Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…Trimethyltin (TMT) is known as a potent neurotoxicant that causes neuronal cell death and neuroinflammation, particularly in the hippocampus. Microglial activation is one of the prominent pathological features of TMT neurotoxicity. …”
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Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Ne... by Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon

“…These results show that both neuroinflammation and neuronal loss profiles occurred concomitantly and appeared to be transitory processes. …”
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Roles of Brain Angiotensin II in Cognitive Function and Dementia by Masaki Mogi, Jun Iwanami, Masatsugu Horiuchi

“…Moreover, basic experiments suggest a role of brain angiotensin II in neural injury, neuroinflammation, and cognitive function and that RAS blockade attenuates cognitive impairment in rodent dementia models of AD. …”
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Multifocal disseminated necrotizing leukoencephalopathy as severe central nervous system toxicity from nivolumab therapy for Hodgkin lymphoma: a case report by Hussein Algahtani, Bader Shirah, Mohamed Najm Aldeen Alameen, Abdulrahman Bin Saeed, Alwaleed Abdulhadi Alqahtani

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Acute cerebral edema: a lethal neurological complication in a patient with COVID-19 infection. Case report and literature review by M. Puodžiūnaitė, R. Sadeckaitė, A. Čikotienė

“…COVID-19 induces CNS damage through various mechanisms including ACE-2 receptor damage, cytokine storm syndrome, secondary hypoxia, blood-brain barrier disruption, and neuroinflammation. Neurological symptoms correlate with the severity of COVID-19 disease and may range from asymptomatic infection to severe and lethal forms. …”
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Cognitive disorders: Potential astrocyte-based mechanism by Shiyu Li, Yeru Chen, Gang Chen

“…Dysfunction of astrocytes is intimately linked to cognitive disorders, and we are attempting to understand this phenomenon predominantly from those perspectives: neuroinflammation, astrocytic senescence, connexin, Ca2 + signaling, mitochondrial dysfunction, and the glymphatic system.…”
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The Effect of Smoking on SIRT3 and Selected Biochemical Variables in Patients with Parkinson’s Disease by Noor Abdulsatar Majeed, Mohammed Bahry Hassin

“…Moreover, biochemical analyzes demonstrated higher levels of oxidative stress markers and pro-inflammatory cytokines in the smoking group, indicating an exacerbation of neuroinflammation and oxidative damage in PD patients who smoke. …”
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Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models by Lisa Blackmer-Raynolds, Lyndsey D. Lipson, Isabel Fraccaroli, Ian N. Krout, Jianjun Chang, Timothy Robert Sampson

“…While APPSAA mice have been shown to develop progressive Aβ pathology and neuroinflammation, the age at which behavioral and cognitive impairments begin to develop has yet to be described. …”
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Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. These processes have been found to be involved in the pathological mechanisms of neurodegenerative diseases. …”
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Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage by Bosco Seong Kyu Yang, Spiros L. Blackburn, Philip L. Lorenzi, Huimahn A. Choi, Aaron M. Gusdon

“…They are comprised of a wide variety of subspecies and are critical for cellular energy metabolism, the integrity of the blood-brain barrier, the formation of cell membranes, and intercellular signaling including neuroinflammation and ferroptosis. In this review, metabolomic and lipidomic pathways associated with aSAH are summarized, centering on key metabolites from each metabolomic domain.…”
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Microbiome immune system interactions in selected neurological disorder by P. Omosigho, G. Sulaiman, O. Okesanya

“…Changes in gut microbiota composition and neuroinflammation mediated by the NLRP3 inflammasome have been observed in AD, suggesting a connection between microbiological variables and the course of the illness. …”
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Alterations in cerebral perfusion and corresponding brain functional networks in systemic lupus erythematosus with cognitive impairment by Huiyang Liu, Hu Liu, Bailing Tian, Pingting Yang, Guoguang Fan

“…Abstract Cognitive impairment (CI) frequently occurs in patients with systemic lupus erythematosus (SLE) and may result from neuroinflammation processes and neurovascular changes in the brain. …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…The authors investigated the effects of psychotropics on pathobiological proteins, proteasomal activity, mitochondrial functions, apoptosis, neuroinflammation, trophic factors, stem cells, and neurogenesis. …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…It has been consistently reported that the pathological process of this clinical syndrome is related to neuroinflammation and microglial proliferation. Glycogen synthase kinase 3β (GSK-3β) is a widely expressed kinase with distinct functions in different types of cells. …”
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Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease by Alexa L. Wright, Aldis P. Weible, Olivia B. Estes, Michael Wehr

“…Ketamine has received growing attention for its effects on neuroplasticity and neuroinflammation, and as a treatment for depression and other mental health disorders. …”
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Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review by Ubaid Ansari, Jimmy Wen, Burhaan Syed, Dawnica Nadora, Romteen Sedighi, Denise Nadora, Vincent Chen, Forshing Lui

“…This literature review extensively analyzes NP2's role in these conditions, thereby highlighting its contributions to synaptic dysfunction, neuroinflammation, and neurotoxic protein aggregation. …”
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The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease by Kemal Ugur Tufekci, Ezgi Civi Bayin, Sermin Genc, Kursad Genc

“…Both mitochondrial dysfunction and neuroinflammation, a common denominator of PD, lead to an increased production of reactive oxygen species, which are detrimental to neurons. …”
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Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy by Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky

“…These products are notified in Italy for the nutritional support in glaucoma and neuroinflammation. PEA has been tested in at least 9 double blind placebo controlled studies, among which two studies were in glaucoma, and found to be safe and effective up to 1.8 g/day, with excellent tolerability. …”
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A Retrospective Cohort Study with Blood Parameters for Early Estimation of Multiple Sclerosis: Ratio Suggestion by Esra Tekin, Sibel Canbaz Kabay, Ayşegül Küçük

“…Conclusion: NLR is considered a neuroinflammation marker. It is argued that NLR reflects systemic inflammation better than neutrophil and lymphocyte counts alone. …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…Monoclonal antibodies (MABs) serve as a promising therapeutic approach for AD by selectively targeting key pathogenic factors, such as amyloid-β (Aβ) peptide, tau protein, and neuroinflammation. Specifically, based on their efficacy in removing Aβ plaques from the brains of patients with AD, the U.S. …”
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