ziv, Natasha Rekhtman, Stephen B. Solomon, Jeremy C. Durack

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