Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model by Yaoyi Zhang, Shuai Lv, Pinyuan Huang, Lingmin Xiao, Nan Lin, En Huang

“…It also promotes PPARG expression to blockage of NF-κB pathway-mediated inflammatory response and neuroinflammation.…”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.…”
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Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide by Hamid Azizi-Malekabadi, Mahmoud Hosseini, Masoume Pourganji, Hoda Zabihi, Mohsen Saeedjalali, Akbar Anaeigoudari

“…The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. …”
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Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis by Marco Rosina, Silvia Scaricamazza, Flaminia Riggio, Gianmarco Fenili, Flavia Giannessi, Alessandro Matteocci, Valentina Nesci, Illari Salvatori, Daniela F. Angelini, Katia Aquilano, Valerio Chiurchiù, Daniele Lettieri Barbato, Nicola Biagio Mercuri, Cristiana Valle, Alberto Ferri

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Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS by Valentina Naef, Devid Damiani, Rosario Licitra, Maria Marchese, Stefania Della Vecchia, Matteo Baggiani, Letizia Brogi, Daniele Galatolo, Silvia Landi, Filippo Maria Santorelli

“…., TTPA, RDH5, VKORC) and suggested a key role of neuroinflammation in driving the retinal defects. Our findings indicate that studying retinal pathology in ARSACS could be crucial for understanding the impact of sacsin depletion and may offer insights into halting disease progression.…”
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Contemporary comprehensive approaches to assessing the effectiveness of experimental model of neurodegenerative disorders with cognitive status changes by M. V. Danukalo, Yu. M. Kolesnyk, O. V. Hancheva

“…The applied pharmacological model of neurodegeneration with subsequent comprehensive assessment of animal behavior in an open field and an 8-arm radial maze is legitimate and can be used to study the early development of neuroinflammation, neuroapoptosis, and synaptogenesis disorders in the experiment.…”
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Understanding the role of potential biomarkers in attenuating multiple sclerosis progression via multiomics and network-based approach. by Nitesh Shriwash, Ayesha Aiman, Prithvi Singh, Seemi Farhat Basir, Anas Shamsi, Mohammad Shahid, Ravins Dohare, Asimul Islam

“…<h4>Background</h4>Multiple sclerosis (MS) is a complex neurological disorder marked by neuroinflammation and demyelination. Understanding its molecular basis is vital for developing effective treatments. …”
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The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions by Ricardo Martins-Ferreira, Josep Calafell-Segura, Bárbara Leal, Javier Rodríguez-Ubreva, Elena Martínez-Saez, Elisabetta Mereu, Paulo Pinho E Costa, Ariadna Laguna, Esteban Ballestar

“…Abstract Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression. …”
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Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications by Yan Zhang, Jin Liu, Junzhe Cheng, Hongkun Hu, Yumeng Ju, Mi Wang, Bangshan Liu

“…In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. …”
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Loss of SNHG4 Attenuated Spinal Nerve Ligation-Triggered Neuropathic Pain through Sponging miR-423-5p by Xia Pan, Cheng Shen, Yayi Huang, Long Wang, Zhongyuan Xia

“…Moreover, knockdown of SNHG4 could repress the neuroinflammation via inhibiting IL-6, IL-12, and TNF-α while inducing IL-10 levels. …”
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A Self-Emulsifying Nanococktail of Pomegranate and Cannabidiol Reduces Cognitive Decline in Mice by Shoseyov O, Palatnik A, Dadon-Freiberg M, Dagan O, Shaltiel Karyo R

“…In parallel, cannabis-derived cannabidiol (CBD) prevented social recognition deficits and reduced neuroinflammation in mice. This work assessed the impact of Nano-PSO:CBD on memory and learning.Methods: A battery of hemp extracts was screened for their effects on acetylcholine esterase inhibition and neuronal protection activities. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Significant changes in gene expression levels associated with neuroinflammation and nociception were observed in both the bladder and lumbosacral dorsal root ganglia (Ls-DRG) of the VCR group. …”
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Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke by Huaqiang Li, Huaqiang Li, Xiaohua Ke, Bianying Feng, Huan Tian, Huan Tian, Zhenzhen Cai, Anren Zhang, Qiuhong Man

“…Although the mechanisms underlying PSCI are complex and multifaceted, involving factors such as atherosclerosis and neuroinflammation, metabolic disorders also play a critical role. …”
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The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease by Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Zaw Myo Hein

“…We discuss how microbial dysbiosis promotes neuroinflammation, vascular dysfunction, and impaired waste clearance in the brain, which are critical factors in the pathogenesis of CSVD. …”
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Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase by Lies De Groef, Manuel Salinas-Navarro, Griet Van Imschoot, Claude Libert, Roosmarijn E. Vandenbroucke, Lieve Moons

“…Given the pivotal role of TNF as a proinflammatory cytokine and neurodegeneration-exacerbating mediator, these findings generate important novel insights into the pathological processes contributing to glaucomatous neurodegeneration and into the interplay of neuroinflammation and neurodegeneration in the CNS.…”
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Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis by Sheryl L. Coutermarsh-Ott, John T. Doran, Caroline Campbell, Tere M. Williams, David S. Lindsay, Irving C. Allen

“…During the chronic phase of infection, caspase-11 deficiency resulted in increased neuroinflammation and tissue cyst burden in the brain. …”
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Analgesic Mechanism of Sinomenine against Chronic Pain by Wei Jiang, Weiming Fan, Tianle Gao, Tao Li, Zhenming Yin, Huihui Guo, Lulu Wang, Yanxing Han, Jian-Dong Jiang

“…Sinomenine may alter the unbalanced neuroimmune interaction and inhibit neuroinflammation, oxidative stress, and central sensitization in chronic pain states. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…It is hypothesized that exercise-induced changes in ncRNA expression may regulate key processes involved in neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, and synaptic function. …”
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Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner by Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris

“…Alzheimer’s disease (AD) is characterized by chronic neuroinflammation, which is partially mediated by dysregulated functions of glial cells. …”
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Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail by Santosh Kumar Prajapati, Shaohua Wang, Sidharth P Mishra, Shalini Jain, Hariom Yadav

“…Remarkably, feeding mice with 1 × 1011 CFU per day in drinking water for 16 weeks significantly reduced cognitive decline (measured by the Morris Water Maze test) and AD pathology markers, such as Aβ aggregation, microglia activation, neuroinflammation, and preserved blood-brain barrier (BBB) tight junctions. …”
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