The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review by I Gusti Ngurah Wien Aryana, Febyan Febyan, Nyoman Gede Grenata Nanda Ustriyana

“…These injuries lack inherent regeneration mechanisms due to the absence of blood vessels and limited progenitor cell entry. Osteoarthritis is characterized by gradual cartilage deterioration. …”
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Effects of competition and bundled payment on the performance of hip replacement surgery in Stockholm, Sweden: results from a quasi-experimental study by Fanny Goude, Göran Garellick, Clas Rehnberg, Mikko Peltola, Henrik Malchau, Sverre Kittelsen

“…The final study sample consisted of 85 275 hip replacement surgeries, where the exposure group consisted of 14 570 surgeries (n=6380 prereform and n=8190 postreform) and the control group consisted of 70 705 surgeries (n=32 799 prereform and n=37 906 postreform).Intervention A reform involving patient choice, free entry of new providers and a bundled payment model for hip replacement surgery, which came into force in 2009 in Region Stockholm, Sweden.Outcome measures Performance is measured as length of stay of the surgical admission, adverse event rate within 90 days following surgery and patient satisfaction 1 year postsurgery.Results The reform successfully improved the adverse event rate (1.6 percentage reduction, p<0.05). …”
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Clinical experiences with robotic computed tomography-guided interventions: A comparison with manual technique by Ashwin Kumar A, Sivakumar Kannappan, Geetha G

“…Key parameters analyzed between the two groups included the volume CT dose index, dose-length product (DLP), target location, target depth, target size, distance from the entry point, needle angulation, procedural time, number of punctures, complications, and re-biopsy rates. …”
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Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle by Malinda HULUGALLA, Alireza MANSOURI, Elham WAEHAMA, Ihshan AKTHAR, Akio MIYAMOTO

“…The results showed that SE did not affect sperm kinetic parameters or the entry of sperm into the uterine glands. SE alone significantly upregulated the mRNA expression of inflammatory cytokines (NFKB2, TNF, IL1B, CXCL8), TLR2/1, and the inflammasome NLRP3, while downregulating NOD1. …”
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Structural insights into how Cas9 targets nucleosomes by Reina Nagamura, Tomoya Kujirai, Junko Kato, Yutaro Shuto, Tsukasa Kusakizako, Hisato Hirano, Masaki Endo, Seiichi Toki, Hiroaki Saika, Hitoshi Kurumizaka, Osamu Nureki

“…In the present study, we perform native-polyacrylamide gel electrophoresis (PAGE)  analyses and find that Cas9 targets the linker DNA and the entry-exit DNA region of the nucleosome but not the DNA tightly wrapped around the histone octamer. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…Furthermore, pretreatment with the HR inhibitor B02 significantly enhanced CIRT sensitivity in a radioresistant PDAC cell line when irradiated in the spread-out Bragg peak but not at the entry position of the beam. These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
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Anterior Segment Optical Coherence Tomography Evaluation of a Dexamethasone Intravitreal Implant in the Crystalline Lens: A Case Report by Santos-Oliveira J, Teixeira-Martins R, Ferreira AM, Macedo JP, Oliveira-Ferreira C

“…An AS-OCT was done to better understand the implant’s location and entry point. Due to decreased visual acuity, the patient was scheduled for surgery. …”
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Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1 by Jiraporn Ousingsawat, Khaoula Talbi, Hilario Gómez-Martín, Anne Koy, Alberto Fernández-Jaén, Hasan Tekgül, Esra Serdaroğlu, Juan Darío Ortigoza-Escobar, Rainer Schreiber, Karl Kunzelmann

“…Results Upon expression, emptying of the endoplasmic reticulum Ca2+ store (store release) and particularly store-operated Ca2+ entry (SOCE) were strongly inhibited, leading to impaired activation of KCa3.1 (KCNN) K+ channels, but not of Na+-activated K+ channels (KNa; SLO2). …”
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Discovery and Characterization of Novel Esterases with Ethyl Carbamate-Hydrolyzing Activity by LIU Qingtao, ZHU Sibao, WANG Tianwen, LI Chuang, QIAN Senhe, ZHANG Wenqing, CHENG Fan, TIAN Shufang

“…Structural analysis indicated that the narrow substrate channel of ES9 might affect the entry of EC, thus affecting its maximum reaction rate (Vmax) toward EC; the relatively high affinity of ES9 for EC might be attributed to the strong hydrogen bonding between them. …”
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Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomi... by Angela O’Dea, Marie Tierney, Brian E. McGuire, John Newell, Liam G. Glynn, Irene Gibson, Eoin Noctor, Andrii Danyliv, Susan B. Connolly, Fidelma P. Dunne

“…The primary outcome variable was the change in fasting plasma glucose (FPG) from study entry to one-year follow-up. Results. At one-year follow-up, the intervention group showed significant improvements over the wait control group on stress, diet self-efficacy, and quality of life. …”
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Strategic Management Modeling for Offshore Tugboat and Support Vessel Operations: A Hybrid SWOT-TOWS Fuzzy DEMATEL-TOPSIS Framework by Ali Burçin Eke, Ozan Batmaz, Muhammed Fatih Gülen, Esma Uflaz, Özcan Arslan

“…These results show that operational cost reduction through technological innovation and emerging market entry is a strategic priority. This study contributes significantly to the existing literature by providing a robust strategic management model tailored to address the unique challenges of offshore maritime operations. …”
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Eligibility of Dapagliflozin and Empagliflozin in a Real-World Heart Failure Population by Erik Håkansson, Helena Norberg, Sara Själander, Krister Lindmark

“…Compared to trial participants, eligible real-world patients were significantly older with worse renal function, more atrial fibrillation, and less diabetes mellitus. Trial entry criteria exclude comparatively young and healthy patients, as well as comparatively old patients with more comorbid conditions.…”
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Validation of a one-step reverse transcription PCR detection method for Tobamovirus maculatessellati, in tomato (Solanum lycopersicum L.) and pepper (Capsicum annuum L.) by Chellappan Padmanabhan, Andrea Gilliard, Kai-Shu Ling, Yazmín Rivera

“…Species-specific identification is crucial to prevent the entry and establishment of plant pathogens and protect the billion-dollar tomato industry. …”
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Proclamation of the All-Russian Empire – the Beginning of the Way to the Great Power Status by V. A. Artamonov

“…Russia could not compare with the great powers of that time neither in terms of economic (industrial, financial) power, nor in terms of the intensity of expansionism. The entry of the Russian Empire into the system of international relations as one of the five great powers – France, Great Britain, Austria, Prussia, and Russia – occurred during the Seven Years War of 1756-1763. …”
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Feasibility and safety of zero-fluoro, “apron-less” approach to repeat pulmonary vein isolation procedures using radiofrequency energy after initial cryoballoon ablation by Vedran Velagic, Vedran Pasara, Ivan Prepolec, Andrija Nekic, Zvonimir Katic, Davor Milicic

“…In all patients successful PV isolation was performed, confirmed by entry and exit block. No major periprocedural complications were observed. …”
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An optimized data analytics pipeline for improving healthcare diagnosis using ensemble learning by Lomat Haider Chowdhury, Shaira Tabassum, Swakkhar Shatabda, Ashir Ahmed

“…Outliers in a medical dataset represent extreme cases and rare conditions, or they may even be generated due to data entry errors. An excessive number of outliers may lead to a skewed and incorrect prediction. …”
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Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang

“…Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel. However, its function in fat deposition is poorly understood, particularly in pigs, which are both an ideal model for human obesity research and a primary meat source for human diets. …”
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Niche markets for sustainable agri-food systems: A systematic review by Kehinde Oluseyi Olagunju, Simone Angioloni, Maurizio Canavari

“…Findings from the selected literature (58 articles) indicate that developing niche markets to deliver sustainable agriculture is subject to various challenges related to risk exposure, entry barriers, changing consumer preferences, and institutional context. …”
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EVALUATION OF SMARTNESS OF THE TOURISM DESTINATION WEBSITES OF THE KLAIPEDA REGION by Julius Ramanauskas, Šarūnas Banevičius, Putinas Bielskis

“…Furthermore, it was observed that there is no unified city card system in place for public transport and entry to museums. The findings of the study offer valuable insights into the potential for enhancing the websites of information tourism centres by evaluating them in light of the objectives of smart city and smart tourism.…”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…The underlying molecular processes revealed that the high and stable expression of SLC7A11 hindered the nuclear entry of GR, thereby suppressing TAP1 transcription and the presentation of MHC-I molecules. …”
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