Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…We previously developed a method that calculated the islet graft function index (GFI) and a patient’s predicted insulin requirement (PIR) using mathematical nonlinear regression. Both PIR and GFI could be used by physicians as tools to monitor islet graft function and to guide supplementing the patient with exogenous insulin to prevent beta-cell exhaustion. …”
Get full text

Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Their luminescence can be tuned in the whole visible region down to the Near Infra-Red I (NIR-I) region while their nonlinear optical responses can be enhanced thanks to cooperative effects. …”
Get full text

Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

“…Given significant and replicable evidence for context-specific PGSBMI performance and effects, we investigated ways to increase model performance taking into account nonlinear effects. Machine learning models (neural networks) increased relative model R2 (mean 23%) across datasets. …”
Get full text

Long-term exposure to PM2.5 and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China by Jia-Hui Li, Hui-Xian Zeng, Jing Wei, Qi-Zhen Wu, Shuang-Jian Qin, Qing-Guo Zeng, Bin Zhao, Guang-Hui Dong, Ji-Chuan Shen, Xiao-Wen Zeng

“…Results: The observed associations typically displayed a nonlinear pattern. Compared to the lowest quartile of PM2.5 and its constituents, the fourth quartile was associated with higher odds of visual impairment in schoolchildren (e.g., the adjusted odds ratio (OR) was 1.23 (95% CI: 1.13, 1.33) for PM2.5, 1.53 (95% CI: 1.40, 1.67) for OM, and 1.35 (95% CI: 1.27, 1.44) for BC), respectively. …”
Get full text

Stock price prediction with attentive temporal convolution-based generative adversarial network by Ying Liu, Xiaohua Huang, Liwei Xiong, Ruyu Chang, Wenjing Wang, Long Chen

“…Stock price prediction presents significant challenges owing to the highly volatile and nonlinear nature of financial markets, which are influenced by various factors including macroeconomic conditions, policy changes, and market sentiment. …”
Get full text

Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

“…However, advanced deep learning models such as Single Cell Variational Inference (scVI) have the capability to capture nonlinear gene expression patterns in the sequencing data. …”
Get full text

Characterisation of cardiovascular disease (CVD) incidence and machine learning risk prediction in middle-aged and elderly populations: data from the China health and retirement lo... by Qing Huang, Zihao Jiang, Bo Shi, Jiaxu Meng, Li Shu, Fuyong Hu, Jing Mi

“…Shapley additive explanations (SHAP) analyses revealed the importance of key features, such as night sleep duration, TG levels, and waist circumference, in predicting outcomes, and highlighted the nonlinear relationships between these features and CVD risk. …”
Get full text

Sex-biased prevalence in infections with heterosexual, direct, and vector-mediated transmission: a theoretical analysis by Andrea Pugliese, Abba B. Gumel, Fabio A. Milner, Jorge X. Velasco-Hernandez

“…In the first model, where the other two transmission modes are not considered, the attack ratios (fractions of the population of each sex that will eventually be infected) can be obtained as solutions of a system of two nonlinear equations, that has a unique solution if the net reproduction number exceeds unity. …”
Get full text

Shock reaction model for impact energy release behavior of Al/PTFE reactive material by Bao-yue Guo, Ke-rong Ren, Xia-yin Ma, Gan Li, Cai-min Huang, Zhi-bin Li, Rong Chen

“…At the same time, the shock reaction model is embedded into the material library of the LS-DYNA nonlinear dynamic simulation software as a secondary development. …”
Get full text

Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors by Saima Rashid, Abdul Bariq, Ilyas Ali, Sobia Sultana, Ayesha Siddiqa, Sayed K. Elagan

“…Through the application of nonlinear least squares, we determine the parameter values applying actual cases collected from Canada. …”
Get full text

Age-stratified analysis of the BMI-kidney stone relationship: findings from a national cross-sectional study by Liuliu Zhou, Wei Gu, Yufeng Jiang, Haimin Zhang

“…BackgroundThe association between body mass index (BMI) and kidney stone formation may vary across different age groups and follow nonlinear patterns.MethodsThis study analyzed data from NHANES 2009–2018, including 14,880 participants aged ≥20 years, to evaluate the association between BMI and the risk of kidney stones. …”
Get full text

Associations of PM2.5 and its components with term preterm rupture of membranes: a retrospective study by Jiangxia Qin, Weiling Liu, Haidong Zou, Chong Zeng, Cifeng Gao, Weiqi Liu

“…Specifically, the interquartile range (IQR) 3 (IQR3) and IQR4 of ${\mathrm{SO}}_{4}^{2-}$ SO 4 2 − exposure during the third trimester increased the risk of TPROM by 18% (95% CIs [1.01–1.39]) and 18% (95% CIs [1.01–1.39]), respectively. A nonlinear relationship was observed between exposure to PM2.5, ${\mathrm{SO}}_{4}^{2-}$ SO 4 2 − , ${\mathrm{NH}}_{4}^{+}$ NH 4 + , and OM during the second trimester and the risk of TPROM. …”
Get full text

Mathematical Modelling and Analysis of Transmission Dynamics of Lassa Fever by E. A. Bakare, E. B. Are, O. E. Abolarin, S. A. Osanyinlusi, Benitho Ngwu, Obiaderi N. Ubaka

“…In this work, a periodically forced seasonal nonautonomous system of a nonlinear ordinary differential equation is developed that captures the dynamics of Lassa fever transmission and seasonal variation in the birth of Mastomys rodents where time was measured in days to capture seasonality. …”
Get full text

Construction and Optimization of Integrated Yield Prediction Model Based on Phenotypic Characteristics of Rice Grown in Small–Scale Plantations by Jihong Sun, Peng Tian, Zhaowen Li, Xinrui Wang, Haokai Zhang, Jiangquan Chen, Ye Qian

“…Although machine learning can handle complex nonlinear problems to enhance prediction accuracy, further improvements in models are still needed to accurately predict rice yields in small areas facing complex planting environments, thereby enhancing model performance. …”
Get full text

The Relationship Between Novel Inflammatory Markers and Serum 25‐Hydroxyvitamin D Among US Adults by Hang Zhao, Yangyang Zhao, Yini Fang, Weibang Zhou, Wenjing Zhang, Jiecheng Peng

“…To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. Upon detecting nonlinear relationships, we used a recursive algorithm to pinpoint the inflection point. …”
Get full text

L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 by Xiaotong Chen, Haiwei Chen, Yuling Chen, Lixin Tang, Jiaqi Liu, Yu-Hua Ou

“…Additionally, we implemented smooth curve fitting and threshold effect analysis, to delineate the complex, nonlinear association between iron intake and HPV infection. …”
Get full text

Oat Nutrition, Traits, and Yield as Affected by the Interaction of Nitrogen Rates and Plant Density in Sandy Soil by Zhiling Lin, Jianqiang Deng, Kai Gao, Zhixin Zhang

“…The pasture biomass increased nonlinearly with increasing planting density and N rate, and the maximum thresholds for C, N, and P uptake were 389.43 g kg⁻¹, 11.19 g kg⁻¹, and 3.10 g kg⁻¹ at N3, respectively. …”
Get full text

Genetic Profile and Associated Characteristics of 150 Korean Patients with Retinitis Pigmentosa by You Na Kim, Yoon Jeon Kim, Chang Ahn Seol, Eul-Ju Seo, Joo Yong Lee, Young Hee Yoon

“…The best-corrected visual acuity (BCVA) deterioration and photoreceptor disruption progression rates were determined based on the major causative mutational genes using nonlinear mixed models, and the differences among them were investigated using the interaction effect. …”
Get full text

Exploring the Association Between Triglyceride-Glucose Indices and Their Derivatives With Obstructive Sleep Apnea: Insights From the National Health and Nutrition Examination Surve... by Zhou Y, Xue F

“…TyG showed a linear relationship with OSA, while TyG-BMI, TyG-WC, and TyG-WHtR exhibited nonlinear relationships. The diagnostic capability was highest for TyG-WC, with an AUC of 0.647.Conclusion: The study confirms strong associations between OSA and the TyG indices, particularly TyG-WC, which demonstrates significant predictive power for OSA risk. …”
Get full text

Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, fro... by Wei Cui, Hongxia Gao, Liran Zhu, Yuanyuan Xu, Haipeng Liu

“…A quasi-Poisson generalized linear regression model combined with a distributed lag nonlinear model was applied to evaluate the association between air pollution and outpatient visits for childhood NAR. …”
Get full text