Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants by Michelle R. Garnsey, Yang Wang, David J. Edmonds, Matthew F. Sammons, Benjamin Reidich, Youngwook Ahn, Yotam Ashkenazi, Anthony Carlo, Matthew A. Cerny, Karen J. Coffman, Jeffrey A. Culver, Anne-Marie Dechert Schmitt, Heather Eng, Ethan L. Fisher, Jemy A. Gutierrez, Larry James, Samantha Jordan, Jeffrey T. Kohrt, Melissa Kramer, Erik A. LaChapelle, Jack C. Lee, Jisun Lee, Dongmei Li, Zhenhong Li, Shenping Liu, Jianhua Liu, Thomas V. Magee, Melissa R. Miller, Michael Moran, Deane M. Nason, Nicole L. Nedoma, Steven V. O’Neil, Mary A. Piotrowski, Jillian Racich, Ruth F. Sommese, Lucy M. Stevens, Ann S. Wright, Jun Xiao, Liying Zhang, Dahui Zhou, Ornella Barrandon, Michelle F. Clasquin

“…Their application to cells endogenously expressing 17B-HSD13 enables quantitative measures of enzymatic inhibition in primary human hepatocytes which has never been reported to date. Application to multiple cellular systems expressing the protective human variants reveals that the most prevalent IsoD variant maintains NAD-dependent catalytic activity towards some but not all substrates, contradicting reports that the truncation results in loss-of-function.…”
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Intravesical Botulinum Toxin for Persistent Autonomic Dysreflexia in a Pediatric Patient by Gina Lockwood, Charles Durkee, Travis Groth

“…Intravesical botulinum toxin has never been reported for this use. Dedicated research is warranted to assess its efficacy, as it was used successfully to abort autonomic dysreflexia in this patient.…”
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Observation of the non-Hermitian skin effect and Fermi skin on a digital quantum computer by Ruizhe Shen, Tianqi Chen, Bo Yang, Ching Hua Lee

“…Yet, its interplay with many-body dynamics have never been experimentally investigated. Here, we report the observation of the NHSE and its many-fermion analog on a universal quantum processor. …”
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An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production by M. D. S. A. Dilrukshi, A. W. Wickramarachchi, D. D. K. Abeyaratne, Brian Shine, Bahram Jafar-Mohammadi, N. P. Somasundaram

“…Non-islet cell tumor hypoglycemia and ACTH-dependent Cushing’s syndrome are extremely rare presentations of an ACC, and co-occurrence of these entities in a single patient is never reported in the literature.…”
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On Consistency of Cross-Approximate Entropy in Cardiovascular and Artificial Environments by Tamara Skoric, Olivera Sarenac, Branislav Milovanovic, Nina Japundzic-Zigon, Dragana Bajic

“…Despite being derived from the firmly established solitary entropies, it has never reached their reputation and deployment. The aim of this study is to identify the problems that preclude wider XApEn implementation and to develop a set of solutions. …”
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A dual benchmarking study of facial forgery and facial forensics by Minh Tam Pham, Thanh Trung Huynh, Thanh Tam Nguyen, Thanh Toan Nguyen, Thanh Thi Nguyen, Jun Jo, Hongzhi Yin, Quoc Viet Hung Nguyen

“…The authors also provide a practical guideline of the benchmarking results, to determine the characteristics of the methods that serve as a comparative reference in this never‐ending war between measures and countermeasures. …”
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Improving expected shortage estimations in the base-stock policy by accounting for undershoots by Eugenia Babiloni, Ester Guijarro

“…., inventory levels are never below the reorder point, and undershoots are not considered. …”
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A Comparative Analysis of the Islamic State and the Muslim State through Historical Developments by Masoud Akhavan Kazemi

“…However, the existence and continuity of states with Islamic titles or appearances in the geography of the Islamic world and throughout the history of Islamic societies have never meant that these states are real and complete examples of “State in Islam”. …”
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The carbon isotopic signature of the upper mantle is heterogeneous by Yves Moussallam, Kenneth T. Koga, Estelle F. Rose–Koga, Cyril Aubaud, Hyun Joo Lee, Guillaume Georgeais

“…Here we report δ13C measurements on a series of CO2–undersaturated melts inclusions from the south–west Indian mid ocean Ridge. These rare magmas never degassed CO2 hence retaining a δ13C signature in direct equilibrium to their source mantle. …”
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Assessment of functional elements of public finance management by A. Z. Namitulina, I. V. Soklakova, E. Yu. Kuzmina, E. A. Buryak

“…Operational public financial management can never be considered without public resources designed to support and implement the activities of all areas of the country’s life. …”
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Unveiling Complexity: Cinematic Representations of Apartheid History and the Post-Apartheid Dutch- Afrikaner Relationship in <em>Black Butterflies</em> (2011) and <em>An Act of Def... by Anne Marieke van der Wal

“…The cinematic representation of Apartheid, and in particular the tendency of using white protagonists to narrate the story of black suffering, has been the object of much scholarly enquiry but this has never included Dutch films. This article explores the representation of Afrikaner anti-Apartheid activism in Dutch cinema through an analysis of the films Black Butterflies (2011) and An Act of Defiance (2017). …”
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Life-Long Physical Activity Involvement and the Risk of Ischemic Stroke in Southern China by Andy H. Lee, Wenbin Liang

“…The risk of ischemic stroke was inversely associated with life-long physical activity exposure, with adjusted odds ratio 0.39 (95% confidence interval 0.25 to 0.59) for participants who had always been involved relative to those who have never been much involved. The dose-response relationship was also significant (𝑃<.001). …”
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24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP+-Induced Oxidative Stress and Apoptosis by Julie Carange, Fanny Longpré, Benoit Daoust, Maria-Grazia Martinoli

“…However, their antioxidative effects on mammalian neuronal cells have never been examined so far. We analyzed the ability of 24-epibrassinolide (24-Epi), a natural BR, to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium- (MPP+-) induced oxidative stress and consequent apoptosis in dopaminergic neurons. …”
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K-12 teachers’ perceptions of the effectiveness of online EFL teaching and learning during the COVID-19 pandemic by Zou Bin, Chen Xinyi, Sun Weifeng

“…School teachers in China have had a taste of online teaching, which never appeared to be a necessity before the COVID-19 pandemic in 2020. …”
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The Societal Impact of Herpes Zoster and Postherpetic Neuralgia on Patients, Life Partners, and Children of Patients in Germany by Thomas Weinke, Andrea Glogger, Isabelle Bertrand, Kati Lukas

“…Former patients and their family never forgot this illness and its considerable impact on their lives, particularly when PHN occurred. …”
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From news images to action: the mobilizing effect of emotional protest images in news coverage by Stephanie Geise, Diana Panke, Axel Heck

“…The political power of images has probably never been stronger than in today's “information age” in which mobile devices allow instant access to news coverage of local, national, and global events, which are generally visualized in some way. …”
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Changes in Chinese Discharged Chronic Mental Patients Attending a Psychiatric Rehabilitation Program with Holistic Care Elements: A Quasi-Experimental Study by Andrew L. Luk, Daniel T.L. Shek

“…A quasi-experimental design involving an experimental group (109 participants attending the program) and a control group (154 patients from a psychiatric outpatient clinic who had never attended any SHG before) was adopted with the participants responding to measures assessing their functioning in the physical, psychological, social, and spiritual domains. …”
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The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial by Katie B Biello, Kenneth H Mayer, Hyman Scott, Pablo K Valente, Jonathan Hill-Rorie, Susan Buchbinder, Lucinda Ackah-Toffey, Patrick S Sullivan, Lisa Hightow-Weidman, Albert Y Liu

“…At baseline, participants self-reported the following: 29% (n=110) had never had an HIV test and 85% (n=324) had never used PrEP. …”
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De quoi l’héroïsme est-il le nom dans No Name de Wilkie Collins et A Tale of Two Cities de Charles Dickens ? by Sophie Naveau

“…Sydney Carton is a man of talents but he has never used them to serve his own name as he has lived in the shadow of another man. …”
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Ion Pillat – de la vilegiaturist la rezident al Balcicului by Carmen Brăgaru

“…Once he delimitates his own domestic refuge, the poet tends to come to this inspiring solar and marine space as often as he can, though he never identifies with the artistic Bohemia, famous at that time, being rather a solitary taster of the landscapes. …”
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