Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period by Toshiyuki Tashiro, Satoshi Seino, Toshihide Sato, Ryosuke Matsuoka, Yasunobu Masuda, Naoshi Fukui

“…The subjects in the HA group were given 200 mg of HA once a day everyday for 12 months, while the subjects in the placebo group were given placebo. …”
Get full text

Condensed tannin from Caragana korshinskii extraction and protection effects on intestinal barrier function in mice by Xiaoyu Niu, Wei Qu, Zhiyu Chen, Hui Li, Peinan Liu, Mei Sun, Jing Yang, Yuanyuan Xing, Dabiao Li

“…The treatment groups were intragastrically administered with 0, 25, 50, 100, 200, and 400 mg/kg BW of CKT aqueous solution once a day. The gavage volume was set at 0.2 mL per 10 g of body weight, administered daily for 21 days. …”
Get full text

Systemic Lupus Erythematosus (SLE) with Acute Nephritis, Antineutrophil Cytoplasmic Antibody- (ANCA-) Associated Vasculitis, and Thrombotic Thrombocytopenic Purpura (TTP): A Rare C... by Sohail Farshad, Christopher Kanaan, Solomiia Savedchuk, Dillon S. Karmo, Alexandra Halalau, Abhishek Swami

“…She was diagnosed with acute lupus nephritis and early microangiopathic hemolytic anemia in the setting of hypertensive urgency and started on intravenous methylprednisolone 500 mg once a day. Within 48 hours, she developed shock with multiorgan dysfunction and succumbed to her illness. …”
Get full text

The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions by Gulbarchyn Alisherovna Asrankulova, Zhyldyz Akmatovna Makhmudova, Zyinat Samidinovna Boronova, Meerim Taalaibekovna Taalaibekova, Zhyldyz Turusbekovna Ayipova, Unsun Satarkulovna Torobaeva

“…Oral administration of ω-3 fatty acids at a dose of 300 mg/kg of animal body weight once a day for 30 days leads to a decrease in the levels of atherogenic low-density lipoproteins, malondialdehyde, increase the level of anti-atherogenic high-density lipoproteins and activity of superoxide dismutase and catalase.…”
Get full text

Involvement of Neuropeptide Y within Paraventricular Nucleus in Electroacupuncture Inhibiting Sympathetic Activities in Hypertensive Rats by Qi Zhang, Yingying Tan, Xin Wen, Fangfang Li

“…EA treatment at the acupoints ST36 and ST40 overlying the peroneal nerves was given once a day for 30 days. The radiotelemetry system was applied to collect the arterial BP recordings. …”
Get full text

To Evaluate the Relationship between Overweight/Obesity Status, Sugar Consumption, and Dental Caries among 12–15-year-old School Children of Moradabad City by Supurna Pandit, Pradeep Tangade, Jeevan Josh, Sanchit Pradhan, Mohnish Muchhal, Aditya Veer Singh

“…Children with more than once a day sugar consumption had higher chance of caries than who consumed once per day (OR = 3.23, CI = 1.20–7.92). …”
Get full text

Abdominal Massage Improves the Symptoms of Irritable Bowel Syndrome by Regulating Mast Cells via the Trypase-PAR2-PKCε Pathway in Rats by Huanan Li, Wei Zhang, Fei Ma, Xiaofan Zhang, Yuyan Wang, Jingui Wang

“…Abdominal massage was performed once a day for 5 minutes for 14 days. On day 14, the rats were euthanized and the tissues were analyzed by transmission electron microscopy (TEM), immunohistochemistry or immunofluorescence staining, and laser confocal focus to visualize the micromorphology of the intestinal mucosa. …”
Get full text

Desferrioxamine Reduces Oxidative Stress in the Lung Contusion by Umit Nusret Basaran, Suleyman Ayvaz, Burhan Aksu, Turan Karaca, Mustafa Cemek, Ihsan Karaboga, Mustafa Inan, Feyza Aksu, Mehmet Pul

“…In the control+DFX and contusion+DFX groups, 100 mg/kg DFX was given intraperitoneally once a day just after the contusion and the day after the contusion. …”
Get full text

Barriers Affecting Promotion of Active Transportation: A Study on Pedestrian and Bicycle Network Connectivity in Melbourne’s West by Isaac Oyeyemi Olayode, Hing-Wah Chau, Elmira Jamei

“…Based on our online interactive survey findings, approximately one-third of the individuals engaged in regular walking, with a frequency ranging from once a day to once every two days. One-third of the participants engaged in walking trips once or twice a week, whereas the remaining two-thirds conducted walking trips less frequently than once a week. …”
Get full text

Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats by Yu Mao, Jing Zhou, Xuesheng Liu, Erwei Gu, Zhi Zhang, Wenjuan Tao

“…We found that the injection of SAHA once a day for 3 days significantly attenuated CFA-induced thermal hyperalgesia from day 4 and lasted 7 days. …”
Get full text

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment by Yaling Dai, Yuhao Zhang, Minguang Yang, Huawei Lin, Yulu Liu, Wenshan Xu, Yanyi Ding, Jing Tao, Weilin Liu

“…EA stimulation was applied to Baihui (GV20) and Shenting (GV24) acupoints for 30 min once a day, five times a week, for four weeks. Our study also included nonacupoint groups to confirm the specificity of EA therapy. …”
Get full text

Effects of orally exposed SiO2 nanoparticles on lipid profiles in gut-liver axis of mice by Kuanhang Li, Zhengzheng Zhou, Yi Cao

“…After 5 days exposure (once a day), we observed that SiO2 NPs induced minimal pathological changes but increased most of the trace elements. …”
Get full text

Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder by Marcin Siwek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Andrzej Juryk, Dominika Dudek

“…The present work aims to compare the impacts of trazodone once-a-day extended-release (XR) vs selective serotonin reuptake inhibitors (SSRIs) on the health status and quality of life in MDD.MethodsData were gathered from 180 subjects through a naturalistic observation study of trazodone effectiveness in depression (TED) and analyzed. …”
Get full text

Rapid Improvement in Neck Disability, Mobility, and Sleep Quality with Chronic Neck Pain Treated by Fu’s Subcutaneous Needling: A Randomized Control Study by Ching-Hsuan Huang, Lung-Hung Tsai, Mao-Feng Sun, Zhonghua Fu, Jian Sun, Li-Wei Chou

“…Participants were equally randomized into the FSN or transcutaneous electrical nerve stimulation (TENS) group who received interventions once a day on day 1, day 2, and day 4. They were assessed by outcome measurements during pre- and post-treatment and followed up for 15 days. …”
Get full text

Oral Administration of Lactobacillus plantarum 299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial by Hannah Andersson, Cecilia Tullberg, Siv Ahrné, Kristina Hamberg, Irini Lazou Ahrén, Göran Molin, Mikael Sonesson, Åsa Håkansson

“…The probiotic bacteria or the placebo product was administered in capsules once a day during 14 days. Saliva was collected and a perceived stress test was filled out at each sampling occasion. …”
Get full text

Suppressive Activity of a Macrolide Antibiotic, Roxithromycin, on Pro-Inflammatory Cytokine Production in Vitro and in Vivo by H. Suzaki, K. Asano, S. Ohki, K. Kanai, T. Mizutani, T. Hisamitsu

“…RXM was administered orally into BALB/c mice at a single dose of 2.5 mg/kg once a day for 5-12 weeks. These mice were then instilled with LPS into the trachea and examined for the presence of cytokines in aqueous lung extracts. …”
Get full text

In Vivo Assessment of Healing Potential of Ointments Containing Bee Products, Vegetal Extracts, and Polymers on Skin Lesions by Calin Vasile Andritoiu, Cristina Lungu, Camelia Elena Iurciuc (Tincu), Corina Elena Andriescu, Corneliu Havarneanu, Marcel Popa, Magdalena Cuciureanu, Liliana Mititelu Tarţău, Bianca Ivanescu

“…The treatment was applied topically, once a day, for 21 days. Clinical and macroscopic evaluation, determination of lesion shrinkage rate, re-epithelialization period, and histopathological examination were performed. …”
Get full text

Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats by Jázmin Ayman, András Buzás, Roberta Dochnal, Miklós Palotai, Miklós Jászberényi, Zsolt Bagosi

“…In parallel, the rats were exposed daily to an intracerebroventricular (icv) injection with 1 μg/2 μL ghrelin or 1 μg/2 μL GHRP-6 or saline solution for 7 days, once a day (at 8:00). On the morning of the eighth day (12 h after the last ip administration) and the ninth day (24 h after the last ip administration), the horizontal and vertical activity were monitored in a conducta system. …”
Get full text

A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication by Jane Loftus, Bradley S. Miller, Craig S. Parzynski, Jose Alvir, Yong Chen, Priti Jhingran, Anu Gupta, Mitch DeKoven, Victoria Divino, Jenny Tse, Jing He, Michael Wajnrajch

“…. • As prescribed, somatropin needs to be injected once a day under the skin. Some children may miss many of their somatropin injections, and this is known as having “low adherence ” to treatment. …”
Get full text

Association of self-reported dental caries with sex, lifestyle, and problematic Internet use among elementary school children in Japan by Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse, Yukiko Yanai

“….: aPR 1.23), tooth brushing (once a day: aPR 1.14 and not every day: aPR 1.41), having no family rules (aPR 1.20), and PIU (YDQ score 3–4: aPR 1.17). …”
Get full text