Cabozantinib Resolves Bone Scans in Tumor-Naïve Mice Harboring Skeletal Injuries by Michael G. Doran, Daniel E. Spratt, John Wongvipat, David Ulmert, Brett S. Carver, Charles L. Sawyers, Michael J. Evans

“…Among malignancies with tropism for the bone (prostate, breast), one striking feature of early clinical reports about this drug has been the rapid and complete resolution of bone scans, a phenomenon almost never observed even among therapies already shown to confer survival benefit. …”
Get full text

What Will the European Climate Look Like in the Future? A Climate Analog Analysis Accounting for Dependencies Between Variables by B. Bulut, M. Vrac, N. deNoblet‐Ducoudré

“…The grid‐based calculation of analogs over the selected European domain was carried out using a newly proposed distance between multivariate distributions, the Wasserstein distance, that has never been used so far for climate analog calculations. …”
Get full text

Musculoskeletal Conditions in the Health Personnel of the Comprehensive Area of COVID-19 by Melba Esperanza Narváez Jaramillo, Cinthya Lizeth Pantoja Narváez, Julio Rodrigo Morillo Cano, Olga Mireya Alonzo Pico

“…<br /><strong>Results:</strong> 86 % said they almost never felt discomfort when doing their work, 57 % reported having discomfort that has prevented them from carrying out their work normally and the same percentage reported almost always feeling pain in the neck, shoulder, back, arms and hands. 43 % recognized that the discomfort felt is a consequence of their workday. …”
Get full text

Consistent patterns of LiDAR-derived measures of savanna vegetation complexity between wet and dry seasons by Zhengyang Wang, Jenia Singh, Andrew B. Davies

“…It is assumed that seasonal variation in vegetation structure is not substantive enough to affect landscape-level correlational analyses, but this assumption has never been explicitly tested in savanna ecosystems. …”
Get full text

The liber sepulturarum of the collegiate church of Saint-Paul of Lyon by Hervé Chopin

“…The liber sepulturarum of the collegiate church of Saint-Paul in Lyon is a unique document that was published but never actually utilised in a more in-depth study. …”
Get full text

Examining the affordable connectivity program and telehealth use: a pilot survey of the affordable connectivity program, telehealth, video and audio visits in a racially diverse, l... by Omolola E. Adepoju, Patrick Dang, Carlos Fuentes, Winston Liaw

“…Only 2 of 10 respondents had heard of ACP and were enrolled, while approximately 4 in 10 had never heard of it. Respondent knowledge/enrollment in the ACP was not significantly associated with telehealth, video consult, or telephone usage. …”
Get full text

Myocardial Gene Expression of T-bet, GATA-3, Ror-γt, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response by Luciana Gabriel Nogueira, Ronaldo Honorato Barros Santos, Alfredo Inácio Fiorelli, Eliane Conti Mairena, Luiz Alberto Benvenuti, Edimar Alcides Bocchi, Noedir Antonio Stolf, Jorge Kalil, Edecio Cunha-Neto

“…Although the T cell-rich myocarditis is known to play a pathogenetic role, the relative contribution of each of the functional T cell subsets has never been thoroughly investigated. We therefore assessed gene expression of cytokines and transcription factors involved in differentiation and effector function of each functional T cell subset (TH1/TH2/TH17/Treg) in CCC, NIC, and heart donor myocardial samples. …”
Get full text

TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. …”
Get full text

Short-Term Health Impact Assessment of Urban PM10 in Bejaia City (Algeria) by Fatima Benaissa, Cara Nichole Maesano, Rezak Alkama, Isabella Annesi-Maesano

“…We used Health Impact Assessment (HIA) to analyze the impact on a given population’s health outcomes in terms of all-causes mortality and respiratory and cardiovascular hospitalizations attributable to short-term exposure to particulate matter less than 10 μm diameter (PM10) in Bejaia city, for which health effects of air pollution have never been investigated. Two scenarios of PM10 reduction were considered: first, a scenario where the PM10 annual mean is decreased by 5 µg/m3, and then a scenario where this PM10 mean is decreased to 20 µg/m3 (World Health Organization annual air quality guideline (WHO-AQG)). …”
Get full text

Role of the hospital pharmacists during COVID-19 pandemic in the RN Macedonia by Zorica Naumovska, Biljana Lazarova, Maja Kovaceva, Aleksandra Kapedanovska Nestorovska, Maja Simonoska Crcarevska, Evgenija Mihajloska, Aleksandar Dimkovski

“…The study revealed that 37.5% of participants always, 20.8% frequently, and 29.2% occasionally felt depressed or fatigued during the pandemic, though 83% never considered leaving their jobs. The survey found that 87.5% of pharmacists experienced shortages of masks, gloves, and disinfectants early in the pandemic, and 100% noted the increased cost of these supplies. …”
Get full text

The role of starting knee angle in squat jump force-velocity profiles: interactions with subjects’ strength levels and imputed push-off distance by Xuelin Qin, Beibei Liu, Ruolin Tang, Yan Liu, Amador García-Ramos, Amador García-Ramos

“…These differences were never influenced by subjects’ strength levels. The standardized HpO produced similar outcomes for maximum power (Pmax) and maximum velocity (v0), and more consistent results for F0 and the F-v slope compared to the actual HpO.DiscussionRegardless of strength levels, standardizing HpO at 90° and allowing subjects to select a starting knee angle between 70° and 90° could simplify the evaluation process and improve the comparability of F-v profiles across subjects when using Samozino’s method.…”
Get full text

Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients by K. Morawska, M. Maciejczyk, S. Zięba, Ł. Popławski, A. Kita-Popławska, J. Krętowski, A. Zalewska

“…The study group consisted of 25 female patients diagnosed with Hashimoto’s disease in its spontaneous euthyroid state who had never received hormonal treatment. In more than half of the examined patients, we observed the level of UWS secretion below 0.2 mL/min, indicating impaired secretory function of the salivary glands. …”
Get full text

Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study by V. N. Afonyushkin, O. E. Sysoeva, O. S. Kozlova, D. V. Shamovskaya

“…A distinctive feature of feline coronavirus infection and, in particular, infectious feline peritonitis, from human COVID-19 infection was considered to be the presence of effusion peritonitis as the main complication leading to death, while respiratory and card iovascular in sufficiency is more characteristic for humans. Never the less, cases of serous peritonitis in humans infected with COVID-19 have already been described. …”
Get full text

Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates by Shantanu Rastogi, Hariprem Rajasekhar, Anju Gupta, Alok Bhutada, Deepa Rastogi, Jen-Tien Wung

“…BW significantly affects weaning among intubated and non-intubated neonates, though in neonates who were never intubated chorioamnionitis, anemia and GER also significantly affected the duration on NCPAP.…”
Get full text

Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk by Luca Miele, Cristina Bosetti, Federica Turati, Gianlodovico Rapaccini, Antonio Gasbarrini, Carlo La Vecchia, Stefania Boccia, Antonio Grieco

“…Compared to nondiabetic subjects who were never smokers, those who were diabetics and ever smokers had an OR of 6.61 (95% CI 3.31–13.25). …”
Get full text

Biocompatibility of variable thicknesses of a novel directly printed aligner in orthodontics by Maximilian Bleilöb, Claudia Welte-Jzyk, Vanessa Knode, Björn Ludwig, Christina Erbe

“…However, cell viability never decreased by more than 30%, meeting EN ISO 10993-5 standards for non-cytotoxicity. …”
Get full text

Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells by Kimberly Thando Peta, Melvin Anyasi Ambele, Michael Sean Pepper

“…Tumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. …”
Get full text

A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes by Stefano Zucchini, Andrea E. Scaramuzza, Riccardo Bonfanti, Pietro Buono, Francesca Cardella, Vittoria Cauvin, Valentino Cherubini, Giovanni Chiari, Giuseppe d’Annunzio, Anna Paola Frongia, Dario Iafusco, Giulio Maltoni, Ippolita Patrizia Patera, Sonia Toni, Stefano Tumini, Ivana Rabbone, Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED)

“…Bicarbonate was quite never been used. Insulin was infused starting from third hour at the rate of 0.05–0.1 U/kg/h in 72% of centers. …”
Get full text

Influence of the Clinical Status on Stress Reticulocytes, CD 36 and CD 49d of SSFA2 Homozygous Sickle Cell Patients Followed in Abidjan by Duni Sawadogo, Aïssata Tolo-Dilkébié, Mahawa Sangaré, Nelly Aguéhoundé, Hermance Kassi, Toussaint Latte

“…We selected 60 SS patients who had never been treated by hydroxyurea. We performed a total blood count. …”
Get full text

IL1RN and KRT13 Expression in Bladder Cancer: Association with Pathologic Characteristics and Smoking Status by Thomas S. Worst, Verena Reiner, Ute Gabriel, Christel Weiß, Philipp Erben, Thomas Martini, Christian Bolenz

“…In tissue samples of current smokers, a significant downregulation of IL1RN was found when compared to never smokers (P=0.013). Conclusion. Decreased expressions of KRT13 and IL1RN are common features of UCB and are associated with aggressive disease. …”
Get full text