Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression by Amanda Gollo Bertollo, Camila Ferreira Santos, Margarete Dulce Bagatini, Zuleide Maria Ignácio

“…This allows endotoxins to enter the bloodstream, contributing to neuroinflammation and altering neurotransmitter production, including serotonin. …”
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Ac2-26 Alleviates Brain Injury after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats via the eNOS Pathway by Jing Gong, Qi-Hang Tai, Guang-Xiao Xu, Xue-Ting Wang, Jing-Li Zhu, Xiao-Qing Zhao, Hai-Bin Sun, Dan Zhu, Wei Gao

“…Ac2-26 and endothelial nitric oxide synthase (eNOS) have been shown to reduce neuroinflammation. This study is aimed at determining the mechanism by which Ac2-26 protects against inflammation during brain injury following CA and CPR. …”
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The Role of Gut Microbiota in Neurodegenerative Diseases by Hanna Porwolik, Agnieszka Porwolik, Magdalena Bodera, Radosław Szydłowski, Agata Porwolik, Barbara Skrzypiec, Anna Hamerla, Anna Kaźmierska, Julia Gawron

“… Introduction: The gut microbiota is a key component of the gut-brain axis, and its dysbiosis promotes neuroinflammation. The microbiome plays a significant role in the pathogenesis of neurodegenerative diseases. …”
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Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies by Sigal Fleisher-Berkovich, Nitzan Sharon, Yvonne Ventura, Valeria Feinshtein, Jonathan Gorelick, Nirit Bernstein, Shimon Ben-Shabat

“…Abstract Introduction Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neuroinflammation, demyelination and axonal loss. Cannabis, an immunomodulating agent, is known for its ability to treat MS effectively. …”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…PP2A activation has shown to reduce neuroinflammation in a mouse model of experimental autoimmune encephalomyelitis (EAE) and is now used to treat multiple sclerosis (MS) clinically. …”
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Exploring environmental factors contributing to Parkinson’s disease in AfrAbian populations by Wael Mohamed

“…In addition, we will investigate how these variables disrupt processes such as excitotoxicity, oxidative stress, and neuroinflammation, all of which are strongly linked to Parkinson’s disease (PD). …”
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Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases by Marjana Brkic, Sriram Balusu, Claude Libert, Roosmarijn E. Vandenbroucke

“…It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. …”
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Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications by Fang Du, Tao Tang, Qingzhu Li, Jiaxin Liu

“…This paper reviews the role of Fyn in the pathological process of cerebral ischemia-reperfusion, including neuroexcitotoxicity and neuroinflammation, to explore how Fyn affects specific signal cascades and leads to cerebral ischemia-reperfusion injury. …”
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Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide by Yazmin M. Flores-Martinez, Manuel A. Fernandez-Parrilla, Jose Ayala-Davila, David Reyes-Corona, Victor M. Blanco-Alvarez, Luis O. Soto-Rojas, Claudia Luna-Herrera, Juan A. Gonzalez-Barrios, Bertha A. Leon-Chavez, Maria E. Gutierrez-Castillo, Irma A. Martínez-Dávila, Daniel Martinez-Fong

“…During the acute phase of neuroinflammation, pro- and anti-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-4, and IL-10) responded differentially at mRNA and protein level. …”
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Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia by Caitlin A. Finney, David A. Brown, Artur Shvetcov

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Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists by Antonietta Bernardo, Luisa Minghetti

“…In the present article, we will review the recent findings supporting a major role for PPAR-𝛾 agonists in controlling neuroinflammation and neurodegeneration through their activities on glial cells, with a particular emphasis on microglial cells as major macrophage population of the brain parenchyma and main actors in brain inflammation.…”
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Neuro-inflammation, depression and fatigue in ESRD: Emerging role of microglia and acupuncture as a new treatment addressing neuro-inflammation in ESRD by Suandika Made, Handayani Rahmaya Nova, Muti Refa Teja

“…The purpose of this study is to propose that neuroinflammation-induced microglial activation may play an important role in these circumstances. …”
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Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…Since the discovery and characterization of the PD-1/PD-L pathway, mounting evidence has emerged regarding its role in regulating neuroinflammation following cerebrovascular injury. Classically, PD-L1 on antigen-presenting cells or tissues binds PD-1 on T cell surfaces resulting in T cell inhibition. …”
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Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells by Jian Li, Xiaolei Zhai, Chaochun Yu

“…Therefore, a comprehensive investigation into the spatial dynamics of immune cells following SCI is essential to uncover their mechanisms in neuroinflammation and repair, and to develop novel therapeutic strategies.…”
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Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin by Franco Cavaleri

“…Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome’s curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. …”
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Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause by Giuseppe Maria Andrea D’Arma, Rosario Francesco Balzano, Federica Masino, Giuseppe Guglielmi

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Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus by Termpanit Chalermpalanupap, David Weinshenker, Jacki M. Rorabaugh

“…., cognition, neuropathology, and neuroinflammation), the functional consequences of hyperphosphorylated tau accrual on LC neurons are not known. …”
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Schwann Cells in Neuromuscular Disorders: A Spotlight on Amyotrophic Lateral Sclerosis by Kathryn R. Moss, Smita Saxena

“…This review explores the role of Schwann cells in ALS pathogenesis, highlighting their influence on disease progression through mechanisms involving demyelination, neuroinflammation, and impaired synaptic function. While Schwann cells have been traditionally viewed as peripheral supportive cells, especially in motor neuron disease, recent evidence indicates that they play a significant role in ALS by impacting motor neuron survival and plasticity, influencing inflammatory responses, and altering myelination processes. …”
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Multifaceted roles of ninjurin1 in immunity, cell death, and disease by Lili Zhu, Yunfei Xu, Yunfei Xu

“…It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. Recent evidence indicates that NINJ1 mediates plasma membrane rupture (PMR) in lytic cell death. …”
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Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain by Sarah Taves, Temugin Berta, Gang Chen, Ru-Rong Ji

“…Microglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS. Microglial activation has been strongly implicated in neurodegeneration in the brain. …”
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