Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection by Uy Hoang, Utkarsh Agrawal, José Manuel Ordóñez-Mena, Zachary Marcum, Jennifer Radin, Andre Araujo, Catherine A Panozzo, Orsolya Balogh, Mihir Desai, Ahreej Eltayeb, Tianyi Lu, Catia Nicodemo, Xinchun Gu, Rosalind Goudie, Xuejuan Fan, Elizabeth Button, Jessica Smylie, Mark Joy, Gavin Jamie, William Elson, Rachel Byford, Joan Madia, Sneha Anand, Filipa Ferreira, Stavros Petrou, David Martin, Simon de Lusignan

“…Practices are selected if they undertake reference virology sampling for the Royal College of General Practitioners Research Surveillance Centre and had previous experience with respiratory illness studies. Any adult, ≥40 years old, presenting with acute respiratory infection with onset ≤10 days, but without RSV within the past 28 days, will be eligible to participate. …”
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Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

“…Therefore, we used this model to evaluate the effects of tofogliflozin on renal lipid metabolism and inflammation. Male 8–10-week-old C57Bl/6 mice were fed a high-fat/high-cholesterol/high-sucrose/bile acid (HF/HC/HS/BA) diet with 0.015% tofogliflozin (Tofo group) or an HF/HC/HS/BA diet alone (SLD group). …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
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Sporadic Burkitt Lymphoma First Presenting as Painful Gingival Swellings and Tooth Hypermobility: A Life-Saving Referral by Erofili Papadopoulou, Maria Kouri, Dimitrios Velonis, Anastasia Andreou, Maria Georgaki, Spyridon Damaskos, Evangelia Piperi, Konstantina Delli, Ioannis K. Karoussis, Antonia Vlachou, Georgia Avgerinou, Antonis Kattamis, Nikolaos G. Nikitakis

“…<b>Case report:</b> An 11-year-old Caucasian female was referred for the evaluation of hypermobility of posterior lower teeth, associated with painful gingival swellings of 20 days duration. …”
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Oral Administration of 17α-Methyltestosterone Increased Male Percentage of Freshwater Crayfish Cherax quadricarinatus by O. Carman, M.Y. Jamal, . Alimuddin

“…This study was aimed to increase male of C. quadricarinatus by oral administration of diet containing 17α-methyltestosterone (MT) towards production efficiency.  Two-week-old of Cherax quadricarinatus were fed ad libitum on diets containing various dose of MT, i.e., 25, 50, 75, 100 and 150 mg/kg diet or diet containing no MT as control, 3 times daily for 30 days.  …”
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Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period by Mengmeng Xu, Le Liu, Zongze Fan, Lizhu Niu, Wenxi Ning, He Cheng, Mengyun Li, Wenying Huo, Pan Zhou, Hongyu Deng, Wen Chen, Long Che

“…A total of 360 70-week-old Jinghong laying hens were randomly assigned to four groups of six replicates each, with 15 chickens per replicate. …”
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Pengaruh Pemberian Berbagai Olahan Telur terhadap Kadar Kolesterol Total Darah Mencit by Putri Mira Magistri, Rismawati YaswiR, Yustini Alioes

“…The experiment used 24 male albino mice (Mus nusculus) age 3 – 4 months old with 30 – 40 grams of body weight. The den used was 24 units of box with size of 28x30x20 cm. …”
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L’aqueduc du Gier : nouvelles données sur le pont-siphon de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by David Baldassari, François Blondel, Stéphane Gaillot

“…The presence of this masonry structure suggests that in Antiquity the main channels of the river probably passed between the piers at the bottom of the eastern slope of the valley.Beyond this indication of the old route of the river, the geoarchaeological approach also provides matter for discussion on the possible causes of the collapse of the bridge, which probably involved one or more consecutive or associated factors: weaknesses in the subsoil, the influence of meteorological factors or natural disasters.The data acquired during this excavation contribute significantly to ideas about the techniques and architectural choices that governed the construction of the bridge, together with more general thinking about the dating of a hydraulic structure as important as the Gier aqueduct, which is of not insignificant impact for the analysis of the urban development of the Roman colony of Lugdunum.…”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…<i>Results</i>: A total of 18 out of 21 CHD patients (mean age 35.8 ± 9.0 years old and 13 (72%) females) completed the program. …”
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Posterior and Anterior Spinal Fusion for the Management of Deformities in Patients with Parkinson's Disease by Masashi Sato, Takeshi Sainoh, Sumihisa Orita, Kazuyo Yamauchi, Yasuchika Aoki, Tetsuhiro Ishikawa, Masayuki Miyagi, Hiroto Kamoda, Miyako Suzuki, Gou Kubota, Yoshihiro Sakuma, Kazuhide Inage, Yasuhiro Oikawa, Junichi Nakamura, Masashi Takaso, Gen Inoue, Tomoaki Toyone, Kazuhisa Takahashi, Seiji Ohtori

“…Case Presentation. Two 70-year-old women had spinal scoliosis and kyphosis due to Parkinson's disease. …”
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Immunomodulatory and growth-promoting effects of Rauwolfia serpentina root powder in broiler chicks challenged with Salmonella Gallinarum by Yingyu Zhang, Hiba Rehman, Farina Khattak, Maryam Tariq, Bushra Nisar Khan, Sadia Chaman, Ayaesha Riaz, Muhammad Ovais Omer, Aqib Ali, Qamar un Nisa, Muhammad Muddassir Ali, Gulbeena Saleem

“…Benth. ex Kurz) powder (RSP) on three key immune-related genes; Suppressor of cytokine signaling 3 (SOCS3), the quiescence-related gene P20K (P20K), and the major histocompatibility complex Class IIβ (MHC class IIβ), gut morphology and growth performance of broiler chicks infected with Salmonella Gallinarum.MethodsTwo hundred and forty day-old Hubbard classic chickens were randomly assigned to four groups: non-challenged control (NC), and Salmonella Gallinarum challenge group (SGC), and two treatment groups fed a basic diet supplemented with 1.5% Rauwolfia serpentina powder (RSP) with SGC (RSP-1) and 3% RSP with SGC (RSP-2), respectively, from day 3 till 28 days of age. …”
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Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation by Iciar Iturmendi-Sabater, Evdokia Anagnostou, Marc A. Fournier, Jennifer Crosbie, Russell Schachar, Robert Nicolson, Stelios Georgiadis, Elizabeth Kelley, Jessica Jones, Jessica Brian, Hsiang-Yuan Lin, Meng-Chuan Lai

“…Method We analysed cross-sectional behavioural and cognitive data of 646 6- to 18-year-old typically developing young people and those with NDCs from the Province of Ontario Neurodevelopmental Network. …”
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Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure by Florent Allain, Virginie Loizeau, Laure Chaufourier, Maya Hallouche, Laurence Herrou, Amir Hodzic, Katrien Blanchart, Annette Belin, Alain Manrique, Paul Milliez, Rémi Sabatier, Damien Legallois

“…There was no difference among baseline characteristics between PCL and control cohorts; mean age was 78.1 ± 12.2 vs. 79.0 ± 12.5 years old (P = 0.46) and 61 patients (43.9%) vs. 63 (34.6%) had HF with left ventricular ejection fraction (LVEF) <40% (P = 0.24). …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Methods: In CRISPR/Cas9-induced aadat knockout (kat2-/-) mice, we examined the effects on emotion, memory, motor function, Trp and its metabolite levels, enzyme activities in the plasma and urine of 8-week-old males compared to wild-type mice. …”
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Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a... by Larissa dos Santos Leonel, Ingrid Alessandra Victoria Wolin, Angélica Danielevicz, Mabel Diesel, Marina Isolde Constantini, João Batista de Oliveira Junior, Allana Andrade Souza, Thaís Reichert, João Gabriel Silveira-Rodrigues, Danusa Dias Soares, Marcelo Fernando Ronsoni, Simone Van De Sande Lee, Alex Rafacho, Guilherme Fleury Fina Speretta, Karla Siqueira Lottermann, Josefina Bertoli, Alexandre Pastoris Muller, Aline Mendes Gerage, Cíntia de La Rocha Freitas, Rodrigo Sudatti Delevatti

“…Participants with T2D, of both sexes, aged at 45 to 80 years old, will be randomized into two groups (aquatic combined training (AQUA) and dry-land combined training (LAND)), both performing combined aerobic and resistance training three times a week on alternate days for 24 weeks. …”
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European Beech (Fagus sylvatica L.): Quasi-Virgin Forest Stand of the Gorgany Mts.: Structure, Vascular Plants Diversity, Health Conditions by Yuriy Shparyk, Ivan Danylyk, Oleksandr Kuzyarin, Ivan Senchak, Nazar Kruk

“…It has been established that the 190-year-old beech quasi-virgin forests of Gorgan are 3-storeyed spruce-fir-beech (Norway spruce – Silver fir – European beech) primary uneven-aged stands with the following parameters: high productivity; normal number of trees; a large stock of growing timber; a low stock of dead-standing trees; a significant stock of dead down trees; a large proportion of trees with damaged crowns; close to the average values of IUFRO classes; successful natural regeneration. …”
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Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo by Jean Ikanga, Jean Ikanga, Saranya Sundaram Patel, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Emile Omba, Alvaro Alonso, Alden L. Gross

“…This study aims to identify dementia subtypes and their cognitive and neuroimaging profiles in older adults with dementia in the Democratic Republic of Congo (DRC) using biomarkers and clinical data.MethodsForty-five individuals with dementia over 65 years old were evaluated using the Community Screening Instrument for Dementia and the informant-based Alzheimer’s Questionnaire. …”
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The Coexistence of Colorectal Polyps in the Right Colon Increases the Malignant Risk of Laterally Spreading Tumors by Xiaonan Shen, Yao Zhang, Yunjia Zhao, Xiaobo Li, Zhizheng Ge, Hua Xiong, Danfeng Sun, Qinyan Gao, Yun Cui, Xiaoyu Chen, Yingxuan Chen, Jingyuan Fang

“…The risk of the polyps’ coexistence phenomenon increased in males compared with females (OR=2.138, p=0.047), especially in those between 50 and 75 years old (OR=7.074, p=0.036). Tumor size (3–4 cm), LSTs with tubulovillous types, and history of polyps statistically increased the risk of the polyp coexistence phenomenon (OR=5.768, p=0.003; OR=36.345, p=0.024; OR=13.245, p<0.0001, respectively). …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Methods: One-year-old female Sert-/- mice and their wild-type (WT) littermates were subjected to a control diet (CD) or the WD for a duration of three weeks. …”
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Embryo Mosaicism Rate in National Referral Hospital of Indonesia Detected Using Next-Generation Sequencing: A Retrospective Study by Achmad Kemal Harzif, Muhammad Ikhsan, Pritta Ameilia Iffanolida, Kresna Mutia, Budi Wiweko, R Muharam, Kanadi Sumapraja, Gita Pratama, Mila Maidarti, Vita Silvana, Amalia Shadrina, Irene Sinta Febriana, Nafi'atul Ummah, Aisyah Retno Puspawardani, Andon Hestiantoro

“…Statistical analysis revealedno significant disparity in mean maternal age among embryos with low-level mosaicism, high mosaicism, and normalchromosomes (33.88 vs. 35 vs. 33.26 years old, respectively). However, a statistically significant difference inmean maternal age (35.84 vs. 33.26 years) was observed between embryos with aneuploidy (monosomy or trisomy)and those with normal chromosomes. …”
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