Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng

“…This paper reviews the structural diversity and biological activity of secondary metabolites isolated from mangrove ecosystem-derived <i>Penicillium</i> species over the past 5 years (January 2020–October 2024), and 417 natural products (including 170 new compounds, among which 32 new compounds were separated under the guidance of molecular networking and the OSMAC approach) are described. …”
Get full text

Co-creation of a gender responsive TB intervention in Nigeria: a researcher-led collaborative study by Chukwuebuka Ugwu, Oluwatoyosi Adekeye, Beate Ringwald, Rachael Thomson, Obioma Chijioke-Akaniro, Chukwuma Anyaike, S Bertel Squire, John Bimba, Tom Wingfield

“…The absence of a comprehensive guidance and the lack of substantial empirical evidence on TB care approaches that are responsive to the needs of men in Nigeria exacerbates this problem. …”
Get full text

Dietary and environmental factors affecting the dynamics of the gut bacteria in Tibetan Awang sheep (Ovis aries) across divergent breeding models by Yuhao Wang, Xinping Wang, Yirong Wang, Yirong Wang, Songyu Liao, Zhaxi Pubu, Jiangcuo Silang, Lixu Chai, Siyue Zhao, Siyue Zhao

“…The present findings provide insights into the microbiota dynamics of Awang sheep and offer guidance for their scientific husbandry management.…”
Get full text

Brief Warm and Aldo-Keto Reductase Family <i>AspiAKR1B1</i> Contribute to Cold Adaptation of <i>Aleurocanthus spiniferus</i> by Zhi-Fei Jia, Yan-Ge Cui, Meng-Yuan Liu, Jeremiah Joe Kabissa, Yong-Yu Xu, Zhi-Wei Kang, Zhen-Zhen Chen

“…This research provides theoretical support for preventing the further spread of <i>A. spiniferus</i> to higher latitudes, and offers technical guidance for developing effective pest control measures.…”
Get full text

Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…The differentially expressed genes were affected for small cell lung cancer, axon guidance, Fc gamma R-mediated phagocytosis, MAPK signaling pathway, focal adhesion, insulin resistance, and metabolic pathways. …”
Get full text

Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey by Metin Pekağırbaş, Mehmet Karakuş, Elif Dönmez, Hüseyin Gökhan Özdemir, Yusuf Özbel, Seray Töz

“…This study aimed to survey (i) the treatment, diagnosis, and control measures preferred by veterinarians, (ii) compare the differences in the first-step diagnostic tests applied, and (iii) identify differences in the guidance for CanL. Methods: This study was conducted between August 2017 and 2019, and an accessible weblink was distributed to veterinary clinics that were registered with the Veterinary Affairs of İzmir. …”
Get full text

Application of machine learning algorithms in predicting new onset hypertension: a study based on the China Health and Nutrition Survey by Manhui Zhang, Xian Xia, Qiqi Wang, Yue Pan, Guanyi Zhang, Zhigang Wang

Get full text

Larviciding for malaria control and elimination in Africa by Gretchen Newby, Prosper Chaki, Mark Latham, Dulcisária Marrenjo, Eric Ochomo, Derric Nimmo, Edward Thomsen, Allison Tatarsky, Elijah O. Juma, Michael Macdonald

“…Such a platform can serve as a resource center for African malaria programmes, collating and disseminating technical guidance, facilitating the exchange of best practices, and aiding malaria programmes and partners in designing and evaluating larviciding projects. …”
Get full text

Defining national research priorities for prostate cancer in Zambia: using the Delphi process for comprehensive cancer policy setting in sub-Saharan Africa by Ajay Aggarwal, Janet Seeley, Virginia Bond, Kennedy Lishimpi, John Kachimba, Musonda Simwinga, Andrew Sentoogo Ssemata, Susan Msadabwe, Dorothy Chilambe Lombe, Monde Mwamba, Richard Muhumuza, Victor Mapulanga

“…The expectation is with this guidance international partners can contribute within the frameworks of the local agenda for sustainable development to be realised.…”
Get full text

Diagnostic Decision-Making Variability Between Novice and Expert Optometrists for Glaucoma: Comparative Analysis to Inform AI System Design by Faisal Ghaffar, Nadine M. Furtado, Imad Ali, Catherine Burns

“… BackgroundWhile expert optometrists tend to rely on a deep understanding of the disease and intuitive pattern recognition, those with less experience may depend more on extensive data, comparisons, and external guidance. Understanding these variations is important for developing artificial intelligence (AI) systems that can effectively support optometrists with varying degrees of experience and minimize decision inconsistencies. …”
Get full text

Pharmacy students’ opinion on mandatory summer internships carried out in community and hospital pharmacies by Lucyna Bułaś, Anna Gołda, Ewa Długosz, Artur Owczarek, Anna Zagaja, Mariola Drozd

“…The survey contained 17 questions that sought to gain insight into their perceptions of the internship’s supervision and guidance of work by tutors and pharmacy staff, involvement in different workplace routines and comparison between formal education and everyday practice. …”
Get full text

Perspectives of People with Type 2 Diabetes Mellitus Towards a Decision Aid Assessing Preferences of Glucose-Lowering Drugs: The Dilemma of Choosing by Roldan Munoz S, Mol PGM, de Vries F, van Dijk PR, Hillege H, Postmus D, de Vries ST

“…Regarding usability, missing information was identified, as well as patients’ perspectives about the usefulness of the DA and its role in shared-decision making.Conclusion: The DA was considered promising for shared-decision making but further improvements regarding its comprehensibility and usability are needed, for which this study provides clear guidance.Keywords: decision aid, diabetes mellitus, type 2, qualitative research, participant preference…”
Get full text

Smart blockchain-powered natural resource asset management and ecological governance countermeasures by Wende Huang, Yuan Han, Qiang Gu, Xiaolong Han, Tiansheng Gao

“…Simultaneously, it is necessary to strengthen policy guidance and legal framework construction to furnish robust guarantees for the application of BT in ecological governance. …”
Get full text

Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study by Jian Xiao, Mengyao Li, Ruwen Cai, Hangxing Huang, Huimin Yu, Ling Huang, Jingyang Li, Ting Yu, Jiani Zhang, Shuqiao Cheng

“…The system’s ability to provide medication guidance and health management was assessed by senior health care professionals using a 5-point Likert scale across 3 groups: outputs generated by the system (DUMS group), outputs refined by pharmacists (intervention group), and outputs generated by ChatGPT-4 (GPT-4 group). …”
Get full text

Impact of pharmacist-prescriber partnerships to track antibiotic prescribing in publicly funded primary care in the Cape Town metropole, South Africa: An implementation study by O Van Hecke, Y Adegoke, M Allwood, K von Pressentin, M Namane, C Butler, M Mendelson, R Coetzee

“…Against AWaRe (access/watch/reserve) guidance, 97% of antibiotics prescribed belonged to the ‘access’ group. …”
Get full text

Comparative analysis of Sentinel-2 and PlanetScope imagery for chlorophyll-a prediction using machine learning models by Eden T. Wasehun, Leila Hashemi Beni, Courtney A. Di Vittorio, Christopher M. Zarzar, Kyana R.L. Young

“…The outcomes of our research provide guidance for enhancing inland water quality monitoring practices on small water bodies, emphasizing the importance of selecting optimal inversion models based on satellite data sources. …”
Get full text

Effects of the maternal and child health handbook and other home-based records on mothers’ non-health outcomes: a systematic review by Akira Shibanuma, Masamine Jimba, Rogie Royce Carandang, Jennifer Lisa Sakamoto, Ekaterina Yarotskaya, Milana Basargina, Mika Kondo Kunieda

“…Barriers to effective communication included a lack of satisfactory explanations regarding the use of home-based records and personalised guidance from healthcare providers. These records were also inconsistently used across different health facilities and professionals.Conclusions The MCH handbook fostered the mother–child bond. …”
Get full text

Systematic review and bayesian network meta-analysis: comparative efficacy and safety of six commonly used biologic therapies for moderate-to-severe Crohn’s disease by Haohang Su, Haohang Su, Shengwei Xiao, Zhiqing Liang, Zhiqing Liang, Tianrong Xun, Jinfang Zhang, Jinfang Zhang, Xixiao Yang, Xixiao Yang

“…Finally, we completed sensitivity and consistency analyses, and evaluated the certainty of evidence through GRADE working group guidance.ResultsWe identified 22 and 20 RCTs for induction and maintenance therapy, respectively. …”
Get full text

Outlining the Psychological Profile of Persistent Depression in Fibromyalgia Patients Through Personality Assessment Inventory (PAI) by Andrea Doreste, Jesus Pujol, Eva Penelo, Víctor Pérez, Laura Blanco-Hinojo, Gerard Martínez-Vilavella, Helena Pardina-Torner, Fabiola Ojeda, Jordi Monfort, Joan Deus

“…<b>Conclusions:</b> The PAI effectively identifies PDD in FM patients and detects concurrent MD episodes, aiding in better prognostic and therapeutic guidance.…”
Get full text

Trends in Mycoplasma pneumoniae infections in pediatric patient preceding, during, and following the COVID-19 pandemic: a comprehensive longitudinal analysis by Jianwei Zhang, Ruoya Wu, Liyan Mo, Jinlong Ding, Ke Huang

“…This study explored how the COVID-19 pandemic has influenced the prevalence of M. pneumoniae and provided guidance for disease treatment and infection prevention.…”
Get full text