Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways by Rongrui Zhang, Yu Xiong, Yujin Ma, Yafei Ma, Nuo Li, Yan Ren, Lili He, Lu Han, Jun Ni, Zhi-xiang Yuan

“…WAPS, a pectin polysaccharide, was identified to coexist with α-glycosidic and β-glycosidic linkages glucan and probably has triple-helix confirmation suggested by Fourier-transform infrared and nuclear magnetic resonance spectroscopy. Cellular experiments indicated that WAPS attenuated the expression of inflammatory cytokines and enhanced macrophage viability. …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…Time resolved nuclear magnetic resonance (NMR) measurements uncover a structural reorganization essential for the transition of I1 to mature lipidic L2 fibrils. …”
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Molecular mobility and dielectric properties of dendronized side chain liquid crystalline polyamines with benzoate groups as lateral spacers by Xavier Montané, Robert Graf, Borja Pascual-José, Roberto Teruel-Juanes, Jordi Guardià, Marta Giamberini, José Antonio Reina, Amparo Ribes-Greus

“…Following these premises, in this work we report on the characterization of side chain liquid crystalline polyamines synthesized by chemical modification of poly[2-(aziridin-1-yl)ethanol] (PAZE) with lateral benzoate groups and the dendron 3,4,5-tris[4-(n-dodecan-1-yloxy)benzyloxy]benzoate (TAP) by using the following techniques: liquid and solid-state Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC), Polarized Optical Microscopy (POM) and Dielectric Thermal Analysis (DETA). …”
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How does the ultrasonic assist CO2 immiscible flooding? by Hengli Wang, Leng Tian, Yanzhong Zhen, Yating Li, Yi Gao, Gaorun Zhong, Kaiqiang Zhang

“…First, the distribution characteristics of residual oil in CO2 immiscible flooding were examined using high pressure mercury injection (HPMI), nuclear magnetic resonance (NMR), and microscopic visualization displacement (MVD) experiments. …”
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Metabolite profiling in assessing ulcerative colitis activity: A systematic review by Danyang Cui, Xu Han, Jiazhu Jin, Yanhong Wang, Zijia Chen, Yang Gong, Miao Jiang

“…Qualitative analysis was performed according to the classification of gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry, or nuclear magnetic resonance. In the active period of UC, metabolites such as lipids, Amino acids showed a certain trend of change. …”
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MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…IntroductionSalivary mucin MUC5B has been suggested to support eubiosis in early oral biofilms by regulating the attachment of commensals, while downregulating dysbiotic activities related to dental caries development, such as microbial carbohydrate transport and metabolism.MethodsTo investigate how the metabolism of glucose, a potential driver for dental caries, in early mono- and dual-species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates was affected by the presence of the complex salivary mucin MUC5B, this study employed nuclear magnetic resonance (NMR)-based metabolomics with the interpretation of network integration.Results and discussionMUC5B reduced early attachment in the presence of glucose compared with uncoated surfaces but maintained even species distribution. …”
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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides by Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin

“…Methods: LBDA-D was identified as an output of this algorithm, in which the original LBDMj sequence was the input, and the three-dimensional solution structure of LBDB was determined using nuclear magnetic resonance. Furthermore, our study involved a comprehensive series of experiments, including morphological studies and in vitro and in vivo antibacterial tests. …”
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Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells by Hyun-Jae Jang, Kang-Hoon Kim, Eun-Jae Park, Jeong A. Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho

“…In this study, compounds 1–17, including undescribed podocarpane-type trinorditerpenoid (3), were purified from C. orbiculatus and their chemical structure were determined by high-resolution electrospray ionization mass (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopic data. To investigate the anti-inflammatory activity of compounds 1–17, nitric oxide (NO) secretion was evaluated in LPS-treated murine macrophages, RAW264.7 cells. …”
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An NMR Study of the Bortezomib Degradation under Clinical Use Conditions by Adele Bolognese, Anna Esposito, Michele Manfra, Lucio Catalano, Fara Petruzziello, Maria Carmen Martorelli, Raffaella Pagliuca, Vittoria Mazzarelli, Maria Ottiero, Melania Scalfaro, Bruno Rotoli

“…Commercial BTZ samples, reconstituted according to the reported commercial instructions and stored at 4∘C, were analyzed by high-field nuclear magnetic resonance spectroscopy in comparison with identical samples bubbled with air and argon, respectively. …”
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Unlocking innovation: Novel films synthesised and structurally analysed from poly (l-lactide-co-ethylene adipate) block copolymers blended with poly(lactic acid) by Athira John, Klementina Pušnik Črešnar, Johan Stanley, Sabina Vohl, Damjan Makuc, Dimitrios N. Bikiaris, Lidija Fras Zemljič

“…The study employs a range of analytical techniques, including Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Polarised Light Microscopy (PLM), Differential Scanning Calorimetry (DSC), and Thermogravimetric Analysis (TGA), to thoroughly characterize the copolymers and blend films. …”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy performed on neural cells at various developmental stages, from human embryonic stem cells to neurons.ResultsThe MetaboLINK analysis of longitudinal metabolomics data has revealed distinct pathways related to amino acids, lipids, and energy metabolism, uniquely associated with specific cell progenies. …”
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Hypoxylon luteogranulatum (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits by Sarunyou Wongkanoun, Esteban Charria-Girón, Marjorie Cedeño-Sanchez, Boonchuai Chainuwong, Sayanh Somrithipol, Eric Kuhnert, Prasert Srikitikulchai, Natapol Pornputtapong, Frank Surup, Jennifer Luangsa-ard, Marc Stadler

“…Its identity was confirmed after purification by preparative high-performance liquid chromatography with nuclear magnetic resonance (NMR) data, and genome analysis of H. lechatii revealed the presence of different hybrid polyketide synthases-non-ribosomal peptide synthetases (PKS-NRPS) hybrid clusters. …”
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Combined multi-scale characterization of pores in ultra-thick coal seams of Jurassic Xishanyao Formation, Tiaohu-Malang sags, Santanghu Basin by Yue CHEN, Qiqi LEI, Dongmin MA, Xin WANG, Xinggang WANG, Diefang HUANG, Gaoxiang RONG

“…Techniques such as high-pressure mercury intrusion porosimetry, low-temperature liquid nitrogen adsorption, nuclear magnetic resonance (NMR), CT scanning, scanning electron microscopy (SEM), and the pore-crack analysis system (PCAS) were used to investigate pore development characteristics. …”
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The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status by Jooa Kwon, Melanie R. Neeland, Justine A. Ellis, Jane Munro, Richard Saffery, Boris Novakovic, Toby Mansell

“…Methods Targeted nuclear magnetic resonance (NMR) metabolomic profiles of plasma of 72 children with JIA and 18 controls were assessed cross-sectionally. …”
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Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control by Nikolay A. Shulga, Vladimir I. Gegechkori, Natalya V. Gorpinchenko, Valery V. Smirnov, Sergey P. Dementyev, Galina V. Ramenskaya

“…The obtained product was purified using preparative chromatography and characterised by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR), and mass spectrometry. The structure was verified using primary research methods to confirm its identity as the target product. …”
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Influence of the carboxylate anion on the CO2 absorption mechanism using based-imidazolium ionic liquids by Diana Murillo-Criado, Fernando Aguilar-Galindo, Isabel Serrano, Miguel A. Gonzalez, Emilia Tojo, Inmaculada Suárez, Baudilio Coto, Maria Jose Tenorio

“…The efficacy of the capture process was assessed by quantifying the formation of an IL-CO₂ adduct using nuclear magnetic resonance (NMR) and attenuated total reflection infrared spectroscopy (ATR-IR). …”
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Decidualized ovarian and rectouterine deep endometriosis disguised as malignancy in the second-trimester of pregnancy: A case report by Lingjie Bao, Ting Wang, Yinping Xiao, Shouxin Gu, Xiaoyu Zhou, Yunxi Zheng, Yun Chen, Xiaofang Yi

“…Transvaginal ultrasound (TVS) showed bilateral adnexal masses of uneven echo with size 8.7 × 7.3 cm in the left ovary and size 5.5 × 4.8 cm in the right ovary, and another cystic mass with size 3.3 × 3.1 cm at rectouterine pouch. Serial nuclear magnetic resonance imaging (MRI) without contrast media for further evaluation indicated that these newly found pelvic masses were suspected to be ovarian endometrioid carcinoma with a metastasized lesion at rectouterine pouch. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…Methods This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from the UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models to explore the role of metabolomics in cirrhosis risk stratification in patients with CLD. …”
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A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data by Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N. Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

“…Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. …”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.MethodsThe derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). The Ellman’s assay was utilized to assess the inhibitory potential of derivatives against hAChE and hBuChE. …”
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